Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models

Authors: Douglas D. Fang, Ran Tao, Guangfeng Wang, Yuanbao Li, Kaixiang Zhang, Chunhua Xu, Guoqin Zhai, Qixin Wang, Jingwen Wang, Chunyang Tang, Ping Min, Dengkun Xiong, Jianyong Chen, Shaomeng Wang, Dajun Yang, Yifan Zhai

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)

Subject Terms: Anaplastic lymphoma kinase (ALK), Focal adhesion kinase (FAK), ROS proto-oncogene 1 receptor tyrosine kinase (ROS1), Solid tumors, Targeted therapies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/1dd21e343843436b9e179e454cd45d0c

An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae.

Authors: Bing Chen, Ke Li, Fenli Zhang, Guoqin Zhai, Wen Gong, Sujing Qiang, Zhengfeng Xue

Source: PLoS ONE, Vol 6, Iss 9, p e25176 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3176322?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/dd04cd38472c43999cc269fe13c878f9