Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer’s disease

Authors: Moutayakine, Amina, Marques, Carolina, López, Óscar, Bagetta, Donatella, Leitzbach, Luisa, Hagenow, Stefanie, Carreiro, Elisabete P., Stark, Holger, Alcaro, Stefano, Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Bioorganic & Medicinal Chemistry 15 August 2022 68

Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation

Authors: Plazas, Erika, Hagenow, Stefanie, Avila Murillo, Monica, Stark, Holger, Cuca, Luis Enrique

Source: In Bioorganic Chemistry May 2020 98

Search for new multi-target compounds against Alzheimer’s disease among histamine H3 receptor ligands

Authors: Bajda, Marek, Łażewska, Dorota, Godyń, Justyna, Zaręba, Paula, Kuder, Kamil, Hagenow, Stefanie, Łątka, Kamil, Stawarska, Ewelina, Stark, Holger, Kieć-Kononowicz, Katarzyna, Malawska, Barbara

Source: In European Journal of Medicinal Chemistry 1 January 2020 185

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands

Authors: Szczepańska, Katarzyna, Karcz, Tadeusz, Siwek, Agata, Kuder, Kamil J., Latacz, Gniewomir, Bednarski, Marek, Szafarz, Małgorzata, Hagenow, Stefanie, Lubelska, Annamaria, Olejarz-Maciej, Agnieszka, Sobolewski, Michał, Mika, Kamil, Kotańska, Magdalena, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: In Bioorganic Chemistry October 2019 91

Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands

Authors: Łażewska, Dorota, Mogilski, Szczepan, Hagenow, Stefanie, Kuder, Kamil, Głuch-Lutwin, Monika, Siwek, Agata, Więcek, Małgorzata, Kaleta, Maria, Seibel, Ulla, Buschauer, Armin, Filipek, Barbara, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: In Bioorganic & Medicinal Chemistry 1 April 2019 27(7):1254-1262

Optimization and preclinical evaluation of novel histamine H3 receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives

Authors: Szczepańska, Katarzyna, Karcz, Tadeusz, Kotańska, Magdalena, Siwek, Agata, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Hagenow, Stefanie, Lubelska, Annamaria, Sobolewski, Michał, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: In Bioorganic & Medicinal Chemistry 15 December 2018 26(23-24):6056-6066

Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H3R ligands

Authors: Khanfar, Mohammad A., Reiner, David, Hagenow, Stefanie, Stark, Holger

Source: In Bioorganic & Medicinal Chemistry 7 August 2018 26(14):4034-4046

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

Authors: Szczepańska, Katarzyna, Karcz, Tadeusz, Mogilski, Szczepan, Siwek, Agata, Kuder, Kamil J., Latacz, Gniewomir, Kubacka, Monika, Hagenow, Stefanie, Lubelska, Annamaria, Olejarz, Agnieszka, Kotańska, Magdalena, Sadek, Bassem, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: In European Journal of Medicinal Chemistry 25 May 2018 152:223-234

Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation

Authors: Łażewska, Dorota, Kaleta, Maria, Hagenow, Stefanie, Mogilski, Szczepan, Latacz, Gniewomir, Karcz, Tadeusz, Lubelska, Annamaria, Honkisz, Ewelina, Handzlik, Jadwiga, Reiner, David, Satała, Grzegorz, Filipek, Barbara, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: In Bioorganic & Medicinal Chemistry 15 May 2018 26(9):2573-2585

Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson’s disease

Authors: Affini, Anna, Hagenow, Stefanie, Zivkovic, Aleksandra, Marco-Contelles, Jose, Stark, Holger

Source: In European Journal of Medicinal Chemistry 25 March 2018 148:487-497

Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands

Authors: Stank, Lars, Frank, Annika, Hagenow, Stefanie, Stark, Holger

Source: MedChemComm. 10(11):1926-1929

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092288271.0x000001&indx=1&recIds=ETOCvdc_100092288271.0x000001

The Search for Histamine H4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives

Authors: Domínguez‐Álvarez, Enrique, Łażewska, Dorota, Szabó, Zsanett, Hagenow, Stefanie, Reiner, David, Gajdács, Márió, Spengler, Gabriella, Stark, Holger, Handzlik, Jadwiga, Kieć‐Kononowicz, Katarzyna

Source: ChemistrySelect. 4(36):10943-10952

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090992445.0x000001&indx=1&recIds=ETOCvdc_100090992445.0x000001

Alkyl derivatives of 1, 3, 5-triazine as histamine H4 receptor ligands

Authors: Łażewska, Dorota, Mogilski, Szczepan, Hagenow, Stefanie, Kuder, Kamil, Głuch-Lutwin, Monika, Siwek, Agata, Więcek, Małgorzata, Kaleta, Maria, Seibel, Ulla, Buschauer, Armin, Filipek, Barbara, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: Bioorganic & medicinal chemistry. 27(7):1254-1262

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077574060.0x000001&indx=1&recIds=ETOCvdc_100077574060.0x000001

Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives

Authors: Szczepańska, Katarzyna, Karcz, Tadeusz, Kotańska, Magdalena, Siwek, Agata, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Hagenow, Stefanie, Lubelska, Annamaria, Sobolewski, Michał, Stark, Holger, Kieć-Kononowicz, Katarzyna

Source: Bioorganic & medicinal chemistry. 26(23-24):6056-6066

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100072276382.0x000001&indx=1&recIds=ETOCvdc_100072276382.0x000001

Multipotente Liganden mit kombinierter Cholinesterase‐ und Monoaminooxidase‐Inhibition sowie Histamin‐H3R‐Antagonismus bei neurodegenerativen Erkrankungen

Authors: Bautista‐Aguilera, Óscar M., Hagenow, Stefanie, Palomino‐Antolin, Alejandra, Farré‐Alins, Víctor, Ismaili, Lhassane, Joffrin, Pierre‐Louis, Jimeno, María L., Soukup, Ondřej, Janočková, Jana, Kalinowsky, Lena, Proschak, Ewgenij, Iriepa, Isabel, Moraleda, Ignacio, Schwed, Johannes S., Romero Martínez, Alejandro, López‐Muñoz, Francisco, Chioua, Mourad, Egea, Javier, Ramsay, Rona R., Marco‐Contelles, José, Stark, Holger

Source: Angewandte Chemie. 129(41):12939-12943

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112202862.0x000001&indx=1&recIds=ETOCvdc_100112202862.0x000001

Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases

Authors: Bautista‐Aguilera, Óscar M., Hagenow, Stefanie, Palomino‐Antolin, Alejandra, Farré‐Alins, Víctor, Ismaili, Lhassane, Joffrin, Pierre‐Louis, Jimeno, María L., Soukup, Ondřej, Janočková, Jana, Kalinowsky, Lena, Proschak, Ewgenij, Iriepa, Isabel, Moraleda, Ignacio, Schwed, Johannes S., Romero Martínez, Alejandro, López‐Muñoz, Francisco, Chioua, Mourad, Egea, Javier, Ramsay, Rona R., Marco‐Contelles, José, Stark, Holger

Source: Angewandte Chemie international edition. 56(41):12765-12769

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112203219.0x000001&indx=1&recIds=ETOCvdc_100112203219.0x000001

Corrigendum to 'Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands' [Eur. J. Med. Chem. 185 (2020) 111785]

Authors: Bajda, Marek, Łażewska, Dorota, Godyń, Justyna, Zaręba, Paula, Kuder, Kamil, Hagenow, Stefanie, Łątka, Kamil, Stawarska, Ewelina, Stark, Holger, Kieć-Kononowicz, Katarzyna, Malawska, Barbara

Source: European journal of medicinal chemistry. 205

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121289616.0x000001&indx=1&recIds=ETOCvdc_100121289616.0x000001

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands.

Authors: Schaller, David¹, Hagenow, Stefanie², Stark, Holger², Wolber, Gerhard¹ gerhard.wolber@fu-berlin.de

Source: PLoS ONE. 6/25/2019, Vol. 14 Issue 6, p1-13. 13p.

Subject Terms: *HISTAMINE receptors, *BINDING site assay, *G protein coupled receptors, *PHYSICAL & theoretical chemistry, *HOMOLOGY (Biology), *LIGANDS (Biochemistry)

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Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson’s Disease

Authors: Hagenow, Stefanie, Affini, Anna, Pioli, Elsa Y., Hinz, Sonja, Zhao, Yan, Porras, Gregory, Namasivayam, Vigneshwaran, Müller, Christa E., Lin, Jian-Sheng, Bezard, Erwan, Stark, Holger

Source: Journal of Medicinal Chemistry; June 2021, Vol. 64 Issue: 12 p8246-8262, 17p