Spirolactone compounds

Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin‐Like Phospholipase Domain Containing 3–Mediated Acceleration of Steatohepatitis

Authors: Banini, Bubu A., Kumar, Divya P., Cazanave, Sophie, Seneshaw, Mulugeta, Mirshahi, Faridoddin, Santhekadur, Prasanna K., Wang, Liangsu, Guan, Hong Ping, Oseini, Abdul M., Alonso, Cristina, Bedossa, Pierre, Koduru, Srinivas V., Min, Hae‐Ki, Sanyal, Arun J.

Source: Hepatology. 73(4):1290-1306

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135391039.0x000001&indx=1&recIds=ETOCvdc_100135391039.0x000001

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Authors: Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.

Source: Science, 2017 Aug 01. 357(6350), 507-511.

Access URL: https://www.jstor.org/stable/26399568

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

Authors: Yang, Xiaodong, Mudgett, John, Bou-About, Ghina, Champy, Marie-France, Jacobs, Hugues, Monassier, Laurent, Pavlovic, Guillaume, Sorg, Tania, Herault, Yann, Petit-Demoulière, Benoit, Lu, Ku, Feng, Wen, Wang, Hongwu ^**, Ma, Li-Jun, Askew, Roger, Erion, Mark D., Kelley, David E., Myers, Robert W., Li, Cai, Guan, Hong-Ping

Source: In Journal of Biological Chemistry November 2016 291(45):23428-23439

Glucagon receptor antagonism induces increased cholesterol absorption

Authors: Guan, Hong-Ping ^*, Yang, Xiaodong ^*, Lu, Ku ^*, Wang, Sheng-Ping ^*, Castro-Perez, Jose M. ^*, Previs, Stephen ^*, Wright, Michael ^†, Shah, Vinit ^*, Herath, Kithsiri ^*, Xie, Dan ^*, Szeto, Daphne ^§, Forrest, Gail ^§, Xiao, Jing Chen ^*, Palyha, Oksana ^*, Sun, Li-Ping ^*, Andryuk, Paula J. ^**, Engel, Samuel S. ^**, Xiong, Yusheng ^††, Lin, Songnian ^††, Kelley, David E. ^*, Erion, Mark D. ^*, Davis, Harry R. ^*, Wang, Liangsu ^*

Source: In Journal of Lipid Research November 2015 56(11):2183-2195

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

Authors: Han, Seongah ^*, Akiyama, Taro E. ^†, Previs, Stephen F. ^*, Herath, Kithsiri ^*, Roddy, Thomas P. ^*, Jensen, Kristian K. ^*, Guan, Hong-Ping ^†, Murphy, Beth A. ^§, McNamara, Lesley A. ^§, Shen, Xun ^*, Strapps, Walter ^**, Hubbard, Brian K. ^*, Pinto, Shirly ^*, Li, Cai ^†, Li, Jing ^*

Source: In Journal of Lipid Research October 2013 54(10):2615-2622

Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice

Authors: Guan, Hong-Ping, Goldstein, Joseph L., Brown, Michael S., Liang, Guosheng

Source: In Journal of Biological Chemistry 4 September 2009 284(36):24644-24652

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.

Authors: Muise, Eric S.¹ eric_muise@merck.com, Guan, Hong-Ping², Liu, Jinqi², Nawrocki, Andrea R.³, Yang, Xiaodong², Wang, Chuanlin², Rodríguez, Carlos G.³, Zhou, Dan³, Gorski, Judith N.³, Kurtz, Marc M.⁴, Feng, Danqing⁵, Leavitt, Kenneth J.⁵, Wei, Lan⁵, Wilkening, Robert R.⁵, Apgar, James M.⁵, Xu, Shiyao⁶, Lu, Ku², Feng, Wen², Li, Ying², He, Huaibing⁶

Source: PLoS ONE. 2/27/2019, Vol. 14 Issue 2, p1-29. 29p.

Subject Terms: *PROTEIN kinases, *MYOCARDIUM, *EXERCISE physiology, *ADIPOSE tissues, *GENETIC transcription

Factors Affecting Insulin-Regulated Hepatic Gene Expression

Authors: Guan, Hong-Ping, Chen, Guoxun

Source: Progress in Molecular Biology and Translational Science. 2014, v. 121, p165-215.

PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Authors: Kershaw, Erin E., Schupp, Michael, Guan, Hong-Ping

Source: American Journal of Physiology; December 2007 pt1, Vol. 293 Issue 6, pE1736-E1745, 10p

Corepressors selectively control the transcriptional activity of PPARγ in adipocytes.

Authors: Guan, Hong-Ping, Ishizuka, Takahiro, Chui, Patricia C.

Source: Genes & Development; February 15 2005, Vol. 19 Issue 4, p453-461, 9p

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRα

Authors: Lehrke, Michael, Lebherz, Corinna, Millington, Segan C., Guan, Hong-Ping, Millar, John, Rader, Daniel J., Wilson, James M., Lazar, Mitchell A. ^*

Source: In Cell Metabolism 2005 1(5):297-308

A futile metabolic cycle activated in adipocytes by antidiabetic agents.

Authors: Guan, Hong-Ping, Li, Yong, Jensen, Mette Valentin

Source: Nature Medicine; October 2002, Vol. 8 Issue 10, p1122-1128, 7p

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Chapter Six - Factors Affecting Insulin-Regulated Hepatic Gene Expression

Authors: Guan, Hong-Ping ^*, Chen, Guoxun

Source: In Progress in Molecular Biology and Translational Science 2014 121:165-215

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PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1.

Authors: Chui, Patricia C.¹, Guan, Hong-Ping¹, Lehrke, Michael¹, Lazar, Mitchell A.¹ lazar@mail.med.upenn.edu

Source: Journal of Clinical Investigation. Aug2005, Vol. 115 Issue 8, p2244-2256. 13p. 1 Black and White Photograph, 7 Graphs.

Subject Terms: *FAT cells, *ADIPOSE tissues, *METABOLISM, *FATTY acids, *SERUM, *PROINSULIN, *PROTEIN metabolism, *CHOLESTEROL metabolism, *ANIMAL experimentation, *CELL culture, *CELL receptors, *COMPARATIVE studies, *GENES, *HYPOGLYCEMIC agents, *INSULIN resistance, *LOW density lipoproteins, *RESEARCH methodology, *MEDICAL cooperation, *MICE, *RESEARCH, *EVALUATION research, *THIAZOLIDINEDIONES, *PHARMACODYNAMICS

Synphilin in normal human brains and in synucleinopathies: studies with new antibodies.

Authors: Murray, Ian V. J., Medford, Marlon A., Guan, Hong-Ping, Rueter, Susan M., Trojanowski, John Q., Lee, Virginia M.-Y.

Source: Acta Neuropathologica; Feb2003, Vol. 105 Issue 2, p177-184, 8p

Subject Terms: PARKINSON'S disease, CELLS, BRAIN, NEURONS, GENETICS, NERVOUS system

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