Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML

Authors: Hassan, Nunki, Yi, Hangyu, Malik, Bilal, Gaspard-Boulinc, Lucie, Samaraweera, Saumya E., Casolari, Debora A., Seneviratne, Janith, Balachandran, Anushree, Chew, Tracy, Duly, Alastair, Carter, Daniel R., Cheung, Belamy B., Norris, Murray, Haber, Michelle, Kavallaris, Maria, Marshall, Glenn M., Zhang, Xu Dong, Liu, Tao, Wang, Jianlong, Liebermann, Dan A., D’Andrea, Richard J., Wang, Jenny Y.

Source: In Blood 4 July 2024 144(1):84-98

Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors

Authors: Novototskaya-Vlasova, Ksenia A., Neznanov, Nickolay S., Molodtsov, Ivan, Hall, Brandon M., Commane, Mairead, Gleiberman, Anatoli S., Murray, Jayne, Haber, Michelle, Norris, Murray D., Leonova, Katerina I., Gudkov, Andrei V.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Dec 01. 119(49), 1-11.

Access URL: https://www.jstor.org/stable/27209491

Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma

Authors: Seneviratne, Janith A., Carter, Daniel R., Mittra, Rituparna, Gifford, Andrew, Kim, Patrick Y., Luo, Jie‐Si, Mayoh, Chelsea, Salib, Alice, Rahmanto, Aldwin S., Murray, Jayne, Cheng, Ngan C., Nagy, Zsuzsanna, Wang, Qian, Kleynhans, Ane, Tan, Owen, Sutton, Selina K., Xue, Chengyuan, Chung, Sylvia A., Zhang, Yizhuo, Sun, Chengtao, Zhang, Li, Haber, Michelle, Norris, Murray D., Fletcher, Jamie I., Liu, Tao, Dilda, Pierre J., Hogg, Philip J., Cheung, Belamy B., Marshall, Glenn M.

Source: International journal of cancer. 152(7):1399-1413

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173069980.0x000001&indx=1&recIds=ETOCvdc_100173069980.0x000001

Methodological advances in the discovery of novel neuroblastoma therapeutics

Authors: Segura, Miguel F., Soriano, Aroa, Roma, Josep, Piskareva, Olga, Jiménez, Carlos, Boloix, Ariadna, Fletcher, Jamie I., Haber, Michelle, Gray, Juliet C., Cerdá-Alberich, Leonor, Martínez de Las Heras, Blanca, Cañete, Adela, Gallego, Soledad, Moreno, Lucas

Source: Expert opinion on drug discovery. 17(2):167-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139267366.0x000001&indx=1&recIds=ETOCvdc_100139267366.0x000001

GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators

Authors: Hanssen, Kimberley M., Wheatley, Madeleine S., Yu, Denise M. T., Conseil, Gwenaëlle, Norris, Murray D., Haber, Michelle, Cole, Susan P. C., Fletcher, Jamie I.

Source: FEBS journal. 289(13):3854-3875

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154881049.0x000001&indx=1&recIds=ETOCvdc_100154881049.0x000001

The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma.

Authors: Azfar, Mujahid, Gao, Weiman, Van den Haute, Chris, Xiao, Lin, Karsa, Mawar, Pandher, Ruby, Karsa, Ayu, Spurling, Dayna, Ronca, Emma, Bongers, Angelika, Guo, Xinyi, Mayoh, Chelsea, Fayt, Youri, Schoofs, Arthur, Burns, Mark R., Verhelst, Steven H. L., Norris, Murray D., Haber, Michelle, Vangheluwe, Peter, Somers, Klaartje

Source: Molecular Oncology; Mar2025, Vol. 19 Issue 3, p913-936, 24p

Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition

Authors: Hanssen, Kimberley M., Haber, Michelle, Fletcher, Jamie I. ^*

Source: In Drug Resistance Updates December 2021 59

Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors

Authors: Xiao, Lin, Yeung, Harrison, Haber, Michelle, Norris, Murray D., Somers, Klaartje

Source: In Trends in Cancer August 2021 7(8):751-777

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Authors: Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M., Liu, Jie, Joshi, Swapna, Rouaen, Jourdin R.C., Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Tolhurst, Ornella, Kankean, Anne, Hayden, Elisha, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei V., Norris, Murray D., Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S.

Source: In Cell Reports 13 April 2021 35(2)

The important role of routine cytopathology in pediatric precision oncology

Authors: Xie, Jinhan, Kumar, Amit, Dolman, M. Emmy M., Mayoh, Chelsea, Khuong‐Quang, Dong‐Anh, Cadiz, Roxanne, Wong‐Erasmus, Marie, Mould, Emily V. A., Grebert‐Wade, Dylan, Barahona, Paulette, Kamili, Alvin, Tsoli, Maria, Failes, Timothy W., Chow, Shu‐Oi, Arndt, Greg M., Bhatia, Kanika, Marshall, Glenn M., Ziegler, David S., Haber, Michelle, Lock, Richard B., Tyrrell, Vanessa, Lau, Loretta, Athanasatos, Penny, Gifford, Andrew J.

Source: Cancer cytopathology. 129(10):805-818

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131025508.0x000001&indx=1&recIds=ETOCvdc_100131025508.0x000001

Cell-Based Methods for the Identification of Myc-Inhibitory Small Molecules

Authors: Burkhart, Catherine A., Haber, Michelle, Norris, Murray D., Gudkov, Andrei V., Nikiforov, Mikhail A.

Source: Methods in molecular biology. 2318:337-346

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626654701&indx=1&recIds=ETOCRN626654701

The RNA‐helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma

Authors: Putra, Vina, Hulme, Amy J., Tee, Andrew E., Sun, Jane Q.J., Atmadibrata, Bernard, Ho, Nicholas, Chen, Jingwei, Gao, Jixuan, Norris, Murray D., Haber, Michelle, Kavallaris, Maria, Henderson, Michelle J., McCarroll, Joshua, Trahair, Toby, Liu, Tao, Liu, Pei Y.

Source: Molecular oncology. 15(4):1162-1179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119328891.0x000001&indx=1&recIds=ETOCvdc_100119328891.0x000001

Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma.

Authors: Seneviratne, Janith A., Ravindrarajah, Daenikka, Carter, Daniel R., Zhai, Vicki, Lalwani, Amit, Krishan, Sukriti, Balachandran, Anushree, Ng, Ernest, Pandher, Ruby, Wong, Matthew, Nero, Tracy L., Wang, Shudong, Norris, Murray D., Haber, Michelle, Liu, Tao, Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M.

Source: Cancer Medicine; Nov2024, Vol. 13 Issue 21, p1-20, 20p

Subject Terms: MOLECULAR biology, HISTONE methyltransferases, GENE expression, ENDOPLASMIC reticulum, TUMOR markers, NEUROBLASTOMA

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

Authors: Salik, Basit, Yi, Hangyu, Hassan, Nunki, Santiappillai, Nancy, Vick, Binje, Connerty, Patrick, Duly, Alastair, Trahair, Toby, Woo, Andrew J., Beck, Dominik, Liu, Tao, Spiekermann, Karsten, Jeremias, Irmela, Wang, Jianlong, Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Liebermann, Dan A., D'Andrea, Richard J., Murriel, Christopher, Wang, Jenny Y.

Source: In Cancer Cell 10 August 2020 38(2):263-278

CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth

Authors: Huynh, Tony, Murray, Jayne, Flemming, Claudia L., Kamili, Alvin, Hofmann, Ute, Cheung, Leanna, Roundhill, Elizabeth A., Yu, Denise M.T., Webber, Hannah T., Schwab, Matthias, Henderson, Michelle J., Haber, Michelle, Norris, Murray D., Fletcher, Jamie I.

Source: In Biochemical Pharmacology February 2020 172

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Authors: Rokita, Jo Lynne, Rathi, Komal S., Cardenas, Maria F., Upton, Kristen A., Jayaseelan, Joy, Cross, Katherine L., Pfeil, Jacob, Egolf, Laura E., Way, Gregory P., Farrel, Alvin, Kendsersky, Nathan M., Patel, Khushbu, Gaonkar, Krutika S., Modi, Apexa, Berko, Esther R., Lopez, Gonzalo, Vaksman, Zalman, Mayoh, Chelsea, Nance, Jonas, McCoy, Kristyn, Haber, Michelle, Evans, Kathryn, McCalmont, Hannah, Bendak, Katerina, Böhm, Julia W., Marshall, Glenn M., Tyrrell, Vanessa, Kalletla, Karthik, Braun, Frank K., Qi, Lin, Du, Yunchen, Zhang, Huiyuan, Lindsay, Holly B., Zhao, Sibo, Shu, Jack, Baxter, Patricia, Morton, Christopher, Kurmashev, Dias, Zheng, Siyuan, Chen, Yidong, Bowen, Jay, Bryan, Anthony C., Leraas, Kristen M., Coppens, Sara E., Doddapaneni, HarshaVardhan, Momin, Zeineen, Zhang, Wendong, Sacks, Gregory I., Hart, Lori S., Krytska, Kateryna, Mosse, Yael P., Gatto, Gregory J., Sanchez, Yolanda, Greene, Casey S., Diskin, Sharon J., Vaske, Olena Morozova, Haussler, David, Gastier-Foster, Julie M., Kolb, E. Anders, Gorlick, Richard, Li, Xiao-Nan, Reynolds, C. Patrick, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B., Raman, Pichai, Wheeler, David A., Maris, John M.

Source: In Cell Reports 5 November 2019 29(6):1675-1689

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

Authors: Gana, Christine C., Hanssen, Kimberley M., Yu, Denise M.T., Flemming, Claudia L., Wheatley, Madeleine S., Conseil, Gwenaëlle, Cole, Susan P.C., Norris, Murray D., Haber, Michelle, Fletcher, Jamie I.

Source: In Biochemical Pharmacology October 2019 168:237-248

Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing

Authors: Hu, Wenxin, Kumar, Amit, Ahmed, Syed Faraz, Qi, Shijiao, Ma, David K. G., Chen, Honglin, Singh, Gurjeet J., Casan, Joshua M. L., Haber, Michelle, Voskoboinik, Ilia, McKay, Matthew R., Trapani, Joseph A., Ekert, Paul G., Fareh, Mohamed

Source: Nature Structural and Molecular Biology; November 2024, Vol. 31 Issue: 11 p1702-1716, 15p

Advances and Challenges in Pediatric and Childhood Cancers

Authors: Hawkins, Cynthia, Pfister, Stefan, Jones, David T.W., Shah, Nirali N., Gilbertson, Richard J., Sweet-Cordero, E. Alejandro, Dyer, Michael A., Mossé, Yael P., Haber, Michelle, DuBois, Steven G.

Source: Cancer cell. 38(4):429-432

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115586974.0x000001&indx=1&recIds=ETOCvdc_100115586974.0x000001

ABCC4/MRP4 contributes to the aggressiveness of Myc‐associated epithelial ovarian cancer

Authors: Jung, Moonsun, Gao, Jixuan, Cheung, Leanna, Bongers, Angelika, Somers, Klaartje, Clifton, Molly, Ramsay, Emma E., Russell, Amanda J., Valli, Emanuele, Gifford, Andrew J., George, Joshy, Kennedy, Catherine J., Wakefield, Matthew J., Topp, Monique, Ho, Gwo‐Yaw, Scott, Clare L., Bowtell, David D., deFazio, Anna, Norris, Murray D., Haber, Michelle, Henderson, Michelle J.

Source: International journal of cancer. 147(8):2225-2238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108083665.0x000001&indx=1&recIds=ETOCvdc_100108083665.0x000001