Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A2 and mitochondrial respiration

Authors: Moon, Sung Ho, Liu, Xinping, Jenkins, Christopher M., Dilthey, Beverly Gibson, Patti, Gary J., Gross, Richard W.

Source: In Journal of Lipid Research September 2024 65(9)

Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

Authors: Moon, Sung Ho ¹, Dilthey, Beverly Gibson ¹, Guan, Shaoping ¹, Sims, Harold F. ¹, Pittman, Sara K. ², Keith, Amy L. ², Jenkins, Christopher M. ¹, Weihl, Conrad C. ², Gross, Richard W. ^{1, 3, 4, 5, 6, ∗}

Source: In iScience 16 June 2023 26(6)

The foundations and development of lipidomics

Authors: Han, Xianlin, Gross, Richard W.

Source: In Journal of Lipid Research February 2022 63(2)

High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress

Authors: Moon, Sung Ho, Dilthey, Beverly Gibson, Liu, Xinping, Guan, Shaoping, Sims, Harold F., Gross, Richard W.

Source: In Journal of Lipid Research 2021 62

A functional role for eicosanoid-lysophospholipids in activating monocyte signaling

Authors: Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Guan, Shaoping, Gross, Richard W. ^*

Source: In Journal of Biological Chemistry 21 August 2020 295(34):12167-12180

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout

Authors: Liu, Xinping, Sims, Harold F., Jenkins, Christopher M., Guan, Shaoping, Dilthey, Beverly G., Gross, Richard W.

Source: In Journal of Biological Chemistry 17 April 2020 295(16):5307-5320

Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2–15-HETE lysophospholipids

Authors: Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Guan, Shaoping, Gross, Richard W.

Source: In Journal of Biological Chemistry 28 June 2019 294(26):10146-10159

Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice

Authors: McCommis, Kyle S., Kovacs, Attila, Weinheimer, Carla J., Shew, Trevor M., Koves, Timothy R., Ilkayeva, Olga R., Kamm, Dakota R., Pyles, Kelly D., King, M. Todd, Veech, Richard L., DeBosch, Brian J., Muoio, Deborah M., Gross, Richard W., Finck, Brian N.

Source: Nature metabolism. 2(11):1232-1247

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187006145.0x000001&indx=1&recIds=ETOCvdc_100187006145.0x000001

Cytochrome c is an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl ether linkage

Authors: Jenkins, Christopher M., Yang, Kui, Liu, Gaoyuan, Moon, Sung Ho, Dilthey, Beverly G., Gross, Richard W.

Source: In Journal of Biological Chemistry 1 June 2018 293(22):8693-8709

Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis

Authors: Kuo, Andrew, Lee, Monica Y., Yang, Kui ^**, Gross, Richard W. ^**, Sessa, William C.

Source: In Journal of Biological Chemistry 19 January 2018 293(3):973-983

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

Alternate Title: Ca2+-activated phospholipases A2 in human heart mitochondria (English)

Authors: Moon, Sung Ho, Liu, Xinping, Cedars, Ari M., Yang, Kui, Kiebish, Michael A., Joseph, Susan M., Kelley, John, Jenkins, Christopher M., Gross, Richard W. ^**

Source: In Journal of Biological Chemistry 5 January 2018 293(1):115-129

The Human Kv1.1 Channel Is Palmitoylated, Modulating Voltage Sensing: Identification of a Palmitoylation Consensus Sequence

Authors: Gubitosi-Klug, Rose A., Mancuso, David J., Gross, Richard W., Kipnis, David M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Apr . 102(17), 5964-5968.

Access URL: https://www.jstor.org/stable/3375236

A Critical Role for PPARα-Mediated Lipotoxicity in the Pathogenesis of Diabetic Cardiomyopathy: Modulation by Dietary Fat Content

Authors: Finck, Brian N., Han, Xianlin, Courtois, Michael, Aimond, Franck, Nerbonne, Jeanne M., Kovacs, Attila, Gross, Richard W., Kelly, Daniel P.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Feb 01. 100(3), 1226-1231.

Access URL: https://www.jstor.org/stable/3138314

The evolution of lipidomics through space and time

Authors: Gross, Richard W.

Source: In BBA - Molecular and Cell Biology of Lipids August 2017 1862(8):731-739

The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

Authors: Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Li, Maoyin, Sims, Harold F., Guan, Shaoping, Gross, Richard W.

Source: In Journal of Biological Chemistry 23 June 2017 292(25):10672-10684

Tubulin Is the Endogenous Inhibitor of the Glyceraldehyde 3-Phosphate Dehydrogenase Isoform That Catalyzes Membrane Fusion: Implications for the Coordinated Regulation of Glycolysis and Membrane Fusion

Authors: Glaser, Paul E., Han, Xianlin, Gross, Richard W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2002 Oct . 99(22), 14104-14109.

Access URL: https://www.jstor.org/stable/3073546

Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size

Authors: Moon, Sung Ho, Mancuso, David J., Sims, Harold F., Liu, Xinping, Nguyen, Annie L., Yang, Kui, Guan, Shaoping, Dilthey, Beverly Gibson, Jenkins, Christopher M., Weinheimer, Carla J., Kovacs, Attila, Abendschein, Dana, Gross, Richard W.

Source: In Journal of Biological Chemistry 9 September 2016 291(37):19687-19700

Genetic Ablation of Calcium-independent Phospholipase A2γ Induces Glomerular Injury in Mice

Authors: Elimam, Hanan, Papillon, Joan, Kaufman, Daniel R., Guillemette, Julie, Aoudjit, Lamine, Gross, Richard W., Takano, Tomoko, Cybulsky, Andrey V.

Source: In Journal of Biological Chemistry 8 July 2016 291(28):14468-14482

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

Authors: Schweitzer, George G. ^*, Chen, Zhouji ^*, Gan, Connie ^*, McCommis, Kyle S. ^*, Soufi, Nisreen ^*, Chrast, Roman ^†, Mitra, Mayurranjan S. ^*, Yang, Kui ^*, Gross, Richard W. ^*, Finck, Brian N. ^*

Source: In Journal of Lipid Research April 2015 56(4):848-858

Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts

Authors: Yao, Cong-Hui, Fowle-Grider, Ronald, Mahieu, Nathanial G., Liu, Gao-Yuan, Chen, Ying-Jr, Wang, Rencheng, Singh, Manmilan, Potter, Gregory S., Gross, Richard W., Schaefer, Jacob, Johnson, Stephen L., Patti, Gary J.

Source: Cell chemical biology. 23(4):483-493

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100051488791.0x000001&indx=1&recIds=ETOCvdc_100051488791.0x000001