An ACVR1R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva

Authors: Kaplan, Frederick S., Groppe, Jay C., Xu, Meiqi, Towler, O. Will, Grunvald, Eduardo, Kalunian, Kenneth, Kallish, Staci, Al Mukaddam, Mona, Pignolo, Robert J., Shore, Eileen M.

Source: American journal of medical genetics.Part A. 188(3):806-817

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140903270.0x000001&indx=1&recIds=ETOCvdc_100140903270.0x000001

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H‐Specific Human Cellular and Zebrafish Models

Authors: Wentworth, Kelly L., Lalonde, Robert L., Groppe, Jay C., Brewer, Niambi, Moody, Tania, Hansberry, Steven, Taylor, Kimberly E., Shore, Eileen M., Kaplan, Frederick S., Pignolo, Robert J., Yelick, Pamela C., Hsiao, Edward C.

Source: Journal of bone and mineral research. 37(11):2058-2076

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191739993.0x000001&indx=1&recIds=ETOCvdc_100191739993.0x000001

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity.

Authors: Groppe, Jay C.¹ (AUTHOR) groppe@tamu.edu, Lu, Guorong¹ (AUTHOR), Tandang-Silvas, Mary R.¹ (AUTHOR), Pathi, Anupama¹ (AUTHOR), Konda, Shruti¹ (AUTHOR), Wu, Jingfeng¹ (AUTHOR), Le, Viet Q.^2,3,4 (AUTHOR), Culbert, Andria L.⁵ (AUTHOR), Shore, Eileen M.⁵ (AUTHOR), Wharton, Kristi A.² (AUTHOR), Kaplan, Frederick S.⁵ (AUTHOR)

Source: Biomolecules (2218-273X). Jul2023, Vol. 13 Issue 7, p1129. 21p.

Subject Terms: *PROTEIN kinases, *GAIN-of-function mutations, *MUTANT proteins, *RECEPTOR-like kinases, *BONE morphogenetic proteins, *ACTIVIN receptors

Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy

Authors: Groppe, Jay C.

Source: Expert opinion on drug discovery. 14(12):1237-1253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131582352.0x000001&indx=1&recIds=ETOCvdc_100131582352.0x000001

Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

Authors: Lu, Guorong, Tandang-Silvas, Mary R., Dawson, Alyssa C., Dawson, Trenton J., Groppe, Jay C.

Source: Bone. 112:71-89

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059044193.0x000001&indx=1&recIds=ETOCvdc_100059044193.0x000001

Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice.

Authors: Lounev, Vitali, Groppe, Jay C, Brewer, Niambi, Wentworth, Kelly L, Smith, Victoria, Xu, Meiqi, Schomburg, Lutz, Bhargava, Pankaj, Mukaddam, Mona Al, Hsiao, Edward C, Shore, Eileen M, Pignolo, Robert J, Kaplan, Frederick S

Source: Journal of Bone & Mineral Research; Apr2024, Vol. 39 Issue 4, p382-398, 17p

Multi‐system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients

Authors: Kaplan, Frederick S., Kobori, Joyce A., Orellana, Carmen, Calvo, Inmaculada, Rosello, Monica, Martinez, Francisco, Lopez, Berta, Xu, Meiqi, Pignolo, Robert J., Shore, Eileen M., Groppe, Jay C.

Source: American journal of medical genetics.Part A. 167(10):2265-2271

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090521686.0x000001&indx=1&recIds=ETOCvdc_100090521686.0x000001

The TβR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding

Authors: Zuniga, Jorge E. ¹, Ilangovan, Udayar, Mahlawat, Pardeep, Hinck, Cynthia S., Huang, Tao, Groppe, Jay C., McEwen, Donald G., Hinck, Andrew P.

Source: In Journal of Molecular Biology 2011 412(4):601-618

Intricacies of BMP receptor assembly

Authors: Nickel, Joachim, Sebald, Walter, Groppe, Jay C., Mueller, Thomas D.

Source: In Cytokine and Growth Factor Reviews 2009 20(5):367-377

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1^R206H‐Specific Human Cellular and Zebrafish Models

Authors: Wentworth, Kelly L., Lalonde, Robert L., Groppe, Jay C., Brewer, Niambi, Moody, Tania, Hansberry, Steven, Taylor, Kimberly E., Shore, Eileen M., Kaplan, Frederick S., Pignolo, Robert J., Yelick, Pamela C., Hsiao, Edward C.

Source: Journal of Bone & Mineral Research; Nov2022, Vol. 37 Issue 11, p2058-2076, 19p

Assembly of TβRI:TβRII:TGFβ Ternary Complex in vitro with Receptor Extracellular Domains is Cooperative and Isoform-dependent

Authors: Zúñiga, Jorge E. ^†, Groppe, Jay C. ^†, Cui, Yumin ^‡, Hinck, Cynthia S., Contreras-Shannon, Verónica ^‡, Pakhomova, Olga N., Yang, Junhua, Tang, Yuping, Mendoza, Valentín, López-Casillas, Fernando, Sun, LuZhe, Hinck, Andrew P.

Source: In Journal of Molecular Biology 2005 354(5):1052-1068

Structure and Dynamics of the Homodimeric Dynein Light Chain km23

Authors: Ilangovan, Udayar ^†, Ding, Wei ^†, Zhong, Yan, Wilson, Christina L., Groppe, Jay C., Trbovich, James T., Zúñiga, Jorge, Demeler, Borries, Tang, Qian, Gao, Guofeng, Mulder, Kathleen M., Hinck, Andrew P.

Source: In Journal of Molecular Biology 2005 352(2):338-354

Microgonotropens and their interactions with DNA. Synthesis of the tripyrrole peptides dien-microgonotropen-a, -b, and -c and characterization of their interactions with dsDNA.

Authors: He, Gong-Xin, Browne, Kenneth A., Groppe, Jay C.

Source: Journal of the American Chemical Society; August 11 1993, Vol. 115, p7061-7071, 11p

An ACVR1^R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva.

Authors: Kaplan, Frederick S., Groppe, Jay C., Xu, Meiqi, Towler, O. Will, Grunvald, Eduardo, Kalunian, Kenneth, Kallish, Staci, Al Mukaddam, Mona, Pignolo, Robert J., Shore, Eileen M.

Source: American Journal of Medical Genetics. Part A; Mar2022, Vol. 188 Issue 3, p806-817, 12p

Expression, Purification, and Characterization of a Soluble Form of the First Extracellular Domain of the Human Type 1 Corticotropin Releasing Factor Receptor

Authors: Perrin, Marilyn H. ^{‡, §}, Fischer, Wolfgang H. ^‡, Kunitake, Koichi S. ^‡, Craig, A. Grey ^‡, Koerber, Steven C. ^‡, Cervini, Laura A. ^‡, Rivier, Jean E. ^{‡, ¶}, Groppe, Jay C. ^‖, Greenwald, Jason ^‖, Nielsen, Søren Møller ^**, Vale, Wylie W. ^{‡, ‡}

Source: In Journal of Biological Chemistry 24 August 2001 276(34):31528-31534

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.