Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responses

Authors: Haskins, Breanne E., Gullicksrud, Jodi A., Wallbank, Bethan A., Dumaine, Jennifer E., Guérin, Amandine, Cohn, Ian S., O'Dea, Keenan M., Pardy, Ryan D., Merolle, Maria I., Shallberg, Lindsey A., Hunter, Emma N., Byerly, Jessica H., Smith, Eleanor J., Buenconsejo, Gracyn Y., McLeod, Briana I., Christian, David A., Striepen, Boris, Hunter, Christopher A.

Source: In Mucosal Immunology June 2024 17(3):387-401

Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell

Authors: Guérin, Amandine, Strelau, Katherine M., Barylyuk, Konstantin, Wallbank, Bethan A., Berry, Laurence, Crook, Oliver M., Lilley, Kathryn S., Waller, Ross F., Striepen, Boris

Source: In Cell Host & Microbe 12 April 2023 31(4):650-664

LIX1-mediated changes in mitochondrial metabolism control the fate of digestive mesenchyme-derived cells

Authors: Guérin, Amandine, Angebault, Claire, Kinet, Sandrina, Cazevieille, Chantal, Rojo, Manuel, Fauconnier, Jérémy, Lacampagne, Alain, Mourier, Arnaud, Taylor, Naomi, de Santa Barbara, Pascal, Faure, Sandrine

Source: In Redox Biology October 2022 56

Histidine limitation alters plant development and influences the TOR network.

Authors: Guérin, Amandine¹ (AUTHOR), Levasseur, Caroline¹ (AUTHOR), Herger, Aline¹ (AUTHOR), Renggli, Dominik² (AUTHOR), Sotiropoulos, Alexandros Georgios¹ (AUTHOR), Kadler, Gabor¹ (AUTHOR), Hou, Xiaoyu¹ (AUTHOR), Schaufelberger, Myriam¹ (AUTHOR), Meyer, Christian³ (AUTHOR), Wicker, Thomas¹ (AUTHOR), Bigler, Laurent² (AUTHOR), Ringli, Christoph¹ (AUTHOR)

Source: Journal of Experimental Botany. 2/25/2025, Vol. 76 Issue 4, p1085-1098. 14p.

Parasitology meets cryo-electron tomography – exciting prospects await

Authors: Theveny, Liam M., Mageswaran, Shrawan Kumar, Chen, William David, Martinez, Matthew, Guérin, Amandine, Chang, Yi-Wei

Source: Trends in parasitology. 38(5):365-378

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100160423954.0x000001&indx=1&recIds=ETOCvdc_100160423954.0x000001

New frontiers in host–parasite interactions, from cell to organism

Authors: Albisetti, Anna, Venugopal, Kannan, Guérin, Amandine

Source: Molecular microbiology. 119(2):275-277

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182089073.0x000001&indx=1&recIds=ETOCvdc_100182089073.0x000001

Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module.

Authors: Gupta, Shibu¹ (AUTHOR), Guérin, Amandine¹ (AUTHOR), Herger, Aline¹ (AUTHOR), Hou, Xiaoyu¹ (AUTHOR), Schaufelberger, Myriam¹ (AUTHOR), Roulard, Romain² (AUTHOR), Diet, Anouck¹ (AUTHOR), Roffler, Stefan¹ (AUTHOR), Lefebvre, Valérie² (AUTHOR), Wicker, Thomas¹ (AUTHOR), Pelloux, Jérôme² (AUTHOR), Ringli, Christoph¹ (AUTHOR) chringli@botinst.uzh.ch

Source: PLoS Genetics. 1/8/2024, Vol. 20 Issue 1, p1-23. 23p.

Subject Terms: *ARABIDOPSIS thaliana, *ROOT hairs (Botany), *CELL growth, *PEPTIDE hormones, *GOLGI apparatus, *EXTRACELLULAR matrix

Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7

Authors: Guérin, Amandine, Roy, Nathan H., Kugler, Emily M., Berry, Laurence, Burkhardt, Janis K., Shin, Jung-Bum, Striepen, Boris

Source: In Cell Host & Microbe 8 September 2021 29(9):1407-1420

Phenotypic switch of smooth muscle cells in paediatric chronic intestinal pseudo‐obstruction syndrome

Authors: Martire, Delphine, Garnier, Sarah, Sagnol, Sébastien, Bourret, Annick, Marchal, Stéphane, Chauvet, Norbert, Guérin, Amandine, Forgues, Dominique, Berrebi, Dominique, Chardot, Christophe, Bellaiche, Marc, Rendu, John, Kalfa, Nicolas, Faure, Sandrine, de Santa Barbara, Pascal

Source: Journal of cellular and molecular medicine. 25(8):4028-4039

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120122199.0x000001&indx=1&recIds=ETOCvdc_100120122199.0x000001

The Biology of the Intestinal Intracellular Parasite Cryptosporidium

Authors: Guérin, Amandine, Striepen, Boris

Source: In Cell Host & Microbe 7 October 2020 28(4):509-515

LIX1 regulates YAP activity and controls gastrointestinal cancer cell plasticity

Authors: Guérin, Amandine, Martire, Delphine, Trenquier, Eva, Lesluyes, Tom, Sagnol, Sébastien, Pratlong, Marine, Lefebvre, Elise, Chibon, Fréderic, Santa Barbara, Pascal, Faure, Sandrine

Source: Journal of cellular and molecular medicine. 24(16):9244-9254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119311670.0x000001&indx=1&recIds=ETOCvdc_100119311670.0x000001

The first Cryptosporidium meeting: a concerted effort to fight cryptosporidiosis

Authors: van Voorhis, Wes, Siwila, Joyce, Kissinger, Jessica C., Vásquez, Natalia Bayona, Robinson, Guy, Baptista, Rodrigo, Khan, Asis, Guérin, Amandine, Chang, Yi-Wei, Noor, Zannatun, Marzook, N. Bishara, Vinayak, Sumiti, Arnold, Sam, Marie, Chelsea, Choy, Robert K.M., Pawlowic, Mattie C., Jumani, Rajiv S.

Source: In Trends in Parasitology June 2024 40(6):431-438

An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma

Authors: Sparvoli, Daniela, Delabre, Jason, Penarete‐Vargas, Diana Marcela, Kumar Mageswaran, Shrawan, Tsypin, Lev M, Heckendorn, Justine, Theveny, Liam, Maynadier, Marjorie, Mendonça Cova, Marta, Berry‐Sterkers, Laurence, Guérin, Amandine, Dubremetz, Jean‐François, Urbach, Serge, Striepen, Boris, Turkewitz, Aaron P, Chang, Yi‐Wei, Lebrun, Maryse

Source: EMBO journal. 41(22)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185738830.0x000001&indx=1&recIds=ETOCvdc_100185738830.0x000001

Live imaging of the Cryptosporidium parvum life cycle reveals direct development of male and female gametes from type I meronts.

Authors: English, Elizabeth D.¹ (AUTHOR), Guérin, Amandine¹ (AUTHOR), Tandel, Jayesh¹ (AUTHOR), Striepen, Boris¹ (AUTHOR) striepen@upenn.edu

Source: PLoS Biology. 4/18/2022, Vol. 20 Issue 4, p1-22. 22p. 1 Diagram, 5 Graphs.

Subject Terms: *CRYPTOSPORIDIUM parvum, *OVUM, *SPERMATOZOA, *PLASMODIUM, *ASEXUAL reproduction, *PARTHENOGENESIS

Dissecting the interface between apicomplexan parasite and host cell : Insights from a divergent AMA–RON2 pair

Authors: Parker, Michelle L., Penarete-Vargas, Diana M., Hamilton, Phineas T., Guérin, Amandine, Dubey, Jitender P., Perlman, Steve J., Spano, Furio, Lebrun, Maryse, Boulanger, Martin J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Jan 01. 113(2), 398-403.

Access URL: https://www.jstor.org/stable/26467370

Efficient invasion by Toxoplasma depends on the subversion of host protein networks

Authors: Guérin, Amandine, Corrales, Rosa, Parker, Michele, Lamarque, Mauld, Jacot, Damien, El Hajj, Hiba, Soldati-Favre, Dominique, Boulanger, Martin, Lebrun, Maryse

Source: Nature microbiology. 2(10):1358-1366

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178375000.0x000001&indx=1&recIds=ETOCvdc_100178375000.0x000001

Rhoptry secretion system structures and regulatory mechanisms in Apicomplexan parasites revealed using cryo-ET

Authors: Kumar Mageswaran, Shrawan, Martinez, Matthew, Guérin, Amandine, Chen, William, Theveny, Liam, Cova, Marta, Molnár, Petra, John, Audrey, Striepen, Boris, Lebrun, Maryse, Chang, Yi-Wei

Source: Biophysical journal. 122(S1):2a-2a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186061719.0x000001&indx=1&recIds=ETOCvdc_100186061719.0x000001

Sustained rhoptry docking and discharge requires Toxoplasma gondii intraconoidal microtubule-associated proteins.

Authors: Dos Santos Pacheco, Nicolas, Tell i Puig, Albert, Guérin, Amandine, Martinez, Matthew, Maco, Bohumil, Tosetti, Nicolò, Delgado-Betancourt, Estefanía, Lunghi, Matteo, Striepen, Boris, Chang, Yi-Wei, Soldati-Favre, Dominique

Source: Nature Communications; 1/12/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: MICROTUBULE-associated proteins, EXPANSION microscopy, TOXOPLASMA gondii, CYTOSKELETAL proteins, LABORATORY mice, MICROTUBULES, ANIMAL disease models

Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography.

Authors: Martinez, Matthew, Mageswaran, Shrawan Kumar, Guérin, Amandine, Chen, William David, Thompson, Cameron Parker, Chavin, Sabine, Soldati-Favre, Dominique, Striepen, Boris, Chang, Yi-Wei

Source: Nature Communications; 8/9/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: APICOMPLEXA, ACTIN, LIFE cycles (Biology), CRYPTOSPORIDIUM parvum, TOXOPLASMA gondii, TOMOGRAPHY

In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems.

Authors: Mageswaran, Shrawan Kumar, Guérin, Amandine, Theveny, Liam M., Chen, William David, Martinez, Matthew, Lebrun, Maryse, Striepen, Boris, Chang, Yi-Wei

Source: Nature Communications; 10/21/2021, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: APICOMPLEXA, CELL membranes, SECRETION, CRYPTOSPORIDIUM parvum, TOXOPLASMA gondii, INTRACELLULAR pathogens, PROTEIN models, MALARIA