Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4

Authors: Hafey, Michael J., Aleksunes, Lauren M., Bridges, Christy C., Brouwer, Kenneth R., Chien, Huan‐Chieh, Leslie, Elaine M., Hu, Shuiying, Li, Yang, Shen, Jinshan, Sparreboom, Alex, Sprowl, Jason, Tweedie, Donald, Lai, Yurong

Source: Clinical pharmacology & therapeutics. 112(3):527-539

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381744.0x000001&indx=1&recIds=ETOCvdc_100158381744.0x000001

A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

Authors: Hafey, Michael J. ^*, Houle, Robert, Tanis, Keith Q., Knemeyer, Ian, Shang, Jackie ¹, Chen, Qing ², Baudy, Andreas, Monroe, James, Sistare, Frank D., Evers, Raymond ³

Source: In Drug Metabolism and Disposition November 2020 48(11):1147-1160

Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity

Authors: Li, Yutai, Evers, Raymond, Hafey, Michael J, Cheon, Kyeongmi, Duong, Hong, Lynch, Donna, LaFranco-Scheuch, Lisa, Pacchione, Stephen, Tamburino, Alex M, Tanis, Keith Q, Geddes, Kristin, Holder, Daniel, Zhang, Nanyan Rena, Kang, Wen, Gonzalez, Raymond J, Galijatovic-Idrizbegovic, Alema, Pearson, Kara M, Lebron, Jose A, Glaab, Warren E, Sistare, Frank D

Source: Toxicological sciences. 170(1):180-198

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087543995.0x000001&indx=1&recIds=ETOCvdc_100087543995.0x000001

Membrane transporters in drug development and as determinants of precision medicine

Authors: Galetin, Aleksandra, Brouwer, Kim L. R., Tweedie, Donald, Yoshida, Kenta, Sjöstedt, Noora, Aleksunes, Lauren, Chu, Xiaoyan, Evers, Raymond, Hafey, Michael J., Lai, Yurong, Matsson, Pär, Riselli, Andrew, Shen, Hong, Sparreboom, Alex, Varma, Manthena V. S., Yang, Jia, Yang, Xinning, Yee, Sook Wah, Zamek-Gliszczynski, Maciej J., Zhang, Lei, Giacomini, Kathleen M.

Source: Nature Reviews Drug Discovery; 20240101, Issue: Preprints p1-26, 26p

Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein

Authors: Chu, Xiao-Yan ^*, Bleasby, Kelly, Yabut, Jocelyn, Cai, Xiaoxin, Chan, Grace Hoyee, Hafey, Michael J., Xu, Shiyao, Bergman, Arthur J., Braun, Matthew P., Dean, Dennis C., Evers, Raymond

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2007 321(2):673-683

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Authors: Powell, David A., Black, W. Cameron, Bleasby, Kelly, Chan, Chi-Chung, Deschenes, Denis, Gagnon, Marc, Gordon, Rob, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J., Huang, Zheng, Isabel, Elise, Leblanc, Yves, Styhler, Angela, Xu, Li-Jing, Zhang, Lei, Oballa, Renata M.

Source: In Bioorganic & Medicinal Chemistry Letters 2011 21(24):7281-7286

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Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition.

Authors: Yutai Li, Hafey, Michael J., Hong Duong, Evers, Raymond, Kyeongmi Cheon, Holder, Daniel J., Galijatovic-Idrizbegovic, Alema, Sistare, Frank D., Glaab, Warren E.

Source: Toxicological Sciences; May2017, Vol. 157 Issue 1, p30-40, 11p, 5 Charts, 4 Graphs

Subject Terms: BILE acids, ANTIBIOTIC prophylaxis, LIVER analysis, DRUG development, TAUROCHOLIC acid

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