The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes

Authors: Tarab-Ravski, Dana, Stotsky-Oterin, Lior, Elisha, Aviad, Kundoor, Govinda Reddy, Ramishetti, Srinivas, Hazan-Halevy, Inbal, Haas, Heinrich, Peer, Dan

Source: In Journal of Controlled Release December 2024 376:286-302

Molecular localization and exchange kinetics in pharmaceutical liposome and mRNA lipoplex nanoparticle products determined by small angle X-ray scattering and pulsed field gradient NMR diffusion measurements

Authors: Schlattmann, Daniel, Weber, Benjamin, Wyszynski, Leonard, Schönhoff, Monika, Haas, Heinrich

Source: In European Journal of Pharmaceutics and Biopharmaceutics August 2024 201

Self-amplifying RNA vaccine protects mice against lethal Ebola virus infection

Authors: Krähling, Verena, Erbar, Stephanie, Kupke, Alexandra, Nogueira, Sara S., Walzer, Kerstin C., Berger, Hendrik, Dietzel, Erik, Halwe, Sandro, Rohde, Cornelius, Sauerhering, Lucie, Aragão-Santiago, Letícia, Moreno Herrero, Jorge, Witzel, Sonja, Haas, Heinrich, Becker, Stephan, Sahin, Ugur

Source: Molecular therapy. 31(2):374-386

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180336888.0x000001&indx=1&recIds=ETOCvdc_100180336888.0x000001

Hybrid core-shell particles for mRNA systemic delivery

Authors: Andretto, Valentina, Repellin, Mathieu, Pujol, Marine, Almouazen, Eyad, Sidi-Boumedine, Jacqueline, Granjon, Thierry, Zhang, Heyang, Remaut, Katrien, Jordheim, Lars Petter, Briançon, Stéphanie, Keil, Isabell Sofia, Vascotto, Fulvia, Walzer, Kerstin C., Sahin, Ugur, Haas, Heinrich, Kryza, David, Lollo, Giovanna

Source: Journal of controlled release. 353:1037-1049

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180181635.0x000001&indx=1&recIds=ETOCvdc_100180181635.0x000001

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

Authors: Aldon, Yoann, McKay, Paul F., Moreno Herrero, Jorge, Vogel, Annette B., Lévai, Réka, Maisonnasse, Pauline, Dereuddre-Bosquet, Nathalie, Haas, Heinrich, Fábián, Katalin, Le Grand, Roger, Sahin, Ugur, Shattock, Robin J.

Source: In Molecular Therapy - Nucleic Acids 3 September 2021 25:483-493

Heparin modulates the cellular uptake of nanomedicinesElectronic supplementary information (ESI) available: Detailed methods and supporting figures. See DOI: 10.1039/d0bm01946a

Authors: Champanhac, Carole, Haas, Heinrich, Landfester, Katharina, Mailänder, Volker

Source: Biomaterials science. 9(4):1227-1231

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116494928.0x000001&indx=1&recIds=ETOCvdc_100116494928.0x000001

On the Influence of Fabrication Methods and Materials for mRNA‐LNP Production: From Size and Morphology to Internal Structure and mRNA Delivery Performance In Vitro and In Vivo.

Authors: Bi, Dongdong, Wilhelmy, Christoph, Unthan, Dennis, Keil, Isabell Sofia, Zhao, Bonan, Kolb, Bastian, Koning, Roman I., Graewert, Melissa A., Wouters, Bert, Zwier, Raphaël, Bussmann, Jeroen, Hankemeier, Thomas, Diken, Mustafa, Haas, Heinrich, Langguth, Peter, Barz, Matthias, Zhang, Heyang

Source: Advanced Healthcare Materials; 10/18/2024, Vol. 13 Issue 26, p1-14, 14p

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

Authors: Vogel, Annette B., Lambert, Laura, Kinnear, Ekaterina, Busse, David, Erbar, Stephanie, Reuter, Kerstin C., Wicke, Lena, Perkovic, Mario, Beissert, Tim, Haas, Heinrich, Reece, Stephen T., Sahin, Ugur, Tregoning, John S.

Source: In Molecular Therapy 7 February 2018 26(2):446-455

Liposomal formulations of lipophilic compounds

PH‐Dependent Behavior of Ionizable Cationic Lipids in mRNA‐Carrying Lipoplexes Investigated by Molecular Dynamics Simulations

Authors: Settanni, Giovanni, Brill, Wolfgang, Haas, Heinrich, Schmid, Friederike

Source: Macromolecular rapid communications. 43(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154937089.0x000001&indx=1&recIds=ETOCvdc_100154937089.0x000001

Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration

Authors: Ziller, Antje, Nogueira, Sara S., Hühn, Evan, Funari, Sergio S., Brezesinski, Gerald, Hartmann, Hermann, Sahin, Ugur, Haas, Heinrich, Langguth, Peter

Source: Molecular pharmaceutics. 15(2):642-651

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614835539&indx=1&recIds=ETOCRN614835539

Optimizing the Delivery of mRNA to Mesenchymal Stem Cells for Tissue Engineering Applications.

Authors: McCormick, Katie, Moreno Herrero, Jorge, Haas, Heinrich, Fattah, Sarinj, Heise, Andreas, O'Brien, Fergal J., Cryan, Sally-Ann

Source: Molecular Pharmaceutics; 2024, Vol. 21 Issue 4, p1662-1676, 15p

Translating nanoparticulate-personalized cancer vaccines into clinical applications: case study with RNA-lipoplexes for the treatment of melanoma

Authors: Grabbe, Stephan, Haas, Heinrich, Diken, Mustafa, Kranz, Lena M, Langguth, Peter, Sahin, Ugur

Source: Nanomedicine. 11(20):2723-2734

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139390187.0x000001&indx=1&recIds=ETOCvdc_100139390187.0x000001

Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering.

Authors: Graewert, Melissa A., Wilhelmy, Christoph, Bacic, Tijana, Schumacher, Jens, Blanchet, Clement, Meier, Florian, Drexel, Roland, Welz, Roland, Kolb, Bastian, Bartels, Kim, Nawroth, Thomas, Klein, Thorsten, Svergun, Dmitri, Langguth, Peter, Haas, Heinrich

Source: Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-13, 13p

Subject Terms: SMALL-angle scattering, FIELD-flow fractionation, SMALL-angle X-ray scattering, NANOPARTICLES, MESSENGER RNA, ENVIRONMENTAL sciences

Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy.

Authors: Wilhelmy, Christoph, Keil, Isabell Sofia, Uebbing, Lukas, Schroer, Martin A., Franke, Daniel, Nawroth, Thomas, Barz, Matthias, Sahin, Ugur, Haas, Heinrich, Diken, Mustafa, Langguth, Peter

Source: Pharmaceutics; Aug2023, Vol. 15 Issue 8, p2068, 17p

Subject Terms: SMALL-angle X-ray scattering, MONONUCLEAR leukocytes, MESSENGER RNA, LIPIDS, IMMUNOTHERAPY, CATIONIC lipids

˜Dieœ Austro-Burgundionen und Logionen :ein Beitrag zur Urgeschichte des südmainländischen Ostfrankens

Authors: Haas, Heinrich

Availability: http://data.europeana.eu/aggregation/europeana/358/item_DR27B6UJLSVSWKMUXVFZ7NDCXMPAZL2H

˜Dieœ Nibelungen in ihren Beziehungen zur Geschichte des Mittelalters

Authors: Haas, Heinrich

Availability: http://data.europeana.eu/aggregation/europeana/358/item_DCDDEWLRPO7DRD6NABJBFVMGIZPJXJSR

˜Derœ Rangau, seine Grafen und ältere Rechts-, Orts- und Landesgeschichte, mit neuen Forschungen über die Abstammung der Burggrafen von Nürnberg :ein Beitrag zu des Freiherrn v. Stillfried-Rattoniz Nürnberg'schen Burggrafen und hohenzoller'schen Forschungen

Authors: Haas, Heinrich

Availability: http://data.europeana.eu/aggregation/europeana/358/item_3J2I476RQ5LT5QQ6HQS4J2CI5MHUUEZV

˜Dieœ Austro-Burgundionen und Logionen :ein Beitrag zur Urgeschichte des südmainländischen Ostfrankens

Authors: Haas, Heinrich

Availability: http://data.europeana.eu/aggregation/europeana/362/item_GUHYBYXGGODJ6RUG2IEPYKK7JAX7FSIW

Urzustände Alemanniens, Schwabens und ihrer Nachbarländer :bei ihrem Uebergang zur ältesten Geschichte Germaniens in histor., geogr. statist. Umrissen

Authors: Haas, Heinrich

Availability: http://data.europeana.eu/aggregation/europeana/368/item_WER4EQ2JELWXSBDRQ2Z33TX7ZNQAYKMB