The effect of gene polymorphism on ticagrelor metabolism: an in vitro study of 22 CYP3A4 variants in Chinese Han population

Authors: Xiaoxia Hu, Peng Wang, Dali Zeng, Guo-xin Hu

Source: PeerJ, Vol 12, p e18109 (2024)

Subject Terms: Ticagrelor, CYP3A4, Gene polymorphism, Drug metabolism, UHPLC-MS/MS, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/18109.pdf; https://peerj.com/articles/18109/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/66001e900cf3414893b63223bd0c9151

Genetic variants, haplotype determination, and function of novel alleles of CYP2B6 in a Han Chinese population

Authors: Li-Qun Zhang, Xin-Yue Li, Lian-Guo Chen, Zhe Chen, Ren-Ai Xu, Jian-Chang Qian, Xiao-yang Zhou, Da-Peng Dai, Guo-Xin Hu, Jian-Ping Cai

Source: Heliyon, Vol 10, Iss 7, Pp e28952- (2024)

Subject Terms: CYP2B6, Genetic variant, Haplotype, Catalytic activity, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024049831; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/5743bf114bd14db7a0d8f78ea271d104

Effect of delayed sowing on grain number, grain weight, and protein concentration of wheat grains at specific positions within spikes

Authors: CHU, Jin-peng, GUO, Xin-hu, ZHENG, Fei-na, ZHANG, Xiu, DAI, Xing-long, HE, Ming-rong

Source: Journal of integrative agriculture. 22(8):2359-2369

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195492703.0x000001&indx=1&recIds=ETOCvdc_100195492703.0x000001

A modified nucleoside O6-methyl-2′-deoxyguanosine-5′-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner

Authors: Zi-Hui Wang, Jin Li, Qian Liu, Jian-Chang Qian, Qing-Qing Li, Qing-Yu Wang, Lv-Tao Zeng, Si-Jia Li, Xin Gao, Jia-Xin Pan, Xu-Fan Gao, Kun Wu, Guo-Xin Hu, Tomoo Iwakuma, Jian-Ping Cai

Source: Pharmacological Research, Vol 199, Iss , Pp 106990- (2024)

Subject Terms: GBM, O6-methyl-dGTP, TMZ, Replication stress, DNA damage, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661823003468; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/58f2957d9e08467d92747532f864bc98

Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats

Authors: Su-su Bao, Peng-fei Tang, Nan-yong Gao, Zhong-xiang Xiao, Jian-chang Qian, Long Zheng, Guo-xin Hu, Huan-hai Xu

Source: PeerJ, Vol 11, p e16051 (2023)

Subject Terms: Apatinib, Tramadol, O-desmethyltramadol, Drug inhibition, Pharmacokinetics, Metabolism, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/16051.pdf; https://peerj.com/articles/16051/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/ae58c2d0561f44daa86958c6fe8c3724

Numerical Simulation of Gas/Solid Flow in a Novel Annular Spouted Bed with Multiple Gas Nozzles

Authors: Xi-wu, Gong, Guo-xin, Hu, Hai-jiang, Zhou, Qian, Shi

Source: 2009 International Conference on Energy and Environment Technology Energy and Environment Technology, 2009. ICEET '09. International Conference on. 1:218-221 Oct, 2009

Relation: 2009 International Conference on Energy and Environment Technology (ICEET)

Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient

Authors: Xiao-Yang Zhou, Xiang-Ran Lu, Ying-Hui Li, Ya-Qing Ma, Shi-Wen Zhao, Fang Wang, Ren-Ai Xu, Guo-Xin Hu, Jian-Ping Cai

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: cytochrome P450 2C9, allelic variant, drug metabolism, enzymatic activity evaluation in vitro, tolbutamide, losartan, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.619339/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1c8e15da34954718b93406f2728abe26

Expression and clinical significance of microRNA - 141 and HMGB1 pathway in different degrees of cardiorenal syndrome

Authors: Lu-jun, Qiao, Jin, Peng, Guo-xin, Hu

Source: Zhongguo ji jiu yi xue. 39(9):840-844

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622538684&indx=1&recIds=ETOCRN622538684

Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay

Authors: Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu, Jian-Ping Cai

Source: Chemistry Central Journal, Vol 11, Iss 1, Pp 1-7 (2017)

Subject Terms: Lesinurad, UHPLC–MS/MS, Rat plasma, Pharmacokinetics, Chemistry, QD1-999

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13065-017-0353-6; https://doaj.org/toc/1752-153X

Access URL: https://doaj.org/article/4a8358317a434bedaa3a94bd723ab404

Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro

Authors: Xiang Zheng, Ping Fang, Su-su Bao, Dan Lin, Jian-ping Cai, Guo-xin Hu

Source: Journal of Pharmacological Sciences, Vol 135, Iss 1, Pp 8-13 (2017)

Subject Terms: Ketamine, CYP2C9, Gene polymorphism, Metabolism, Intrinsic clearance, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861317301226; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/82c779b6f58c4a0595d6b3b83034c196

Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro

Authors: Xiao-Yang Zhou, Xiao-Xia Hu, Chen-Chen Wang, Xiang-Ran Lu, Zhe Chen, Qian Liu, Guo-Xin Hu, Jian-Ping Cai

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: cytochrome P450 3A4, drug metabolism, quinine, 3-hydroxylation, polymorphism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00591/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/7306474d650d41a2b902ec0f3b2d9bd1

Surgical treatment of a cervical spine fracture in an ankylosing spondylitis patient with severe global spine kyphosis and chin-on-chest deformity

Authors: Guo, Xin-Hu, Ji, Hong-Quan

Source: Chinese medical journal. 132(21):2644-2646

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624294117&indx=1&recIds=ETOCRN624294117

Characterization of a Novel CYP2C9 Mutation (1009C>A) Detected in a Warfarin-Sensitive Patient

Authors: Shun-Bin Luo, Chuan-Bao Li, Da-Peng Dai, Shuang-Hu Wang, Zhen-He Wang, Pei-Wu Geng, Jie Cai, Zhe-Li Jiang, Cheng-Wei Pu, Ke Shang, Xin-Min Yuan, Ya-Po Cao, Guo-Xin Hu, Jian-Ping Cai

Source: Journal of Pharmacological Sciences, Vol 125, Iss 2, Pp 150-156 (2014)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319301379; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/ca8b0de2b96044acb05474074d26c394

Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats.

Authors: Guo-Xin Hu, Han Lin, Qing-Quan Lian, Shu-Hua Zhou, Jingjing Guo, Hong-Yu Zhou, Yanhui Chu, Ren-Shan Ge

Source: PLoS ONE, Vol 8, Iss 3, p e49976 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3606385?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/df0d97c065184bd49aba358049bcd381

Effects of CYP2C19 variants on the metabolism of tapentadol in vitro.

Authors: Ren-ai Xu, Ping Fang, Zhize Ye, Mingming Han, Jian-Ping Cai, Guo-Xin Hu

Source: Iranian Journal of Basic Medical Sciences; May2022, Vol. 25 Issue 5, p659-663, 5p

Subject Terms: CYTOCHROME P-450 CYP2C19, METABOLISM, CYTOCHROME P-450, CATALYTIC activity, MICROSOMES

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Fatigue properties of titanium alloy thin foils for MEMS applications

Authors: Zhang, Bin, Lei, Li-Ming, Yang, Jia, Guo, Xin-Hu, Zhang, Guang-Ping

Source: In Materials Letters 15 December 2012 89:302-304

Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells.

Authors: Da-Peng Dai, Wei Gan, Hiroshi Hayakawa, Jia-Lou Zhu, Xiu-Qing Zhang, Guo-Xin Hu, Tao Xu, Zhe-Li Jiang, Li-Qun Zhang, Xue-Da Hu, Ben Nie, Yue Zhou, Jin Li, Xiao-Yang Zhou, Jian Li, Tie-Mei Zhang, Qing He, Dong-Ge Liu, Hai-Bo Chen, Nan Yang

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/17/2018, Vol. 115 Issue 16, p4218-4222, 5p

Subject Terms: REACTIVE oxygen species, MUTAGENESIS, GENE expression, MESSENGER RNA, LUCIFERASE genetics

Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro.

Authors: Ping Fang, Peng-fei Tang, Ren-ai Xu, Xiang Zheng, Jian Wen, Su-su Bao, Jian-ping Cai, Guo-xin Hu

Source: Hepatic Medicine: Evidence & Research; Dec2017, Vol. 9, p3503-3510, 8p

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro.

Authors: Zhe Wang, Li Wang, Ren-ai Xu, Yun-yun Zhan, Cheng-ke Huang, Da-peng Dai, Jian-ping Cai, Guo-xin Hu

Source: Drug Design, Development & Therapy; 2016, Vol. 10, p1909-1916, 8p