Alzheimer’s Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies

Authors: Hales, Chadwick M.

Source: In Medical Clinics of North America March 2025 109(2):463-483

The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias

Authors: Bender, Alexis A., McIntosh, Rebecca L., Sudduth, Sean, Harris, Michaela, Tuckey, Kathy, Morgan, John C., Jungerman, Joanna M., Cox, Abby, Moore, Miranda A., Ingram, Bryshia, Pier, Ellyn, Johnson, Theodore M., Loring, David W., Hepburn, Kenneth, Medders, Laura, Levey, Allan I., Lah, James J., Hales, Chadwick M.

Source: Journal of the American Geriatrics Society. 70(4):1257-1267

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187165401.0x000001&indx=1&recIds=ETOCvdc_100187165401.0x000001

Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration

Authors: Johnson, Ashlyn G., Webster, James A., Hales, Chadwick M.

Source: NEUROBIOLOGY OF AGING. 112:55-73

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164870174.0x000001&indx=1&recIds=ETOCvdc_100164870174.0x000001

Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36

Authors: McEachin, Zachary T., Gendron, Tania F., Raj, Nisha, García-Murias, María, Banerjee, Anwesha, Purcell, Ryan H., Ward, Patricia J., Todd, Tiffany W., Merritt-Garza, Megan E., Jansen-West, Karen, Hales, Chadwick M., García-Sobrino, Tania, Quintáns, Beatriz, Holler, Christopher J., Taylor, Georgia, San Millán, Beatriz, Teijeira, Susana, Yamashita, Toru, Ohkubo, Ryuichi, Boulis, Nicholas M., Xu, Chongchong, Wen, Zhexing, Streichenberger, Nathalie, Fogel, Brent L., Kukar, Thomas, Abe, Koji, Dickson, Dennis W., Arias, Manuel, Glass, Jonathan D., Jiang, Jie, Tansey, Malú G., Sobrido, María-Jesús, Petrucelli, Leonard, Rossoll, Wilfried, Bassell, Gary J.

Source: In Neuron 22 July 2020 107(2):292-305

Lower Prevalence of Asymptomatic Alzheimer's Disease Among Healthy African Americans.

Authors: Lah, James J., Tian, Ganzhong, Risk, Benjamin B., Hanfelt, John J., Wang, Liangkang, Zhao, Liping, Hales, Chadwick M., Johnson, Erik C.B., Elmor, Morgan B., Malakauskas, Sarah J., Heilman, Craig, Wingo, Thomas S., Dorbin, Cornelya D., Davis, Crystal P., Thomas, Tiffany I., Hajjar, Ihab M., Levey, Allan I., Parker, Monica W.

Source: Annals of Neurology; Sep2024, Vol. 96 Issue 3, p463-475, 13p

Subject Terms: ALZHEIMER'S disease, GAUSSIAN mixture models, CEREBROSPINAL fluid, DISEASE risk factors, AFRICAN Americans

Proteomic networks of gray and white matter reveal tissue‐specific changes in human tauopathy.

Authors: Johnson, Ashlyn G., Dammer, Eric B., Webster, James A., Duong, Duc M., Seyfried, Nicholas T., Hales, Chadwick M.

Source: Annals of Clinical & Translational Neurology; Aug2024, Vol. 11 Issue 8, p2138-2152, 15p

Subject Terms: GRAY matter (Nerve tissue), WHITE matter (Nerve tissue), PROGRESSIVE supranuclear palsy, CHRONIC traumatic encephalopathy, ALZHEIMER'S disease

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology

Authors: Chemparathy, Augustine, Le Guen, Yann, Chen, Sunny, Lee, Eun-Gyung, Leong, Lesley, Gorzynski, John E., Jensen, Tanner D., Ferrasse, Alexis, Xu, Guangxue, Xiang, Hong, Belloy, Michael E., Kasireddy, Nandita, Peña-Tauber, Andrés, Williams, Kennedy, Stewart, Ilaria, Talozzi, Lia, Wingo, Thomas S., Lah, James J., Jayadev, Suman, Hales, Chadwick M., Peskind, Elaine, Child, Daniel D., Roeber, Sigrun, Keene, C. Dirk, Cong, Le, Ashley, Euan A., Yu, Chang-En, Greicius, Michael D.

Source: In Neuron 3 April 2024 112(7):1110-1116

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

Authors: Seyfried, Nicholas T., Dammer, Eric B., Swarup, Vivek, Nandakumar, Divya, Duong, Duc M., Yin, Luming, Deng, Qiudong, Nguyen, Tram, Hales, Chadwick M., Wingo, Thomas, Glass, Jonathan, Gearing, Marla, Thambisetty, Madhav, Troncoso, Juan C., Geschwind, Daniel H., Lah, James J., Levey, Allan I.

Source: In Cell Systems 25 January 2017 4(1):60-72

Aggregation Properties of the Small Nuclear Ribonucleoprotein U1-70K in Alzheimer Disease

Authors: Diner, Ian, Hales, Chadwick M., Bishof, Isaac, Rabenold, Lake, Duong, Duc M., Yi, Hong ^**, Laur, Oskar, Gearing, Marla, Troncoso, Juan, Thambisetty, Madhav, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

Source: In Journal of Biological Chemistry 19 December 2014 289(51):35296-35313

Integration of plasma and CSF metabolomics with CSF proteomic reveals novel associations between lipid mediators and central nervous system vascular and energy metabolism.

Authors: Borkowski, Kamil, Seyfried, Nicholas T., Arnold, Matthias, Lah, James J., Levey, Allan I., Hales, Chadwick M., Dammer, Eric B., Blach, Colette, Louie, Gregory, Kaddurah-Daouk, Rima, Newman, John W.

Source: Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-13, 13p

Subject Terms: CENTRAL nervous system, CARDIOVASCULAR system, CEREBROSPINAL fluid examination, METABOLOMICS, PROTEOMICS, ENERGY metabolism, EPOXIDE hydrolase

CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual

Authors: Yun, Yeomin, Hong, Sung-Ah, Kim, Ka-Kyung, Baek, Daye, Lee, Dongsu, Londhe, Ashwini M., Lee, Minhyung, Yu, Jihyeon, McEachin, Zachary T., Bassell, Gary J., Bowser, Robert, Hales, Chadwick M., Cho, Sung-Rae, Kim, Janghwan, Pae, Ae Nim, Cheong, Eunji, Kim, Sangwoo, Boulis, Nicholas M., Bae, Sangsu, Ha, Yoon

Source: Communications biology. 3(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130041730.0x000001&indx=1&recIds=ETOCvdc_100130041730.0x000001

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

Authors: Bai, Bing, Hales, Chadwick M., Chen, Ping-Chung, Gozal, Yair, Dammer, Eric B., Fritz, Jason J., Wang, Xusheng, Xia, Qiangwei, Duong, Duc M., Street, Craig, Cantero, Gloria, Cheng, Dongmei, Jones, Drew R., Wu, Zhiping, Li, Yuxin, Diner, Ian, Heilman, Craig J., Rees, Howard D., Wu, Hao, Li Lin, Szulwach, Keith E., Gearing, Marla, Mufson, Elliott J., Bennett, David A., Montin, Thomas J., Seyfried, Nicholas T., Wingo, Thomas S., Yi E. Sun, Jin, Peng, Hanfelt, John, Willcock, Donna M., Levey, Allan, Lah, James J., Peng, Junmin

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Oct 01. 110(41), 16562-16567.

Access URL: https://www.jstor.org/stable/23749562

Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

Authors: Xu, Zihui, Poidevin, Mickael, Li, Xuekun, Li, Yujing, Shu, Liqi, Nelson, David L., Li, He, Hales, Chadwick M., Gearing, Marla, Wingo, Thomas S., Jin, Peng

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 May 01. 110(19), 7778-7783.

Access URL: https://www.jstor.org/stable/42656382

Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson's Disease.

Authors: Tandra, Gabriella, Yoone, Amy, Mathew, Rhea, Wang, Minzhi, Hales, Chadwick M., Mitchell, Cassie S.

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 15, p12339, 17p

Subject Terms: PARKINSON'S disease, CARBIDOPA, NATURAL language processing, DOPAMINE, ANTIHISTAMINES, ANGIOTENSIN converting enzyme, KNOWLEDGE graphs

5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease

Authors: Kuehner, Janise N., Chen, Junyu, Bruggeman, Emily C., Wang, Feng, Li, Yangping, Xu, Chongchong, McEachin, Zachary T., Li, Ziyi, Chen, Li, Hales, Chadwick M., Wen, Zhexing, Yang, Jingjing, Yao, Bing

Source: In Cell Reports 27 April 2021 35(4)

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis

Authors: Raj, Nisha, McEachin, Zachary T., Harousseau, William, Zhou, Ying, Zhang, Feiran, Merritt-Garza, Megan E., Taliaferro, J. Matthew, Kalinowska, Magdalena, Marro, Samuele G., Hales, Chadwick M., Berry-Kravis, Elizabeth, Wolf-Ochoa, Marisol W., Martinez-Cerdeño, Veronica, Wernig, Marius, Chen, Lu, Klann, Eric, Warren, Stephen T., Jin, Peng, Wen, Zhexing, Bassell, Gary J.

Source: In Cell Reports 13 April 2021 35(2)

APOE loss‐of‐function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.

Authors: Guen, Yann Le, Chemparathy, Augustine, Chen, Sunny, Leong, Lesley, Gorzynski, John John, Xue, Guangxue, Belloy, Michael E, Kasireddy, Nandita, Tauber, Andres Peña, Williams, Kennedy, Wingo, Thomas S., Lah, James J., Jayadev, Suman, Hales, Chadwick M, Peskind, Elaine R, Child, Daniel D, Keene, C Dirk, Le, Cong, Ashley, Euan, Yu, Chang‐En

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 24, Vol. 19, p1-3, 3p

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins

Authors: Rangaraju, Srikant, Dammer, Eric B., Raza, Syed Ali, Gao, Tianwen, Xiao, Hailian, Betarbet, Ranjita, Duong, Duc M., Webster, James A., Hales, Chadwick M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

Source: Molecular neurodegeneration. 13(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129350652.0x000001&indx=1&recIds=ETOCvdc_100129350652.0x000001

A PROOF OF CONCEPT PHASE II STUDY REPURPOSING ATOMOXETINE FOR NEUROPROTECTION IN MILD COGNITIVE IMPAIRMENT: EVIDENCE FOR TARGET ENGAGEMENT, REGULATION OF CSF BIOMARKERS, AND DISEASE-MODIFYING POTENTIAL

Authors: Levey, Allan I., Lah, James J., Hu, William T., Wingo, Thomas S., Hales, Chadwick M., Manzanares, Cecelia, Tansey, Malu G., Goldstein, David S., Zhao, Liping, Galasko, Douglas R., Edland, Steven D., Hanfelt, John, Weinshenker, David

Source: Alzheimer's & dementia. 15(7):P1263-P1264

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091200909.0x000001&indx=1&recIds=ETOCvdc_100091200909.0x000001

A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.

Authors: Levey, Allan I^1,2, alevey@emory.edu, Qiu, Deqiang^1,3, Zhao, Liping^1,4, Hu, William T^1,2, Duong, Duc M⁵, Higginbotham, Lenora^1,2, Dammer, Eric B⁵, Seyfried, Nicholas T^1,5, Wingo, Thomas S^1,2,6, Hales, Chadwick M^1,2, Tansey, Malú Gámez⁷, Goldstein, David S⁸, Abrol, Anees⁹, Calhoun, Vince D⁹, Goldstein, Felicia C^1,2, Hajjar, Ihab^1,2, Fagan, Anne M¹⁰, Galasko, Doug¹¹, Edland, Steven D¹¹, Hanfelt, John^1,4

Source: Brain: A Journal of Neurology; Jun2022, Vol. 145 Issue 6, p1924-1938, 15p