Celastrol has beneficial effects on pulmonary hypertension associated with bronchopulmonary dysplasia: Preclinical study outcomes

Authors: Pilard, Claire-Marie ^{a, b, c}, Cardouat, Guillaume ^{a, b}, Gauthereau, Isabel ^{a, b}, Gassiat, Laure ^{a, b}, Dubois, Mathilde ^{a, b, 1}, Robillard, Paul ^{a, b}, Sauvestre, Fanny ^d, Pelluard, Fanny ^d, Berenguer, Sophie ^d, Sarreau, Melie ^d, Claverol, Stéphane ^h, Tokarski, Caroline ^h, Sentilhes, Loïc ^e, Coatleven, Frederic ^e, Vincienne, Marie ^e, Marthan, Roger ^{a, b, f}, Dumas-de-la-roque, Eric ^{a, b, c}, Berger, Patrick ^{a, b, f}, Friedberg, Mark K. ^g, Renesme, Laurent ^{a, b, c, 2}, Freund-Michel, Véronique ^{a, b, 3}, Guibert, Christelle ^{a, b, ⁎, 3}

Source: In Biomedicine & Pharmacotherapy March 2025 184

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity

Authors: Cardouat, Guillaume, Douard, Matthieu, Bouchet, Clément, Roubenne, Lukas, Kmecová, Zuzana, Esteves, Pauline, Brette, Fabien, Guignabert, Christophe, Tu, Ly, Campagnac, Marilyne, Robillard, Paul, Coste, Florence, Delcambre, Frédéric, Thumerel, Matthieu, Begueret, Hugues, Maurac, Arnaud, Belaroussi, Yaniss, Klimas, Jan, Ducret, Thomas, Quignard, Jean-François, Vacher, Pierre, Baudrimont, Isabelle, Marthan, Roger, Berger, Patrick, Guibert, Christelle, Freund-Michel, Véronique

Source: In Biomedicine & Pharmacotherapy May 2024 174

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption

Authors: Germande, Ophélie, Baudrimont, Magalie, Beaufils, Fabien, Freund-Michel, Véronique, Ducret, Thomas, Quignard, Jean-François, Errera, Marie-Hélène, Lacomme, Sabrina, Gontier, Etienne, Mornet, Stéphane, Bejko, Megi, Muller, Bernard, Marthan, Roger, Guibert, Christelle, Deweirdt, Juliette, Baudrimont, Isabelle

Source: Nanotoxicology. 16(1):29-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148478365.0x000001&indx=1&recIds=ETOCvdc_100148478365.0x000001

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

Authors: Germande, Ophélie ^{a, b, c}, Beaufils, Fabien ^{a, b, d}, Daffe, Guillemine ^e, Gonzalez, Patrice ^{a, c}, Mornet, Stéphane ^f, Bejko, Megi ^f, Errera, Marie-Hélène ^g, Lacomme, Sabrina ^{a, h}, Gontier, Etienne ^{a, h}, Guibert, Christelle ^b, Baudrimont, Isabelle ^{a, b, 1}, Baudrimont, Magalie ^{a, c, 1, ∗}

Source: In Chemosphere September 2022 303 Part 2

The effect of CGRP and SP and the cell signaling dialogue between sensory neurons and endothelial cells.

Authors: Leroux, Alice, Roque, Micaela, Casas, Elina, Leng, Jacques, Guibert, Christelle, L'Azou, Beatrice, Oliveira, Hugo, Amédée, Joëlle, Paiva dos Santos, Bruno

Source: Biological Research; 9/11/2024, Vol. 57 Issue 1, p1-15, 15p

Subject Terms: CALCITONIN gene-related peptide, SUBSTANCE P, EXTRACELLULAR matrix, NITRIC-oxide synthases, CELL physiology, MICROFLUIDIC devices

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension

Authors: Rode, Baptiste, Bailey, Marc A., Marthan, Roger, Beech, David J., Guibert, Christelle

Source: Physiology. 33(1000034):261-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616353419&indx=1&recIds=ETOCRN616353419

Expression and role of connexin-based gap junctions in pulmonary inflammatory diseases

Authors: Freund-Michel, Véronique, Muller, Bernard, Marthan, Roger, Savineau, Jean-Pierre, Guibert, Christelle

Source: In Pharmacology and Therapeutics August 2016 164:105-119

Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

Authors: Coste, Florence, Guibert, Christelle, Magat, Julie, Abell, Emma, Vaillant, Fanny, Dubois, Mathilde, Courtois, Arnaud, Diolez, Philippe, Quesson, Bruno, Marthan, Roger, Savineau, Jean-Pierre, Muller, Bernard, Freund-Michel, Véronique

Source: Respiratory research. 18(1):1-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111727162.0x000001&indx=1&recIds=ETOCvdc_100111727162.0x000001

Short-term mechanisms activated by NGF to induce pulmonary arterial hyperreactivity

Authors: Bouchet, Clement, Cardouat, Guillaume, Douard, Matthieu, Robillard, Paul, Marthan, Roger, Guibert, Christelle, Freund-Michel, Véronique

Source: Archives of cardiovascular diseases.Supplements. 14(2):157-158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175042426.0x000001&indx=1&recIds=ETOCvdc_100175042426.0x000001

Mitochondria: Roles in pulmonary hypertension

Authors: Freund-Michel, Véronique, Khoyrattee, Nafiisha, Savineau, Jean-Pierre, Muller, Bernard, Guibert, Christelle

Source: In International Journal of Biochemistry and Cell Biology October 2014 55:93-97

OP2113, a new drug for chronic hypoxia‐induced pulmonary hypertension treatment in rat.

Authors: Roubenne, Lukas, Laisné, Margaux, Benoist, David, Campagnac, Marilyne, Prunet, Bénédicte, Pasdois, Philippe, Cardouat, Guillaume, Ducret, Thomas, Quignard, Jean‐François, Vacher, Pierre, Baudrimont, Isabelle, Marthan, Roger, Berger, Patrick, Le Grand, Bruno, Freund‐Michel, Véronique, Guibert, Christelle

Source: British Journal of Pharmacology; Nov2023, Vol. 180 Issue 21, p2802-2821, 20p

Subject Terms: RATS, PULMONARY hypertension, ELECTRON paramagnetic resonance, REACTIVE oxygen species, OXIDATIVE stress, WESTERN immunoblotting

Editorial: Model organisms and experimental models: opportunities and challenges in vascular physiology research.

Authors: Pulgar, Victor M., Guibert, Christelle, Ahmed, Al-Shaimaa Faissal, Trask, Aaron J.

Source: Frontiers in Physiology; 2023, p1-4, 4p

Subject Terms: PHYSIOLOGY, AORTIC rupture, CARDIOVASCULAR system

Celastrol: A new potential therapeutic option in pulmonary hypertension associated to bronchopulmonary dysplasia

Authors: Pilard, Claire-Marie, Dubois, Mathilde, Gauthereau, Isabel, Robillard, Paul, Kobersy, Joe, Dumas-De-La-Roque, Eric, Renesme, Laurent, Guibert, Christelle

Source: Archives of cardiovascular diseases.Supplements. 14(2):154-154

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175042473.0x000001&indx=1&recIds=ETOCvdc_100175042473.0x000001

Targeting Piezo1 channels to reverse pulmonary artery vasoconstriction in rat model of pulmonary hypertension

Authors: Porto-Ribeiro, Thais, Barbeau, Solène, Guibert, Christelle, Ducret, Thomas, Quignard, Jean-Francois

Source: Archives of cardiovascular diseases.Supplements. 14(2):154-154

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175042455.0x000001&indx=1&recIds=ETOCvdc_100175042455.0x000001

Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery

Authors: Courtois, Arnaud, Andujar, Pascal, Ladeiro, Yannick, Ducret, Thomas, Rogerieux, Françoise, Lacroix, Ghislaine, Baudrimont, Isabelle, Guibert, Christelle, Roux, Etienne, Canal-Raffin, Mireille, Brochard, Patrick, Marano, Francelyne, Marthan, Roger, Muller, Bernard

Source: In Toxicology and Applied Pharmacology 2010 245(2):203-210

Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells

Authors: Ducret, Thomas, Guibert, Christelle, Marthan, Roger, Savineau, Jean-Pierre

Source: In Cell Calcium 2008 43(4):315-323

Voltage-independent calcium influx in smooth muscle

Authors: Guibert, Christelle, Ducret, Thomas, Savineau, Jean-Pierre

Source: In Progress in Biophysics and Molecular Biology 2008 98(1):10-23

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism.

Authors: Bouchet, Clément, Cardouat, Guillaume, Douard, Matthieu, Coste, Florence, Robillard, Paul, Delcambre, Frédéric, Ducret, Thomas, Quignard, Jean-François, Vacher, Pierre, Baudrimont, Isabelle, Marthan, Roger, Berger, Patrick, Guibert, Christelle, Freund-Michel, Véronique

Source: Cells (2073-4409); Sep2022, Vol. 11 Issue 18, pN.PAG-N.PAG, 19p

Subject Terms: NERVE growth factor, OXIDATIVE stress, NEUROTROPHINS, SECRETION, NEUROTROPHIN receptors

Piezo1 Channel Activation Reverses Pulmonary Artery Vasoconstriction in an Early Rat Model of Pulmonary Hypertension: The Role of Ca 2+ Influx and Akt-eNOS Pathway.

Authors: Porto Ribeiro, Thais, Barbeau, Solène, Baudrimont, Isabelle, Vacher, Pierre, Freund-Michel, Véronique, Cardouat, Guillaume, Berger, Patrick, Guibert, Christelle, Ducret, Thomas, Quignard, Jean-François

Source: Cells (2073-4409); Aug2022, Vol. 11 Issue 15, p2349-2349, 18p

Subject Terms: PULMONARY artery, PULMONARY hypertension, VASOCONSTRICTION, ANIMAL disease models, CALCIUM channels, BLOOD flow, INTRACELLULAR calcium

Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia.

Authors: Barbeau, Solène, Joushomme, Alexandre, Chappe, Yann, Cardouat, Guillaume, Baudrimont, Isabelle, Freund-Michel, Véronique, Guibert, Christelle, Marthan, Roger, Berger, Patrick, Vacher, Pierre, Percherancier, Yann, Quignard, Jean-François, Ducret, Thomas

Source: Biomolecules (2218-273X); Jul2022, Vol. 12 Issue 7, pN.PAG-N.PAG, 23p

Subject Terms: TRPV cation channels, CALCIUM channels, FLUORESCENCE resonance energy transfer, CELL membranes, HYPOXEMIA, TRP channels