Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/−) mice

Authors: Kepreotis, Sacha V., Oh, Jae Gyun, Park, Mina, Yoo, Jimeen, Lee, Cholong, Mercola, Mark, Hajjar, Roger J., Jeong, Dongtak

Source: In Molecular Therapy - Nucleic Acids 11 June 2024 35(2)

Extracellular Vesicle–Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart

Authors: Li, Xisheng, La Salvia, Sabrina, Liang, Yaxuan, Adamiak, Marta, Kohlbrenner, Erik, Jeong, Dongtak, Chepurko, Elena, Ceholski, Delaine, Lopez-Gordo, Estrella, Yoon, Seonghun, Mathiyalagan, Prabhu, Agarwal, Neha, Jha, Divya, Lodha, Shweta, Daaboul, George, Phan, Anh, Raisinghani, Nikhil, Zhang, Shihong, Zangi, Lior, Gonzalez-Kozlova, Edgar, Dubois, Nicole, Dogra, Navneet, Hajjar, Roger J., Sahoo, Susmita

Source: Circulation. 148(5):405-425

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195234279.0x000001&indx=1&recIds=ETOCvdc_100195234279.0x000001

Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts

Authors: Rogalska, Malgorzata E., Vafiadaki, Elizabeth, Erpapazoglou, Zoi, Haghighi, Kobra, Green, Lisa, Mantzoros, Christos S., Hajjar, Roger J., Tranter, Michael, Karakikes, Ioannis, Kranias, Evangelia G., Stillitano, Francesca, Kafasla, Panagiota, Sanoudou, Despina

Source: In Metabolism January 2023 138

Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck

Authors: Bikou, Olympia, Tharakan, Serena, Yamada, Kelly P., Kariya, Taro, Aguero, Jaume, Gordon, Alexandra, Mazurek, Renata, Aikawa, Tadao, Kohlbrenner, Erik, Fish, Kenneth M., Hajjar, Roger J., Ishikawa, Kiyotake

Source: Human gene therapy. 33(9/10):550-559

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149985396.0x000001&indx=1&recIds=ETOCvdc_100149985396.0x000001

As new cell and gene therapies emerge from academia, we must RISE to the opportunity: Career feature.

Authors: Uma Naresh, Nandhitha, Hammill, Dana, Kessel, Mark, Hajjar, Roger J., Yozwiak, Nathan L.

Source: Nature Biotechnology; Jan2025, Vol. 43 Issue 1, p143-146, 4p

Direct reprogramming induces vascular regeneration post muscle ischemic injury

Authors: Kaur, Keerat ^{1, 2, 3}, Hadas, Yoav ^{1, 2, 3, 6}, Kurian, Ann Anu ^{1, 2, 3}, Żak, Magdalena M. ^{1, 2, 3}, Yoo, Jimeen ^{1, 2, 3}, Mahmood, Asharee ^{1, 2, 3}, Girard, Hanna ^{1, 2, 3}, Komargodski, Rinat ^{1, 2, 3}, Io, Toshiro ⁴, Santini, Maria Paola ¹, Sultana, Nishat ^{1, 2, 3}, Sharkar, Mohammad Tofael Kabir ^{1, 2, 3}, Magadum, Ajit ^{1, 2, 3}, Fargnoli, Anthony ¹, Yoon, Seonghun ^{1, 2, 3}, Chepurko, Elena ^{1, 2, 3}, Chepurko, Vadim ^{1, 2, 3}, Eliyahu, Efrat ^{2, 5}, Pinto, Dalila ^{6, 7, 8, 9, 10}, Lebeche, Djamel ¹, Kovacic, Jason C. ¹, Hajjar, Roger J. ¹¹, Rafii, Shahin ¹², Zangi, Lior ^{1, 2, 3, ∗}

Source: In Molecular Therapy 6 October 2021 29(10):3042-3058

Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome

Authors: Arze, Cesar A., Springer, Simeon, Dudas, Gytis, Patel, Sneha, Bhattacharyya, Agamoni, Swaminathan, Harish, Brugnara, Carlo, Delagrave, Simon, Ong, Tuyen, Kahvejian, Avak, Echelard, Yann, Weinstein, Erica G., Hajjar, Roger J., Andersen, Kristian G., Yozwiak, Nathan L.

Source: In Cell Host & Microbe 11 August 2021 29(8):1305-1315

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation

Authors: Raad, Nour, Bittihn, Philip, Cacheux, Marine, Jeong, Dongtak, Ilkan, Zeki, Ceholski, Delaine, Kohlbrenner, Erik, Zhang, Lu, Cai, Chen-Leng, Kranias, Evangelia G., Hajjar, Roger J., Stillitano, Francesca, Akar, Fadi G.

Source: Circulation. 144(6):441-454

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189186627.0x000001&indx=1&recIds=ETOCvdc_100189186627.0x000001

AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine.

Authors: Mazurek, Renata, Tharakan, Serena, Mavropoulos, Spyros A., Singleton, Deanndria T., Bikou, Olympia, Sakata, Tomoki, Kariya, Taro, Yamada, Kelly, Kohlbrenner, Erik, Liang, Lifan, Ravichandran, Anjali J., Watanabe, Shin, Hajjar, Roger J., Ishikawa, Kiyotake

Source: Nature Communications; 12/1/2024, Vol. 15 Issue 1, p1-12, 12p

Subject Terms: CORONARY occlusion, YORKSHIRE swine, ARTIFICIAL blood circulation, GENE expression, HEART failure

Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy

Authors: Wasala, Nalinda B., Yue, Yongping, Lostal, William, Wasala, Lakmini P., Niranjan, Nandita, Hajjar, Roger J., Babu, Gopal J., Duan, Dongsheng

Source: In Molecular Therapy 4 March 2020 28(3):845-854

AAV1.SERCA2a Gene Therapy Reverses Pulmonary Fibrosis by Blocking the STAT3/FOXM1 Pathway and Promoting the SNON/SKI Axis

Authors: Bisserier, Malik, Milara, Javier, Abdeldjebbar, Yassine, Gubara, Sarah, Jones, Carly, Bueno-Beti, Carlos, Chepurko, Elena, Kohlbrenner, Erik, Katz, Michael G., Tarzami, Sima, Cortijo, Julio, Leopold, Jane, Hajjar, Roger J., Sassi, Yassine, Hadri, Lahouaria

Source: In Molecular Therapy 5 February 2020 28(2):394-410

Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Authors: Abu-Alfa, Ali K., Amann, Kerstin, Aonuma, Kazutaka, Appel, Lawrence J., Baigent, Colin, Bakris, George L., Banerjee, Debasish, Boletis, John N., Bozkurt, Biykem, Butler, Javed, Chan, Christopher T., Costanzo, Maria Rosa, Dubin, Ruth F., Filippatos, Gerasimos, Gikonyo, Betty M., Gikonyo, Dan K., Hajjar, Roger J., Iseki, Kunitoshi, Ishii, Hideki, Knoll, Greg A., Lenihan, Colin R., Lentine, Krista L., Lerma, Edgar V., Macedo, Etienne, Mark, Patrick B., Noiri, Eisei, Palazzuoli, Alberto, Pecoits-Filho, Roberto, Pitt, Bertram, Rigatto, Claudio, Rossignol, Patrick, Setoguchi, Soko, Sood, Manish M., Störk, Stefan, Suri, Rita S., Szummer, Karolina, Tang, Sydney C.W., Tangri, Navdeep, Thompson, Aliza, Vijayaraghavan, Krishnaswami, Walsh, Michael, Wang, Angela Yee-Moon, Weir, Matthew R., House, Andrew A., Wanner, Christoph, Sarnak, Mark J., Piña, Ileana L., McIntyre, Christopher W., Komenda, Paul, Kasiske, Bertram L., Deswal, Anita, deFilippi, Christopher R., Cleland, John G.F., Anker, Stefan D., Herzog, Charles A., Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., McCullough, Peter A.

Source: In Kidney International June 2019 95(6):1304-1317

Role of the PRC2-Six1-miR-25 signaling axis in heart failure

Authors: Oh, Jae Gyun, Jang, Seung Pil, Yoo, Jimeen, Lee, Min-Ah, Lee, Seung Hee, Lim, Taejoong, Jeong, Eden, Kho, Changwon, Kook, Hyun, Hajjar, Roger J., Park, Woo Jin, Jeong, Dongtak

Source: In Journal of Molecular and Cellular Cardiology April 2019 129:58-68

The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling

Authors: Lee, Min‐Ah, Raad, Nour, Song, Min Ho, Yoo, Jimeen, Lee, Miyoung, Jang, Seung Pil, Kwak, Tae Hwan, Kook, Hyun, Choi, Eun‐Kyoung, Cha, Tae‐Joon, Hajjar, Roger J., Jeong, Dongtak, Park, Woo Jin

Source: Journal of cellular and molecular medicine. 24(20):11768-11778

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108674647.0x000001&indx=1&recIds=ETOCvdc_100108674647.0x000001

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

Authors: Magadum, Ajit, Singh, Neha, Kurian, Ann Anu, Munir, Irsa, Mehmood, Talha, Brown, Kemar, Sharkar, Mohammad Tofael Kabir, Chepurko, Elena, Sassi, Yassine, Oh, Jae Gyun, Lee, Philyoung, Santos, Celio X.C., Gaziel-Sovran, Avital, Zhang, Guoan, Cai, Chen-Leng, Kho, Changwon, Mayr, Manuel, Shah, Ajay M., Hajjar, Roger J., Zangi, Lior

Source: Circulation. 141(15):1249-1265

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188865429.0x000001&indx=1&recIds=ETOCvdc_100188865429.0x000001

Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases

Authors: Miyashita, Satoshi, Hammoudi, Nadjib, Watanabe, Shin, Bikou, Olympia, Yamada, Kelly, Aguero, Jaume, Nomoto, Koichi, Kariya, Taro, Fish, Kenneth, Hajjar, Roger J., Ishikawa, Kiyotake

Source: Journal of cardiovascular translational research. 13(4):648-658

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172224000.0x000001&indx=1&recIds=ETOCvdc_100172224000.0x000001

Specific Modified mRNA Translation System

Authors: Magadum, Ajit, Kurian, Ann Anu, Chepurko, Elena, Sassi, Yassine, Hajjar, Roger J., Zangi, Lior

Source: Circulation. 142(25):2485-2488

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150447531.0x000001&indx=1&recIds=ETOCvdc_100150447531.0x000001

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis.

Authors: Feng Xiao, Ngoc Uyen Nhi Nguyen, Ping Wang, Shujuan Li, Ching-Cheng Hsu, Suwannee Thet, Wataru Kimura, Xiang Luo, Lam, Nicholas T., Menendez-Montes, Ivan, Elhelaly, Waleed M., Campos Cardoso, Alisson, Macedo Pereira, Ana Helena, Singh, Rohit, Sadayappan, Sakthivel, Kanchwala, Mohammed, Chao Xing, Ladha, Feria A., Hinson, J. Travis, Hajjar, Roger J.

Source: Circulation; 9/3/2024, Vol. 150 Issue 10, p791-805, 15p

Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension

Authors: Strauss, Benjamin, Sassi, Yassine, Bueno-Beti, Carlos, Ilkan, Zeki, Raad, Nour, Cacheux, Marine, Bisserier, Malik, Turnbull, Irene C., Kohlbrenner, Erik, Hajjar, Roger J., Hadri, Lahouaria, Akar, Fadi G.

Source: In Journal of Molecular and Cellular Cardiology February 2019 127:20-30

Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden

Authors: Kawai, Hideki, Chaudhry, Farhan, Shekhar, Aditya, Petrov, Artiom, Nakahara, Takehiro, Tanimoto, Takashi, Kim, Dongbin, Chen, Jiqiu, Lebeche, Djamel, Blankenberg, Francis G., Pak, Koon Y., Kolodgie, Frank D., Virmani, Renu, Sengupta, Partho, Narula, Navneet, Hajjar, Roger J., Strauss, Harry W., Narula, Jagat

Source: In JACC: Cardiovascular Imaging December 2018 11(12):1823-1833