Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice

Authors: dos Santos Ferreira, Diego, Jesus de Oliveira Pinto, Bruno Luís, Kumar, Vidhya, Cardoso, Valbert Nascimento, Fernandes, Simone Odília, Souza, Cristina Maria, Cassali, Geovanni Dantas, Moore, Anna, Sosnovik, David E., Farrar, Christian T., Leite, Elaine Amaral, Alves, Ricardo José, de Oliveira, Mônica Cristina, Guimarães, Alexander Ramos, Caravan, Peter

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine July 2017 13(5):1693-1701

Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis

Authors: Ferreira, Diêgo dos Santos, Faria, Samilla Dornelas, Lopes, Sávia Caldeira de Araújo, Teixeira, Cláudia Salviano, Malachias, Angelo, Magalhães-Paniago, Rogério, de Souza Filho, José Dias, Oliveira, Bruno Luis de Jesus Pinto, Guimarães, Alexander Ramos, Ferreira, Lucas Antônio Miranda, Alves, Ricardo José, Oliveira, Mônica Cristina, Caravan, Peter

Source: Ferreira, D. d. S., S. D. Faria, S. C. d. A. Lopes, C. S. Teixeira, A. Malachias, R. Magalhães-Paniago, J. D. de Souza Filho, et al. 2016. “Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis.” International Journal of Nanomedicine 11 (1): 3737-3751. doi:10.2147/IJN.S109966. http://dx.doi.org/10.2147/IJN.S109966.

Subject Terms: hydroxyapatite-targeted formulations, bisphosphonates, pH-responsive nanostructures, bone-tumor treatment

File Description: application/pdf

Relation: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984992/pdf/; International Journal of Nanomedicine

Access URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002477