Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

Authors: Graelmann, Frederike J., Gondorf, Fabian, Majlesain, Yasmin, Niemann, Birte, Klepac, Katarina, Gosejacob, Dominic, Gottschalk, Marlene, Mayer, Michelle, Iriady, Irina, Hatzfeld, Philip, Lindenberg, Sophie K., Wunderling, Klaus, Thiele, Christoph, Abdullah, Zeinab, He, Wei, Hiller, Karsten, Händler, Kristian, Beyer, Marc D., Ulas, Thomas, Pfeifer, Alexander, Esser, Charlotte, Weighardt, Heike, Förster, Irmgard, Reverte-Salisa, Laia

Source: In Molecular Metabolism July 2024 85

Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease

Authors: Kapellos, Theodore S., Baßler, Kevin, Fujii, Wataru, Nalkurthi, Christina, Schaar, Anna C., Bonaguro, Lorenzo, Pecht, Tal, Galvao, Izabela, Agrawal, Shobhit, Saglam, Adem, Dudkin, Erica, Frishberg, Amit, de Domenico, Elena, Horne, Arik, Donovan, Chantal, Kim, Richard Y., Gallego-Ortega, David, Gillett, Tessa E., Ansari, Meshal, Schulte-Schrepping, Jonas, Offermann, Nina, Antignano, Ignazio, Sivri, Burcu, Lu, Wenying, Eapen, Mathew S., van Uelft, Martina, Osei-Sarpong, Collins, van den Berge, Maarten, Donker, Hylke C., Groen, Harry J.M., Sohal, Sukhwinder S., Klein, Johanna, Schreiber, Tina, Feißt, Andreas, Yildirim, Ali Önder, Schiller, Herbert B., Nawijn, Martijn C., Becker, Matthias, Händler, Kristian, Beyer, Marc, Capasso, Melania, Ulas, Thomas, Hasenauer, Jan, Pizarro, Carmen, Theis, Fabian J., Hansbro, Philip M., Skowasch, Dirk, Schultze, Joachim L.

Source: In Cell Reports 27 June 2023 42(6)

Human variation in population-wide gene expression data predicts gene perturbation phenotype

Authors: Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Carraro, Caterina, Sun, Laura L., Reiz, Benedikt, Gemünd, Ioanna, Saglam, Adem, Rahmouni, Souad, Georges, Michel, Arts, Peer, Hoischen, Alexander, Joosten, Leo A.B., van de Veerdonk, Frank L., Netea, Mihai G., Händler, Kristian, Mukherjee, Sach, Ulas, Thomas, Schultze, Joachim L., Aschenbrenner, Anna C.

Source: In iScience 18 November 2022 25(11)

Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation

Authors: Embgenbroich, Maria, van der Zande, Hendrik J. P., Hussaarts, Leonie, Schulte-Schrepping, Jonas, Pelgrom, Leonard R., García-Tardón, Noemí, Schlautmann, Laura, Stoetzel, Isabel, Händler, Kristian, Lambooij, Joost M., Zawistowska-Deniziak, Anna, Hoving, Lisa, de Ruiter, Karin, Wijngaarden, Marjolein A., Pijl, Hanno, van Dijk, Ko Willems, Everts, Bart, van Harmelen, Vanessa, Yazdanbakhsh, Maria, Schultze, Joachim L., Guigas, Bruno, Burgdorf, Sven

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug 01. 118(31), 1-10.

Access URL: https://www.jstor.org/stable/27052717

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Authors: Jackson, Joshua, Wischhof, Lena, Scifo, Enzo, Pellizzer, Anna, Wang, Yiru, Piazzesi, Antonia, Gentile, Debora, Siddig, Sana, Stork, Miriam, Hopkins, Chris E., Händler, Kristian, Weis, Joachim, Roos, Andreas, Schultze, Joachim L., Nicotera, Pierluigi, Ehninger, Dan, Bano, Daniele

Source: In Molecular Metabolism July 2022 61

Further evidence of biallelic NAV3 variants associated with recessive neurodevelopmental disorder with dysmorphism, developmental delay, intellectual disability, and behavioral abnormalities.

Authors: Kakar, Naseebullah, Mascarenhas, Selinda, Ali, Asmat, Azmatullah, Ijlal Haider, Syed M., Badiger, Vaishnavi Ashok, Ghofrani, Mobina Shadman, Kruse, Nathalie, Hashmi, Sohana Nadeem, Pozojevic, Jelena, Balachandran, Saranya, Toft, Mathias, Malik, Sajid, Händler, Kristian, Fatima, Ambrin, Iqbal, Zafar, Shukla, Anju, Spielmann, Malte, Radhakrishnan, Periyasamy

Source: Human Genetics; Jan2025, Vol. 144 Issue 1, p55-65, 11p

Subject Terms: MEDICAL sciences, LIFE sciences, MEDICAL genetics, DEVELOPMENTAL delay, YOUNG adults

Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis

Authors: Wang, Ming, Yang, Yalong, Cansever, Dilay, Wang, Yiming, Kantores, Crystal, Messiaen, Sébastien, Moison, Delphine, Livera, Gabriel, Chakarov, Svetoslav, Weinberger, Tobias, Stremmel, Christopher, Fijak, Monika, Klein, Britta, Pleuger, Christiane, Lian, Zhexiong, Ma, Wentao, Liu, Qingzhi, Klee, Kathrin, Händler, Kristian, Ulas, Thomas, Schlitzer, Andreas, Schultze, Joachim L., Becher, Burkhard, Greter, Melanie, Liu, Zhaoyuan, Ginhoux, Florent, Epelman, Slava, Schulz, Christian, Meinhardt, Andreas, Bhushan, Sudhanshu

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jan 01. 118(1), 1-12.

Access URL: https://www.jstor.org/stable/27006454

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Authors: Altmüller, Janine, Angelov, Angel, Aschenbrenner, Anna C., Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Becker, Matthias, Bezdan, Daniela, Bitzer, Michael, Blumert, Conny, Bonifacio, Ezio, Bork, Peer, Boyke, Bunk, Blum, Helmut, Casadei, Nicolas, Clavel, Thomas, Colome-Tatche, Maria, Cornberg, Markus, De La Rosa Velázquez, Inti Alberto, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Franzenburg, Sören, Frick, Julia-Stefanie, Gabernet, Gisela, Gagneur, Julien, Ganzenmueller, Tina, Gauder, Marie, Geißert, Janina, Goesmann, Alexander, Göpel, Siri, Grundhoff, Adam, Grundmann, Hajo, Hain, Torsten, Hanses, Frank, Hehr, Ute, Heimbach, André, Hoeper, Marius, Horn, Friedemann, Hübschmann, Daniel, Hummel, Michael, Iftner, Thomas, Iftner, Angelika, Illig, Thomas, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Keppler, Oliver T., Kim-Hellmuth, Sarah, Klein, Christoph, Knop, Michael, Kohlbacher, Oliver, Köhrer, Karl, Korbel, Jan, Kremsner, Peter G., Kühnert, Denise, Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin U., Makarewicz, Oliwia, Marini, Federico, Marz, Manja, McHardy, Alice C., Mertes, Christian, Münchhoff, Maximilian, Nahnsen, Sven, Nöthen, Markus, Ntoumi, Francine, Nürnberg, Peter, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Pink, Isabell, Poetsch, Anna R., Protzer, Ulrike, Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Reiche, Kristin, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Scheithauer, Simone, Schiffer, Philipp, Schmid-Burgk, Jonathan, Schneider, Wulf, Schulte, Eva-Christina, Schultze, Joachim L., Sczyrba, Alexander, Sharaf, Mariam L., Singh, Yogesh, Sonnabend, Michael, Stegle, Oliver, Stoye, Jens, Theis, Fabian, Ulas, Thomas, Vehreschild, Janne, Velavan, Thirumalaisamy P., Vogel, Jörg, Volland, Sonja, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Winkler, Sylke, Ziebuhr, John, Krämer, Benjamin, Knoll, Rainer, Bonaguro, Lorenzo, ToVinh, Michael, Raabe, Jan, Astaburuaga-García, Rosario, Schulte-Schrepping, Jonas, Kaiser, Kim Melanie, Rieke, Gereon J., Bischoff, Jenny, Monin, Malte B., Hoffmeister, Christoph, Schlabe, Stefan, De Domenico, Elena, Reusch, Nico, Händler, Kristian, Reynolds, Gary, Blüthgen, Nils, Hack, Gudrun, Finnemann, Claudia, Nischalke, Hans D., Strassburg, Christian P., Stephenson, Emily, Su, Yapeng, Gardner, Louis, Yuan, Dan, Chen, Daniel, Goldman, Jason, Rosenstiel, Philipp, Schmidt, Susanne V., Latz, Eicke, Hrusovsky, Kevin, Ball, Andrew J., Johnson, Joe M., Koenig, Paul-Albert, Schmidt, Florian I., Haniffa, Muzlifah, Heath, James R., Kümmerer, Beate M., Keitel, Verena, Jensen, Björn, Stubbemann, Paula, Kurth, Florian, Sander, Leif E., Nattermann, Jacob

Source: In Immunity 9 November 2021 54(11):2650-2669

Creld1 regulates myocardial development and function

Authors: Beckert, Vera, Rassmann, Sebastian, Kayvanjoo, Amir Hossein, Klausen, Christina, Bonaguro, Lorenzo, Botermann, Dominik Simon, Krause, Melanie, Moreth, Kristin, Spielmann, Nadine, da Silva-Buttkus, Patricia, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabě, Händler, Kristian, Ulas, Thomas, Aschenbrenner, Anna C., Mass, Elvira, Wachten, Dagmar

Source: In Journal of Molecular and Cellular Cardiology July 2021 156:45-56

The stem cell—specific protein TRIM71 inhibits maturation and activity of the prodifferentiation miRNA let-7 via two independent molecular mechanisms

Authors: Torres-Fernández, Lucia A., Mitschka, Sibylle, Ulas, Thomas, Weise, Stefan, Dahm, Kilian, Becker, Matthias, Händler, Kristian, Beyer, Marc, Windhausen, Julia, Schultze, Joachim L.

Source: RNA. 27(7):805-828

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627025437&indx=1&recIds=ETOCRN627025437

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Authors: Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Bonifacio, Ezio, Bork, Peer, Clavel, Thomas, Colome-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, Frick, Julia-Stefanie, Gagneur, Julien, Goesmann, Alexander, Hain, Torsten, Hummel, Michael, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Kohlbacher, Oliver, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Ossowski, Stephan, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Schulte, Eva-Christina, Schultze, Joachim L., Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, Theis, Fabian, Vehreschild, Janne, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Ziebuhr, John, Schulte-Schrepping, Jonas, Reusch, Nico, Paclik, Daniela, Baßler, Kevin, Schlickeiser, Stephan, Zhang, Bowen, Krämer, Benjamin, Krammer, Tobias, Brumhard, Sophia, Bonaguro, Lorenzo, De Domenico, Elena, Wendisch, Daniel, Grasshoff, Martin, Kapellos, Theodore S., Beckstette, Michael, Pecht, Tal, Saglam, Adem, Dietrich, Oliver, Mei, Henrik E., Schulz, Axel R., Conrad, Claudia, Kunkel, Désirée, Vafadarnejad, Ehsan, Xu, Cheng-Jian, Horne, Arik, Herbert, Miriam, Drews, Anna, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, Müller-Redetzky, Holger, Heim, Katrin-Moira, Machleidt, Felix, Uhrig, Alexander, Bosquillon de Jarcy, Laure, Jürgens, Linda, Stegemann, Miriam, Glösenkamp, Christoph R., Volk, Hans-Dieter, Goffinet, Christine, Wyler, Emanuel, Georg, Philipp, Schneider, Maria, Dang-Heine, Chantip, Neuwinger, Nick, Kappert, Kai, Tauber, Rudolf, Corman, Victor, Raabe, Jan, Kaiser, Kim Melanie, Vinh, Michael To, Rieke, Gereon, Meisel, Christian, Ulas, Thomas, Becker, Matthias, Geffers, Robert, Witzenrath, Martin, Drosten, Christian, Suttorp, Norbert, von Kalle, Christof, Kurth, Florian, Händler, Kristian, Aschenbrenner, Anna C., Nattermann, Jacob

Source: In Cell 17 September 2020 182(6):1419-1440

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Authors: Cirovic, Branko, de Bree, L. Charlotte J., Groh, Laszlo, Blok, Bas A., Chan, Joyce, van der Velden, Walter J.F.M., Bremmers, M.E.J., van Crevel, Reinout, Händler, Kristian, Picelli, Simone, Schulte-Schrepping, Jonas, Klee, Kathrin, Oosting, Marije, Koeken, Valerie A.C.M., van Ingen, Jakko, Li, Yang, Benn, Christine S., Schultze, Joachim L., Joosten, Leo A.B., Curtis, Nigel, Netea, Mihai G., Schlitzer, Andreas

Source: In Cell Host & Microbe 12 August 2020 28(2):322-334

Succinate utilisation by Salmonella is inhibited by multiple regulatory systems.

Authors: Wenner, Nicolas¹, nicolas.wenner@gmail.com, Zhu, Xiaojun¹, Rowe, Will P. M.¹, Händler, Kristian², Hinton, Jay C. D.¹

Source: PLoS Genetics; 3/8/2024, Vol. 20 Issue 3, p1-34, 34p

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

Authors: Schmidleithner, Lisa, Thabet, Yasser, Schönfeld, Eva, Köhne, Maren, Sommer, Daniel, Abdullah, Zeinab, Sadlon, Timothy, Osei-Sarpong, Collins, Subbaramaiah, Kotha, Copperi, Francesca, Haendler, Kristian, Varga, Tamas, Schanz, Oliver, Bourry, Svenja, Bassler, Kevin, Krebs, Wolfgang, Peters, Annika E., Baumgart, Ann-Kathrin, Schneeweiss, Maria, Klee, Kathrin, Schmidt, Susanne V., Nüssing, Simone, Sander, Jil, Ohkura, Naganari, Waha, Andreas, Sparwasser, Tim, Wunderlich, F. Thomas, Förster, Irmgard, Ulas, Thomas, Weighardt, Heike, Sakaguchi, Shimon, Pfeifer, Alexander, Blüher, Matthias, Dannenberg, Andrew J., Ferreirós, Nerea, Muglia, Louis J., Wickenhauser, Claudia, Barry, Simon C., Schultze, Joachim L., Beyer, Marc

Source: In Immunity 21 May 2019 50(5):1232-1248

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

Authors: Hatzioannou, Aikaterini, Banos, Aggelos, Sakelaropoulos, Theodore, Fedonidis, Constantinos, Vidali, Maria-Sophia, Köhne, Maren, Händler, Kristian, Boon, Louis, Henriques, Ana, Koliaraki, Vasiliki, Georgiadis, Panagiotis, Zoidakis, Jerome, Termentzi, Aikaterini, Beyer, Marc, Chavakis, Triantafyllos, Boumpas, Dimitrios, Tsirigos, Aristotelis, Verginis, Panayotis

Source: Nature immunology. 21(1):75-85

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193494051.0x000001&indx=1&recIds=ETOCvdc_100193494051.0x000001

LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome.

Authors: Pozojevic, Jelena, Sivaprasad, Radhika, Laß, Joshua, Haarich, Franziska, Trinh, Joanne, Kakar, Naseebullah, Schulz, Kristin, Händler, Kristian, Verrijn Stuart, Annemarie A., Giltay, Jacques C., van Gassen, Koen L., Caliebe, Almuth, Holterhus, Paul-Martin, Spielmann, Malte, Hornig, Nadine C.

Source: Scientific Reports; 7/15/2024, Vol. 14 Issue 1, p1-9, 9p

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Authors: Christ, Anette, Günther, Patrick, Lauterbach, Mario A.R., Duewell, Peter, Biswas, Debjani, Pelka, Karin, Scholz, Claus J., Oosting, Marije, Haendler, Kristian, Baßler, Kevin, Klee, Kathrin, Schulte-Schrepping, Jonas, Ulas, Thomas, Moorlag, Simone J.C.F.M., Kumar, Vinod, Park, Min Hi, Joosten, Leo A.B., Groh, Laszlo A., Riksen, Niels P., Espevik, Terje, Schlitzer, Andreas, Li, Yang, Fitzgerald, Michael L., Netea, Mihai G., Schultze, Joachim L., Latz, Eicke

Source: In Cell 11 January 2018 172(1-2):162-175

RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo

Authors: Fülle, Lorenz, Steiner, Nancy, Funke, Markus, Gondorf, Fabian, Pfeiffer, Franziska, Siegl, Julia, Opitz, Friederike V., Haßel, Silvana K., Erazo, Anna Belen, Schanz, Oliver, Stunden, H. James, Blank, Michael, Gröber, Carsten, Händler, Kristian, Beyer, Marc, Weighardt, Heike, Latz, Eicke, Schultze, Joachim L., Mayer, Günter, Förster, Irmgard

Source: In Molecular Therapy 3 January 2018 26(1):95-104

Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration

Authors: Sloot, Yvette J. E., Rabold, Katrin, Ulas, Thomas, De Graaf, Dennis M., Heinhuis, Bas, Händler, Kristian, Schultze, Joachim L., Netea, Mihai G., Smit, Johannes W. A., Joosten, Leo A. B., Netea-Maier, Romana T.

Source: Cellular oncology. 42(5):691-703

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130350809.0x000001&indx=1&recIds=ETOCvdc_100130350809.0x000001

BCL7A‐containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation

Authors: Wischhof, Lena, Lee, Hang‐Mao, Tutas, Janine, Overkott, Clemens, Tedt, Eileen, Stork, Miriam, Peitz, Michael, Brüstle, Oliver, Ulas, Thomas, Händler, Kristian, Schultze, Joachim L, Ehninger, Dan, Nicotera, Pierluigi, Salomoni, Paolo, Bano, Daniele

Source: EMBO journal. 41(23)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186356503.0x000001&indx=1&recIds=ETOCvdc_100186356503.0x000001