Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries

Authors: Abello, Javier ^a, Yin, Ying ^a, Zhao, Yonghui ^b, Maurer, Josh ^b, Lee, Jihui ^a, Bodell, Cherokee ^a, Richee, Jahmiera ^a, Clevenger, Abigail J. ^c, Burton, Zarek ^a, Goeckel, Megan E. ^a, Lin, Michelle ^d, Grainger, Stephanie ^e, Halabi, Carmen M. ^d, Raghavan, Shreya A. ^c, Sah, Rajan ^{b, f}, Stratman, Amber N. ^{a, ⁎}

Source: In European Journal of Cell Biology March 2025 104(1)

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues

Authors: Neupane, Sanjiv, Williamson, Daniel B., Roth, Robyn A., Halabi, Carmen M., Haltiwanger, Robert S., Holdener, Bernadette C.

Source: In Journal of Biological Chemistry July 2024 300(7)

A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation

Authors: Brengle, Bridget M., Lin, Michelle, Roth, Robyn A., Jones, Kara D., Wagenseil, Jessica E., Mecham, Robert P., Halabi, Carmen M.

Source: MATRIX BIOLOGY. 117:1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190024488.0x000001&indx=1&recIds=ETOCvdc_100190024488.0x000001

Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration

Authors: Spears, Larry D., Adak, Sangeeta, Dong, Guifang, Wei, Xiaochao, Spyropoulos, George, Zhang, Qiang, Yin, Li, Feng, Chu, Hu, Donghua, Lodhi, Irfan J., Hsu, Fong-Fu, Rajagopal, Rithwick, Noguchi, Kevin K., Halabi, Carmen M., Brier, Lindsey, Bice, Annie R., Lananna, Brian V., Musiek, Erik S., Avraham, Oshri, Cavalli, Valeria, Holth, Jerrah K., Holtzman, David M., Wozniak, David F., Culver, Joseph P., Semenkovich, Clay F.

Source: In Journal of Lipid Research 2021 62

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K~A~T~P channel overactivity

Authors: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa, Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.

Source: Journal of clinical investigation. 130(3):1116-1121

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623253671&indx=1&recIds=ETOCRN623253671

Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations.

Authors: Hanson, Alex, McClenaghan, Conor, Weng, Kuo-Chan, Colijn, Sarah, Stratman, Amber N, Halabi, Carmen M, Grange, Dorothy K, Silva, Jonathan R, Nichols, Colin G

Source: Function; 2024, Vol. 5 Issue 5, p1-12, 12p

Subject Terms: VASCULAR smooth muscle, VASCULAR resistance, GENE expression, CARDIOVASCULAR system, BLOOD pressure, POTASSIUM channels

Macrophage angiotensin II type 2 receptor triggers neuropathic pain

Authors: Shepherd, Andrew J., Mickle, Aaron D., Golden, Judith P., Mack, Madison R., Halabi, Carmen M., de Kloet, Annette D., Samineni, Vijay K., Kim, Brian S., Krause, Eric G., Gereau, Robert W., Mohapatra, Durga P.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Aug . 115(34), E8057-E8066.

Access URL: https://www.jstor.org/stable/26530209

Sodium‐activated potassium channels moderate excitability in vascular smooth muscle

Authors: Li, Ping, Halabi, Carmen M., Stewart, Richard, Butler, Alice, Brown, Bobbie, Xia, Xiaoming, Santi, Celia, England, Sarah, Ferreira, Juan, Mecham, Robert P., Salkoff, Lawrence

Source: Journal of physiology. 597(20):5093-5108

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099908740.0x000001&indx=1&recIds=ETOCvdc_100099908740.0x000001

In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy.

Authors: Williams, Matthew J.¹, Halabi, Carmen M.¹, Patel, Hiral M.¹, Joseph, Zachary¹, McCommis, Kyle², Weinheimer, Carla³, Kovacs, Attila³, Lima, Florence⁴, Finck, Brian², Malluche, Hartmut⁴, Hruska, Keith A.^1,5,6 Hruska_k@kids.wustl.edu

Source: American Journal of Physiology: Renal Physiology. May2024, Vol. 326 Issue 5, pF751-F767. 17p.

Subject Terms: *CHRONIC kidney failure, *HEART metabolism, *CARDIAC hypertrophy, *VASCULAR smooth muscle, *ARTERIAL diseases

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans

Authors: Lee, Vivian S., Halabi, Carmen M., Hoffman, Erin P., Carmichael, Nikkola, Leshchiner, Ignaty, Lian, Christine G., Bierhals, Andrew J., Vuzman, Dana, Medicine, Brigham Genomic, Mecham, Robert P., Frank, Natasha Y., Stitziel, Nathan O.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Aug 01. 113(31), 8759-8764.

Access URL: https://www.jstor.org/stable/26471037

Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities

Authors: Igoucheva, Olga, Alexeev, Vitali, Halabi, Carmen M., Adams, Sheila M., Stoilov, Ivan, Sasaki, Takako, Arita, Machiko, Donahue, Adele, Mecham, Robert P., Birk, David E., Chu, Mon-Li

Source: In Journal of Biological Chemistry 28 August 2015 290(35):21443-21459

Sickle cell disease—Under pressure

Authors: Halabi, Carmen M., Hulbert, Monica L.

Source: Pediatric blood & cancer. 68(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117667199.0x000001&indx=1&recIds=ETOCvdc_100117667199.0x000001

Novel coenzyme Q6 genetic variant increases susceptibility to pneumococcal disease

Authors: Walker, Emma C., Javati, Sarah, Todd, Elizabeth M., Matlam, John-Paul, Lin, Xue, Bryant, Michelle, Krone, Emily, Ramani, Rashmi, Chandra, Pallavi, Green, Taylor P., Anaya, Edgar P., Zhou, Julie Y., Alexander, Katherine A., Tong, R. Spencer, Yuasi, Lapule, Boluarte, Sebastian, Yang, Fan, Greenberg, Lina, Nerbonne, Jeanne M., Greenberg, Michael J., Clemens, Regina A., Philips, Jennifer A., Wilson, Leslie D., Halabi, Carmen M., DeBosch, Brian J., Blyth, Christopher C., Druley, Todd E., Kazura, James W., Pomat, William S., Morley, Sharon Celeste

Source: Nature Immunology; 20240101, Issue: Preprints p1-12, 12p

ZBTB46 coordinates angiogenesis and immunity to control tumor outcome

Authors: Kabir, Ashraf Ul, Zeng, Carisa, Subramanian, Madhav, Wu, Jun, Kim, Minseo, Krchma, Karen, Wang, Xiaoli, Halabi, Carmen M., Pan, Hua, Wickline, Samuel A., Fremont, Daved H., Artyomov, Maxim N., Choi, Kyunghee

Source: Nature Immunology; 20240101, Issue: Preprints p1-9, 9p

Changes in transmural mass transport correlate with ascending thoracic aortic aneurysm diameter in a fibulin-4 E57K knockin mouse model.

Authors: Crandall, Christie L., Yufan Wu, Kailash, Keshav A., Bersi, Mathew R., Halabi, Carmen M., Wagenseil, Jessica E.

Source: American Journal of Physiology: Heart & Circulatory Physiology; Jul2023, Vol. 325 Issue 1, pH113-H124, 12p

Subject Terms: THORACIC aneurysms, ASCENDING aorta aneurysms, THORACIC aorta, LABORATORY mice, EXTRACELLULAR matrix proteins

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

Authors: Elenbaas, Jared S., Pudupakkam, Upasana, Ashworth, Katrina J., Kang, Chul Joo, Patel, Ved, Santana, Katherine, Jung, In-Hyuk, Lee, Paul C., Burks, Kendall H., Amrute, Junedh M., Mecham, Robert P., Halabi, Carmen M., Alisio, Arturo, Di Paola, Jorge, Stitziel, Nathan O.

Source: Nature Communications; 3/18/2023, Vol. 14 Issue 1, p1-18, 18p

Subject Terms: EXTRACELLULAR matrix proteins, VON Willebrand factor, BLOOD platelet aggregation, BLOOD platelet activation, VASCULAR diseases, CARDIOVASCULAR diseases

Interference with PPARγ Function in Smooth Muscle Causes Vascular Dysfunction and Hypertension

Authors: Halabi, Carmen M., Beyer, Andreas M., de Lange, Willem J., Keen, Henry L., Baumbach, Gary L., Faraci, Frank M., Sigmund, Curt D.

Source: In Cell Metabolism 2008 7(3):215-226

The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses.

Authors: Cook, Melissa E., Bradstreet, Tara R., Webber, Ashlee M., Kim, Jongshin, Santeford, Andrea, Harris, Kevin M., Murphy, Maegan K., Tran, Jennifer, Abdalla, Nada M., Schwarzkopf, Elizabeth A., Greco, Suellen C., Halabi, Carmen M., Apte, Rajendra S., Blackshear, Perry J., Edelson, Brian T.

Source: Science Immunology; 2022, Vol. 7 Issue 76, p1-18, 18p

Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain.

Authors: Giri, Tusar, Jiang, Jia, Xu, Zhiqiang, McCarthy, Ronald, Halabi, Carmen M., Tycksen, Eric, Cahill, Alison G., England, Sarah K., Palanisamy, Arvind

Source: Scientific Reports; 2/24/2022, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: FETAL brain, OXYTOCIN, OXIDATIVE stress, INDUCED labor (Obstetrics), BIOLOGICAL models, RATS, PERINEUM

Chapter 12 - Elastin purification and solubilization

Authors: Halabi, Carmen M., Mecham, Robert P.

Source: In Methods in Cell Biology 2018 143:207-222