Machine learning-powered, high-affinity modification strategies for aptamers

Authors: Gubu Amu, Xin Yang, Hang Luo, Sifan Yu, Huarui Zhang, Yuan Tian, Yuanyuan Yu, Shijian Ding, Yufei Pan, Zefeng Chen, Yixin He, Yuan Ma, Baoting Zhang, Ge Zhang

Source: Acta Materia Medica, Vol 4, Iss 1, Pp 122-136 (2025)

Subject Terms: Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0065; https://doaj.org/toc/2737-7946

Access URL: https://doaj.org/article/d4577f2d9f6940879a1c88af113fcf57

Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

Authors: Liangliang Zhang, Duanwei Liang, Changmai Chen, Yuan Wang, Gubu Amu, Jiali Yang, Lijia Yu, Ivan J. Dmochowski, Xinjing Tang

Source: Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 237-244 (2018)

Subject Terms: oligonucleotides, circular siRNA, off-target effect, gene regulation, RNA digestion, circular oligonucleotides, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253117303062; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/7b069acb5ffb4ce4841d0debe1a4898d

Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential

Authors: Gubu, Amu, Ma, Yuan, Yu, Sifan, Zhang, Huarui, Chen, Zefeng, Ni, Shuaijian, Abdullah, Razack, Xiao, Huan, Zhang, Yihao, Dai, Hong, Luo, Hang, Yu, Yuanyuan, Wang, Luyao, Jiang, Hewen, Zhang, Ning, Tian, Yuan, Li, Haitian, Lu, Aiping, Zhang, Baoting, Zhang, Ge

Source: In Molecular Therapy - Nucleic Acids 12 March 2024 35(1)

A bimolecular modification strategy for developing long-lasting bone anabolic aptamer

Authors: Zhang, Huarui ^{1, 6}, Yu, Sifan ^{1, 3, 4, 6, ∗}, Ni, Shuaijian ^{3, 6}, Gubu, Amu ^{2, 6}, Ma, Yuan ^{2, 6}, Zhang, Yihao ¹, Li, Haitian ², Wang, Yuzhe ⁵, Wang, Luyao ², Zhang, Zongkang ¹, Yu, Yuanyuan ², Lyu, Aiping ², Zhang, Baoting ^{1, ∗∗}, Zhang, Ge ^{2, ∗∗∗}

Source: In Molecular Therapy - Nucleic Acids 12 December 2023 34

Nucleic acid amphiphiles: Synthesis, properties, and applications

Authors: Gubu, Amu, Zhang, Xueli, Lu, Aiping, Zhang, Baoting, Ma, Yuan, Zhang, Ge

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:144-163

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing.

Authors: Zhang, Xueli¹ (AUTHOR) juhao@bjmu.edu.cn, Gubu, Amu¹ (AUTHOR) amu@bjmu.edu.cn, Xu, Jianfei¹ (AUTHOR) xjf@bjmu.edu.cn, Yan, Ning¹ (AUTHOR) 1716386027@bjmu.edu.cn, Su, Wenbo¹ (AUTHOR) 1711210115@pku.edu.cn, Feng, Di¹ (AUTHOR) fengdi@bjmu.edu.cn, Wang, Qian¹ (AUTHOR) qian.wang@bjmu.edu.cn, Tang, Xinjing^1,2 (AUTHOR) xinjingt@bjmu.edu.cn

Source: Molecules. Jul2022, Vol. 27 Issue 14, pN.PAG-N.PAG. 9p.

Subject Terms: *GENE silencing, *SMALL interfering RNA, *GREEN fluorescent protein, *SMALL molecules, *VITAMINS, *ACTIVATION (Chemistry)

Circular Antisense Oligonucleotides for Specific RNase-H-Mediated microRNA Inhibition with Reduced Off-Target Effects and Nonspecific Immunostimulation

Authors: Gubu, Amu, Su, Wenbo, Zhao, Xiaoran, Zhang, Xueli, Fan, Xinli, Wang, Jing, Wang, Qian, Tang, Xinjing

Source: Journal of Medicinal Chemistry; November 2021, Vol. 64 Issue: 21 p16046-16055, 10p

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Synthesis and "DNA Interlocks" Formation of Small Circular Oligodeoxynucleotides.

Authors: Gubu, Amu, Wang, Jing, Jin, Hongwei, Tang, Xinjing

Source: ACS Applied Materials & Interfaces; 3/18/2020, Vol. 12 Issue 11, p12584-12590, 7p

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Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.

Authors: Xiao Zhang¹, Lian-Huan Wei¹, Yuxin Wang², Yu Xiao¹, Jun Liu¹, Wei Zhang¹, Ning Yan³, Gubu Amu³, Xinjing Tang³, Liang Zhang², liangzhang2014@sjtu.edu.cn, Guifang Jia^1,4, guifangjia@pku.edu.cn

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/19/2019, Vol. 116 Issue 8, p2919-2924, 6p

Bioorthogonal Metabolic DNA Labelling using Vinyl Thioether‐Modified Thymidine and o‐Quinolinone Quinone Methide.

Authors: Gubu, Amu, Li, Long, Ning, Yan, Zhang, Xiaoyun, Lee, Seonghyun, Feng, Mengke, Li, Qiang, Lei, Xiaoguang, Jo, Kyubong, Tang, Xinjing

Source: Chemistry - A European Journal; 4/17/2018, Vol. 24 Issue 22, p5895-5900, 6p

Subject Terms: DNA metabolism, SULFIDES, THYMIDINE, QUINOLONE antibacterial agents, CELL nuclei, DNA analysis