Pharmacokinetic and preclinical safety studies of endolysin-based therapeutic for intravenous administration

Authors: Antonova, Nataliia P., Vasina, Daria V., Grigoriev, Igor V., Laishevtsev, Aleksei I., Kapustin, Andrey V., Savinov, Vasiliy A., Vorobev, Aleksei M., Aleshkin, Andrei V., Zackharova, Anastasia A., Remizov, Timofey A., Makarov, Valentine V., Yudin, Sergey M., Gushchin, Vladimir A.

Source: In International Journal of Antimicrobial Agents November 2024 64(5)

Pharmacokinetics and Preclinical Safety Studies of Modified Endolysin-based Gel for Topical Application

Authors: Antonova, Nataliia P., Vasina, Daria V., Grigoriev, Igor V., Usachev, Evgeny V., Aleshkin, Andrey V., Vorobev, Aleksei M., Laishevtsev, Aleksei I., Kapustin, Andrey V., Savinov, Vasiliy A., Anurova, Mariia N., Zackharova, Anastasia A., Remizov, Timofey A., Makarov, Valentine V., Yudin, Sergey M., Gushchin, Vladimir A.

Source: In Journal of Pharmaceutical Sciences August 2024 113(8):2093-2100

Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity

Authors: Akasov, Roman A., Chepikova, Olga E., Pallaeva, Tatiana N., Gorokhovets, Neonila V., Siniavin, Andrei E., Gushchin, Vladimir A., Savvateeva, Lyudmila V., Vinokurov, Ivan A., Khochenkov, Dmitry A., Zamyatnin, Andrey A., Jr, Khaydukov, Evgeny V.

Source: In BBA - General Subjects May 2024 1868(5)

New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses

Authors: Siniavin, Andrei E., Gushchin, Vladimir A., Shastina, Natal'ya S., Darnotuk, Elizaveta S., Luyksaar, Sergey I., Russu, Leonid I., Inshakova, Anna M., Shidlovskaya, Elena V., Vasina, Daria V., Kuznetsova, Nadezhda A., Savina, Daria M., Zorkov, Ilya D., Dolzhikova, Inna V., Sheremet, Anna B., Logunov, Denis Y., Zigangirova, Nailya A., Gintsburg, Alexander L.

Source: In Antiviral Research May 2024 225

Silent HDV epidemics culminates in high levels of liver cirrhosis in endemic region despite 20 years of HBV vaccination

Authors: Isaeva, Olga V., Kyuregyan, Karen K., Karlsen, Anastasia A., Kuzmin, Oleg V., Potemkin, Ilya A., Kichatova, Vera S., Asadi Mobarkhan, Fedor A., Mullin, Eugeniy V., Kozhanova, Tatyana V., Manuylov, Victor A., Pochtovyy, Andrey A., Gushchin, Vladimir A., Saryglar, Anna A., Ilchenko, Lyudmila Yu., Mikhailov, Mikhail I.

Source: Journal of viral hepatitis. 30(3):182-194

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175265662.0x000001&indx=1&recIds=ETOCvdc_100175265662.0x000001

Development of a bead-based multiplex immunoassay for simultaneous quantitative detection of IgG serum antibodies against seven vaccine-preventable diseases

Authors: Bykonia, Evgeniia N., Kleymenov, Denis A., Mazunina, Elena P., Popova, Liubov I., Manuylov, Victor A., Gushchin, Vladimir A., Tkachuk, Artem P., Gintsburg, Alexander L.

Source: In Journal of Immunological Methods January 2023 512

Sputnik V protection from COVID-19 in people living with HIV under antiretroviral therapy

Authors: Gushchin, Vladimir A., Tsyganova, Elena V., Ogarkova, Darya A., Adgamov, Ruslan R., Shcheblyakov, Dmitry V., Glukhoedova, Nataliia V., Zhilenkova, Aleksandra S., Kolotii, Alexey G., Zaitsev, Roman D., Logunov, Denis Y., Gintsburg, Alexander L., Mazus, Alexey I.

Source: In eClinicalMedicine April 2022 46

Ultrawideband power detector GaAs MMIC's

Authors: Zagorodny, Andrey S., Voronin, Nikolay N., Yunusov, Igor V., Gushchin, Vladimir A.

Source: 2014 15th International Conference of Young Specialists on Micro/Nanotechnologies and Electron Devices (EDM) Micro/Nanotechnologies and Electron Devices (EDM), 2014 15th International Conference of Young Specialists on. :164-166 Jun, 2014

Relation: 2014 15th International Conference of Young Specialists on Micro/Nanotechnologies and Electron Devices (EDM)

An open, non-randomised, phase 1/2 trial on the safety, tolerability, and immunogenicity of single-dose vaccine “Sputnik Light” for prevention of coronavirus infection in healthy adults

Authors: Tukhvatulin, Amir I., Dolzhikova, Inna V., Shcheblyakov, Dmitry V., Zubkova, Olga V., Dzharullaeva, Alina S., Kovyrshina, Anna V., Lubenets, Nadezhda L., Grousova, Daria M., Erokhova, Alina S., Botikov, Andrei G., Izhaeva, Fatima M., Popova, Olga, Ozharovskaia, Tatiana A., Esmagambetov, Ilias B., Favorskaya, Irina A., Zrelkin, Denis I., Voronina, Daria V., Shcherbinin, Dmitry N., Semikhin, Alexander S., Simakova, Yana V., Tokarskaya, Elizaveta A., Shmarov, Maksim M., Nikitenko, Natalia A., Gushchin, Vladimir A., Smolyarchuk, Elena A., Zubkova, Tatiana G., Zakharov, Konstantin A., Vasilyuk, Vasiliy B., Borisevich, Sergei V., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.

Source: In The Lancet Regional Health - Europe December 2021 11

Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera

Authors: Nikiforova, Maria A., Kuznetsova, Nadezhda A., Shchetinin, Alexey M., Butenko, Alexander M., Kozlova, Alina A., Larichev, Viktor P., Vakalova, Elena V., Azarian, Alla R., Rubalsky, Oleg V., Bashkina, Olga A., Tkachuk, Artem P., Gushchin, Vladimir A., Gintsburg, Alexander L.

Source: In Infection, Genetics and Evolution March 2021 88

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Authors: Logunov, Denis Y ^{*, *}, Dolzhikova, Inna V ^*, Shcheblyakov, Dmitry V, Tukhvatulin, Amir I, Zubkova, Olga V, Dzharullaeva, Alina S, Kovyrshina, Anna V, Lubenets, Nadezhda L, Grousova, Daria M, Erokhova, Alina S, Botikov, Andrei G, Izhaeva, Fatima M, Popova, Olga, Ozharovskaya, Tatiana A, Esmagambetov, Ilias B, Favorskaya, Irina A, Zrelkin, Denis I, Voronina, Daria V, Shcherbinin, Dmitry N, Semikhin, Alexander S, Simakova, Yana V, Tokarskaya, Elizaveta A, Egorova, Daria A, Shmarov, Maksim M, Nikitenko, Natalia A, Gushchin, Vladimir A, Smolyarchuk, Elena A, Zyryanov, Sergey K, Borisevich, Sergei V, Naroditsky, Boris S, Gintsburg, Alexander L

Source: In The Lancet 20-26 February 2021 397(10275):671-681

Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation

Authors: Khaitov, Musa, Nikonova, Alexandra, Shilovskiy, Igor, Kozhikhova, Ksenia, Kofiadi, Ilya, Vishnyakova, Lyudmila, Nikolskii, Alexander, Gattinger, Pia, Kovchina, Valeria, Barvinskaia, Ekaterina, Yumashev, Kirill, Smirnov, Valeriy, Maerle, Artem, Kozlov, Ivan, Shatilov, Artem, Timofeeva, Anastasiia, Andreev, Sergey, Koloskova, Olesya, Kuznetsova, Nadezhda, Vasina, Daria, Nikiforova, Maria, Rybalkin, Sergei, Sergeev, Ilya, Trofimov, Dmitriy, Martynov, Alexander, Berzin, Igor, Gushchin, Vladimir, Kovalchuk, Aleksey, Borisevich, Sergei, Valenta, Rudolf, Khaitov, Rakhim, Skvortsova, Veronica

Source: Allergy. 76(9):2840-2854

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129457134.0x000001&indx=1&recIds=ETOCvdc_100129457134.0x000001

Current Trends in HIV Infection in the Republic of Crimea.

Authors: Mazus, Aleksei, Antonova, Anastasiia, Adgamov, Ruslan, Ogarkova, Daria, Kuznetsova, Anna, Pochtovyi, Andrei, Tsyganova, Elena, Zlobin, Vladimir, Gushchin, Vladimir, Plutnitskii, Andrei, Gintsburg, Aleksandr

Source: Viruses (1999-4915); Nov2024, Vol. 16 Issue 11, p1716, 14p

Subject Terms: HIV infections, VIRAL load, CD4 lymphocyte count, DIAGNOSIS of HIV infections, ANTIRETROVIRAL agents

Immunogenicity and Efficacy of Combined mRNA Vaccine Against Influenza and SARS-CoV-2 in Mice Animal Models.

Authors: Mazunina, Elena P., Gushchin, Vladimir A., Bykonia, Evgeniia N., Kleymenov, Denis A., Siniavin, Andrei E., Kozlova, Sofia R., Mukasheva, Evgenya A., Shidlovskaya, Elena V., Kuznetsova, Nadezhda A., Usachev, Evgeny V., Zlobin, Vladimir I., Burtseva, Elena I., Ivanov, Roman A., Logunov, Denis Y., Gintsburg, Alexander L.

Source: Vaccines; Nov2024, Vol. 12 Issue 11, p1206, 16p

Subject Terms: COMBINED vaccines, INFLUENZA A virus, H1N1 subtype, VACCINE effectiveness, VACCINE immunogenicity, SEASONAL influenza

Attenuation of viral replication foci in nuclei by 1,6 Hexanediol implicates phase separation in the assembly of baculoviral replication factories

Authors: Finoshin, Alexander D. ^a, Kravchuk, Oksana I. ^a, Adameyko, Kim I. ^a, Ryabchenko, Anfisa S. ^a, Gushchin, Vladimir A. ^{b, c, d}, Lyuvpina, Yulia V. ^a, Mikhailov, Victor S. ^{a, ⁎}

Source: In Journal of Virological Methods June 2025 335

Resistance to peptidoglycan-degrading enzymes

Authors: Grishin, Alexander V., Karyagina, Anna S., Vasina, Daria V., Vasina, Irina V., Gushchin, Vladimir A., Lunin, Vladimir G.

Source: Critical reviews in microbiology. 46(6):703-726

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121743514.0x000001&indx=1&recIds=ETOCvdc_100121743514.0x000001

Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections.

Authors: Vasina, Daria V., Antonova, Nataliia P., Gushchin, Vladimir A., Aleshkin, Andrey V., Fursov, Mikhail V., Fursova, Anastasiia D., Gancheva, Petya G., Grigoriev, Igor V., Grinkevich, Pavel, Kondratev, Alexey V., Kostarnoy, Alexey V., Lendel, Anastasiya M., Makarov, Valentine V., Nikiforova, Maria A., Pochtovyi, Andrei A., Prudnikova, Tatiana, Remizov, Timofey A., Shevlyagina, Natalia V., Siniavin, Andrei E., Smirnova, Nina S.

Source: Journal of Biomedical Science; 7/24/2024, Vol. 31 Issue 1, p1-21, 21p

Subject Terms: GRAM-negative bacterial diseases, CARBAPENEM-resistant bacteria, BURKHOLDERIA cepacia, GRAM-negative bacteria, ANTIMICROBIAL peptides

Company/Entity: WORLD Health Organization

Dynamics of SARS-CoV-2 Major Genetic Lineages in Moscow in the Context of Vaccine Prophylaxis.

Authors: Gushchin, Vladimir A.^1,2 (AUTHOR) wowaniada@gmail.com, Pochtovyi, Andrei A.^1,2 (AUTHOR) wowaniada@gmail.com, Kustova, Daria D.^1,2 (AUTHOR), Ogarkova, Darya A.¹ (AUTHOR), Tarnovetskii, Ivan Y.³ (AUTHOR), Belyaeva, Elizaveta D.¹ (AUTHOR), Divisenko, Elizaveta V.¹ (AUTHOR), Vasilchenko, Lyudmila A.¹ (AUTHOR), Shidlovskaya, Elena V.¹ (AUTHOR), Kuznetsova, Nadezhda A.¹ (AUTHOR), Tkachuk, Artem P.¹ (AUTHOR), Slutskiy, Egor A.³ (AUTHOR), Speshilov, Gleb I.³ (AUTHOR), Komarov, Andrei G.³ (AUTHOR), Tsibin, Alexander N.³ (AUTHOR), Zlobin, Vladimir I.¹ (AUTHOR), Logunov, Denis Y.¹ (AUTHOR), Gintsburg, Alexander L.^1,4 (AUTHOR)

Source: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 23, p14670. 16p.

Subject Terms: *SARS-CoV-2 Omicron variant, *SARS-CoV-2, *VACCINES, *PREVENTIVE medicine, *COVID-19 pandemic

Geographic Terms: MOSCOW (Russia)

Non-labeled selective virus detection with novel SERS-active porous silver nanofilms fabricated by Electron Beam Physical Vapor Deposition

Authors: Durmanov, Nikolay N., Guliev, Rustam R., Eremenko, Arkady V., Boginskaya, Irina A., Ryzhikov, Ilya A., Trifonova, Ekaterina A., Putlyaev, Egor V., Mukhin, Aleksei N., Kalnov, Sergey L., Balandina, Marina V., Tkachuk, Artem P., Gushchin, Vladimir A., Sarychev, Andrey K., Lagarkov, Andrey N., Rodionov, Ilya A., Gabidullin, Aidar R., Kurochkin, Ilya N.

Source: In Sensors & Actuators: B. Chemical March 2018 257:37-47

SARS-CoV-2 evolution in a patient with secondary B-cell immunodeficiency: A clinical case

Authors: Mukhina, Olgo A., Fomina, Daria S., Parshin, Vasiliy V., Gushchin, Vladimir A., Dolzhikova, Inna V., Shchetinin, Alexey M., Chudakov, Dmitriy M., Alekseeva, Evgeniia, Korostin, Dmitriy, Bazykin, Georgii A., Klink, Galya, Logunov, Denis Yu., Lysenko, Maryana A.

Source: Human vaccines & immunotherapeutics. 18(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179695471.0x000001&indx=1&recIds=ETOCvdc_100179695471.0x000001