Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing

Authors: Binsheng Gong, Dan Li, Paweł P. Łabaj, Bohu Pan, Natalia Novoradovskaya, Danielle Thierry-Mieg, Jean Thierry-Mieg, Guangchun Chen, Anne Bergstrom Lucas, Jennifer S. LoCoco, Todd A. Richmond, Elizabeth Tseng, Rebecca Kusko, Scott Happe, Timothy R. Mercer, Carlos Pabón-Peña, Michael Salmans, Hagen U. Tilgner, Wenzhong Xiao, Donald J. Johann, Wendell Jones, Weida Tong, Christopher E. Mason, David P. Kreil, Joshua Xu

Source: Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/73cc5c3ee70441e7acfa9bce7c026093

IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells

Authors: Victoria A. Wong, Kristie N. Dinh, Guangchun Chen, Lucile E. Wrenshall

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: IL-2Rα, maternal microchimerism, knock out, nucleus, cell proliferation, cell size, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1369818/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/15a0acba40854b888608f0e2e52f686e

Comprehensive microRNA-seq transcriptomic profiling across 11 organs, 4 ages, and 2 sexes of Fischer 344 rats

Authors: Xintong Yao, Shanyue Sun, Yi Zi, Yaqing Liu, Jingcheng Yang, Luyao Ren, Guangchun Chen, Zehui Cao, Wanwan Hou, Yueqiang Song, Jun Shang, He Jiang, Zhihui Li, Haiyan Wang, Peipei Zhang, Leming Shi, Quan-Zhen Li, Ying Yu, Yuanting Zheng

Source: Scientific Data, Vol 9, Iss 1, Pp 1-10 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/487af00bb63e49dbadaec770d2e0f4a1

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

Authors: Binsheng Gong, Dan Li, Rebecca Kusko, Natalia Novoradovskaya, Yifan Zhang, Shangzi Wang, Carlos Pabón-Peña, Zhihong Zhang, Kevin Lai, Wanshi Cai, Jennifer S. LoCoco, Eric Lader, Todd A. Richmond, Vinay K. Mittal, Liang-Chun Liu, Donald J. Johann, James C. Willey, Pierre R. Bushel, Ying Yu, Chang Xu, Guangchun Chen, Daniel Burgess, Simon Cawley, Kristina Giorda, Nathan Haseley, Fujun Qiu, Katherine Wilkins, Hanane Arib, Claire Attwooll, Kevin Babson, Longlong Bao, Wenjun Bao, Anne Bergstrom Lucas, Hunter Best, Ambica Bhandari, Halil Bisgin, James Blackburn, Thomas M. Blomquist, Lisa Boardman, Blake Burgher, Daniel J. Butler, Chia-Jung Chang, Alka Chaubey, Tao Chen, Marco Chierici, Christopher R. Chin, Devin Close, Jeffrey Conroy, Jessica Cooley Coleman, Daniel J. Craig, Erin Crawford, Angela del Pozo, Ira W. Deveson, Daniel Duncan, Agda Karina Eterovic, Xiaohui Fan, Jonathan Foox, Cesare Furlanello, Abhisek Ghosal, Sean Glenn, Meijian Guan, Christine Haag, Xinyi Hang, Scott Happe, Brittany Hennigan, Jennifer Hipp, Huixiao Hong, Kyle Horvath, Jianhong Hu, Li-Yuan Hung, Mirna Jarosz, Jennifer Kerkhof, Benjamin Kipp, David Philip Kreil, Paweł Łabaj, Pablo Lapunzina, Peng Li, Quan-Zhen Li, Weihua Li, Zhiguang Li, Yu Liang, Shaoqing Liu, Zhichao Liu, Charles Ma, Narasimha Marella, Rubén Martín-Arenas, Dalila B. Megherbi, Qingchang Meng, Piotr A. Mieczkowski, Tom Morrison, Donna Muzny, Baitang Ning, Barbara L. Parsons, Cloud P. Paweletz, Mehdi Pirooznia, Wubin Qu, Amelia Raymond, Paul Rindler, Rebecca Ringler, Bekim Sadikovic, Andreas Scherer, Egbert Schulze, Robert Sebra, Rita Shaknovich, Qiang Shi, Tieliu Shi, Juan Carlos Silla-Castro, Melissa Smith, Mario Solís López, Ping Song, Daniel Stetson, Maya Strahl, Alan Stuart, Julianna Supplee, Philippe Szankasi, Haowen Tan, Lin-ya Tang, Yonghui Tao, Shraddha Thakkar, Danielle Thierry-Mieg, Jean Thierry-Mieg, Venkat J. Thodima, David Thomas, Boris Tichý, Nikola Tom, Elena Vallespin Garcia, Suman Verma, Kimbley Walker, Charles Wang, Junwen Wang, Yexun Wang, Zhining Wen, Valtteri Wirta, Leihong Wu, Chunlin Xiao, Wenzhong Xiao, Shibei Xu, Mary Yang, Jianming Ying, Shun H. Yip, Guangliang Zhang, Sa Zhang, Meiru Zhao, Yuanting Zheng, Xiaoyan Zhou, Christopher E. Mason, Timothy Mercer, Weida Tong, Leming Shi, Wendell Jones, Joshua Xu

Source: Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)

Subject Terms: Oncopanel sequencing, Target enrichment, Molecular diagnostics, Reproducibility, Analytical performance, Precision medicine, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/c5365bb671514dddbb3d5b324f62ed28

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

Authors: Wendell Jones, Binsheng Gong, Natalia Novoradovskaya, Dan Li, Rebecca Kusko, Todd A. Richmond, Donald J. Johann, Halil Bisgin, Sayed Mohammad Ebrahim Sahraeian, Pierre R. Bushel, Mehdi Pirooznia, Katherine Wilkins, Marco Chierici, Wenjun Bao, Lee Scott Basehore, Anne Bergstrom Lucas, Daniel Burgess, Daniel J. Butler, Simon Cawley, Chia-Jung Chang, Guangchun Chen, Tao Chen, Yun-Ching Chen, Daniel J. Craig, Angela del Pozo, Jonathan Foox, Margherita Francescatto, Yutao Fu, Cesare Furlanello, Kristina Giorda, Kira P. Grist, Meijian Guan, Yingyi Hao, Scott Happe, Gunjan Hariani, Nathan Haseley, Jeff Jasper, Giuseppe Jurman, David Philip Kreil, Paweł Łabaj, Kevin Lai, Jianying Li, Quan-Zhen Li, Yulong Li, Zhiguang Li, Zhichao Liu, Mario Solís López, Kelci Miclaus, Raymond Miller, Vinay K. Mittal, Marghoob Mohiyuddin, Carlos Pabón-Peña, Barbara L. Parsons, Fujun Qiu, Andreas Scherer, Tieliu Shi, Suzy Stiegelmeyer, Chen Suo, Nikola Tom, Dong Wang, Zhining Wen, Leihong Wu, Wenzhong Xiao, Chang Xu, Ying Yu, Jiyang Zhang, Yifan Zhang, Zhihong Zhang, Yuanting Zheng, Christopher E. Mason, James C. Willey, Weida Tong, Leming Shi, Joshua Xu

Source: Genome Biology, Vol 22, Iss 1, Pp 1-38 (2021)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/7cb57d840cc4477294d87b6e0d997c1a

Immune Evasion Strategies of Ranaviruses and Innate Immune Responses to These Emerging Pathogens

Authors: Leon Grayfer, Francisco De Jesús Andino, Guangchun Chen, Gregory V. Chinchar, Jacques Robert

Source: Viruses, Vol 4, Iss 7, Pp 1075-1092 (2012)

Subject Terms: Iridovirus, ranavirus, FV3, frog virus 3, innate immunity, macrophage, anti-viral, immune-evasion, cytokines, inflammation, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4915/4/7/1075; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e9228cf407184bb09ca3e3ac92fba787

Antiviral Immunity in Amphibians

Authors: Jacques Robert, Guangchun Chen

Source: Viruses, Vol 3, Iss 11, Pp 2065-2086 (2011)

Subject Terms: iridovirus, viral infection, amphibian, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/1999-4915/3/11/2065/; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/daa9e575f6a5472891476970d8ec1e4d

Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells.

Authors: Jianhua Gong, Zhongde Wang, Irina Polejaeva, Ravi Salgia, Chien-Min Kao, Chin-Tu Chen, Guangchun Chen, Liaohai Chen

Source: PLoS ONE, Vol 9, Iss 3, p e90059 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090059&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/62def8f28fa541b094985444c7b6bac6

IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.

Authors: Wong, Victoria A., Dinh, Kristie N., Guangchun Chen, Wrenshall, Lucile E.

Source: Frontiers in Immunology; 2024, p01-13, 13p

Subject Terms: VASCULAR smooth muscle, REGULATORY T cells, CELL size, CELL death, CELLULAR control mechanisms, MUSCLE cells, DELETION mutation

Immune Evasion Strategies of Ranaviruses and Innate Immune Responses to These Emerging Pathogens.

Authors: Grayfer, Leon, Jesús Andino, Francisco De, Guangchun Chen, Chinchar, Gregory V., Robert, Jacques

Source: Viruses (1999-4915); Jul2012, Vol. 4 Issue 7, p1075-1092, 18p, 2 Color Photographs, 1 Map

Subject Terms: IRIDOVIRUSES, NATURAL immunity, FROG diseases, MACROPHAGES, CYTOKINES

Antiviral Immunity in Amphibians.

Authors: Guangchun Chen, Robert, Jacques

Source: Viruses (1999-4915); Nov2011, Vol. 3 Issue 11, p2065-2086, 22p, 1 Color Photograph, 1 Black and White Photograph, 3 Diagrams

Subject Terms: IRIDOVIRUSES, AMPHIBIAN diseases, IMMUNOLOGY, VIRUS diseases, VIRUS disease transmission, VETERINARY virology, IMMUNE response, IMMUNE system, BIODIVERSITY

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression.

Authors: Liquan Yang¹, Guangchun Chen¹, Mohanty, Sonali¹, Scott, Glynis², Fazal, Fabeha³, Rahman, Arshad³, Begum, Shahinoor⁴, Hynes, Richard O.⁴, Lei Xu^1,2 ei_xu@urmc.rochester.edu

Source: Cancer Research. Aug2011, Vol. 71 Issue 16, p5558-5568. 11p.

Subject Terms: *NEOVASCULARIZATION, *CANCER, *CANCER cells, *CELLS, *PROTEIN kinase C

Relationships and Hybridization among Smilax china and Its Affinities: Evidence from Allozyme Data.

Authors: Aili Wang, Yeye Chen, Guangchun Chen, Joongku Lee, Chengxin Fu

Source: Biochemical Genetics; Jun2008, Vol. 46 Issue 5/6, p281-292, 12p, 3 Charts, 1 Map

Subject Terms: SMILAX, PLANT species, ISOENZYMES, CHROMOSOMES

Modulation of Androgen Receptor Transactivation by FoxH1.

Authors: Guangchun Chen^1,2, Nomura, Masatoshi¹ nomura@med.kyushu-u.ac.jp, Morinaga, Hidetaka¹, Matsubara, Eri¹, Okabe, Taijiro¹, Goto, Kiminobu¹, Yanase, Toshihiko¹, Hong Zheng³, Jian Lu², Nawata, Hajime¹

Source: Journal of Biological Chemistry. 10/28/2005, Vol. 280 Issue 43, p36355-36363. 9p. 1 Diagram, 6 Graphs.

Subject Terms: *ANDROGENS, *ANDROGEN drugs, *PROSTATE cancer, *GROWTH factors, *PROSTATE cancer treatment, *RESEARCH

Androgen receptor mutants detected in recurrent prostate cancer exhibit diverse functional characteristics.

Authors: Guangchun Chen, Xiaohui Wang, Shimin Zhang, Ying Lu, Yinghao Sun, Jinshan Zhang, Zongbin Li, Jian Lu

Source: Prostate; Jun2005, Vol. 63 Issue 4, p395-406, 12p

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