Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort

Authors: Bianchi, Matteo, Kozyrev, Sergey V., Notarnicola, Antonella, Hultin Rosenberg, Lina, Karlsson, Åsa, Pucholt, Pascal, Rothwell, Simon, Alexsson, Andrei, Sandling, Johanna K., Andersson, Helena, Cooper, Robert G., Padyukov, Leonid, Tjärnlund, Anna, Dastmalchi, Maryam, Lindblad‐Toh, Kerstin, Pielberg, Gerli Rosengren, Lobell, Anna, Murén, Eva, Ahlgren, Kerstin M., Rönnblom, Lars, Eloranta, Maija‐Leena, Andersson, Göran, Landegren, Nils, Kämpe, Olle, Söderkvist, Peter, Rosenberg, Lina Hultin, Syvänen, Ann‐Christine, Leonard, Dag, Almlöf, Jonas Carlsson, Dahlqvist, Johanna, Hagberg, Niklas, Lidén, Maria, Mathioudaki, Argyri, Meadows, Jennifer R. S., Nordin, Jessika, Nordmark, Gunnel, Yavuz, Sule, Lundberg, Ingrid E., Gunnarsson, Iva, Svenungsson, Elisabet, Eriksson, Daniel, Molberg, Øyvind, Farias, Fabiana H. G., Bengtsson, Christine, Rantapää‐Dahlqvist, Solbritt, Jonsson, Roland, Omdal, Roald, Jönsen, Andreas, Bengtsson, Anders A., Sjöwall, Christopher, Skogh, Thomas, Wahren‐Herlenius, Marie, Jalal, Awat, Hanna, Balsam, Hellström, Helena, Husmark, Tomas, Häggström, Åsa, Svärd, Anna, Pyndt Diederichsen, Louise, Chinoy, Hector, Lamb, Janine A.

Source: Arthritis & rheumatology. 74(2):342-352

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Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases

Authors: Lundtoft, Christian, Pucholt, Pascal, Martin, Myriam, Bianchi, Matteo, Lundström, Emeli, Eloranta, Maija‐Leena, Sandling, Johanna K., Sjöwall, Christopher, Jönsen, Andreas, Gunnarsson, Iva, Rantapää‐Dahlqvist, Solbritt, Bengtsson, Anders A., Leonard, Dag, Baecklund, Eva, Jonsson, Roland, Hammenfors, Daniel, Forsblad‐d'Elia, Helena, Eriksson, Per, Mandl, Thomas, Magnusson Bucher, Sara, Norheim, Katrine B., Auglænd Johnsen, Svein Joar, Omdal, Roald, Kvarnström, Marika, Wahren‐Herlenius, Marie, Notarnicola, Antonella, Andersson, Helena, Molberg, Øyvind, Diederichsen, Louise Pyndt, Almlöf, Jonas, Syvänen, Ann‐Christine, Kozyrev, Sergey V., Lindblad‐Toh, Kerstin, Rönnblom, Lars, Nordmark, Gunnel, Lundberg, Ingrid E., Rosenberg, Lina Hultin, Alexsson, Andrei, Bengtsson, Christine, Svenungsson, Elisabet, Almlöf, Jonas Carlsson, Hagberg, Niklas, Meadows, Jennifer R. S., Nordin, Jessika, Yavuz, Sule, Tjärnlund, Anna, Theander, Elke, Thorlacius, Guðný Ella, Chinoy, Hector, Enocsson, Helena, Lamb, Janine, Brun, Johan G., Wetterö, Jonas, Ramírez Sepúlveda, Jorge I., Imgenberg‐Kreuz, Juliana, Hjorton, Karin, Brokstad, Karl A., Skarstein, Kathrine, Norheim, Katrine Brække, Vasaitis, Lilian, Jonsson, Malin V., Dastmalchi, Maryam, Cooper, Robert G., Bucher, Sara Magnusson, Appel, Silke, Rothwell, Simon, Johnsen, Svein Joar, Aqrawi, Lara Adnan, Jensen, Janicke Liaaen, Palm, Øyvind, Liden, Maria, Skogh, Thomas, Hanna, Balsam, Hallengren, Christina Ståhl, Hellström, Helena, Häggström, Åsa, Mohammad, Aladdin, Husmark, Tomas, Svärd, Anna, Jalal, Awat, Pielberg, Gerli Rosengren, Lobell, Anna, Karlsson, Åsa, Murén, Eva, Andersson, Göran, Ahlgren, Kerstin M., Landegren, Nils, Kämpe, Olle, Söderkvist, Peter, Nilsson, Bo, Blom, Anna M., Diaz‐Gallo, Lina Marcela

Source: Arthritis & rheumatology. 74(8):1440-1450

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Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Authors: Hjorton, Karin, Hagberg, Niklas, Israelsson, Elisabeth, Jinton, Lisa, Berggren, Olof, Sandling, Johanna, Thörn, Kristofer, Mo, John, Eloranta, Maija-Leena, Rönnblom, Lars

Source: Arthritis research & therapy. 20(1):1-11

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Immunogenetics in systemic lupus erythematosus: Transitioning from genetic associations to cellular effects.

Authors: Hagberg, Niklas¹ (AUTHOR) niklas.hagberg@medsci.uu.se, Lundtoft, Christian¹ (AUTHOR), Rönnblom, Lars¹ (AUTHOR)

Source: Scandinavian Journal of Immunology. Oct2020, Vol. 92 Issue 4, p1-11. 11p.

Subject Terms: *SYSTEMIC lupus erythematosus, *IMMUNOGENETICS, *AUTOIMMUNE diseases, *IMMUNE system, *GENETIC polymorphisms

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Authors: Hjorton, Karin, Hagberg, Niklas, Pucholt, Pascal, Eloranta, Maija-Leena, Rönnblom, Lars

Source: Arthritis research & therapy. 22(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171974110.0x000001&indx=1&recIds=ETOCvdc_100171974110.0x000001

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling.

Authors: Lundtoft, Christian¹, Pucholt, Pascal¹, Imgenberg-Kreuz, Juliana¹, Carlsson-Almlöf, Jonas², Eloranta, Maija-Leena¹, Syvänen, Ann-Christine², Nordmark, Gunnel¹, Sandling, Johanna K.¹, Kockum, Ingrid³, Olsson, Tomas³, Rönnblom, Lars¹, Hagberg, Niklas¹, niklas.hagberg@medsci.uu.se

Source: PLoS Genetics; 10/26/2020, Vol. 16 Issue 10, p1-22, 22p

Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype.

Authors: Berggren, Olof¹, Hagberg, Niklas¹, Alexsson, Andrei¹, Weber, Gert², Rönnblom, Lars¹, Eloranta, Maija-Leena¹ maija-leena.eloranta@medsci.uu.se

Source: PLoS ONE. 8/28/2017, Vol. 12 Issue 8, p1-16. 16p.

Subject Terms: *SYSTEMIC lupus erythematosus, *B cells, *DENDRITIC cells, *IMMUNOASSAY, *FLOW cytometry, *RHEUMATOLOGY, *IMMUNE complexes, *AUTOIMMUNE diseases, *PHYSIOLOGY

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.

Authors: Nilsson, Magnus, Rhedin, Magdalena, Hendrickx, Ramon, Berglund, Susanne, Piras, Antonio, Blomgran, Parmis, Cavallin, Anders, Collins, Mia, Dahl, Göran, Dekkak, Bilel, Ericsson, Therese, Hagberg, Niklas, Holmberg, Ann Aurell, Leffler, Agnes, Lundqvist, Anders J, Markou, Thomais, Pinkerton, James, Rönnblom, Lars, Siu, Stacey, Taylor, Vanessa

Source: Drug Design, Development & Therapy; Aug2022, Vol. 16, p2901-2917, 17p

Interaction between the rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus.

Authors: Reid, Sarah, Hagberg, Niklas, Sandling, Johanna K., Alexsson, Andrei, Pucholt, Pascal, Sjöwall, Christopher, Lerang, Karoline, Jönsen, Andreas, Gunnarsson, Iva, Syvänen, Ann- Christine, Troldborg, Anne Margrethe, Voss, Anne, Bengtsson, Anders A., Molberg, Øyvind, Jacobsen, Søren, Svenungsson, Elisabet, Rönnblom, Lars, Leonard, Dag

Source: Annals of the Rheumatic Diseases; Sep2021, Vol. 80 Issue 9, p1183-1189, 13p

Subject Terms: RESEARCH, LUPUS nephritis, RESEARCH methodology, CELL receptors, MYOCARDIAL infarction, GENETIC polymorphisms, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, SMOKING, SYSTEMIC lupus erythematosus, CARRIER proteins, PHENOTYPES

Chapter 19 - The Interferon System in Lupus Erythematosus

Authors: Hagberg, Niklas, Rönnblom, Lars

Source: In Systemic Lupus Erythematosus 2016:153-158

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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Authors: Gaziano, Liam, Giambartolomei, Claudia, Pereira, Alexandre C., Gaulton, Anna, Posner, Daniel C., Swanson, Sonja A., Ho, Yuk-Lam, Iyengar, Sudha K., Kosik, Nicole M., Vujkovic, Marijana, Gagnon, David R., Bento, A. Patrícia, Barrio-Hernandez, Inigo, Rönnblom, Lars, Hagberg, Niklas, Lundtoft, Christian, Langenberg, Claudia, Pietzner, Maik, Valentine, Dennis, Gustincich, Stefano, Tartaglia, Gian Gaetano, Allara, Elias, Surendran, Praveen, Burgess, Stephen, Zhao, Jing Hua, Peters, James E., Prins, Bram P., Angelantonio, Emanuele Di, Devineni, Poornima, Shi, Yunling, Lynch, Kristine E., DuVall, Scott L., Garcon, Helene, Thomann, Lauren O., Zhou, Jin J., Gorman, Bryan R., Huffman, Jennifer E., O’Donnell, Christopher J., Tsao, Philip S., Beckham, Jean C., Pyarajan, Saiju, Muralidhar, Sumitra, Huang, Grant D., Ramoni, Rachel, Beltrao, Pedro, Danesh, John, Hung, Adriana M., Chang, Kyong-Mi, Sun, Yan V., Joseph, Jacob, Leach, Andrew R., Edwards, Todd L., Cho, Kelly, Gaziano, J. Michael, Butterworth, Adam S., Casas, Juan P.

Source: Nature Medicine; April 2021, Vol. 27 Issue: 4 p668-676, 9p

Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness.

Authors: Segerberg, Filip, Lundtoft, Christian, Reid, Sarah, Hjorton, Karin, Leonard, Dag, Nordmark, Gunnel, Carlsten, Mattias, Hagberg, Niklas

Source: Frontiers in Immunology; 9/11/2019, p1-12, 12p

Subject Terms: KILLER cell receptors, KILLER cells, LUPUS nephritis, DESMOGLEINS, AUTOANTIBODIES, SYSTEMIC lupus erythematosus, CELL physiology, SYSTEMIC scleroderma

The SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE.

Authors: Hagberg, Niklas, Joelsson, Martin, Leonard, Dag, Reid, Sarah, Eloranta, Maija-Leena, Mo, John, Nilsson, Magnus K., Syvänen, Ann-Christine, Bryceson, Yenan T., Rönnblom, Lars

Source: Annals of the Rheumatic Diseases; Jul2018, Vol. 77 Issue 7, p1071-1077, 8p, 1 Chart, 5 Graphs

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List of Contributors

Authors: Agmon-Levin, Nancy, Alarcón, Graciela S., Amengual, Olga, Ardoin, Stacy P., Atkinson, John P., Atsumi, Tatsuya, Ayoub, Isabelle, Bermas, Bonnie L., Bernatsky, Sasha, Bertsias, George, Blanco, Patrick, Bohgaki, Miyuki, Bonsmann, Gisela, Borghi, Maria Orietta, Boumpas, Dimitrios T., Bourn, Rebecka, Buyon, Jill P., Caricchio, Roberto, Catalina, Michelle D., Chan, Edward K.L., Chang, Christopher, Chartrand, Sandra, Chighizola, Cecilia Beatrice, Clarke, Ann E., Crispín, José C., Dai, Chao, Damato, Erika M., Deng, Yun, Denniston, Alastair K.O., Devlin, Amy, Diamond, Betty, Dooley, Mary Anne, Drijvers, Jefte M., du Bois, Roland M., Du, Yong, Ernandez, T., Ferretti, Concetta, Fischer, Aryeh, Fisher, Samantha, Frangou, Eleni A., Fritzler, Marvin J., Furie, Richard, Fu, Shu Man, Gaskin, Felicia, Gilkeson, Gary S., Gladman, Dafna, Goldman, Rosalind Ramsey, González-Naranjo, Luis A., Gordon, Caroline, Grammer, Amrie C., Greidinger, Eric L., Hagberg, Niklas, Hanly, John G., Hansen, James E., Han, Shuhong, Hasni, Sarfaraz A., Hedrich, Christian M., Horowitz, Diane, Huang, Xin, Izmirly, Peter M., Jacquemin, Clément, James, Judith, Jarjour, Wael N., Kaplan, Mariana J., Khamashta, Munther, Koike, Takao, Kono, Dwight H., Konya, Christine, Kuhn, Annegret, Kyttaris, Vasileios C., La Cava, Antonio, Lahita, Robert G., Landmann, Aysche, Lipsky, Peter E., Lo, Mindy S., Lu, Qianjin, Mahieu, Mary, Malkiel, Susan, Manzi, Susan, Marder, Galina, Mayadas, T.N., Means, Terry K., Meroni, Pier Luigi, Merrill, Joan T., Mohan, Chandra, Mok, Chi Chiu, Moulton, Vaishali R., Murray, Philip I., Oates, Jim C., Paz, Ziv, Pendergraft, William F., III, Perl, Andras, Pillai, Shiv, Pons-Estel, Guillermo J., Qu, Bo, Rahman, Anisur, Ramsey-Goldman, Rosalind, Reeves, Westley H., Rodríguez-Rodríguez, Noé, Rönnblom, Lars, Rosetti, Florencia, Rovin, Brad H., Ryals, Matthew M., Saggu, G., Sammaritano, Lisa R., Satoh, Minoru, Sawalha, Amr H., Saxena, Amit, Sciascia, Savino, Shaharir, Syahrul, Shao, Chengqun, Shen, Nan, Shmerling, Robert, Shoenfeld, Yehuda, Shumyak, Stepan, Slight-Webb, Samantha, Stillman, Isaac Ely, Stojan, George, Sung, Sun-Sang J., Theofilopoulos, Argyrios N., Thomas Jr., Donald E., Tissera, Hiromi, Touma, Zahi, Tsao, Betty P., Ugarte-Gil, Manuel F., Urowitz, Murray B., Volpe, Bruce T., Wang, Hongyang, Wener, Mark H., Wu, Haijing, Xu, Yuan, Yang, Lijun, Yu, C. Yung, Zhuang, Haoyang

Source: In Systemic Lupus Erythematosus 2016:xix-xxiii

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes.

Authors: Leonard, Dag, Eloranta, Maija-Leena, Hagberg, Niklas, Berggren, Olof, Tandre, Karolina, Alm, Gunnar, Rönnblom, Lars

Source: Annals of the Rheumatic Diseases; Sep2016, Vol. 75 Issue 9, p1728-1734, 7p, 1 Chart, 5 Graphs

Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the SLE risk allele rs7574865[T].

Authors: Hagberg, Niklas, Rönnblom, Lars

Source: Annals of the Rheumatic Diseases; Mar2019, Vol. 78 Issue 3, p429-431, 3p, 1 Graph

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