Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)Research in context

Authors: Paul Coppo, Michael Bubenheim, Ygal Benhamou, Linus Völker, Paul Brinkkötter, Lucas Kühne, Paul Knöbl, Maria Eva Mingot-Castellano, Cristina Pascual-Izquierdo, Javier de la Rubia, Julio del Rio Garma, Shruti Chaturvedi, Camila Masias, Marshall Mazepa, X. Long Zheng, György Sinkovits, Marienn Réti, Christopher J. Patriquin, Katerina Pavenski, Tiago Boechat, João Farias, Eduardo Flavio Oliveira Ribeiro, Michaela Larissa Lobo de Andrade, Agnès Veyradier, Bérangère Joly, Raïda Bouzid, Kazuya Sakai, Masanori Matsumoto, Pasquale Agosti, Ilaria Mancini, Flora Peyvandi, Eleni Gavriilaki, Matthew Stubbs, Amjad Hmaid, Spero Cataland, Bernhard Lämmle, Marie Scully

Source: EClinicalMedicine, Vol 82, Iss , Pp 103168- (2025)

Subject Terms: Thrombotic thrombocytopenic purpura, Caplacizumab, ADAMTS13, Rituximab, Prognosis, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537025001002; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/f47d9b445fac49a89eeb21f6650caaf4

Corrigendum: Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs

Authors: Lisa Hurler, Erik J. M. Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo J. M. G. E. Brandwijk, Wieke de Bruin, Paul A. Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: early complement activation, classical pathway activation, lectin pathway activation, C1-INH complexes, assay development and validation, C1s/C1-INH complex, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561850/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/17d7e367c33e4e75b5d0f0a66d9224a1

Delayed Onset of Thrombotic Microangiopathy (TMA) upon Prolonged Carfilzomib Therapy in Multiple Myeloma: A Case Report and Comprehensive Review

Authors: Andrea Ceglédi, Ágnes Király, Andrea Várkonyi, Szabolcs Tasnády, Hajnalka Andrikovics, Mónika Fekete, Bálint G. Szabó, Zsuzsanna Szemlaky, Ágnes Szilágyi, György Sinkovits, Zoltán Prohászka, Marienn Réti, Gábor Mikala

Source: Pharmaceuticals, Vol 17, Iss 12, p 1722 (2024)

Subject Terms: thrombotic microangiopathy, carfilzomib, multiple myeloma, plasmapheresis, delayed onset, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/12/1722; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/2831d34d6047484686e90d4b121f051d

sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID

Authors: Lisa Hurler, Federica Mescia, Laura Bergamaschi, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka, Paul A. Lyons, Erik J.M. Toonen

Source: iScience, Vol 27, Iss 7, Pp 110162- (2024)

Subject Terms: Molecular biology, Virology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224013877; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/c31feab468854ebe94d7e145210e988d

Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection

Authors: Maya Avraham, György Sinkovits, Lisa Hurler, Zoltán Prohászka, Zvi Fishelson

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: COVID-19, mortalin, Grp75, complement, overall survival, risk factor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337215/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/21e882abd74e42188584942cd0e69748

Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history

Authors: Petra Kiszel, Pál Sík, János Miklós, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9a5b36c88cb94465a85cd53c56b66376

Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children

Authors: György Sinkovits, János Schnur, Lisa Hurler, Petra Kiszel, Zita Z. Prohászka, Pál Sík, Erika Kajdácsi, László Cervenak, Veronika Maráczi, Máté Dávid, Borbála Zsigmond, Éva Rimanóczy, Csaba Bereczki, Loek Willems, Erik J. M. Toonen, Zoltán Prohászka

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8eba6aaa585a488d8818aeeb17b89b5d

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

Authors: Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: mannose binding lectin (MBL), MBL2 genotypes, COVID-19, severe acute respiratory coronavirus 2 (SARS-CoV-2), lectin pathway activation, lectin pathway of complement, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1162171/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/766e52fb320d462daa94e2918960d612

Hemolytic uremic syndrome in the setting of COVID-19 successfully treated with complement inhibition therapy: An instructive case report of a previously healthy toddler and review of literature

Authors: Matija Matošević, Ivanka Kos, Maša Davidović, Maja Ban, Hana Matković, Ivan Jakopčić, Ivana Vuković Brinar, Ágnes Szilágyi, Dorottya Csuka, György Sinkovits, Zoltán Prohászka, Kristina Vrljičak, Lovro Lamot

Source: Frontiers in Pediatrics, Vol 11 (2023)

Subject Terms: hemolytic uremic syndrome, HUS, thrombotic microangiopathy, TMA, COVID-19, complement blockade, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2023.1092860/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/e7efc578371b4f5eb05cbe2fb4098080

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs

Authors: Lisa Hurler, Erik J. M. Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo J. M. G. E. Brandwijk, Wieke de Bruin, Paul A. Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Federica Mescia, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: early complement activation, classical pathway activation, lectin pathway activation, C1-INH complexes, assay development and validation, C1s/C1-INH complex, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039765/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f02a6bd361d045c78f7547d1d47f9c78

Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study

Authors: Brandon M. Henry, György Sinkovits, Ivan Szergyuk, Maria Helena Santos de Oliveira, Giuseppe Lippi, Justin L. Benoit, Emmanuel J. Favaloro, Naomi Pode-Shakked, Stefanie W. Benoit, David S. Cooper, Veronika Müller, Zsolt Iványi, János Gál, Marienn Réti, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Blanka Mező, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Zoltán Prohászka

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: complement system, coronavirus disease 2019, SARS-CoV-2, acute kidney injury, renal replacement therapy (RRT), Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.796109/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/3aa544203e3b4abd9b4ecc6d15642d6b

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Authors: György Sinkovits, Blanka Mező, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Lisa Hurler, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Zoltán Prohászka

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: SARS-CoV-2 infection, mortality, severity, complement system, coronavirus disease (COVID-19), complement activation and consumption, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.663187/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/67ea6f4569ef49ea92cd7c5838956c30

Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation

Authors: Blanka Mezö, Orsolya Horváth, György Sinkovits, Nóra Veszeli, Gergely Kriván, Zoltán Prohászka

Source: Frontiers in Medicine, Vol 7 (2020)

Subject Terms: hematopoietic stem cell transplantation, HSCT, transplant-associated thrombotic microangiopathy, TA-TMA, complement, pediatric, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmed.2020.569291/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/fd556096c5804bcb84c8acab1dc7e0f5

Elevated Systemic Pentraxin-3 Is Associated With Complement Consumption in the Acute Phase of Thrombotic Microangiopathies

Authors: Eszter Trojnar, Mihály Józsi, Zsóka Szabó, Marienn Réti, Péter Farkas, Kata Kelen, George S. Reusz, Attila J. Szabó, Nóra Garam, Bálint Mikes, György Sinkovits, Blanka Mező, Dorottya Csuka, Zoltán Prohászka

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: pentraxin-3, C-reactive protein, thrombotic microangiopathies, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, alternative pathway, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.00240/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2c55557813bf4ca7b39e7ede92db00de

Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura

Authors: György Sinkovits, Ágnes Szilágyi, Péter Farkas, Dóra Inotai, Anikó Szilvási, Attila Tordai, Katalin Rázsó, Marienn Réti, Zoltán Prohászka

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: thrombotic thrombocytopenic purpura, anti-ADAMTS13 autoantibodies, IgG subclasses, ADAMTS13-inhibitors, HLA-DRB1-DQB1 haplotypes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01646/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aba693e6313e429fbea205b631df491a