Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL

Authors: Tamara Kempter, Paulina Richter-Pechańska, Katarzyna Michel, Tobias Rausch, Büşra Erarslan-Uysal, Cornelia Eckert, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Gunnar Cario, Stefan Köhrer, Andishe Attarbaschi, Jan O. Korbel, Joachim B. Kunz, Andreas E. Kulozik

Source: Blood Advances, Vol 9, Iss 6, Pp 1267-1279 (2025)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952925000151; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/926fbc018ab84c44ab4d39eb6cda033b

Multinational retrospective analysis of bridging therapy prior to chimeric antigen receptor t cells for relapsed/refractory acute lymphoblastic leukemia in children and young adults

Authors: Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Coffey, Arend von Stackelberg, Semjon Willier, Brigitte Strahm, Christina Peters, Tobias Feuchtinger

Source: Journal of Hematology & Oncology, Vol 18, Iss 1, Pp 1-5 (2025)

Subject Terms: B-ALL, CAR T cells, Bridging therapy, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/0263ffd4bac14370ad72a7821af885c6

Update on long-term outcomes of a cohort of patients with TCF3::HLF positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation

Authors: Aida Zeckanovic, Brice Mouttet, Luciana Vinti, Philip Ancliff, Benoît Brethon, Gunnar Cario, Sarah Elitzur, Volkan Hazar, Joachim Kunz, Anja Möricke, Jerry Stein, Yöntem Yaman, Jochen Buechner, Magnus Aasved Hjort, David O’Connor, Angus Hodder, Jack Bartram, Julia Alten, Draga Barbaric, Gabriele Escherich, Nicolas Boissel, Loïc Vasseur, Emmanuelle Clappier, Laure Farnault, Sarah Bonnet, Katharine Patrick, Martin Schrappe, Sema Anak, André Baruchel, Franco Locatelli, Martin Stanulla, Arend von Stackelberg, Nicole Bodmer, Jean-Pierre Bourquin

Source: Haematologica, Vol 999, Iss 1 (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11930; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/5de4bd0b06014bb79d6b371d127ff850

Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients

Authors: Lenka Hovorkova, Lucie Winkowska, Justina Skorepova, Manuela Krumbholz, Adela Benesova, Vaclava Polivkova, Julia Alten, Michela Bardini, Claus Meyer, Rathana Kim, Toby N. Trahair, Emmanuelle Clappier, Sabina Chiaretti, Michelle Henderson, Rosemary Sutton, Lucie Sramkova, Jan Stary, Katerina Machova Polakova, Rolf Marschalek, Markus Metzler, Giovanni Cazzaniga, Gunnar Cario, Jan Trka, Marketa Zaliova, Jan Zuna

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)

Subject Terms: Acute lymphoblastic leukemia, Chronic myeloid leukemia, Genomic breakpoints, BCR, ABL1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/7d6bde3a548d4461bac54306fa7daa23

No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study

Authors: Valentino Conter, Maria Grazia Valsecchi, Paola De Lorenzo, Virginie Gandemer, Mats Heyman, Vaskar Saha, Paulina Diaz, Chi-Kong Li, Andishe Attarbaschi, Gabriele Escherich, Jan Stary, Martin Schrappe, Rob Pieters, Gunnar Cario, Andrea Biondi

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11692; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/f949751deeea4e34bb67721d54d9a8aa

An artificial intelligence-assisted clinical framework to facilitate diagnostics and translational discovery in hematologic neoplasiaResearch in context

Authors: Ming Tang, Željko Antić, Pedram Fardzadeh, Stefan Pietzsch, Charlotte Schröder, Adrian Eberhardt, Alena van Bömmel, Gabriele Escherich, Winfried Hofmann, Martin A. Horstmann, Thomas Illig, J. Matt McCrary, Jana Lentes, Markus Metzler, Wolfgang Nejdl, Brigitte Schlegelberger, Martin Schrappe, Martin Zimmermann, Karolina Miarka-Walczyk, Agata Patsorczak, Gunnar Cario, Bernhard Y. Renard, Martin Stanulla, Anke Katharina Bergmann

Source: EBioMedicine, Vol 104, Iss , Pp 105171- (2024)

Subject Terms: Clinical framework, Data integration, Machine learning, Leukaemia, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002068; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/73ab5d4f744341ce91b017ca5e0c00a9

Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults

Authors: Tobias Feuchtinger, Peter Bader, Marion Subklewe, Maike Breidenbach, Semjon Willier, Markus Metzler, Nicola Gökbuget, Julia Hauer, Fabian Müller, Paul-Gerhardt Schlegel, Michael Frühwald, Christoph Schmid, Anja Troeger, Claudia Baldus, Roland Meisel, Annette Künkele, Max Topp, Jean-Pierre Bourquin, Gunnar Cario, Arend von Stackelberg, Christina Peters

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11444; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/cc15f38b071a42af82ad7fe1cd60fd9d

Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group

Authors: Stefanie V. Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina U. Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian P. Kratz, Martin Schrappe, Matthias Schwab, Richard S. Houlston, Gunnar Cario, Martin Stanulla

Source: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-15 (2023)

Subject Terms: Childhood acute lymphoblastic leukemia, Treatment-related toxicity, Hepatotoxicity, Hyperbilirubinemia, UGT1A, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/9a13023e87354932b2b585a4703304a8

Deciphering the molecular complexity of the IKZF1plus genomic profile using Optical Genome Mapping

Authors: Jonathan L. Lühmann, Martin Zimmermann, Winfried Hofmann, Anke K. Bergmann, Anja Möricke, Gunnar Cario, Martin Schrappe, Brigitte Schlegelberger, Martin Stanulla, Doris Steinemann

Source: Haematologica, Vol 109, Iss 5 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11363; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/7181ed27e0e34a71955daa8b4851e16e

AP-1 Transcription Factor Complex Members FOSB and FOS are Linked With CNS Infiltration and Inferior Prognosis in Childhood T-ALL

Authors: Lea Spory, Johannes Zimmermann, Michaela Vossen-Gajcy, Thomas Beder, Lorenz Bastian, Ameera Alsadeq, Dorothee Winterberg, Fotini Vogiatzi, Tim Wirbelauer, Hilal Bhat, Arndt Borkhardt, Sanil Bhatia, Martin Schrappe, Gunnar Cario, Denis M. Schewe, Lennart Lenk

Source: HemaSphere, Vol 7, Iss 9, p e945 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000945; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/4121c3b59dfa474f93d735267a543fa8

The Gene Expression Classifier ALLCatchR Identifies B-cell Precursor ALL Subtypes and Underlying Developmental Trajectories Across Age

Authors: Thomas Beder, Björn-Thore Hansen, Alina M. Hartmann, Johannes Zimmermann, Eric Amelunxen, Nadine Wolgast, Wencke Walter, Marketa Zaliova, Željko Antić, Philippe Chouvarine, Lorenz Bartsch, Malwine J. Barz, Miriam Bultmann, Johanna Horns, Sonja Bendig, Jan Kässens, Christoph Kaleta, Gunnar Cario, Martin Schrappe, Martin Neumann, Nicola Gökbuget, Anke Katharina Bergmann, Jan Trka, Claudia Haferlach, Monika Brüggemann, Claudia D. Baldus, Lorenz Bastian

Source: HemaSphere, Vol 7, Iss 9, p e939 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000939; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/2812070292a849ae896c8b9b71b1503f

S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA

Authors: Peter Bader, Anna Alsonso, Andishe Attarbaschi, Nicole Bodmer, Halvard Bonig, Saskia Burridge, Jean-Pierre Bourquin, Veit Bücklein, Gunnar Cario, Macarena Oporto Espuelas, Tobias Feuhtinger, Anna Fuereder, Julia Hauer, Martin Hutter, Krzysztof Kałwak, Annette Künkele, Roland Meisel, Monika Mielcarek-Siedziuk, Ingo Müller, Sara Napolitano, Olaf Penack, Susana Rives, Claudia Rossig, Arend von Stackelberg, Andrea Jarisch, Sara Ghorashian, Adriana Balduzzi

Source: HemaSphere, Vol 7, p e239539e (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000967356.23953.9e; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/0de9358a98e24532b581f74cf2758208

P333: SUBCLONAL AND CLONAL VARIANTS IN TP53 AND KRAS COMBINED WITH POOR TREATMENT RESPONSE IDENTIFY A SUBGROUP OF ULTRA-HIGH-RISK PATIENTS OF PEDIATRIC T-LYMPHOBLASTIC LEUKEMIA (T-ALL)

Authors: Tamara Kempter, Paulina Richter-Pechanska, Katarzyna Michel, Tobias Rausch, Büşra Erarslan-Uysal, Cornelia Eckert, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Gunnar Cario, Renate Kirschner-Schwabe, Stefan Koehrer, Jan Korbel, Joachim Kunz, Andreas E Kulozik

Source: HemaSphere, Vol 7, p e9493074 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968244.94930.74; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/77ee918485564004bb875af4218b482e

P322: DECIPHERING THE UNDERLYING MOLECULAR COMPLEXITY OF THE IKZF1PLUS SIGNATURE

Authors: Jonathan Lühmann, Winfried Hofmann, Anke Katharina Bergmann, Anja Möricke, Gunnar Cario, Martin Schrappe, Brigitte Schlegelberger, Martin Zimmermann, Martin Stanulla, Doris Steinemann

Source: HemaSphere, Vol 7, p e3002627 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968200.30026.27; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/f78e65b1beb74f32b2a19b0517e8b389

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors

Authors: Agnes Bonifacius, Britta Lamottke, Sabine Tischer-Zimmermann, Rebecca Schultze-Florey, Lilia Goudeva, Hans-Gert Heuft, Lubomir Arseniev, Rita Beier, Gernot Beutel, Gunnar Cario, Birgit Fröhlich, Johann Greil, Leo Hansmann, Justin Hasenkamp, Michaela Höfs, Patrick Hundsdoerfer, Edgar Jost, Kinan Kafa, Oliver Kriege, Nicolaus Kröger, Stephan Mathas, Roland Meisel, Michaela Nathrath, Mervi Putkonen, Sarina Ravens, Hans Christian Reinhardt, Elisa Sala, Martin G. Sauer, Clemens Schmitt, Roland Schroers, Nina Kristin Steckel, Ralf Ulrich Trappe, Mareike Verbeek, Daniel Wolff, Rainer Blasczyk, Britta Eiz-Vesper, Britta Maecker-Kolhoff

Source: The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)

Subject Terms: Therapeutics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/90b7781e7f1547e9ab2df6d697ea2d7d

Incidence and Characteristics of Hypersensitivity Reactions to PEG-asparaginase Observed in 6136 Children With Acute Lymphoblastic Leukemia Enrolled in the AIEOP-BFM ALL 2009 Study Protocol

Authors: Carmelo Rizzari, Anja Möricke, Maria Grazia Valsecchi, Valentino Conter, Martin Zimmermann, Daniela Silvestri, Andishe Attarbaschi, Felix Niggli, Draga Barbaric, Jan Stary, Sarah Elitzur, Gunnar Cario, Luciana Vinti, Joachim Boos, Massimo Zucchetti, Claudia Lanvers-Kaminsky, Arend von Stackelberg, Andrea Biondi, Martin Schrappe

Source: HemaSphere, Vol 7, Iss 6, p e893 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000893; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/2b0123de29844cabb6a049ad6f40e6f9

Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction

Authors: Anja Möricke, Carmelo Rizzari, Julia Alten, Andishe Attarbaschi, Rita Beier, Andrea Biondi, Birgit Burkhardt, Nicole Bodmer, Joachim Boos, Gunnar Cario, Valentino Conter, Christian Flotho, Andreas Kulozik, Claudia Lanvers-Kaminsky, Georg Mann, Felix Niggli, Daniela Silvestri, Arend von Stackelberg, Martin Stanulla, Maria-Grazia Valsecchi, Martin Schrappe, Martin Zimmermann

Source: HemaSphere, Vol 7, Iss 6, p e888 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000888; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/1f57053bb60c4f92992766869d084c51

Definition and Prognostic Value of Ph-like and IKZF1plus Status in Children With Down Syndrome and B-cell Precursor Acute Lymphoblastic Leukemia

Authors: Chiara Palmi, Silvia Bresolin, Stefanie Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Sanil Bhatia, Arndt Borkhardt, Claudia Saitta, Marta Galbiati, Michela Bardini, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruy te Kronnie, Gunnar Cario, Giovanni Cazzaniga

Source: HemaSphere, Vol 7, Iss 6, p e892 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000892; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/8b3553e763074371b4c8f44d90e57a09

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia

Authors: Janina Heilmann, Simon Vieth, Anja Möricke, Andishe Attarbaschi, Draga Barbaric, Nicole Bodmer, Antonella Colombini, Luciano Dalla-Pozza, Sarah Elitzur, Shai Izraeli, Georg Mann, Felix Niggli, Daniela Silvestri, Jan Stary, Carmelo Rizzari, Maria Grazia Valsecchi, Ester Zapotocka, Martin Zimmermann, Gunnar Cario, Martin Schrappe, Valentino Conter

Source: Haematologica, Vol 108, Iss 12 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11037; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/a5f28bc6ae894130a7bbc7721322ffde

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia

Authors: Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Ahmad Mayar, Anna Dietterle, Gina Münch, Christian Vokuhl, Julia Richter, Andrew G. Polson, Thomas Schüler, Ulf D. Kahlert, Matthias Peipp, Thomas Valerius, Martin Schrappe, Gunnar Cario, Hassan Jumaa, Elias Hobeika, Monika Brüggemann, Ameera Alsadeq, Denis M. Schewe

Source: HemaSphere, Vol 6, Iss 8, p e754 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000754; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/ee2a0191775641108c609751c3210508