DNA damage–induced p53 downregulates expression of RAG1 through a negative feedback loop involving miR-34a and FOXP1

Authors: Ochodnicka-Mackovicova, Katarina ^{1, 2}, van Keimpema, Martine ^{1, 2}, Spaargaren, Marcel ^{1, 2, 3}, van Noesel, Carel J.M. ^{1, 2}, Guikema, Jeroen E.J. ^{1, 2, ∗}

Source: In Journal of Biological Chemistry December 2024 300(12)

RAG1/2 induces double‐stranded DNA breaks at non‐Ig loci in the proximity of single sequence repeats in developing B cells.

Authors: Ochodnicka‐Mackovicova, Katarina, Mokry, Michal, Haagmans, Martin, Bradley, Ted E., van Noesel, Carel J.M., Guikema, Jeroen E.J.

Source: European Journal of Immunology; Oct2024, Vol. 54 Issue 10, p1-13, 13p

Subject Terms: DNA sequencing, B cells, RECOMBINANT DNA, DNA damage, NIBRIN

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma

Authors: Bloedjes, Timon A., de Wilde, Guus, Maas, Chiel, Eldering, Eric, Bende, Richard J., van Noesel, Carel J.M., Pals, Steven T., Spaargaren, Marcel, Guikema, Jeroen E.J. ^*

Source: In Blood Advances 8 September 2020 4(17):4151-4164

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors

Authors: Bahjat, Mahnoush, de Wilde, Guus, van Dam, Tijmen, Maas, Chiel, Bloedjes, Timon, Bende, Richard J., van Noesel, Carel J.M., Luijks, Dieuwertje M., Eldering, Eric, Kersten, Marie José, Guikema, Jeroen E.J.

Source: Cell cycle. 18(18):2307-2322

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110829790.0x000001&indx=1&recIds=ETOCvdc_100110829790.0x000001

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains

Authors: Slot, Linda M., Hoogeboom, Robbert, Smit, Laura A., Wormhoudt, Thera A.M., Biemond, Bart J., Oud, Monique E.C.M., Schilder-Tol, Esther J.M., Mulder, André B., Jongejan, Aldo, van Kampen, Antoine H.C., Kluin, Philip M., Guikema, Jeroen E.J., Bende, Richard J., van Noesel, Carel J.M.

Source: In The American Journal of Pathology December 2016 186(12):3273-3284

NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

Authors: Ochodnicka-Mackovicova, Katarina, Bahjat, Mahnoush, Bloedjes, Timon A., Maas, Chiel, de Bruin, Alexander M., Bende, Richard J., van Noesel, Carel J.M., Guikema, Jeroen E.J. ^*

Source: In Blood 10 September 2015 126(11):1324-1335

Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells

Authors: Staszewski, Ori, Baker, Richard E., Ucher, Anna J., Martier, Raygene, Stavnezer, Janet, Guikema, Jeroen E.J.

Source: In Molecular Cell 21 January 2011 41(2):232-242

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model

Authors: Lascano, Valeria, Guadagnoli, Marco, Schot, Jan G., Luijks, Dieuwertje M., Guikema, Jeroen E.J., Cameron, Katherine, Hahne, Michael, Pals, Steven, Slinger, Erik, Kipps, Thomas J., van Oers, Marinus H.J., Eldering, Eric, Medema, Jan Paul, Kater, Arnon P.

Source: In Blood 5 December 2013 122(24):3960-3963

research paper CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases.

Authors: Guikema, Jeroen E.J.^1,2, Vellenga, Edo², Abdulahad, Wayel H.¹, Hovenga, Sjoerd², Bos, Nicolaas A.¹ N.A.Bos@med.rug.nl

Source: British Journal of Haematology. Feb2004, Vol. 124 Issue 3, p299-308. 10p.

Subject Terms: *PLASMA cell leukemia, *PLASMA cells, *LEUKEMIA, *HEMATOLOGY, *THERAPEUTICS

Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro.

Authors: Guikema, Jeroen E.J., Vellenga, Edo, Bakkus, Marleen H.C., Bos, Nicolaas A.

Source: British Journal of Haematology. Oct2002, Vol. 119 Issue 1, p54. 8p.

Subject Terms: *MULTIPLE myeloma, *B cells, *CELL differentiation

A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi

Authors: Hoogeboom, Robbert, van Kessel, Kok P.M., Hochstenbach, Frans, Wormhoudt, Thera A., Reinten, Roy J.A., Wagner, Koen, Kater, Arnon P., Guikema, Jeroen E.J., Bende, Richard J., van Noesel, Carel J.M.

Source: The Journal of Experimental Medicine; January 2013, Vol. 210 Issue: 1 p59-70, 12p

Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients

Authors: Guikema, Jeroen E.J. ^*, Rosati, Stefano, Akkermans, Karine, Bende, Richard J., van Noesel, Carel J.M., van Krieken, Johan H., Hansmann, Martin L., Schuuring, Ed, Kluin, Philip M.

Source: In Blood 1 April 2005 105(7):2997-2998

Altered Replication Timing of IGH Alleles in Burkitt's Lymphoma Depends on IGH Breakpoint Position.

Authors: Guikema, Jeroen E.J. ^*, de Boer, Conny ^*, Gadiot, Jules ^*, Schuuring, Ed ^*, Kluin, Philip M.

Source: In Blood 16 November 2004 104(11):4276-4276