Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab

Authors: Tsoi, Lam C., Hacini-Rachinel, Feriel, Fogel, Paul, Rousseau, Francois, Xing, Xianying, Patrick, Matthew T., Billi, Allison C., Berthier, Celine C., Kahlenberg, J. Michelle, Lazzari, Anne, Wiegmann, Henning, Ständer, Sonja, Piketty, Christophe, Julia, Valerie, Krishnaswamy, Jayendra Kumar, Gudjonsson, Johann E.

Source: Journal of allergy and clinical immunology. 149(4):1329-1339

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A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Authors: Janela, Baptiste, Patel, Amit A., Lau, Mai Chan, Goh, Chi Ching, Msallam, Rasha, Kong, Wan Ting, Fehlings, Michael, Hubert, Sandra, Lum, Josephine, Simoni, Yannick, Malleret, Benoit, Zolezzi, Francesca, Chen, Jinmiao, Poidinger, Michael, Satpathy, Ansuman T., Briseno, Carlos, Wohn, Christian, Malissen, Bernard, Murphy, Kenneth M., Maini, Alexander A., Vanhoutte, Leen, Guilliams, Martin, Vial, Emmanuel, Hennequin, Laurent, Newell, Evan, Ng, Lai Guan, Musette, Philippe, Yona, Simon, Hacini-Rachinel, Feriel, Ginhoux, Florent

Source: In Immunity 16 April 2019 50(4):1069-1083

Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis

Authors: Boiteau, Jean-Guy, Ouvry, Gilles, Arlabosse, Jean-Marie, Astri, Stéphanie, Beillard, Audrey, Bhurruth-Alcor, Yushma, Bonnary, Laetitia, Bouix-Peter, Claire, Bouquet, Karine, Bourotte, Marilyne, Cardinaud, Isabelle, Comino, Catherine, Deprez, Benoît, Duvert, Denis, Féret, Angélique, Hacini-Rachinel, Feriel, Harris, Craig S., Luzy, Anne-Pascale, Mathieu, Arnaud, Millois, Corinne, Orsini, Nicolas, Pascau, Jonathan, Pinto, Artur, Piwnica, David, Polge, Gaëlle, Reitz, Arnaud, Reversé, Kevin, Rodeville, Nicolas, Rossio, Patricia, Spiesse, Delphine, Tabet, Samuel, Taquet, Nathalie, Tomas, Loïc, Vial, Emmanuel, Hennequin, Laurent F.

Source: In Bioorganic & Medicinal Chemistry 15 February 2018 26(4):945-956

Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis

Authors: Hacini-Rachinel, Feriel, Gomez de Agüero, Mercedes, Kanjarawi, Reem, Moro-Sibilot, Ludovic, Le Luduec, Jean-Benoit, Macari, Claire, Boschetti, Gilles, Bardel, Emilie, Langella, Philippe, Dubois, Bertrand, Kaiserlian, Dominique

Source: In The Journal of Allergy and Clinical Immunology January 2018 141(1):163-170

Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds.

Authors: Hacini‐Rachinel, Feriel¹ (AUTHOR) feriel.hacini‐rachinel@novartis.com, Hauchard, Alice¹ (AUTHOR), Bruno, Sandro¹ (AUTHOR), Paulat, Guido¹ (AUTHOR), Cojean, Celine¹ (AUTHOR), Loesle, Perrine¹ (AUTHOR), Schneider, Martin Alexander¹ (AUTHOR), Bourne, Marta¹ (AUTHOR), Elain, Gaelle¹ (AUTHOR), Roth, Lukas¹ (AUTHOR), Urban, Beatrice¹ (AUTHOR), Viebrock, Sabine¹ (AUTHOR), Leon, Anette Orjuela¹ (AUTHOR), Roehn, Till A.¹ (AUTHOR), Loesche, Christian¹ (AUTHOR), Werfel, Thomas² (AUTHOR), Thoma, Gebhard³ (AUTHOR), Zerwes, Hans‐Günter¹ (AUTHOR) hg.zerwes@online.de

Source: Experimental Dermatology. May2024, Vol. 33 Issue 5, p1-9. 9p.

Subject Terms: *ATOPIC dermatitis, *TOPICAL drug administration, *PLASTIC surgery, *SKIN diseases, *STAT proteins

Discovery of a novel series of selective macrocyclic PKCTheta inhibitors

Authors: Crosignani, Stefano, Campos, Sebastien, Bouix-Peter, Claire, Harris, Craig, Talbot, Eric, Hu, Haiyang, Wang, Shun, Maclean, John, Zanelli, Ugo, Taylor, Simon, Foote, Kevin, Hacini-Rachinel, Feriel, Nicodeme, Edwige, Julia, Valerie

Source: In Bioorganic & Medicinal Chemistry Letters 1 March 2024 100

Sulfoximines as potent RORγ inverse agonists

Authors: Ouvry, Gilles, Bihl, Franck, Bouix-Peter, Claire, Christin, Olivier, Defoin-Platel, Claire, Deret, Sophie, Feret, Christophe, Froude, David, Hacini-Rachinel, Feriel, Harris, Craig S., Hervouet, Catherine, Lafitte, Guillaume, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Parnet, Veronique, Pascau, Coralie, Pascau, Jonathan, Pierre, Romain, Raffin, Catherine, Rossio, Patricia, Spiesse, Delphine, Taquet, Nathalie, Thoreau, Etienne, Vatinel, Rodolphe, Vial, Emmanuel, Hennequin, Laurent F.

Source: Bioorganic & medicinal chemistry letters. 28(8):1269-1273

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Identification of novel TACE inhibitors compatible with topical application

Authors: Ouvry, Gilles, Berton, Yaël, Bhurruth-Alcor, Yushma, Bonnary, Laetitia, Bouix-Peter, Claire, Bouquet, Karine, Bourotte, Marilyne, Chambon, Sandrine, Comino, Catherine, Deprez, Benoît, Duvert, Denis, Duvert, Gwenaëlle, Hacini-Rachinel, Feriel, Harris, Craig S., Luzy, Anne-Pascale, Mathieu, Arnaud, Millois, Corinne, Pascau, Jonathan, Pinto, Artur, Polge, Gaëlle, Reitz, Arnaud, Reversé, Kevin, Rosignoli, Carine, Taquet, Nathalie, Hennequin, Laurent F.

Source: Bioorganic & medicinal chemistry letters. 27(8):1848-1853

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100052134304.0x000001&indx=1&recIds=ETOCvdc_100052134304.0x000001

Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

Authors: Thoma, Gebhard, Decoret, Odile, Vangrevelinghe, Eric, Trunzer, Markus, Decker, Andrea, Orjuela Leon, Anette, Beerli, Christian, Bruno, Sandro, Hauchard, Alice, Paulat, Guido, Zerwes, Hans-Guenter, Hacini-Rachinel, Feriel

Source: Journal of Medicinal Chemistry; 11/9/2023, Vol. 66 Issue 21, p15042-15053, 12p

Live and heat-treated probiotics differently modulate IL10 mRNA stabilization and microRNA expression

Authors: Demont, Audrey, Hacini-Rachinel, Feriel, Doucet-Ladevèze, Rémi, Ngom-Bru, Catherine, Mercenier, Annick, Prioult, Guénolée, Blanchard, Carine

Source: Journal of allergy and clinical immunology. 137(4):1264-1267.e10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128748193.0x000001&indx=1&recIds=ETOCvdc_100128748193.0x000001

Oral Probiotic Control Skin Inflammation by Acting on Both Effector and Regulatory T Cells.

Authors: Hacini-Rachinel, Feriel^1,2,3, Gheit, Hanane^1,2,3, Le Luduec, Jean-Benoit^1,2,3, Dif, Fariel⁴, Nancey, Stéphane^1,2,3,5, Kaiserlian, Dominique^1,2,3 dominique.kaiserlian@inserm.fr

Source: PLoS ONE. 2009, Vol. 4 Issue 3, p1-9. 9p. 2 Diagrams, 5 Graphs.

Subject Terms: *SKIN inflammation, *T cells, *PROBIOTICS, *ALLERGIES, *PROTEINS, *CONTACT dermatitis

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Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Authors: Nakamizo, Satoshi, Dutertre, Charles-Antoine, Khalilnezhad, Ahad, Zhang, Xiao Meng, Lim, Shawn, Lum, Josephine, Koh, Geraldine, Foong, Charlene, Yong, Pearly Jean Ai, Tan, Kahbing Jasmine, Sato, Reiko, Tomari, Kaori, Yvan-Charvet, Laurent, He, Helen, Guttman-Yassky, Emma, Malleret, Benoit, Shibuya, Rintaro, Iwata, Masashi, Janela, Baptiste, Goto, Tsuyoshi, Lucinda, Tan Siyun, Tang, Mark B.Y., Theng, Colin, Julia, Valerie, Hacini-Rachinel, Feriel, Kabashima, Kenji, Ginhoux, Florent

Source: The Journal of Experimental Medicine; September 2021, Vol. 218 Issue: 9 pe20202345-e20202345, 1p