Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis

Authors: Tan, Xinle ^a, Testoni, Giorgia ^b, Sullivan, Mitchell A. ^{c, d}, López-Soldado, Iliana ^b, Vilaplana, Francisco ^e, Gilbert, Robert G. ^{f, g, ⁎}, Guinovart, Joan J. ^b, Schulz, Benjamin L. ^h, Duran, Jordi ^{i, j}

Source: In International Journal of Biological Macromolecules February 2025 291

Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation

Authors: Pathmanapan, Sinthu, Poon, Raymond, De Renshaw, Tomasa Barrientos, Nadesan, Puviindran, Nakagawa, Makoto, Seesankar, Gireesh A., Loe, Adrian Kwan Ho, Zhang, Hongyuan H., Guinovart, Joan J., Duran, Jordi, Newgard, Christopher B., Wunder, Jay S., Alman, Benjamin A.

Source: In Cell Reports 27 June 2023 42(6)

Increased liver glycogen levels enhance exercise capacity in mice

Authors: López-Soldado, Iliana, Guinovart, Joan J., Duran, Jordi

Source: In Journal of Biological Chemistry August 2021 297(2)

Scientists in Education: A Biomedical Research Institute's Perspective

Authors: Guinovart, Joan J. (ORCID 0000-0003-0770-9592), Arimon, Muriel (ORCID 0000-0002-0894-3324)

Source: Biochemistry and Molecular Biology Education. Nov-Dec 2020 48(6):559-562.

Peer Reviewed: Y

Page Count: 4

Descriptors: Foreign Countries, Scientists, Biomedicine, Science Careers, Science Education, Elementary School Science, Secondary School Science

Geographic Terms: Spain (Barcelona)

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Authors: Sadiku, Pranvera, Willson, Joseph A., Ryan, Eilise M., Sammut, David, Coelho, Patricia, Watts, Emily R., Grecian, Robert, Young, Jason M., Bewley, Martin, Arienti, Simone, Mirchandani, Ananda S., Sanchez Garcia, Manuel A., Morrison, Tyler, Zhang, Ailing, Reyes, Leila, Griessler, Tobias, Jheeta, Privjyot, Paterson, Gordon G., Graham, Christopher J., Thomson, John P., Baillie, Kenneth, Thompson, A.A. Roger, Morgan, Jessie-May, Acosta-Sanchez, Abel, Dardé, Veronica M., Duran, Jordi, Guinovart, Joan J., Rodriguez-Blanco, Gio, Von Kriegsheim, Alex, Meehan, Richard R., Mazzone, Massimiliano, Dockrell, David H., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., Walmsley, Sarah R.

Source: In Cell Metabolism 2 February 2021 33(2):411-423

Suppression of glycogen synthesis as a treatment for Lafora disease: Establishing the window of opportunity

Authors: Varea, Olga, Duran, Jordi, Aguilera, Mònica, Prats, Neus, Guinovart, Joan J.

Source: In Neurobiology of Disease January 2021 147

Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice

Authors: López-Soldado, Iliana, Guinovart, Joan J., Duran, Jordi

Source: In Journal of Biological Chemistry January-June 2021 296

Hallmarks of oxidative stress in the livers of aged mice with mild glycogen branching enzyme deficiency

Authors: Malinska, Dominika, Testoni, Giorgia, Duran, Jordi, Brudnicka, Alicja, Guinovart, Joan J., Duszynski, Jerzy

Source: In Archives of Biochemistry and Biophysics 30 November 2020 695

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Authors: Gentry, Matthew S., Afawi, Zaid, Armstrong, Dustin D., Delgado-Escueta, Antonio, Goldberg, Y. Paul, Grossman, Tamar R., Guinovart, Joan J., Harris, Frank, Hurley, Thomas D., Michelucci, Roberto, Minassian, Berge A., Sanz, Pascual, Worby, Carolyn A., Serratosa, Jose M.

Source: In Epilepsy & Behavior February 2020 103 Part A

Active Glycogen Synthase in the Liver Prevents High-Fat Diet-Induced Glucose Intolerance, Decreases Food Intake, and Lowers Body Weight.

Authors: López-Soldado, Iliana^1,2,3 (AUTHOR) iliana.lopez@irbbarcelona.org, Guinovart, Joan J.^1,2,3 (AUTHOR), Duran, Jordi^1,2,4,5 (AUTHOR) iliana.lopez@irbbarcelona.org

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p2574. 11p.

Subject Terms: *INGESTION, *GLYCOGEN, *GLUCOSE intolerance, *FOOD consumption, *BODY weight, *ADIPOSE tissues, *HYPERGLYCEMIA, *FAT

Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome

Authors: Testoni, Giorgia, Olmeda, Bárbara, Duran, Jordi, López-Rodríguez, Elena, Aguilera, Mònica, Hernández-Álvarez, María Isabel, Prats, Neus, Pérez-Gil, Jesús, Guinovart, Joan J

Source: Human molecular genetics. 29(21):3554-3565

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117918201.0x000001&indx=1&recIds=ETOCvdc_100117918201.0x000001

Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility

Authors: Duran, Jordi, Brewer, M. Kathryn, Hervera, Arnau, Gruart, Agnès, del Rio, Jose Antonio, Delgado-García, José M., Guinovart, Joan J.

Source: Molecular neurobiology. 57(11):4657-4666

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172094042.0x000001&indx=1&recIds=ETOCvdc_100172094042.0x000001

Arousal-induced cortical activity triggers lactate release from astrocytes

Authors: Zuend, Marc, Saab, Aiman S., Wyss, Matthias T., Ferrari, Kim David, Hösli, Ladina, Looser, Zoe J., Stobart, Jillian L., Duran, Jordi, Guinovart, Joan J., Barros, L. Felipe, Weber, Bruno

Source: Nature metabolism. 2(2):179-191

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172055385.0x000001&indx=1&recIds=ETOCvdc_100172055385.0x000001

Maintenance of liver glycogen during long‐term fasting preserves energy state in mice

Authors: López‐Soldado, Iliana, Bertini, Angelo, Adrover, Anna, Duran, Jordi, Guinovart, Joan J.

Source: FEBS letters. 594(11):1698-1710

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107512695.0x000001&indx=1&recIds=ETOCvdc_100107512695.0x000001

Lafora disease offers a unique window into neuronal glycogen metabolism

Authors: Gentry, Matthew S., Guinovart, Joan J., Minassian, Berge A., Roach, Peter J., Serratosa, Jose M.

Source: In Journal of Biological Chemistry 11 May 2018 293(19):7117-7125

Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis.

Authors: Brewer, M. Kathryn, Torres, Pascual, Ayala, Victòria, Portero-Otin, Manuel, Pamplona, Reinald, Andrés-Benito, Pol, Ferrer, Isidro, Gentry, Matthew S., Guinovart, Joan J., Duran, Jordi

Source: Journal of Neurochemistry; May2024, Vol. 168 Issue 5, p744-759, 16p

Subject Terms: MOTOR neuron diseases, AMYOTROPHIC lateral sclerosis, GLYCOGEN, LIFE spans, LABORATORY mice, ANIMAL disease models, CENTRAL nervous system

Brain glycogen in health and disease

Authors: Duran, Jordi, Guinovart, Joan J. ^*

Source: In Molecular Aspects of Medicine December 2015 46:70-77

p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.

Authors: Santamans, Ayelén M.¹, Montalvo-Romeral, Valle¹, Mora, Alfonso¹, Lopez, Juan Antonio^1,2, González-Romero, Francisco³, Jimenez-Blasco, Daniel^4,5,6, Rodríguez, Elena¹, Pintor-Chocano, Aránzazu¹, Casanueva-Benítez, Cristina¹, Acín-Pérez, Rebeca¹, Leiva-Vega, Luis¹, Duran, Jordi^7,8, Guinovart, Joan J.^7,8, Jiménez-Borreguero, Jesús¹, Enríquez, José Antonio^1,6, Villlalba-Orero, María^1,2, Bolaños, Juan P.^4,5,6, Aspichueta, Patricia^3,9,10, Vázquez, Jesús^1,2, González-Terán, Bárbara¹, gsabio@cnic.es

Source: PLoS Biology; 11/10/2021, Vol. 15 Issue 11, p1-35, 35p, 7 Color Photographs, 2 Black and White Photographs, 1 Diagram, 1 Chart

Processivity and Subcellular Localization of Glycogen Synthase Depend on a Non-catalytic High Affinity Glycogen-binding Site

Authors: Díaz, Adelaida, Martínez-Pons, Carlos, Fita, Ignacio, Ferrer, Juan C., Guinovart, Joan J.

Source: In Journal of Biological Chemistry 27 May 2011 286(21):18505-18514

Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis

Authors: Ros, Susana, Zafra, Delia, Valles-Ortega, Jordi, García-Rocha, Mar, Forrow, Stephen, Domínguez, Jorge, Calbó, Joaquim, Guinovart, Joan J.

Source: In Journal of Biological Chemistry 26 November 2010 285(48):37170-37177