Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

Authors: Winter-Holt, Jon J., Bardelle, Catherine, Chiarparin, Elisabetta, Dale, Ian L., Davey, Paul R. J., Davies, Nichola L., Denz, Christopher, Fillery, Shaun M., Guérot, Carine M., Fujin Han, Hughes, Samantha J., Kulkarni, Meghana, Zhaoqun Liu, Milbradt, Alexander, Moss, Thomas A., Huijun Niu, Patel, Joe, Rabow, Alfred A., Schimpl, Marianne, Junjie Shi

Source: Journal of Medicinal Chemistry; 2/24/2022, Vol. 65 Issue 4, p3306-3331, 26p

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Authors: Finlay, M. Raymond V., Barton, Peter, Bickerton, Sue, Bista, Michal, Colclough, Nicola, Cross, Darren A. E., Evans, Laura, Floc’h, Nicolas, Gregson, Clare, Guérot, Carine M., Hargreaves, David, Kang, Xiaoming, Lenz, Eva M., Li, Xu, Liu, Yi, Lorthioir, Olivier, Martin, Matthew J., McKerrecher, Darren, McWhirter, Claire, O’Neill, Daniel, Orme, Jonathan P., Mosallanejad, Arash, Rahi, Amar, Smith, Paul D., Talbot, Verity, Ward, Richard A., Wrigley, Gail, Wylot, Marta, Xue, Lin, Yao, Tieguang, Ye, Yang, Zhao, Xiliang

Source: Journal of Medicinal Chemistry; September 2021, Vol. 64 Issue: 18 p13704-13718, 15p

Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C–N/C–C Bond Formations.

Authors: Fillery, Shaun M., Gregson, Clare L., Guérot, Carine M.

Source: Organic Letters; Nov2019, Vol. 21 Issue 22, p9128-9132, 5p

Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C–N/C–C Bond Formations

Authors: Fillery, Shaun M., Gregson, Clare L., Guérot, Carine M.

Source: Organic Letters; November 2019, Vol. 21 Issue: 22 p9128-9132, 5p

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Authors: Winter-Holt, Jon J., Bardelle, Catherine, Chiarparin, Elisabetta, Dale, Ian L., Davey, Paul R. J., Davies, Nichola L., Denz, Christopher, Fillery, Shaun M., Guérot, Carine M., Han, Fujin, Hughes, Samantha J., Kulkarni, Meghana, Liu, Zhaoqun, Milbradt, Alexander, Moss, Thomas A., Niu, Huijun, Patel, Joe, Rabow, Alfred A., Schimpl, Marianne, Shi, Junjie, Sun, Dongqing, Yang, Dejian, Guichard, Sylvie

Source: Journal of Medicinal Chemistry; 20220101, Issue: Preprints