Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome

Authors: Barbaro, Maria Raffaella ¹, Cremon, Cesare ¹, Marasco, Giovanni ^{1, 2}, Savarino, Edoardo ³, Guglielmetti, Simone ⁴, Bonomini, Francesca ², Palombo, Marta ², Fuschi, Daniele ¹, Rotondo, Luca ¹, Mantegazza, Giacomo ⁴, Duncan, Robin ⁴, di Sabatino, Antonio ^{5, 6}, Valente, Sabrina ², Pasquinelli, Gianandrea ^{1, 2}, Vergnolle, Nathalie ⁷, Stanghellini, Vincenzo ^{1, 2}, Collins, Stephen M. ⁸, Barbara, Giovanni ^{1, 2, ∗}

Source: In Gastroenterology November 2024 167(6):1152-1166

Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA

Authors: Perruzza, Lisa, Rezzonico Jost, Tanja, Raneri, Matteo, Gargari, Giorgio, Palatella, Martina, De Ponte Conti, Benedetta, Seehusen, Frauke, Heckmann, Julia, Viemann, Dorothee, Guglielmetti, Simone, Grassi, Fabio

Source: In Cell Reports Medicine 16 July 2024 5(7)

Human in vivo assessment of the survival and germination of Heyndrickxia coagulans SNZ1969 spores delivered via gummy candies

Authors: Perotti, Susanna, Mantegazza, Giacomo, Pierallini, Elena, Kirika, Natalja, Duncan, Robin, Telesca, Nicolò, Sarrica, Andrea, Guglielmetti, Simone

Source: In Current Research in Food Science 2024 9

Safety considerations in the use of nonviable microbial cells as health-promoting agents in food and dietary supplements

Authors: Guglielmetti, Simone ^*

Source: In Current Opinion in Food Science December 2023 54

Reduction of Staphylococcus epidermidis in the mammary tumor microbiota induces antitumor immunity and decreases breast cancer aggressiveness

Authors: Bernardo, Giancarla, Le Noci, Valentino, Ottaviano, Emerenziana, De Cecco, Loris, Camisaschi, Chiara, Guglielmetti, Simone, Di Modica, Martina, Gargari, Giorgio, Bianchi, Francesca, Indino, Serena, Sartori, Patrizia, Borghi, Elisa, Sommariva, Michele, Tagliabue, Elda, Triulzi, Tiziana, Sfondrini, Lucia

Source: In Cancer Letters 28 February 2023 555

Use of kefir-derived lactic acid bacteria for the preparation of a fermented soy drink with increased estrogenic activity

Authors: Mantegazza, Giacomo ^a, Dalla Via, Alessandro ^a, Licata, Armando ^a, Duncan, Robin ^a, Gardana, Claudio ^a, Gargari, Giorgio ^a, Alamprese, Cristina ^a, Arioli, Stefania ^a, Taverniti, Valentina ^a, Karp, Matti ^b, Guglielmetti, Simone ^{a, ⁎}

Source: In Food Research International February 2023 164

The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial

Authors: Meroño, Tomás, Peron, Gregorio, Gargari, Giorgio, González-Domínguez, Raúl, Miñarro, Antonio, Vegas-Lozano, Esteban, Hidalgo-Liberona, Nicole, Del Bo', Cristian, Bernardi, Stefano, Kroon, Paul Antony, Carrieri, Barbara, Cherubini, Antonio, Riso, Patrizia, Guglielmetti, Simone, Andrés-Lacueva, Cristina

Source: In Food Research International September 2022 159

Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

Authors: Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J., Guglielmetti, Simone, Greiff, Victor, Grassi, Fabio

Source: In Cell Reports 19 July 2022 40(3)

Combination of different probiotics and berry-derived (poly)phenols can modulate immune response in dendritic cells

Authors: Taverniti, Valentina, Del Bo', Cristian, Fiore, Walter, Gargari, Giorgio, Arioli, Stefania, Riso, Patrizia, Guglielmetti, Simone, Frøkiær, Hanne

Source: In Journal of Functional Foods July 2022 94

Discriminatory and cooperative effects within the mouse gut microbiota in response to flaxseed and its oil and lignan components

Authors: Taibi, Amel, Ku, Michelle, Lin, Zhen, Gargari, Giorgio, Kubant, Alla, Lepp, Dion, Power, Krista A., Guglielmetti, Simone, Thompson, Lilian U., Comelli, Elena M.

Source: In The Journal of Nutritional Biochemistry December 2021 98

Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with “leaky gut”: The MaPLE trial

Authors: Peron, Gregorio, Gargari, Giorgio, Meroño, Tomás, Miñarro, Antonio, Lozano, Esteban Vegas, Escuder, Pol Castellano, González-Domínguez, Raúl, Hidalgo-Liberona, Nicole, Del Bo’, Cristian, Bernardi, Stefano, Kroon, Paul Antony, Carrieri, Barbara, Cherubini, Antonio, Riso, Patrizia, Guglielmetti, Simone, Andrés-Lacueva, Cristina

Source: In Clinical Nutrition October 2021 40(10):5288-5297

Does the type of hip fracture affect functional recovery in elderly patients undergoing inpatient rehabilitation?

Authors: Arcolin, Ilaria, Godi, Marco, Giardini, Marica, Guglielmetti, Simone, Corna, Stefano

Source: In Injury August 2021 52(8):2373-2378

A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Authors: Del Bo', Cristian, Bernardi, Stefano, Cherubini, Antonio, Porrini, Marisa, Gargari, Giorgio, Hidalgo-Liberona, Nicole, González-Domínguez, Raúl, Zamora-Ros, Raul, Peron, Gregorio, Marino, Mirko, Gigliotti, Letizia, Winterbone, Mark S., Kirkup, Benjamin, Kroon, Paul A., Andres-Lacueva, Cristina, Guglielmetti, Simone, Riso, Patrizia

Source: In Clinical Nutrition May 2021 40(5):3006-3018

Berries-Gut Microbiota Interaction and Impact on Human Health: A Systematic Review of Randomized Controlled Trials.

Authors: Marino, Mirko, Venturi, Samuele, Gargari, Giorgio, Del Bo, Cristian, Martini, Daniela, Porrini, Marisa, Guglielmetti, Simone, Riso, Patrizia

Source: Food Reviews International; Nov2024, Vol. 40 Issue 9, p2618-2640, 23p

Subject Terms: GUT microbiome, HUMAN microbiota, CLINICAL trials, RANDOMIZED controlled trials, BIOACTIVE compounds

Serum zonulin and colorectal cancer risk.

Authors: Marino, Mirko, Mignozzi, Silvia, Michels, Karin B., Cintolo, Marcello, Penagini, Roberto, Gargari, Giorgio, Ciafardini, Clorinda, Ferraroni, Monica, Patel, Linia, Del Bo', Cristian, Leone, Pierfrancesco, Airoldi, Aldo, Vecchi, Maurizio, Bonzi, Rossella, Oreggia, Barbara, Carnevali, Pietro, Vangeli, Marcello, Mutignani, Massimiliano, Guglielmetti, Simone, Riso, Patrizia

Source: Scientific Reports; 11/15/2024, Vol. 14 Issue 1, p1-9, 9p

Subject Terms: INTESTINAL barrier function, COLON cancer, COLORECTAL cancer, POLYMERASE chain reaction, RECTAL cancer

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

Authors: Rigoni, Rosita ^∗, Fontana, Elena ^∗, Dobbs, Kerry, Marrella, Veronica, Taverniti, Valentina, Maina, Virginia, Facoetti, Amanda, D’Amico, Giovanna, Al-Herz, Waleed, Cruz-Munoz, Mario Ernesto, Schuetz, Catharina, Gennery, Andrew R., Garabedian, Elizabeth K., Giliani, Silvia, Draper, Deborah, Dbaibo, Ghassan, Geha, Raif S., Meyts, Isabelle, Tousseyn, Thomas, Neven, Benedicte, Moshous, Despina, Fischer, Alain, Schulz, Ansgar, Finocchi, Andrea, Kuhns, Douglas B., Fink, Danielle L., Lionakis, Michail S., Swamydas, Muthulekha, Guglielmetti, Simone, Alejo, Julie, Myles, Ian A., Pittaluga, Stefania, Notarangelo, Luigi D., Villa, Anna, Cassani, Barbara

Source: In The Journal of Allergy and Clinical Immunology November 2020 146(5):1165-1179

Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

Authors: Hidalgo-Liberona, Nicole, González-Domínguez, Raúl, Vegas, Esteban, Riso, Patrizia, Del Bo, Cristian, Bernardi, Stefano, Peron, Gregorio, Guglielmetti, Simone, Gargari, Giorgio, Kroon, Paul Antony

Source: Journal of agricultural and food chemistry. 68(44):12476-12484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625285780&indx=1&recIds=ETOCRN625285780

Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications

Authors: Peron, Gregorio, Hidalgo-Liberona, Nicole, González-Domínguez, Raúl, Garcia-Aloy, Mar, Guglielmetti, Simone, Bernardi, Stefano, Kirkup, Benjamin, Kroon, Paul Antony, Cherubini, Antonio, Riso, Patrizia

Source: Journal of agricultural and food chemistry. 68(7):1780-1789

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623760970&indx=1&recIds=ETOCRN623760970

Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

Authors: Zagato, Elena, Pozzi, Chiara, Bertocchi, Alice, Schioppa, Tiziana, Saccheri, Fabiana, Guglietta, Silvia, Fosso, Bruno, Melocchi, Laura, Nizzoli, Giulia, Troisi, Jacopo, Marzano, Marinella, Oresta, Bianca, Spadoni, Ilaria, Atarashi, Koji, Carloni, Sara, Arioli, Stefania, Fornasa, Giulia, Asnicar, Francesco, Segata, Nicola, Guglielmetti, Simone, Honda, Kenya, Pesole, Graziano, Vermi, William, Penna, Giuseppe, Rescigno, Maria

Source: Nature microbiology. 5(3):511-524

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164213327.0x000001&indx=1&recIds=ETOCvdc_100164213327.0x000001

A (poly)phenol-rich diet reduces serum and faecal calprotectin in older adults with increased intestinal permeability: the MaPLE randomised controlled trial.

Authors: Marino, Mirko, Del Bo', Cristian, Martini, Daniela, Perna, Simone, Porrini, Marisa, Cherubini, Antonio, Gargari, Giorgio, Meroño, Tomás, Hidalgo-Liberona, Nicole, Andres-Lacueva, Cristina, Kroon, Paul A, Guglielmetti, Simone, Riso, Patrizia

Source: BMC Geriatrics; 8/24/2024, Vol. 24 Issue 1, p1-11, 11p

Subject Terms: CD54 antigen, INTESTINAL barrier function, INTERLEUKIN-6 receptors, TUMOR necrosis factors, CALPROTECTIN