Exploring the Role of Hypoxia and HIF-1α in the Intersection of Type 2 Diabetes Mellitus and Endometrial Cancer.

Authors: Geetha, Alagappan V. S.¹ (AUTHOR), Harithpriya, Kannan^1,2 (AUTHOR), Ganesan, Kumar² (AUTHOR), Ramkumar, Kunka Mohanram¹ (AUTHOR) ramkumak@srmist.edu.in

Source: Current Oncology. Feb2025, Vol. 32 Issue 2, p106. 17p.

Subject Terms: *HYPOXIA-inducible factor 1, *TYPE 2 diabetes, *ENDOMETRIAL cancer, *INSULIN resistance, *INFLAMMATION, *HYPOXEMIA, *OXIDATIVE stress, *OBESITY

Elucidating the Interplay of Hypoxia-Inducible Factor and Circadian Clock Signaling in Obstructive Sleep Apnea Patients.

Authors: Gabryelska, Agata¹ (AUTHOR) agata.gabryelska@umed.lodz.pl, Turkiewicz, Szymon¹ (AUTHOR) piotr.bialasiewicz@umed.lodz.pl, Gajewski, Adrian² (AUTHOR) adrian.gajewski@umed.lodz.pl, Białasiewicz, Piotr¹ (AUTHOR) marta.ditmer@umed.lodz.pl, Strzelecki, Dominik³ (AUTHOR) dominik.strzelecki@umed.lodz.pl, Ditmer, Marta¹ (AUTHOR) marcin.sochal@umed.lodz.pl, Chałubiński, Maciej² (AUTHOR) maciej.chalubinski@umed.lodz.pl, Sochal, Marcin¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p971. 10p.

Subject Terms: *HYPOXIA-inducible factor 1, *SLEEP apnea syndromes, *HYPOXIA-inducible factors, *CLOCK genes, *MOLECULAR clock

Inflammation and Apoptosis-Related Damage in Lung, Liver, and Kidney Tissues due to Subarachnoidal Hemorrhage.

Authors: OGUZOGLU, Ali Serdar¹ a.serdaroguzoglu@yahoo.co.uk, ASCI, Halil², CANAN, Musa¹, SENOL, Nilgün¹, OZMEN, Ozlem³

Source: Medical Journal of Suleyman Demirel University. Dec2024, Vol. 31 Issue 4, p310-317. 8p.

Subject Terms: *HYPOXIA-inducible factor 1, *INFLAMMATION, *APOPTOSIS, *CEREBRAL cortex, *HEMORRHAGE, *IMMUNOHISTOCHEMISTRY, *SUBARACHNOID hemorrhage, *BRAIN damage, *BRAIN-derived neurotrophic factor

Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A , EPAS1 and HIF3A in Human Colostrum Cells.

Authors: Zarychta, Julia^1,2 (AUTHOR) dprzywara17@gmail.com, Kowalczyk, Adrian^1,2 (AUTHOR) adriankowalczyk31@gmail.com, Słowik, Karolina¹ (AUTHOR) slowikarolina@o2.pl, Przywara, Dominika^2,3 (AUTHOR) alicja.petniak@umlub.pl, Petniak, Alicja³ (AUTHOR) janusz.kocki@umlub.pl, Kondracka, Adrianna⁴ (AUTHOR) adriannakondracka@wp.pl, Wójtowicz-Marzec, Monika⁵ (AUTHOR) monika.wojtowicz-marzec@umlub.pl, Słyk-Gulewska, Patrycja⁴ (AUTHOR) slyk.patrycja@gmail.com, Kwaśniewska, Anna⁴ (AUTHOR) anna.kwasniewska@umlub.pl, Kocki, Janusz³ (AUTHOR), Gil-Kulik, Paulina³ (AUTHOR) pgil.poczt@vp.pl

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11042. 17p.

Subject Terms: *LACTATION, *HYPOXIA-inducible factor 1, *ESCHERICHIA coli, *GENE expression, *BREAST milk, *IRON supplements

Hypoxia as a Target for Combination with Transarterial Chemoembolization in Hepatocellular Carcinoma.

Authors: Wang, Zizhuo¹ (AUTHOR) wzz199902@163.com, Li, Qing² (AUTHOR) 20224032007@stu.suda.edu.cn, Liang, Bin¹ (AUTHOR) bliang@hust.edu.cn

Source: Pharmaceuticals (14248247). Aug2024, Vol. 17 Issue 8, p1057. 18p.

Subject Terms: *HYPOXIA-inducible factor 1, *HYPOXIA-inducible factors, *CHEMOEMBOLIZATION, *TREATMENT effectiveness, *EPITHELIAL-mesenchymal transition

The Role of PTEN in Chemoresistance Mediated by the HIF-1α/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia.

Authors: Antonio-Andres, Gabriela¹ (AUTHOR) gabya_24@yahoo.com.mx, Morales-Martinez, Mario^2,3 (AUTHOR), Jimenez-Hernandez, Elva⁴ (AUTHOR) elvajimenez@yahoo.com, Huerta-Yepez, Sara¹ (AUTHOR) shuerta@dentistry.ucla.edu

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7767. 14p.

Subject Terms: *NF-kappa B, *HYPOXIA-inducible factor 1, *LYMPHOBLASTIC leukemia, *ACUTE leukemia, *MONONUCLEAR leukocytes, *TRANSCRIPTION factors, *DRUG resistance in cancer cells

The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization.

Authors: Huang, Ke^1,2 (AUTHOR) huangk18@lzu.edu.cn, Yang, Weijia² (AUTHOR) shimx2021@lzu.edu.cn, Shi, Mingxuan² (AUTHOR) wangshq2020@lzu.edu.cn, Wang, Shiqi² (AUTHOR), Li, Yi² (AUTHOR) yil@lzu.edu.cn, Xu, Zhaoqing¹ (AUTHOR) yil@lzu.edu.cn

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6797. 18p.

Subject Terms: *HYPOXIA-inducible factor 1, *OXIDATIVE stress, *MYOCARDIAL ischemia, *CYTOSKELETON, *CORONARY disease, *CHEMICAL models, *COBALT

Understanding Hypoxia-Driven Tumorigenesis: The Interplay of HIF1A, DNA Methylation, and Prolyl Hydroxylases in Head and Neck Squamous Cell Carcinoma.

Authors: Ostapowicz, Julia^1,2,3 (AUTHOR) julia.ostapowicz@wco.pl, Ostrowska, Kamila^2,3,4 (AUTHOR), Rawłuszko-Wieczorek, Agnieszka A.⁵ (AUTHOR) arawluszko@ump.edu.pl, Wojtera, Bartosz^3,4 (AUTHOR), Koczot, Sabina⁴ (AUTHOR), Golusiński, Wojciech⁴ (AUTHOR), Suchorska, Wiktoria M.^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6495. 16p.

Subject Terms: *DNA methylation, *HYPOXIA-inducible factor 1, *SQUAMOUS cell carcinoma, *HYDROXYLASES, *TRANSCRIPTION factors, *GENE expression

A Molecular Perspective on HIF-1α and Angiogenic Stimulator Networks and Their Role in Solid Tumors: An Update.

Authors: Magar, Anuja Gajanan^1,2 (AUTHOR), Morya, Vivek Kumar¹ (AUTHOR) moryavivek@hallym.ac.kr, Kwak, Mi Kyung¹ (AUTHOR), Oh, Ji Ung¹ (AUTHOR), Noh, Kyu Cheol¹ (AUTHOR) moryavivek@hallym.ac.kr

Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3313. 24p.

Subject Terms: *HYPOXIA-inducible factor 1, *VASCULAR endothelial growth factors, *FIBROBLAST growth factors, *PLATELET-derived growth factor, *ANGIOPOIETIN-1, *ERYTHROPOIETIN receptors, *METABOLIC reprogramming, *GROWTH factors

Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers.

Authors: Sone, Kazuki^1,2 (AUTHOR), Sakamaki, Yuka³ (AUTHOR), Hirose, Satomi^1,2 (AUTHOR), Inagaki, Mai⁴ (AUTHOR), Tachikawa, Masanori⁴ (AUTHOR), Yoshino, Daisuke⁵ (AUTHOR), Funamoto, Kenichi^1,2,6 (AUTHOR) funamoto@tohoku.ac.jp

Source: Scientific Reports. 3/2/2024, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *VASCULAR endothelial cells, *HYPOXIA-inducible factor 1, *HOMEOSTASIS, *BLOOD sugar, *CELL migration, *MICROFLUIDIC devices, *MONOMOLECULAR films

Investigating the Impact of Astragalus Polysaccharide on Angiogenesis in Human Adipose-Derived Stem Cells.

Authors: WEN KE¹, ZHANG JUN¹, SHI JINGJUN^1,2, CHEN XU^1,2, HUANG JINLONG^1,2 hjlsurgeon@163.com

Source: Indian Journal of Pharmaceutical Sciences. Mar/Apr2024, Vol. 86 Issue 2, p620-624. 5p.

Subject Terms: *HYPOXIA-inducible factor 1, *HUMAN stem cells, *NF-kappa B, *ASTRAGALUS (Plants), *BAX protein, *POLYSACCHARIDES, *REGENERATIVE medicine, *PROTEIN expression

Effect of Cyclophilin A on Biological Behavior of Placental Trophoblast Cells in Severe Preeclampsia by Regulating HIF-1 Alpha Signaling Pathway.

Authors: HAN WANG¹, JUAN DU¹, XIANGBING JIANG¹ gongkfayrt538967@163.com

Source: Indian Journal of Pharmaceutical Sciences. Mar/Apr2024, Vol. 86 Issue 2, p525-530. 6p.

Subject Terms: *HYPOXIA-inducible factor 1, *TROPHOBLAST, *CYCLOPHILINS, *TUMOR necrosis factors, *MESSENGER RNA, *CELLULAR signal transduction, *PREECLAMPSIA

Protective effect of intermittent hypobaric hypoxia against radiation-induced liver damage in Sprague-Dawley rats.

Authors: Li, Wenzhe¹ (AUTHOR), Xu, Li¹ (AUTHOR), Wang, Yajing^1,2 (AUTHOR), Li, Wenjun¹ (AUTHOR), Maimaiti, Meiligu¹ (AUTHOR), Kou, Bin¹ (AUTHOR), Liu, Chenchen¹ (AUTHOR), Zhang, Meng¹ (AUTHOR), Xia, Hongjuan¹ (AUTHOR), Yuan, Fang¹ (AUTHOR) zyyfmxj@163.com

Source: Technology & Health Care. 2024, Vol. 32 Issue 2, p595-604. 10p.

Subject Terms: *SPRAGUE Dawley rats, *HYPOXIA-inducible factor 1, *TUMOR necrosis factors, *LIVER, *LIVER function tests

HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract.

Authors: Takashima, Masaru¹ (AUTHOR), Nagaya, Masaya¹ (AUTHOR), Takamura, Yoshihiro² (AUTHOR), Inatani, Masaru² (AUTHOR), Oki, Masaya^1,3 (AUTHOR) ma4sa6ya@u-fukui.ac.jp

Source: PLoS ONE. 2/28/2024, Vol. 19 Issue 2, p1-17. 17p.

Subject Terms: *HYPOXIA-inducible factor 1, *CATARACT, *ANIMAL disease models, *SUPPRESSOR cells, *VISION disorders

Metastatic potentials classified with hypoxia‐inducible factor 1 downstream genes in pan‐cancer cell lines.

Authors: Nakamichi, Kazuya^1,2 (AUTHOR), Yamamoto, Yusuke² (AUTHOR), Semba, Kentaro^1,3 (AUTHOR) ksemba@waseda.jp, Nakayama, Jun^1,2,4 (AUTHOR) jnakayama.re@gmail.com

Source: Genes to Cells. Feb2024, Vol. 29 Issue 2, p169-177. 9p.

Subject Terms: *HYPOXIA-inducible factor 1, *CELL lines, *WARBURG Effect (Oncology), *STERNUM, *POST-translational modification

Hypoxic microenvironment promotes dermal fibroblast migration and proliferation via a BNIP3‐autophagy pathway.

Authors: Zhang, Can¹ (AUTHOR), Li, Hongmei² (AUTHOR), Jiang, Min¹ (AUTHOR), Zhang, Qiong³ (AUTHOR), Chen, Jigang⁴ (AUTHOR), Jia, Jiezhi³ (AUTHOR), Zhang, Ze¹ (AUTHOR), Yu, Huiqing^5,6,7 (AUTHOR) yhqdyx@cqu.edu.cn, Zhang, Jiaping^1,3 (AUTHOR) japzhang@aliyun.com, Zhang, Junhui^5,6,7 (AUTHOR) junhuizhang1990@163.com

Source: FEBS Journal. Jan2024, Vol. 291 Issue 2, p358-375. 18p.

Subject Terms: *HYPOXIA-inducible factor 1, *FIBROBLASTS, *CHRONIC wounds & injuries, *THROMBOPOIETIN receptors

ACY-241, a histone deacetylase 6 inhibitor, suppresses the epithelial-mesenchymal transition in lung cancer cells by downregulating hypoxia-inducible factor-1 alpha.

Authors: Seong-Jun Park¹, Naeun Lee¹, Chul-Ho Jeong¹ chjeong75@kmu.ac.kr

Source: Korean Journal of Physiology & Pharmacology. Jan2024, Vol. 28 Issue 1, p83-91. 9p.

Subject Terms: *HYPOXIA-inducible factor 1, *EPITHELIAL-mesenchymal transition, *HISTONE deacetylase inhibitors, *CANCER cells, *LUNG cancer, *SMALL interfering RNA

Glucose Regulates Glucose Transport and Metabolism via mTOR Signaling Pathway in Bovine Placental Trophoblast Cells.

Authors: Shi, Liyuan¹ (AUTHOR) sly2021214030@126.com, Kang, Kun¹ (AUTHOR), Wang, Zhisheng¹ (AUTHOR) zswangsicau@126.com, Wang, Junmei¹ (AUTHOR), Xiao, Jianxin¹ (AUTHOR), Peng, Quanhui¹ (AUTHOR), Hu, Rui¹ (AUTHOR), Zhou, Jia¹ (AUTHOR), Zhang, Xiaohong¹ (AUTHOR), Yue, Ziqi¹ (AUTHOR), Zou, Huawei¹ (AUTHOR), Xue, Bai¹ (AUTHOR), Wang, Lizhi¹ (AUTHOR)

Source: Animals (2076-2615). Jan2024, Vol. 14 Issue 1, p40. 13p.

Subject Terms: *TROPHOBLAST, *HYPOXIA-inducible factor 1, *GLUCOSE metabolism, *PROTEIN kinase B, *CELLULAR signal transduction, *GLUCOSE, *PHOSPHOGLYCERATE kinase

HIF-1α/BNIP3-Mediated Endoplasmic Reticulum Degradation via Autophagy Protects Against Ischemia Reperfusion-Induced Acute Kidney Injury.

Authors: Zhao, Hao^1,2 (AUTHOR), Yang, Ming¹ (AUTHOR), Han, Yachun¹ (AUTHOR), Jiang, Na¹ (AUTHOR), Liu, Yan¹ (AUTHOR), Li, Chenrui¹ (AUTHOR), Yang, Jinfei¹ (AUTHOR), Luo, Shilu¹ (AUTHOR), Liu, Chongbin¹ (AUTHOR), Sun, Lin¹ (AUTHOR), Liu, Fuyou¹ (AUTHOR), Liu, Yu¹ (AUTHOR) rory@csu.edu.cn

Source: Antioxidants & Redox Signaling. Feb2025, Vol. 42 Issue 4/6, p212-227. 16p.

Subject Terms: *HYPOXIA-inducible factor 1, *ENDOPLASMIC reticulum, *PROTEINS, *APOPTOSIS, *REPERFUSION injury, *ACUTE kidney failure, *AUTOPHAGY

Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene.

Authors: Nguyen, Thuy-Hang¹ (AUTHOR), Paprzycki, Lise¹ (AUTHOR), Legrand, Alexandre¹ (AUTHOR), Declèves, Anne-Emilie² (AUTHOR), Heher, Philipp³ (AUTHOR), Limpens, Maelle¹ (AUTHOR), Belayew, Alexandra¹ (AUTHOR), Banerji, Christopher R. S.^3,4 (AUTHOR), Zammit, Peter S.³ (AUTHOR), Tassin, Alexandra¹ (AUTHOR) alexandra.tassin@umons.ac.be

Source: Skeletal Muscle. 12/16/2023, Vol. 13 Issue 1, p1-14. 14p.

Subject Terms: *HYPOXIA-inducible factor 1, *HYPOXEMIA, *MUSCULAR dystrophy, *MUSCLE regeneration, *RESPIRATORY muscles, *MUSCLE cells