MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions.

Authors: Chiou, Shene, Cawthorne, Wayne, Soerianto, Thomas, Hofferek, Vinzenz, Patel, Komal M., Garnish, Sarah E., Tovey Crutchfield, Emma C., Hall, Cathrine, Hildebrand, Joanne M., McConville, Malcolm J., Lawlor, Kate E., Hawkins, Edwin D., Samson, Andre L., Murphy, James M.

Source: Cell Death & Disease; Nov2024, Vol. 15 Issue 11, p1-10, 10p

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Authors: Lalaoui, Najoua, Boyden, Steven E., Oda, Hirotsugu, Wood, Geryl M., Stone, Deborah L., Chau, Diep, Liu, Lin, Stoffels, Monique, Kratina, Tobias, Lawlor, Kate E., Zaal, Kristien J. M., Hoffmann, Patrycja M., Etemadi, Nima, Shield-Artin, Kristy, Biben, Christine, Tsai, Wanxia Li, Blake, Mary D., Kuehn, Hye Sun, Yang, Dan, Anderton, Holly, Silke, Natasha, Wachsmuth, Laurens, Zheng, Lixin, Moura, Natalia Sampaio, Beck, David B., Gutierrez-Cruz, Gustavo, Ombrello, Amanda K., Pinto-Patarroyo, Gineth P., Kueh, Andrew J., Herold, Marco J., Hall, Cathrine, Wang, Hongying, Chae, Jae Jin, Dmitrieva, Natalia I., McKenzie, Mark, Light, Amanda, Barham, Beverly K., Jones, Anne, Romeo, Tina M., Zhou, Qing, Aksentijevich, Ivona, Mullikin, James C., Gross, Andrew J., Shum, Anthony K., Hawkins, Edwin D., Masters, Seth L., Lenardo, Michael J., Boehm, Manfred, Rosenzweig, Sergio D., Pasparakis, Manolis, Voss, Anne K., Gadina, Massimo, Kastner, Daniel L., Silke, John

Source: Nature. 577(7788):103-108

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193702158.0x000001&indx=1&recIds=ETOCvdc_100193702158.0x000001

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

Authors: Vince, James E., De Nardo, Dominic, Gao, Wenqing, Vince, Angelina J., Hall, Cathrine, McArthur, Kate, Simpson, Daniel, Vijayaraj, Swarna, Lindqvist, Lisa M., Bouillet, Philippe, Rizzacasa, Mark A., Man, Si Ming, Silke, John, Masters, Seth L., Lessene, Guillaume, Huang, David C.S., Gray, Daniel H.D., Kile, Benjamin T., Shao, Feng, Lawlor, Kate E.

Source: In Cell Reports 27 November 2018 25(9):2339-2353

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Authors: Anderton, Holly, Bandala-Sanchez, Esther, Simpson, Daniel, Rickard, James, Ng, Ashley, Rago, Ladina, Hall, Cathrine, Vince, James, Silke, John, Liccardi, Gianmaria, Feltham, Rebecca

Source: Cell death and differentiation. 26(5):877-889

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131596059.0x000001&indx=1&recIds=ETOCvdc_100131596059.0x000001

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Authors: Lawlor, Kate E., Feltham, Rebecca, Yabal, Monica, Conos, Stephanie A., Chen, Kaiwen W., Ziehe, Stephanie, Graß, Carina, Zhan, Yifan, Nguyen, Tan A., Hall, Cathrine, Vince, Angelina J., Chatfield, Simon M., D’Silva, Damian B., Pang, Kenneth C., Schroder, Kate, Silke, John, Vaux, David L., Jost, Philipp J., Vince, James E.

Source: In Cell Reports 18 July 2017 20(3):668-682

An immunohistochemical atlas of necroptotic pathway expression.

Authors: Chiou, Shene, Al-Ani, Aysha H, Pan, Yi, Patel, Komal M, Kong, Isabella Y, Whitehead, Lachlan W, Light, Amanda, Young, Samuel N, Barrios, Marilou, Sargeant, Callum, Rajasekhar, Pradeep, Zhu, Leah, Hempel, Anne, Lin, Ann, Rickard, James A, Hall, Cathrine, Gangatirkar, Pradnya, Yip, Raymond KH, Cawthorne, Wayne, Jacobsen, Annette V

Source: EMBO Molecular Medicine; Jul2024, Vol. 16 Issue 7, p1717-1749, 33p

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

Authors: Johnston, Amelia J., Murphy, Kate T., Jenkinson, Laura, Laine, David, Emmrich, Kerstin, Faou, Pierre, Weston, Ross, Jayatilleke, Krishnath M., Schloegel, Jessie, Talbo, Gert, Casey, Joanne L., Levina, Vita, Wong, W. Wei-Lynn, Dillon, Helen, Sahay, Tushar, Hoogenraad, Joan, Anderton, Holly, Hall, Cathrine, Schneider, Pascal, Tanzer, Maria, Foley, Michael, Scott, Andrew M., Gregorevic, Paul, Liu, Spring Yingchun, Burkly, Linda C., Lynch, Gordon S., Silke, John, Hoogenraad, Nicholas J.

Source: In Cell 10 September 2015 162(6):1365-1378

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

Authors: Rickard, James A., O’Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby J., Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti, Silke, John

Source: In Cell 22 May 2014 157(5):1175-1188

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Authors: Hildebrand, Joanne M., Kauppi, Maria, Majewski, Ian J., Liu, Zikou, Cox, Allison J., Miyake, Sanae, Petrie, Emma J., Silk, Michael A., Li, Zhixiu, Tanzer, Maria C., Brumatti, Gabriela, Young, Samuel N., Hall, Cathrine, Garnish, Sarah E., Corbin, Jason, Stutz, Michael D., Di Rago, Ladina, Gangatirkar, Pradnya, Josefsson, Emma C., Rigbye, Kristin, Anderton, Holly, Rickard, James A., Tripaydonis, Anne, Sheridan, Julie, Scerri, Thomas S., Jackson, Victoria E., Czabotar, Peter E., Zhang, Jian-Guo, Varghese, Leila, Allison, Cody C., Pellegrini, Marc, Tannahill, Gillian M., Hatchell, Esme C., Willson, Tracy A., Stockwell, Dina, de Graaf, Carolyn A., Collinge, Janelle, Hilton, Adrienne, Silke, Natasha, Spall, Sukhdeep K., Chau, Diep, Athanasopoulos, Vicki, Metcalf, Donald, Laxer, Ronald M., Bassuk, Alexander G., Darbro, Benjamin W., Fiatarone Singh, Maria A., Vlahovich, Nicole, Hughes, David, Kozlovskaia, Maria, Ascher, David B., Warnatz, Klaus, Venhoff, Nils, Thiel, Jens, Biben, Christine, Blum, Stefan, Reveille, John, Hildebrand, Michael S., Vinuesa, Carola G., McCombe, Pamela, Brown, Matthew A., Kile, Benjamin T., McLean, Catriona, Bahlo, Melanie, Masters, Seth L., Nakano, Hiroyasu, Ferguson, Polly J., Murphy, James M., Alexander, Warren S., Silke, John

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174591315.0x000001&indx=1&recIds=ETOCvdc_100174591315.0x000001

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.

Authors: Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Tovey Crutchfield, Emma C., Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki

Source: Nature Communications; 9/28/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: APOPTOSIS, SINGLE nucleotide polymorphisms, HEMATOPOIETIC stem cells, BIOLOGICAL membranes, CELL death

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Authors: Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129870329.0x000001&indx=1&recIds=ETOCvdc_100129870329.0x000001

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

Authors: Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.

Source: Cell Death and Differentiation; 20230101, Issue: Preprints p1-13, 13p

Dual roles for LUBAC signaling in thymic epithelial cell development and survival

Authors: Jain, Reema, Zhao, Kelin, Sheridan, Julie M., Heinlein, Melanie, Kupresanin, Fiona, Abeysekera, Waruni, Hall, Cathrine, Rickard, James, Bouillet, Philippe, Walczak, Henning, Strasser, Andreas, Silke, John, Gray, Daniel H. D.

Source: Cell Death and Differentiation; October 2021, Vol. 28 Issue: 10 p2946-2956, 11p

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Authors: Lalaoui, Najoua, Merino, Delphine, Giner, Goknur, Vaillant, François, Chau, Diep, Liu, Lin, Kratina, Tobias, Pal, Bhupinder, Whittle, James R., Etemadi, Nima, Berthelet, Jean, Gräsel, Julius, Hall, Cathrine, Ritchie, Matthew E., Ernst, Matthias, Smyth, Gordon K., Vaux, David L., Visvader, Jane E., Lindeman, Geoffrey J., Silke, John

Source: Cell Death and Differentiation; October 2020, Vol. 27 Issue: 10 p2768-2780, 13p

Correction to: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Authors: Anderton, Holly, Bandala-Sanchez, Esther, Simpson, Daniel S., Rickard, James A., Ng, Ashley P., Di Rago, Ladina, Hall, Cathrine, Vince, James E., Silke, John, Liccardi, Gianmaria, Feltham, Rebecca

Source: Cell Death and Differentiation; 20240101, Issue: Preprints p1-2, 2p

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