LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Authors: Alborzinia, Hamed, Chen, Zhiyi, Yildiz, Umut, Freitas, Florencio Porto, Vogel, Felix C E, Varga, Julianna Patricia, Batani, Jasmin, Bartenhagen, Christoph, Schmitz, Werner, Büchel, Gabriele, Michalke, Bernhard, Zheng, Jashuo, Meierjohann, Svenja, Girardi, Enrico, Espinet, Elisa, Flórez, Andrés F, Santos, Ancely Ferreira, Aroua, Nesrine, Cheytan, Tasneem, Haenlin, Julie, Schlicker, Lisa, Xavier da Silva, Thamara N, Przybylla, Adriana, Zeisberger, Petra, Superti‐Furga, Giulio, Eilers, Martin, Conrad, Marcus, Fabiano, Marietta, Schweizer, Ulrich, Fischer, Matthias, Schulze, Almut, Trumpp, Andreas, Friedmann Angeli, José Pedro

Source: EMBO molecular medicine. 15(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189952299.0x000001&indx=1&recIds=ETOCvdc_100189952299.0x000001

EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2.

Authors: Wolf, Lucie M., Lambert, Annika M., Haenlin, Julie, Boutros, Michael

Source: Journal of Cell Science; Aug2021, Vol. 134 Issue 16, p1-1, 1p

Subject Terms: WNT proteins, UBIQUITIN-conjugating enzymes, WNT signal transduction, PROTEIN stability, UBIQUITIN ligases, UBIQUITINATION