Activity cliff-aware reinforcement learning for de novo drug design

Authors: Xiuyuan Hu, Guoqing Liu, Yang Zhao, Hao Zhang

Source: Journal of Cheminformatics, Vol 17, Iss 1, Pp 1-11 (2025)

Subject Terms: AI for drug design, Activity cliff, Reinforcement learning, Contrastive loss, Information technology, T58.5-58.64, Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/1758-2946

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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies

Authors: Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

Source: BMC Geriatrics, Vol 25, Iss 1, Pp 1-14 (2025)

Subject Terms: Anxiety, Older adults, Aged-care models, Influencing factors, China, Geriatrics, RC952-954.6

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Relation: https://doaj.org/toc/1471-2318

Access URL: https://doaj.org/article/ef3b7595764249a3b682bbd1de56f3d8

Investigating the distribution of heat transfer in a thick-walled functionally graded cylindrical shell under heat flux

Authors: Buqing Zhang, Zhiqiang Long, Guoqing Liu, Zhengxin Wu, Qiang Yan

Source: Journal of Engineering and Applied Science, Vol 72, Iss 1, Pp 1-20 (2025)

Subject Terms: Heat transfer, Finite element, Cylindrical shell, Functionally graded material, Engineering (General). Civil engineering (General), TA1-2040

File Description: electronic resource

Relation: https://doaj.org/toc/1110-1903; https://doaj.org/toc/2536-9512

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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target

Authors: Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

Source: Cancer Cell International, Vol 25, Iss 1, Pp 1-17 (2025)

Subject Terms: ATP-dependent chromatin remodeling, Hepatocellular carcinoma, Cancer stem cells, Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

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Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/702b408f6ea54184abfd8a938b15c4a1

TPL-DA: A Novel Threshold-Free Pseudolabel Learning Framework for Domain Adaptive Semantic Segmentation of High-Resolution Remote Sensing Images

Authors: Yan Ren, Jie Long, Xiaowen Gao, Ming Zhang, Guoqing Liu, Nan Su

Source: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, Vol 18, Pp 1926-1945 (2025)

Subject Terms: Domain adaptive semantic segmentation (DASS), high-resolution remote sensing (HRRS), self-training (ST), threshold, uncertainty estimation, Ocean engineering, TC1501-1800, Geophysics. Cosmic physics, QC801-809

File Description: electronic resource

Relation: https://ieeexplore.ieee.org/document/10758236/; https://doaj.org/toc/1939-1404; https://doaj.org/toc/2151-1535

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Real‐world use of emicizumab in Chinese children with hemophilia A: Retrospective data from a comprehensive care center

Authors: Qianqian Mao, Zhenping Chen, Guoqing Liu, Gang Li, Yingzi Zhen, Xiaoling Cheng, Zekun Li, Wanru Yao, Di Ai, Zhengping Li, Nan Wang, Man‐Chiu Poon, Runhui Wu

Source: Pediatric Investigation, Vol 8, Iss 4, Pp 244-252 (2024)

Subject Terms: Hemophilia A, Emicizumab, Prophylaxis, Pediatrics, RJ1-570

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Relation: https://doaj.org/toc/2574-2272

Access URL: https://doaj.org/article/0639b61b5d1347f384d5a41cfb1f970a

Digital twinning of river basins towards full-scale, sustainable and equitable water management and disaster mitigation

Authors: Yifan Yang, Chen Xie, Ziwu Fan, Zhonghou Xu, Bruce W. Melville, Guoqing Liu, Lei Hong

Source: npj Natural Hazards, Vol 1, Iss 1, Pp 1-7 (2024)

Subject Terms: Meteorology. Climatology, QC851-999, Disasters and engineering, TA495

File Description: electronic resource

Relation: https://doaj.org/toc/2948-2100

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PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT

Authors: Zejin Zhang, Zhenzhen Yan, Tao Yuan, Xiaona Zhao, Minghui Wang, Guoqing Liu, Lijun Gan, Wei Qin

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: cardio-oncology, cardiotoxicity, PD-1 inhibitor, collagen distribution, EndMT, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1549487/full; https://doaj.org/toc/1663-9812

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Recombinant characterization and pathogenicity of a novel L1C RFLP-1-4-4 variant of porcine reproductive and respiratory syndrome virus in China

Authors: Xinyi Huang, Guoqing Liu, Tong Chang, Yongbo Yang, Tao Wang, Dasong Xia, Xinyu Qi, Xulong Zhu, Ziyi Wei, Xiaoxiao Tian, Haiwei Wang, Zhijun Tian, Xuehui Cai, Tongqing An

Source: Veterinary Research, Vol 55, Iss 1, Pp 1-14 (2024)

Subject Terms: Porcine reproductive and respiratory syndrome virus, L1C-1-4-4 variant, recombination, pathogenicity, cross-protection, Veterinary medicine, SF600-1100

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Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/6932ca2f819c4c1bbab00cc4b0b2f915

Bilateral duplex kidney and ureter with multiple stones: a case report

Authors: Guoqing Liu, Xin Zhang, Xinyuan Yu, Junjie Chen, ZhaoRong Xu, Xiao Li

Source: BMC Urology, Vol 24, Iss 1, Pp 1-4 (2024)

Subject Terms: Duplex kidney, Duplex ureter, Multiple renal calculi, Diseases of the genitourinary system. Urology, RC870-923

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Relation: https://doaj.org/toc/1471-2490

Access URL: https://doaj.org/article/62dc72f6bc3d4f8693d50c776a25be86

Significant PK variability of plasma-derived FIX concentrates in chinese children with Haemophilia B: A fixed single-dose study of factor IX-CTBB

Authors: Guoqing Liu, Di Ai, Gang Li, Yingzi Zhen, Xinyi Wu, Wanru Yao, Yunyun Wei, Zekun Li, Yaohan Zhou, Runhui Wu, Zhenping Chen

Source: Global Medical Genetics, Vol 12, Iss 2, Pp 100040- (2025)

Subject Terms: Haemophilia B, Pharmacokinetics, Children, Plasma-derived FIX, Genetics, QH426-470, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: http://www.sciencedirect.com/science/article/pii/S2699940425000414; https://doaj.org/toc/2699-9404

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Relative bioavailability of selenium yeast, selenomethionine, hydroxyl-selenomethionine and nano-selenium for broilers

Authors: Guoqing Liu, Sumei Cao, Liang Huang, Xuanxu Lin, Zheng Sun, Gang Lin, Liyang Zhang, Lin Lu, Xugang Luo, Xiudong Liao

Source: Frontiers in Veterinary Science, Vol 11 (2025)

Subject Terms: bioavailability, broiler, selenium concentration, selenium source, selenoprotein expression, Veterinary medicine, SF600-1100

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Relation: https://www.frontiersin.org/articles/10.3389/fvets.2024.1542557/full; https://doaj.org/toc/2297-1769

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Intermediate-dose immune tolerance induction outperforms with faster success, less bleeding, and no added cost in comparison with low dose: a multicenter randomized clinical trial

Authors: Zhengping Li, Zekun Li, Xiaoling Cheng, Heng Zhang, Can Yang, Qian Xu, Zhenping Chen, Yingzi Zhen, Gang Li, Guoqing Liu, Wanru Yao, Min Zhou, Jiao Jin, Jie Huang, Yongjun Fang, Liangzhi Xie, Man-Chiu Poon, Runhui Wu

Source: Research and Practice in Thrombosis and Haemostasis, Vol 9, Iss 1, Pp 102639- (2025)

Subject Terms: immune tolerance induction, intermediate dose, low dose, randomized clinical trial, severe hemophilia A, Diseases of the blood and blood-forming organs, RC633-647.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2475037924003340; https://doaj.org/toc/2475-0379

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Evaluation of gamma rays shielding properties of bismuth tungstate with different morphologies

Authors: Qiang Yan, Yong Li, Guowei Wang, Zhengxin Wu, Haitao Zhang, Chuyuan Mao, Zhiqiang Long, Guoqing Liu

Source: Nuclear Engineering and Technology, Vol 57, Iss 1, Pp 103133- (2025)

Subject Terms: Bismuth tungstate, Hydrothermal method, Gamma ray shielding, Nuclear engineering. Atomic power, TK9001-9401

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Relation: http://www.sciencedirect.com/science/article/pii/S1738573324003802; https://doaj.org/toc/1738-5733

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Hamiltonian diversity: effectively measuring molecular diversity by shortest Hamiltonian circuits

Authors: Xiuyuan Hu, Guoqing Liu, Quanming Yao, Yang Zhao, Hao Zhang

Source: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-11 (2024)

Subject Terms: Computer-aided drug design, Molecular generation, Molecular diversity, Shortest Hamiltonian circuit, Information technology, T58.5-58.64, Chemistry, QD1-999

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Relation: https://doaj.org/toc/1758-2946

Access URL: https://doaj.org/article/c0d736e2d9cf4c51b97ec6bb283d90c3

Study on the Response Relationship between Neutrons and Void Height of Steel-Shell Concrete Composite Structure

Authors: Hongbo ZHAO, Guoqing LIU, Ziwu FAN, Long SUN, Lingchao MENG, Langlang WANG, Yunfei HONG

Source: Journal of Isotopes, Vol 37, Iss 4, Pp 353-362 (2024)

Subject Terms: neutrons, steel-shell concrete, void height, response relationship, regression analysis, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

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Relation: https://doaj.org/toc/1000-7512

Access URL: https://doaj.org/article/6e69779c48c845919ef5de051d55ecbf

Low‐dose immune tolerance induction for severe hemophilia A inhibitor patients: Immunosuppressants are generally not necessary for inhibitor‐titer below 200 BU/mL

Authors: Zhengping Li, Jie Sun, Zekun Li, Zhenping Chen, Guoqing Liu, Wanru Yao, Xiaoling Cheng, Gang Li, Yingzi Zhen, Di Ai, Yaohan Zhou, Qianqian Mao, Man‐Chiu Poon, Runhui Wu

Source: Pediatric Investigation, Vol 8, Iss 2, Pp 91-100 (2024)

Subject Terms: Hemophilia A, High‐titer inhibitor, Immune tolerance induction, Immunosuppressant, Low‐dose, Pediatrics, RJ1-570

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Relation: https://doaj.org/toc/2574-2272

Access URL: https://doaj.org/article/59e84e21e68e4af39c0dc1ebd74e8ec9

Repurposing Copper(II)/THPTA as A Bioorthogonal Catalyst for Thiazolidine Bond Cleavage

Authors: Chengyun Ma, Guoqing Liu, Juan Yin, Jianan Sun, Disheng Luo, Dechun Yang, Shuo Pang, Wei Hou, Xinya Hemu, Bangce Ye, Xiaobao Bi

Source: Advanced Science, Vol 11, Iss 42, Pp n/a-n/a (2024)

Subject Terms: bioorthogonal catalysts, bond cleavage reactions, copper ions, living systems, metals, thiazolidines, Science

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Relation: https://doaj.org/toc/2198-3844

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The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection

Authors: Wenhuang Guo, Jianwei Peng, Jiarui Su, Jingbo Xia, Weiji Deng, Peilun Li, Yilin Chen, Guoqing Liu, Shen Wang, Junhao Huang

Source: PeerJ, Vol 12, p e18413 (2024)

Subject Terms: Cardiovascular function, Cytokines, Exercise, FNDC5, Irisin, Medicine, Biology (General), QH301-705.5

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Relation: https://peerj.com/articles/18413.pdf; https://peerj.com/articles/18413/; https://doaj.org/toc/2167-8359

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Economic analysis of hydrogen energy systems: A global perspective

Authors: Guoqing Liu, Tingting Guo, Ping Wang, Hua Jiang, Hongguang Wang, Xue Zhao, Xiaoyan Wei, Ying Xu

Source: Heliyon, Vol 10, Iss 18, Pp e36219- (2024)

Subject Terms: Hydrogen energy systems, Wind energy, Capital expenses, Environmental sustainability, Science (General), Q1-390, Social sciences (General), H1-99

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Relation: http://www.sciencedirect.com/science/article/pii/S2405844024122505; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/c7d291a05c1c4edd950080a5c797db1f