Performance of the pooled cohort equations and D:A:D risk scores among individuals with HIV in a global cardiovascular disease prevention trial: a cohort study leveraging data from REPRIEVE

Authors: Grinspoon, Steven K ^{a, †, **}, Zanni, Markella V ^{a, †, *}, Triant, Virginia A ^{b, c}, Kantor, Amy ^e, Umbleja, Triin ^e, Diggs, Marissa R ^a, Chu, Sarah M ^a, Fitch, Kathleen V ^a, Currier, Judith S ^f, Bloomfield, Gerald S ^g, Casado, José L ⁱ, de la Peña, Mireia ^j, Fantry, Lori E ^k, Gardner, Edward ^l, Aberg, Judith A ^m, Malvestutto, Carlos D ⁿ, Fichtenbaum, Carl J ^o, Lu, Michael T ^d, Ribaudo, Heather J ^e, Douglas, Pamela S ^h

Source: In The Lancet HIV February 2025 12(2):e118-e129

Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023

Authors: Burak, Mehmet Furkan ^{1, 2, ⁎}, Stanley, Takara L ^{4, 15}, Lawson, Elizabeth A ⁵, Campbell, Sophia L ⁴, Lynch, Lydia ¹, Hasty, Alyssa H ⁶, Domingos, Ana I ⁷, Dixit, Vishwa D ⁸, Hotamışlıgil, Gökhan S ^{2, 3}, Sheedy, Frederick J ⁹, Dixon, Anne E ¹⁰, Brinkley, Tina E ¹¹, Hill, Joseph A ¹², Donath, Marc Y ^{13, 14}, Grinspoon, Steven K ⁴

Source: In The American Journal of Clinical Nutrition July 2024 120(1):257-268

Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations

Authors: Karady, Julia, Lu, Michael T., Bergström, Göran, Mayrhofer, Thomas, Taron, Jana, Foldyna, Borek, Paradis, Kayla, McCallum, Sara, Aberg, Judith A., Currier, Judith S., Fitch, Kathleen V., Fulda, Evelynne S., Bloomfield, Gerald S., Overton, Edgar T., Lind, Lars, Östgren, Carl Johan, Elvstam, Olof, Söderberg, Stefan, Jernberg, Tomas, Pepe, Rosalie, Dubé, Michael P., Mushatt, David, Fichtenbaum, Carl J., Malvestutto, Carlos, Zanni, Markella V., Hoffmann, Udo, Ribaudo, Heather, Grinspoon, Steven K., Douglas, Pamela S.

Source: In JACC: Advances June 2024 3(6)

Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial

Authors: Bhattacharya, Romit, Uddin, Md Mesbah, Patel, Aniruddh P., Niroula, Abhishek, Finneran, Phoebe, Bernardo, Rachel, Fitch, Kathleen V., Lu, Michael T., Bloomfield, Gerald S., Malvestutto, Carlos, Aberg, Judy A., Fichtenbaum, Carl J., Hornsby, Whitney, Ribaudo, Heather J., Libby, Peter, Ebert, Benjamin L., Zanni, Markella V., Douglas, Pamela S., Grinspoon, Steven K., Natarajan, Pradeep

Source: In Blood Advances 27 February 2024 8(4):959-967

Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV

Authors: Douglas, Pamela S., McCallum, Sara, Lu, Michael T., Umbleja, Triin, Fitch, Kathleen V., Foldyna, Borek, Zanni, Markella V., Fulda, Evelynne S., Bloomfield, Gerald S., Fichtenbaum, Carl J., Overton, Edgar T., Aberg, Judith A., Malvestutto, Carlos D., Burdo, Tricia H., Arduino, Roberto C., Ho, Ken S., Yin, Michael T., Ribaudo, Heather J., Grinspoon, Steven K.

Source: AIDS. 37(3):423-434

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194420591.0x000001&indx=1&recIds=ETOCvdc_100194420591.0x000001

The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium

Authors: Becetti, Imen, Bwenyi, Esther L, de Araujo, Ivan E, Ard, Jamy, Cryan, John F, Farooqi, Ismaa Sadaf, Ferrario, Carrie R, Gluck, Marci E, Holsen, Laura M, Kenny, Paul J, Lawson, Elizabeth A, Lowell, Bradford B, Schur, Ellen A, Stanley, Takara L, Tavakkoli, Ali, Grinspoon, Steven K, Singhal, Vibha

Source: In The American Journal of Clinical Nutrition July 2023 118(1):314-328

Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV

Authors: Kolossváry, Márton, deFilippi, Chris, McCallum, Sara, Fitch, Kathleen V., Diggs, Marissa R., Fulda, Evelynne S., Ribaudo, Heather J., Fichtenbaum, Carl J., Aberg, Judith A., Malvestutto, Carlos D., Currier, Judith S., Casado, Jose L., Gutiérrez, Félix, Sereti, Irini, Douglas, Pamela S., Zanni, Markella V., Grinspoon, Steven K.

Source: In eBioMedicine April 2023 90

The importance of methods for site performance evaluation in REPRIEVE, a longitudinal, global, multicenter trial

Authors: Fulda, Evelynne S., Fichtenbaum, Carl J., Kileel, Emma M., Zanni, Markella V., Aberg, Judith A., Malvestutto, Carlos, Cardoso, Sandra Wagner, Berzins, Baiba, Lira, Rita, Harden, Regina, Robbins, Gregory, Martinez, Maria, Nieves, Sylvia Davila, McCallum, Sara, Cruz, Jorge Leon, Umbleja, Triin, Sprenger, Heather, Giguel, Francoise, Bone, Frederic, Wood, Ken, Byroads, Mark, Paradis, Kayla, Lu, Michael T., Douglas, Pamela S., Ribaudo, Heather J., Grinspoon, Steven K., Fitch, Kathleen V.

Source: In Contemporary Clinical Trials January 2023 124

Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk

Authors: Fitch, Kathleen V., McCallum, Sara A., Erlandson, Kristine M., Overton, Edgar Turner, Zanni, Markella V., Fichtenbaum, Carl, Aberg, Judith A., Fulda, Evelynne S., Kileel, Emma M., Moran, Laura E., Bloomfield, Gerald S., Novak, Richard M., Pérez-Frontera, Sigrid, Abrams-Downey, Alexandra, Pierone, Gerald, Kumarasamy, Nagalingeswaran, Ruxrungtham, Kiat, Mngqibisa, Rosie, Douglas, Pamela S., Ribaudo, Heather J., Grinspoon, Steven K.

Source: AIDS. 36(14):1997-2003

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194418241.0x000001&indx=1&recIds=ETOCvdc_100194418241.0x000001

Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV

Authors: Overton, Edgar T., Weir, Isabelle R., Zanni, Markella V., Fischinger, Stephanie, MacArthur, Rodger D., Aberg, Judith A., Fitch, Kathleen V., Frank, Michael, Albrecht, Helmut, Goodenough, Elliot, Rhame, Frank S., Fichtenbaum, Carl J., Bloomfield, Gerald S., Malvestutto, Carlos, Supparatpinyo, Khuanchai, McCallum, Sara, Douglas, Pamela S., Alter, Galit, Ribaudo, Heather, Grinspoon, Steven K.

Source: Journal of acquired immune deficiency syndromes. 90(4):377-381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169107124.0x000001&indx=1&recIds=ETOCvdc_100169107124.0x000001

Statins for primary cardiovascular disease prevention among people with HIV: emergent directions

Authors: Fitch, Kathleen V., Fulda, Evelynne S., Grinspoon, Steven K.

Source: Current opinion in HIV & AIDS. 17(5):293-300

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169103455.0x000001&indx=1&recIds=ETOCvdc_100169103455.0x000001

Approach to the Patient With Lipodystrophy

Authors: Fourman, Lindsay T, Grinspoon, Steven K

Source: Journal of clinical endocrinology & metabolism. 107(6):1714-1726

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164412647.0x000001&indx=1&recIds=ETOCvdc_100164412647.0x000001

Role of renin–angiotensin–aldosterone system activation and other metabolic variables in relation to arterial inflammation in HIV

Authors: Shen, Grace, Thomas, Teressa S., Walpert, Allie R., McClure, Colin M., Fitch, Kathleen V., deFilippi, Christopher, Torriani, Martin, Buckless, Colleen G., Adler, Gail K., Grinspoon, Steven K., Srinivasa, Suman

Source: Clinical endocrinology. 97(5):581-587

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100162416730.0x000001&indx=1&recIds=ETOCvdc_100162416730.0x000001

Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)

Authors: Bloomfield, Gerald S., Weir, Isabelle R., Ribaudo, Heather J., Fitch, Kathleen V., Fichtenbaum, Carl J., Moran, Laura E., Bedimo, Roger, de Filippi, Christopher, Morse, Caryn G., Piccini, Jonathan, Zanni, Markella V., Lu, Michael T., Hoffmann, Udo, Grinspoon, Steven K., Douglas, Pamela S.

Source: Journal of acquired immune deficiency syndromes. 89(3):349-359

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155078896.0x000001&indx=1&recIds=ETOCvdc_100155078896.0x000001

Pitavastatin Is Well-Tolerated With no Detrimental Effects on Physical Function.

Authors: Erlandson, Kristine M, Umbleja, Triin, Ribaudo, Heather J, Schrack, Jennifer A, Overton, Edgar T, Fichtenbaum, Carl J, Fitch, Kathleen V, Roa, Jhoanna C, Diggs, Marissa R, Wood, Kenneth, Zanni, Markella V, Bloomfield, Gerald S, Malvestutto, Carlos, Aberg, Judith A, Rodriguez-Barradas, Maria C, Morones, Rosalba Gomez, Breaux, Katherine, Douglas, Pamela S, Grinspoon, Steven K, Brown, Todd T

Source: Clinical Infectious Diseases; Feb2025, Vol. 80 Issue 2, p425-433, 9p

Subject Terms: CARDIOVASCULAR disease prevention, MYALGIA, RISK assessment, ANTILIPEMIC agents, PATIENT safety, RESEARCH funding, HIV-positive persons, STATISTICAL sampling, BLIND experiment, FRAIL elderly, FUNCTIONAL status, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, CARDIOVASCULAR diseases risk factors, MUSCLE strength, STATINS (Cardiovascular agents), COMPARATIVE studies, CONFIDENCE intervals, WALKING speed, EXERCISE tests, PHYSICAL activity, GRIP strength

Proteinuria and albuminuria among a global primary cardiovascular disease prevention cohort of people with HIV.

Authors: Overton, Edgar T., Kantor, Amy, Fitch, Kathleen V., Mosepele, Mosepele, Aberg, Judith A., Fichtenbaum, Carl J., McComsey, Grace A., Malvestutto, Carlos, Lu, Michael T., Negredo, Eugenia, Bernardino, Jose, Hickman, Aubri B., Douglas, Pamela S., Grinspoon, Steven K., Zanni, Markella, Ribaudo, Heather, Wyatt, Christina

Source: AIDS (02699370); Jan2025, Vol. 39 Issue 1, p31-39, 9p

A neurobiological link between transportation noise exposure and metabolic disease in humans

Authors: Osborne, Michael T., Naddaf, Nicki, Abohashem, Shady, Radfar, Azar, Ghoneem, Ahmed, Dar, Tawseef, Wang, Ying, Patrich, Tomas, Oberfeld, Blake, Tung, Brian, Pitman, Roger K., Mehta, Nehal N., Shin, Lisa M., Lo, Janet, Rajagopalan, Sanjay, Koenen, Karestan C., Grinspoon, Steven K., Fayad, Zahi A., Tawakol, Ahmed

Source: In Psychoneuroendocrinology September 2021 131

Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial

Authors: Kolossváry, Márton, Schnittman, Samuel R., Zanni, Markella V., Fitch, Kathleen V., Fichtenbaum, Carl J., Aberg, Judith A., Bloomfield, Gerald S., Malvestutto, Carlos D., Currier, Judith, Diggs, Marissa R., deFilippi, Christopher, Eckard, Allison Ross, Curran, Adrian, Centinbas, Murat, Sadreyev, Ruslan, Foldyna, Borek, Mayrhofer, Thomas, Karady, Julia, Taron, Jana, McCallum, Sara, Lu, Michael T., Ribaudo, Heather J., Douglas, Pamela S., Grinspoon, Steven K.

Source: JAMA Cardiology; March 2025, Vol. 10 Issue: 3 p254-264, 11p

Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin–Angiotensin–Aldosterone System

Authors: Srinivasa, Suman, Thomas, Teressa S, Feldpausch, Meghan N, Adler, Gail K, Grinspoon, Steven K

Source: Journal of clinical endocrinology & metabolism. 106(12):3398-3412

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139435140.0x000001&indx=1&recIds=ETOCvdc_100139435140.0x000001

What have we learned from the REPRIEVE trial and where do we go from here?

Authors: Grinspoon, Steven K.¹ sgrinspoon@mgh.harvard.edu, Lu, Michael T.², Zanni, Markella V.¹, Diggs, Marissa R.¹, Chu, Sarah M.¹, Ribaudo, Heather J.³, Douglas, Pamela S.⁴

Source: HIV Medicine. Dec2024, Vol. 25 Issue 12, p1283-1288. 6p.

Subject Terms: *ANTILIPEMIC agents, *HIV-positive persons, *MAJOR adverse cardiovascular events, *CARDIOVASCULAR diseases risk factors, *GLOBAL burden of disease, *LDL cholesterol, *STATINS (Cardiovascular agents), *AMYLOID plaque, *COLLAGEN