Protective Effect and Molecular Mechanism of Hirudin on Kidney of Diabetic Rats

Authors: HE Yiqian, XIE Jun, ZHAO Bingjia, LIANG Xiaochun, QU Ling

Source: Xiehe Yixue Zazhi, Vol 15, Iss 6, Pp 1372-1381 (2024)

Subject Terms: diabetes mellitus, kidney injury, hirudin, fibrosis, janus kinase 2, signal transduction and transcriptional activator 3, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1674-9081

Access URL: https://doaj.org/article/52073450e600464498536030f6a88219

Construction of hydrogen peroxide-scavenging liposomes based on vitamin E and evaluation of its in vitro anticoagulant effect

Authors: YANG Qinghua, ZHANG Jianxiang, ZHOU Zhenhua

Source: 陆军军医大学学报, Vol 46, Iss 21, Pp 2475-2484 (2024)

Subject Terms: hydrogen peroxide scavenging, liposome, anti-inflammatory and antioxidant, anticoagulant effect, oxalate vitamin e, hirudin, Medicine (General), R5-920

File Description: electronic resource

Relation: https://aammt.tmmu.edu.cn/html/202404044.htm; https://doaj.org/toc/2097-0927

Access URL: https://doaj.org/article/aa253ff4ec4f4d46bfede4e92a37e994

Biomimetic nanoparticles co-deliver hirudin and lumbrukinase to ameliorate thrombus and inflammation for atherosclerosis therapy

Authors: Mengying Cheng, Tianxiang Yue, Hong Wang, Lai Jiang, Qiaoling Huang, Fanzhu Li

Source: Asian Journal of Pharmaceutical Sciences, Vol 20, Iss 1, Pp 100990- (2025)

Subject Terms: Atherosclerosis, Hirudin, Lumbrukinase, Biomimetic nanoparticle, Thrombolysis, Anti-inflammatory, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1818087624001077; https://doaj.org/toc/1818-0876

Access URL: https://doaj.org/article/571f475b97544263866e610f84f7ee56

Recombinant hirudin and PAR-1 regulate macrophage polarisation status in diffuse large B-cell lymphoma

Authors: Qiang Pei, Zihui Li, Jingjing Zhao, Haixi Zhang, Tao Qin, Juan Zhao

Source: BMC Biotechnology, Vol 24, Iss 1, Pp 1-14 (2024)

Subject Terms: Diffuse large B-cell lymphoma, Macrophage polarisation, Recombinant hirudin, PAR-1, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1472-6750

Access URL: https://doaj.org/article/5c5ec079d55049b894161ea2f19e2f57

Hirudin promotes cerebral angiogenesis and exerts neuroprotective effects in MCAO/R rats by activating the Wnt/β-catenin pathway

Authors: He, Linrong ^{a, 1}, Lei, Ruolan ^{a, 1}, Li, Shuangyang ^b, Zhao, Xiaoying ^a, He, Xinying ^a, Yang, Xinyue ^a, Liu, Ping ^c, Zhang, Dechou ^b, Jiang, Yu ^{a, ⁎}

Source: In Journal of Stroke and Cerebrovascular Diseases March 2025 34(3)

Neuroprotective effects of hirudin against cerebral ischemia-reperfusion injury via inhibition of CCL2-mediated ferroptosis and inflammatory pathways

Authors: Liao, Junbao ^{a, 1}, Chen, Huahui ^{a, 1}, Liao, Yiwei ^b, Luo, Can ^a, Wang, Zhi ^a, Zhang, Fan ^a, Fu, Chuanyi ^{a, ⁎}

Source: In Brain Research Bulletin May 2025 224

Novel drug delivery systems for hirudin-based product development and clinical applications

Authors: Mo, Liqing ^{a, b, 1}, Yang, Can ^{a, b, 1}, Dai, Yingxuan ^{a, 1}, Liu, Wei ^a, Gong, Yuhong ^a, Guo, Yujie ^{a, b, c}, Zhu, Yuxi ^{d, e}, Cao, Yan ^{a, c}, Xiao, Xuecheng ^{a, b, c}, Du, Shi ^{d, f, ⁎}, Lu, Shan ^{a, b, c, ⁎}, He, Jianhua ^{a, b, c, ⁎}

Source: In International Journal of Biological Macromolecules January 2025 287

Time dependent reduction in platelet aggregation using the multiplate analyser and hirudin blood due to platelet clumping.

Authors: Chapman, Kent¹, Favaloro, Emmanuel J.^2,3 emmanuel.favaloro@health.nsw.gov.au

Source: Platelets. May2018, Vol. 29 Issue 3, p305-308. 4p.

Subject Terms: *COLLAGEN, *HIRUDIN, *BLOOD collection, *PLATELET aggregation inhibitors, *RISTOCETIN

Review of the use of parenteral direct thrombin inhibitors in carotid endarterectomy in patients with a history of heparin-induced thrombocytopenia

Authors: King, Melissa A. ^a, Walker, Matthew ^b, Hussaini, Trana ^c, Misskey, Jonathan ^a, Faulds, Jason ^{a, ∗}

Source: In JVS-Vascular Insights 2024 2

Therapeutic Potentials of Medicinal Leech in Chinese Medicine.

Authors: Wu, Shaohua, Zhou, Yaya, Wang, Yang, Zhang, Zuping

Source: American Journal of Chinese Medicine; 2024, Vol. 52 Issue 4, p1027-1051, 25p

Subject Terms: THERAPEUTICS, PREVENTIVE medicine, CHINESE medicine, LEECH therapy, MITOGEN-activated protein kinases, METABOLIC disorders, CARDIOVASCULAR diseases, SKIN diseases, LEECHES, HIRUDIN, HYPERTENSION, ATHEROSCLEROSIS, THROMBIN, MOLECULAR structure, PLASTIC surgery, INTERLEUKINS, OBESITY, CHEMICAL inhibitors

Go West: Hirudins and Decorsin/Ornatin-like Platelet Aggregation Inhibitors in Two Representatives of American Hematophagous Leeches.

Authors: Pfordt, Victoria¹, Kalatehjari, Pegah^1,2, Tolksdorf, Céline^3,4, Rauch, Bernhard H.⁴, Müller, Christian¹ christian.mueller@uni-greifswald.de

Source: Parasitologia. Dec2022, Vol. 2 Issue 4, p313-325. 13p.

Subject Terms: *PLATELET aggregation inhibitors, *HIRUDIN, *LEECHES, *ANTITHROMBINS, *ANTICOAGULANTS

Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug

Authors: Qiang Li, Yubin Liu, Boyuan Ren, Jiayan Jin, Lin Zhang, ChuTse Wu, JiDe Jin

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: recombinant neorudin, hirudin, arteriovenous bypass thrombosis, thrombus, peripheral blood, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1443475/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/564f5a058f424ba8bbe3b9611133f426

In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation.

Authors: Sajjadi, Seyed Mehdi¹, Rahimi, Hamzeh², Mohammadi, Saeed³, Faranoush, Mohammad⁴, Mirzahoseini, Hasan⁵ mirzahoseini@pasteur.ac.ir, Toogeh, Gholamreza⁶ gh_toogeh@yahoo.com

Source: Research in Pharmaceutical Sciences. Feb2017, Vol. 12 Issue 1, p60-66. 7p.

Subject Terms: *HIRUDIN, *ANTICOAGULANTS, *HIRUDO medicinalis, *CYSTEINE, *POLYETHYLENE glycol, *THERAPEUTICS

In-vitro antileishmanial potential of peptide drug hirudin.

Authors: Khan, Hanif¹, Nadhman, Akhtar² akhtar.nadhman@iiu.edu.pk, Azam, Syed Sikander³, Anees, Mariam¹ mariam@qau.edu.pk, Khan, Imran², Ullah, Ikram², Sohail, Muhammad Farhan⁴, Shahnaz, Gul⁴, Yasinzai, Masoom²

Source: Chemical Biology & Drug Design. Jan2017, Vol. 89 Issue 1, p67-73. 7p.

Subject Terms: *HIRUDIN, *LEISHMANIASIS treatment, *PROTEINASES, *MACROPHAGES, *CELL-mediated cytotoxicity, *THERAPEUTICS

Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function.

Authors: Shabareesh, PRV¹, Kaur, Kanwal J.¹

Source: Chemical Biology & Drug Design. Jul2016, Vol. 88 Issue 1, p129-141. 13p.

Subject Terms: *HIRUDIN, *PEPTIDE synthesis, *ANTITHROMBINS, *GLYCOSYLATION, *ENZYME kinetics, *MACROMOLECULAR synthesis, *MOLECULAR docking, *CIRCULAR dichroism

Enhanced antithrombotic effect of hirudin by bovine serum albumin nanoparticles.

Authors: Jing, Fanbo¹ (AUTHOR) jingbf178@sina.com, Xu, Wen¹ (AUTHOR), Liu, Donghua¹ (AUTHOR), Wang, Chenjing¹ (AUTHOR), Sui, Zhongguo¹ (AUTHOR)

Source: Journal of Experimental Nanoscience. May2016, Vol. 11 Issue 8, p619-629. 11p.

Subject Terms: *HIRUDIN, *SERUM albumin, *NANOPARTICLES, *FIBRINOLYTIC agents, *DIFFERENTIAL scanning calorimetry, *PHARMACOLOGY

Hirudin inhibit the formation of NLRP3 inflammasome in cardiomyocytes via suppressing oxidative stress and activating mitophagy

Authors: Luo, Gang ^{a, 1}, Chen, Li ^{a, 1}, Chen, Mingtai ^{b, c, 1}, Mao, Linshen ^{a, 1}, Zeng, Qihu ^a, Zou, Yuan ^d, Xue, Jinyi ^d, Liu, Ping ^a, Wu, Qibiao ^{b, ∗∗}, Yang, Sijin ^{a, b, ∗∗∗}, Liu, Mengnan ^{a, b, ∗}

Source: In Heliyon 15 January 2024 10(1)

Natural Hirudin Increases Rat Flap Viability by Anti-Inflammation via PARs/p38/NF-κB Pathway.

Authors: Peng, Liu¹, Pan, Xinyuan¹, Yin, Guoqian²

Source: BioMed Research International. 12/7/2015, Vol. 2015, p1-7. 7p.

Subject Terms: *HIRUDIN, *ANTI-inflammatory agents, *SURGICAL flaps, *MITOGEN-activated protein kinases, *CELL adhesion molecules, *WESTERN immunoblotting, *THROMBIN, *PROTEINASES, *ANIMAL experimentation, *CELL receptors, *CELLULAR signal transduction, *INFLAMMATION, *INJECTIONS, *INTERLEUKINS, *PHYSIOLOGIC salines, *PROTEIN kinases, *RATS, *STATISTICAL sampling, *SKIN, *PLASTIC surgery, *TUMOR necrosis factors, *DNA-binding proteins

Structural and Dynamic Insight into Hirudin Epitopes-HLADRB1 0101 Complexes and their Modified Peptide Ligands: A Molecular Dynamic Simulation Study.

Authors: Asgari, Saeme¹, Mirzahoseini, Hasan² mirzahoseini@pasteur.ac.ir, Karimipour, Morteza³, Ebrahim-Habibi, Azadeh^4,5

Source: Tropical Journal of Pharmaceutical Research. Dec2015, Vol. 14 Issue 12, p2171-2178. 8p.

Subject Terms: *HIRUDIN, *MOLECULAR dynamics, *MOLECULAR structure, *MOLECULAR recognition, *EPITOPES, *MEAN square algorithms, *PEPTIDES, *LIGANDS (Biochemistry)

Critical Appraisal of Bivalirudin versus Heparin for Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials.

Authors: Bavry, Anthony A.^1,2 anthony.bavry@va.gov, Elgendy, Islam Y.², Mahmoud, Ahmed², Jadhav, Manoj P.², Huo, Tianyao²

Source: PLoS ONE. May2015, Vol. 10 Issue 5, p1-14. 14p.

Subject Terms: *HIRUDIN, *GLYCOPROTEINS, *ANGIOPLASTY, *HEPARIN, *META-analysis, *CLINICAL trials