Mucosal inflammation downregulates PHD1 expression promoting a barrier‐protective HIF‐1α response in ulcerative colitis patients

Authors: Brown, Eric, Rowan, Catherine, Strowitzki, Moritz J., Fagundes, Raphael R., Faber, Klaas Nico, Güntsch, Annemarie, Halligan, Doug N., Kugler, Julia, Jones, Fiona, Lee, Chee T., Doherty, Glen, Taylor, Cormac T.

Source: FASEB journal. 34(3):3732-3742

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110341562.0x000001&indx=1&recIds=ETOCvdc_100110341562.0x000001

Prolyl Hydroxylase Inhibition Mitigates Pouchitis

Authors: Harnoss, Jonathan M, Gebhardt, Jasper M, Radhakrishnan, Praveen, Leowardi, Christine, Burmeister, Julius, Halligan, Doug N, Yuan, Shuai, Kennel, Kilian B, Strowitzki, Moritz J, Schaible, Anja, Lasitschka, Felix, Taylor, Cormac T, Schneider, Martin

Source: Inflammatory bowel diseases. 26(2):192-205

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Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis

Authors: Manresa, Mario C., Smith, Leila, Casals‐Diaz, Laura, Fagundes, Raphael R., Brown, Eric, Radhakrishnan, Praveen, Murphy, Stephen J., Crifo, Bianca, Strowitzki, Moritz J., Halligan, Doug N., van den Bogaard, Ellen H., Niehues, Hanna, Schneider, Martin, Taylor, Cormac T., Steinhoff, Martin

Source: Allergy. 74(4):753-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083051922.0x000001&indx=1&recIds=ETOCvdc_100083051922.0x000001

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes

Authors: Crifo, Bianca, Schaible, Bettina, Brown, Eric, Halligan, Doug N., Scholz, Carsten C., Fitzpatrick, Susan F., Kirwan, Anna, Roche, Helen M., Criscuoli, Mattia, Naldini, Antonella

Source: Journal of immunology. 202(5):1521-1530

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The hypoxia-inducible factor (HIF) couples immunity with metabolism

Authors: Halligan, Doug N., Murphy, Stephen J.E., Taylor, Cormac T.

Source: In Seminars in Immunology October 2016 28(5):469-477

Su1772 – Inflammation-Dependent Transcriptional Re-Programming of the Hif Pathway in the Mucosa of Ulcerative Colitis Patients

Authors: Brown, Eric, Rowan, Catherine, Strowitzki, Moritz, Rosa, Raphael Fagundes, Guentsch, Annemarie, Halligan, Doug N., Doherty, Glen, Taylor, Cormac

Source: Gastroenterology. 156(6):S-606-S-606

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100080830843.0x000001&indx=1&recIds=ETOCvdc_100080830843.0x000001

Su1810 – Combinatorial Treatment with a Hif-Hydroxylase Inhibitor and Cyclosporine Provides Enhanced Protection in Colitis Through Improved Barrier Function

Authors: Halligan, Doug N., Khan, Mohammed, Brown, Eric, Rowan, Catherine, Coulter, Ivan, Doherty, Glen, Tambuwala, Murtaza M., Taylor, Cormac

Source: Gastroenterology. 156(6):S-621-S-621

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FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Authors: Scholz, Carsten C.^1,2,3,4, carsten.scholz@uzh.ch, Rodriguez, Javier¹, Pickel, Christina⁴, Burr, Stephen⁵, Fabrizio, Jacqueline-alba⁶, Nolan, Karen A.⁴, Spielmann, Patrick⁴, Cavadas, Miguel A. S.^1,3, Crifo, Bianca^2,3, Halligan, Doug N.^2,3, Nathan, James A.⁵, Peet, Daniel J.⁶, Wenger, Roland H.⁴, Von Kriegsheim, Alex¹, Cummins, Eoin P.^2,3, Taylor, Cormac T.^1,2,3

Source: PLoS Biology; 1/11/2016, Vol. 14 Issue 1, p1-22, 22p, 4 Color Photographs, 2 Black and White Photographs, 1 Graph

Hypoxia-inducible factor hydroxylase inhibition enhances the protective effects of cyclosporine in colitis.

Authors: Halligan, Doug N.^1,2, Khan, Mohammed N.³, Brown, Eric¹, Rowan, Catherine R.⁴, Coulter, Ivan S.², Doherty, Glen A.⁴, Tambuwala, Murtaza M.³, Taylor, Cormac T.¹ Cormac.taylor@ucd.ie

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. Aug2019, Vol. 317 Issue 2, pG90-G97. 8p.

Subject Terms: *HYPOXIA-inducible factors, *INFLAMMATORY bowel diseases, *DEXTRAN, *COLITIS, *IMMUNOSUPPRESSION, *DEXTRAN sulfate