Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Authors: Shah, Viral ^{1, 2, 3}, Giotopoulos, George ^{4, 5}, Osaki, Hikari ^{4, 5}, Meyerhöfer, Markus ^{1, 2, 3}, Meduri, Eshwar ^{4, 5}, Gallego-Crespo, Aaron ^{1, 2, 3}, Behrendt, Malte A. ^{1, 2, 3}, Saura-Pañella, Maria ^{1, 2, 3}, Tarkar, Aarti ⁶, Schubert, Benedict ^{1, 2, 3}, Yun, Haiyang ^{4, 5, 7}, Horton, Sarah J. ^{4, 5}, Agrawal-Singh, Shuchi ^{4, 5}, Haehnel, Patricia S. ^{1, 2, 3}, Basheer, Faisal ^{4, 5}, Lugo, Dave ⁸, Eleftheriadou, Ioanna ⁶, Barbash, Olena ⁶, Dhar, Arindam ⁶, Kühn, Michael W. M. ^{1, 2, 3, 9}, Guezguez, Borhane ^{1, 2, 3, 9}, Theobald, Matthias ^{1, 2, 3, 9}, Kindler, Thomas ^{1, 2, 3, 9}, Gallipoli, Paolo ¹⁰, Yeh, Paul ¹¹, Dawson, Mark A. ¹², Prinjha, Rab K. ⁸, Huntly, Brian J. P. ^{4, 5, ∗∗}, Sasca, Daniel ^{1, 2, 3, 9, 13, ∗}

Source: In Blood 13 February 2025 145(7):748-764

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells

Authors: Beyer, Mandy, Henninger, Sven J., Haehnel, Patricia S., Mustafa, Al-Hassan M., Gurdal, Ece, Schubert, Bastian, Christmann, Markus, Sellmer, Andreas, Mahboobi, Siavosh, Drube, Sebastian, Sippl, Wolfgang, Kindler, Thomas, Krämer, Oliver H.

Source: In Cell Chemical Biology 17 March 2022 29(3):398-411

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Authors: Sasca, Daniel, Szybinski, Jakub, Schüler, Andrea, Shah, Viral, Heidelberger, Jan, Haehnel, Patricia S., Dolnik, Anna, Kriege, Oliver, Fehr, Eva-Marie, Gebhardt, Wolf H., Reid, George, Scholl, Claudia, Theobald, Matthias, Bullinger, Lars, Beli, Petra, Kindler, Thomas ^*

Source: In Blood 23 May 2019 133(21):2305-2319

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

Authors: Sasca, Daniel, Hähnel, Patricia S., Szybinski, Jakub, Khawaja, Kaml, Kriege, Oliver, Pante, Saskia V., Bullinger, Lars, Strand, Susanne, Strand, Dennis, Theobald, Matthias, Kindler, Thomas ^*

Source: In Blood 3 July 2014 124(1):121-133

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy

Authors: Hähnel, Patricia S., Enders, Birgit, Sasca, Daniel, Roos, Wynand P., Kaina, Bernd, Bullinger, Lars, Theobald, Matthias, Kindler, Thomas

Source: In Blood 10 April 2014 123(15):2355-2366

Transcriptional Response to Standard AML Drugs Identifies Synergistic Combinations.

Authors: More, Piyush, Ngaffo, Joëlle Aurelie Mekontso, Goedtel-Armbrust, Ute, Hähnel, Patricia S., Hartwig, Udo F., Kindler, Thomas, Wojnowski, Leszek

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 16, p12926, 17p

Subject Terms: CYTARABINE, DRUG standards, GENE expression profiling, ACUTE myeloid leukemia, GENE expression, OLDER patients

Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer

Authors: Becker, Silvan ^*, Markova, Boyka ^*, Wiewrodt, Rainer ^‡, Hoffarth, Sandra ^*, Hähnel, Patricia S. ^*, Pleiner, Sina ^*, Schmidt, Lars Hennig ^‡, Breitenbuecher, Frank ^*, Schuler, Martin ^{*, †}

Source: In Journal of Thoracic Oncology December 2011 6(12):1976-1983

Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis

Authors: Stolz, Claudia, Hess, Georg, Hähnel, Patricia S., Grabellus, Florian, Hoffarth, Sandra, Schmid, Kurt W., Schuler, Martin

Source: In Blood 15 October 2008 112(8):3312-3321

An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression

Authors: Marques, Celio A., Hähnel, Patricia S., Wölfel, Catherine, Thaler, Sonja, Huber, Christoph, Theobald, Matthias, Schuler, Martin

Source: In Blood 1 February 2008 111(3):1413-1419

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study.

Authors: Neuberger, Elmo W. I.¹ (AUTHOR), Brahmer, Alexandra¹ (AUTHOR), Ehlert, Tobias¹ (AUTHOR), Botzenhardt, Suzan² (AUTHOR), De Falco, Alfonso¹ (AUTHOR), Enders, Birgit³ (AUTHOR), Hähnel, Patricia S.³ (AUTHOR), Heintz, Achim⁴ (AUTHOR), Schimanski, Carl C.⁵ (AUTHOR), Kindler, Thomas³ (AUTHOR), Simon, Perikles¹ (AUTHOR) simonpe@uni-mainz.de

Source: Experimental Physiology. Mar2025, p1. 12p. 4 Illustrations, 1 Chart.