Measurement of 2-hydroxyglutarate enantiomers in serum by chiral gas chromatography-tandem mass spectrometry and its application as a biomarker for IDH mutant gliomas

Authors: Strain, Shinji K., Groves, Morris D., Olino, Kelly L., Emmett, Mark R.

Source: In Clinical Mass Spectrometry January 2020 15:16-24

Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer

Authors: Malani, Rachna, Fleisher, Martin, Kumthekar, Priya, Lin, Xuling, Omuro, Antonio, Groves, Morris D., Lin, Nancy U., Melisko, Michelle, Lassman, Andrew B., Jeyapalan, Suriya, Seidman, Andrew, Skakodub, Anna, Boire, Adrienne, DeAngelis, Lisa M., Rosenblum, Marc, Raizer, Jeffrey, Pentsova, Elena

Source: Journal of neuro-oncology. 148(3):599-606

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Differentiation of 2‐hydroxyglutarate enantiomers and its lactones by gas chromatography/electron ionization tandem mass spectrometry

Authors: Strain, Shinji K., Groves, Morris D., Emmett, Mark R.

Source: Rapid communications in mass spectrometry. 33(17):1401-1409

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Phase 1 lead‐in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma

Authors: Maraka, Stefania, Groves, Morris D., Mammoser, Aaron G., Melguizo‐Gavilanes, Isaac, Conrad, Charles A., Tremont‐Lukats, Ivo W., Loghin, Monica E., O'Brien, Barbara J., Puduvalli, Vinay K., Sulman, Erik P., Hess, Kenneth R., Aldape, Kenneth D., Gilbert, Mark R., de Groot, John F., Alfred Yung, W.K., Penas‐Prado, Marta

Source: Cancer. 125(3):424-433

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Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

Authors: Butowski, Nicholas, Campian, Jian, Recht, Lawrence, Lim, Michael, Ashby, Lynn, Drappatz, Jan, Hirte, Hal, Iwamoto, Fabio, Mechtler, Laszlo, Goldlust, Samuel, Becker, Kevin, Barnett, Gene, Nicholas, Garth, Desjardins, Annick, Benkers, Tara, Wagle, Naveed, Groves, Morris, Kesari, Santosh, Horvath, Zsolt, Merrell, Ryan, Curry, Richard, O'Rourke, James, Schuster, David, Wong, Mark, Mrugala, Maciej, Jensen, Randy, Trusheim, John, Lesser, Glenn, Belanger, Karl, Sloan, Andrew, Purow, Benjamin, Fink, Karen, Raizer, Jeffrey, Schulder, Michael, Nair, Suresh, Peak, Scott, Perry, James, Brandes, Alba, Weller, Michael, Mohile, Nimish, Landolfi, Joseph, Olson, Jon, Finocchiaro, Gaetano, Jennens, Ross, DeSouza, Paul, Robinson, Bridget, Crittenden, Marka, Shih, Kent, Flowers, Alexandra, Ong, Shirley, Connelly, Jennifer, Hadjipanayis, Costas, Giglio, Pierre, Mott, Frank, Mathieu, David, Lessard, Nathalie, Sepulveda, Sanchez Juan, Lövey, József, Wheeler, Helen, Inglis, Po-Ling, Hardie, Claire, Bota, Daniela, Lesniak, Maciej, Portnow, Jana, Frankel, Bruce, Junck, Larry, Thompson, Reid, Berk, Lawrence, McGhie, John, Macdonald, David, Saran, Frank, Soffietti, Riccardo, Blumenthal, Deborah, André de, Sá Barreto Costa Marcos, Nowak, Anna, Singhal, Nimit, Hottinger, Andreas, Schmid, Andrea, Srkalovic, Gordan, Baskin, David, Fadul, Camilo, Nabors, Louis, LaRocca, Renato, Villano, John, Paleologos, Nina, Kavan, Petr, Pitz, Marshall, Thiessen, Brian, Idbaih, Ahmed, Frenel, Jean Sébastien, Domont, Julien, Grauer, Oliver, Hau, Peter, Marosi, Christine, Sroubek, Jan, Hovey, Elizabeth, Sridhar, P.S., Cher, Lawrence, Dunbar, Erin, Coyle, Thomas, Raymond, Jane, Barton, Kevin, Guarino, Michael, Raval, Sumul, Stea, Baldassarre, Dietrich, Jorge, Hopkins, Kirsten, Erridge, Sara, Steinbach, Joachim-Peter, Pineda, Losada Estela, Balana, Quintero Carmen, Sonia del, Barco Berron, Wenczl, Miklós, Molnár, Katalin, Hideghéty, Katalin, Lossos, Alexander, Myra van, Linde, Levy, Ana, Harrup, Rosemary, Patterson, William, Lwin, Zarnie, Sathornsumetee, Sith, Lee, E-Jian, Ho, Jih-Tsun, Emmons, Steven, Duic, J. Paul, Shao, Spencer, Ashamalla, Hani, Weaver, Michael, Lutzky, Jose, Avgeropoulos, Nicholas, Hanna, Wahid, Nadipuram, Mukund, Cecchi, Gary, O'Donnell, Robert, Pannullo, Susan, Carney, Jennifer, Hamilton, Mark, MacNeil, Mary, Beaney, Ronald, Fabbro, Michel, Schnell, Oliver, Fietkau, Rainer, Stockhammer, Guenther, Malinova, Bela, Odrazka, Karel, Sames, Martin, Miguel Gil, Gil, Razis, Evangelia, Lavrenkov, Konstantin, Castro, Guillermo, Ramirez, Francisco, Baldotto, Clarissa, Viola, Fabiana, Malheiros, Suzana, Lickliter, Jason, Gauden, Stanislaw, Dechaphunkul, Arunee, Thaipisuttikul, Iyavut, Thotathil, Ziad, Ma, Hsin-I, Cheng, Wen-Yu, Chang, Chin-Hong, Salas, Fernando, Dietrich, Pierre-Yves, Mamot, Christoph, Nayak, Lakshmi, Nag, Shona, Tran, David D, Recht, Lawrence D, Goldlust, Samuel A, O'Rourke, Donald M, Hamilton, Mark G, Wick, Wolfgang, Green, Jennifer, He, Yi, Turner, Christopher D, Yellin, Michael J, Keler, Tibor, Davis, Thomas A, Stupp, Roger, Sampson, John H

Source: In The Lancet Oncology October 2017 18(10):1373-1385

Most common sites on MRI of intracranial neoplastic leptomeningeal disease

Authors: Debnam, J. Matthew, Mayer, Rory R., Chi, T. Linda, Ketonen, Leena, Weinberg, Jeffrey S., Wei, Wei, Groves, Morris D., Guha-Thakurta, Nandita

Source: Journal of clinical neuroscience. 45:252-256

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Leptomeningeal Disease

Authors: Groves, Morris D.

Source: In Neurosurgery Clinics of North America 2011 22(1):67-78

Diagnostic Tools for Neoplastic Meningitis: Detecting Disease, Identifying Patient Risk, and Determining Benefit of Treatment

Authors: Chamberlain, Marc C., Glantz, Michael, Groves, Morris D., Wilson, Wyndham H.

Source: In Seminars in Oncology 2009 36 Supplement 2:S35-S45

Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial

Authors: Nassiri, Farshad, Patil, Vikas, Yefet, Leeor S., Singh, Olivia, Liu, Jeff, Dang, Rachel M. A., Yamaguchi, Takafumi N., Daras, Mariza, Cloughesy, Timothy F., Colman, Howard, Kumthekar, Priya U., Chen, Clark C., Aiken, Robert, Groves, Morris D., Ong, Shirley S., Ramakrishna, Rohan, Vogelbaum, Michael A., Khagi, Simon, Kaley, Thomas, Melear, Jason M., Peereboom, David M., Rodriguez, Analiz, Yankelevich, Maxim, Nair, Suresh G., Puduvalli, Vinay K., Aldape, Kenneth, Gao, Andrew, López-Janeiro, Álvaro, de Andrea, Carlos E., Alonso, Marta M., Boutros, Paul, Robbins, Joan, Mason, Warren P., Sonabend, Adam M., Stupp, Roger, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F., Zadeh, Gelareh

Source: Nature Medicine; 20230101, Issue: Preprints p1-9, 9p

Reply to Unexpectedly low rates of neuropsychiatric adverse effects associated with mefloquine repurposed for the treatment of glioblastoma

Authors: Maraka, Stefania, Groves, Morris D., Penas‐Prado, Marta

Source: Cancer. 125(8):1385-1386

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085023774.0x000001&indx=1&recIds=ETOCvdc_100085023774.0x000001

Leptomeningeal metastases presenting exclusively with ocular disturbance in 34 patients: A tertiary care cancer hospital experience

Authors: Mayer, Rory Richard, Frankfort, Benjamin Jay, Strickland, Ben A., Debnam, James Matthew, McCutcheon, Ian E., Groves, Morris D., Weinberg, Jeffrey S.

Source: In Journal of Clinical Neuroscience May 2017 39:151-154

A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma.

Authors: Puduvalli, Vinay K, Wu, Jing, Yuan, Ying, Armstrong, Terri S, Vera, Elizabeth, Wu, Jimin, Xu, Jihong, Giglio, Pierre, Colman, Howard, Walbert, Tobias, Raizer, Jeffrey, Groves, Morris D, Tran, David, Iwamoto, Fabio, Avgeropoulos, Nicholas, Paleologos, Nina, Fink, Karen, Peereboom, David, Chamberlain, Marc, Merrell, Ryan

Source: Neuro-Oncology; Oct2020, Vol. 22 Issue 10, p1505-1515, 11p

ATIM-24. INTERIM RESULTS OF A PHASE II MULTICENTER STUDY OF THE CONDITIONALLY REPLICATIVE ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB (KEYTRUDA) FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)

Authors: Zadeh, Gelareh, Lang, Frederick, Daras, Mariza, Cloughesy, Timothy, Colman, Howard, Ong, Shirley, Ramakrishna, Rohan, Vogelbaum, Michael, Groves, Morris, Nassiri, Farshad, Frederick, L Sue, Gammon, Karen, Fulling, Sheila, Rowland, Kari Anne, Mitchell, Erin, Ewald, Brett, Tufaro, Frank, Peterkin, Joanna

Source: Neuro-oncology. 20(suppl 6):vi6-vi6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094743702.0x000001&indx=1&recIds=ETOCvdc_100094743702.0x000001

CMET-22. INTRATHECAL (IT) TRAZTUZUMAB (T) FOR THE TREATMENT OF LEPTOMENINGEAL METASTASES (LM) IN PATIENTS (PTS) WITH HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2-POSITIVE (HER2+) CANCER: A MULTICENTER PHASE 1/2 STUDY

Authors: Kumthekar, Priya, Gradishar, William, Lin, Nancy, Pentsova, Elena, Groves, Morris, Jeyapalan, Suriya, Melisko, Michelle, Grimm, Sean, B. Lassman, Andrew, Raizer, Jeffrey

Source: Neuro-oncology. 20(suppl 6):vi58-vi58

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094743406.0x000001&indx=1&recIds=ETOCvdc_100094743406.0x000001

ATIM-16. PHASE 1 STUDY RESULTS OF M7824 (MSB0011359C), A BIFUNCTIONAL FUSION PROTEIN TARGETING TGF- AND PD-L1, AMONG PATIENTS WITH RECURRENT GLIOBLASTOMA (rGBM)

Authors: Khasraw, Mustafa, Weller, Michael, Estelles, David Lorente, Kolibaba, Kathryn, Lee, Chee, Gedye, Craig, De La Fuente, Macarena, Vicente, David, Reardon, David, Ojalvo, Laureen, Helwig, Christoph, Gourmelon, Carole, Groves, Morris

Source: Neuro-oncology. 20(suppl 6):vi4-vi4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094742898.0x000001&indx=1&recIds=ETOCvdc_100094742898.0x000001

PATH-22. THE DEVELOPMENT OF A NEW ASSAY TO MEASURE 2-HYDROXYGLUTARATE (2-hg) ENANTIOMER LEVELS AND THE UTILITY OF 2-hg AS A BIOMARKER FOR MANAGEMENT OF IDH MUTANT GLIOMAS

Authors: Strain, Shinji, Groves, Morris, Emmett, Mark

Source: Neuro-oncology. 20(suppl 6):vi163-vi163

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094739215.0x000001&indx=1&recIds=ETOCvdc_100094739215.0x000001

ACTR-13. A BAYESIAN ADAPTIVE RANDOMIZED PHASE II TRIAL OF BEVACIZUMAB VERSUS BEVACIZUMAB PLUS VORINOSTAT IN ADULTS WITH RECURRENT GLIOBLASTOMA FINAL RESULTS

Authors: Puduvalli, Vinay, Wu, Jing, Yuan, Ying, Armstrong, Terri, Wu, Jimin, Giglio, Pierre, Xu, Jihong, Colman, Howard, Walbert, Tobias, Raizer, Jeffrey, Groves, Morris, Iwamoto, Fabio, Tran, David, Avgeropoulos, Nicholas, Paleologos, Nina, Fink, Karen, Peereboom, David, Chamberlain, Marc, Merrell, Ryan, Penas-Prado, Marta, Yung, W K Alfred, Gilbert, Mark

Source: Neuro-oncology. 20(suppl 6):vi13-vi13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094738575.0x000001&indx=1&recIds=ETOCvdc_100094738575.0x000001

Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications.

Authors: Boire, Adrienne, Brandsma, Dieta, Brastianos, Priscilla K, Rhun, Emilie Le, Ahluwalia, Manmeet, Junck, Larry, Glantz, Michael, Groves, Morris D, Lee, Eudocia Q, Lin, Nancy, Raizer, Jeffrey, Rudà, Roberta, Weller, Michael, Bent, Martin J Van den, Vogelbaum, Michael A, Chang, Susan, Wen, Patrick Y, Soffietti, Riccardo

Source: Neuro-Oncology; May2019, Vol. 21 Issue 5, p571-584, 14p

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