Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation.

Authors: Carruthers, Emma R.^1,2,3 (AUTHOR), Grimsey, Natasha L.^1,2,3 (AUTHOR) n.grimsey@auckland.ac.nz

Source: British Journal of Pharmacology. Jul2024, Vol. 181 Issue 14, p2247-2269. 23p.

Subject Terms: *CANNABINOID receptors, *GENETIC translation, *G protein coupled receptors, *AMINO acid sequence, *MOLECULAR pharmacology, *CONSCIOUSNESS raising

Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future

Authors: Whiting, Zak M., Yin, Jiazhen, de la Harpe, Sara M., Vernall, Andrea J., Grimsey, Natasha L.

Source: Trends in pharmacological sciences. 43(9):754-771

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168519107.0x000001&indx=1&recIds=ETOCvdc_100168519107.0x000001

Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β‐arrestins and GPCR kinases

Authors: Patel, Monica, Matti, Christoph, Grimsey, Natasha L., Legler, Daniel F., Javitch, Jonathan A., Finlay, David B., Glass, Michelle

Source: British journal of pharmacology. 179(10):2223-2239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147374759.0x000001&indx=1&recIds=ETOCvdc_100147374759.0x000001

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor.

Authors: Patel, Monica¹ (AUTHOR), Grimsey, Natasha L.² (AUTHOR), Banister, Samuel D.^3,4 (AUTHOR), Finlay, David B.¹ (AUTHOR), Glass, Michelle¹ (AUTHOR) michelle.glass@otago.ac.nz

Source: Pharmacology Research & Perspectives. Dec2023, Vol. 11 Issue 6, p1-15. 15p.

Subject Terms: *CANNABINOID receptors, *SYNTHETIC receptors, *MOLECULAR pharmacology, *OPERATIONS research, *G proteins, *LIGAND analysis

Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists

Authors: Patel, Monica, Manning, Jamie J., Finlay, David B., Javitch, Jonathan A., Banister, Samuel D., Grimsey, Natasha L., Glass, Michelle

Source: In Biochemical Pharmacology May 2020 175

Synthesis and Characterization of a Cannabinoid Type 2 Receptor Photoactivated Prodrug

Authors: Yin, Jiazhen, Sharma, Raahul, Tyndall, Joel D. A., Grimsey, Natasha L., Vernall, Andrea J.

Source: ChemPhotoChem. 7(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181697891.0x000001&indx=1&recIds=ETOCvdc_100181697891.0x000001

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications

Authors: Grimsey, Natasha L., Savinainen, Juha R., Attili, Bala, Ahamed, Muneer ^⁎

Source: In Drug Discovery Today February 2020 25(2):330-343

Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations.

Authors: Foyzun, Tahira, Whiting, Maddie, Velasco, Kate K., Jacobsen, Jessie C., Connor, Mark, Grimsey, Natasha L.

Source: British Journal of Pharmacology; Aug2024, Vol. 181 Issue 15, p2391-2412, 22p

Subject Terms: SINGLE nucleotide polymorphisms, CANNABINOID receptors, MOLECULAR pharmacology, GENETIC variation, BIOLOGICAL variation, GENE frequency

Highlights and hot topics in GPCR research from 'Down Under'.

Authors: Smith, Nicola J., May, Lauren T., Grimsey, Natasha L.

Source: British Journal of Pharmacology; Jul2024, Vol. 181 Issue 14, p2091-2094, 4p

Subject Terms: G protein coupled receptors, SECOND messengers (Biochemistry), TOXICOLOGISTS

RAMP and MRAP accessory proteins have selective effects on expression and signalling of the CB1, CB2, GPR18 and GPR55 cannabinoid receptors.

Authors: Glenn, Nathaniel A. K., Finlay, David B., Carruthers, Emma R., Mountjoy, Kathleen G., Walker, Christopher S., Grimsey, Natasha L.

Source: British Journal of Pharmacology; Jul2024, Vol. 181 Issue 14, p2212-2231, 20p

Subject Terms: CANNABINOID receptors, G protein coupled receptors, MELANOCORTIN receptors, PEPTIDES, PROTEIN receptors, G proteins

Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1, 8-naphthyridin-2-(1H)-one-3-carboxamide scaffoldElectronic supplementary information (ESI) available. See DOI: 10.1039/c8md00448j

Authors: Cooper, Anna G., Oyagawa, Caitlin R. M., Manning, Jamie J., Singh, Sameek, Hook, Sarah, Grimsey, Natasha L., Glass, Michelle, Tyndall, Joel D. A., Vernall, Andrea J.

Source: MedChemComm. 9(12):2055-2067

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100074138849.0x000001&indx=1&recIds=ETOCvdc_100074138849.0x000001

Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain

Authors: Dowie, Megan J., Grimsey, Natasha L., Hoffman, Therri, Faull, Richard L.M., Glass, Michelle

Source: In Journal of Chemical Neuroanatomy September 2014 59-60:62-71

Sensitive and Accurate Quantification of Human Leukocyte Migration Using High-Content Discovery-1 Imaging System and ATPlite Assay

Authors: Grimsey, Natasha L., Moodley, Kriebashne S., Glass, Michelle, Graham, E. Scott ^*

Source: In SLAS Discovery March 2012 17(3):386-393

Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway

Authors: Grimsey, Natasha L., Goodfellow, Catherine E., Dragunow, Mike, Glass, Michelle

Source: In BBA - Molecular Cell Research August 2011 1813(8):1554-1560

Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias.

Authors: Sharma, Raahul, Singh, Sameek, Whiting, Zak M., Molitor, Maximilian, Vernall, Andrea J., Grimsey, Natasha L.

Source: International Journal of Molecular Sciences; Apr2023, Vol. 24 Issue 7, p6406, 18p

Subject Terms: CANNABINOID receptors, ARRESTINS, LIPOPHILICITY, CYCLIC adenylic acid

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics

Authors: Grimsey, Natasha L., Graham, E. Scott, Dragunow, Mike, Glass, Michelle

Source: In Biochemical Pharmacology 1 October 2010 80(7):1050-1062

Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β‑Hydrolase Domain 6 (ABHD6).

Authors: Mardon, Karine, Patel, Jayendra Z., Savinainen, Juha R., Stimson, Damion H. R., Oyagawa, Caitlin R. M., Grimsey, Natasha L., Migotto, Mary-anne, Njiru, Grace F. M., Hamilton, Brett R., Cowin, Gary, Yli-Kauhaluoma, Jari, Vanduffel, Wim, Blakey, Idriss, Bhalla, Rajiv, Cawthorne, Christopher, Celen, Sofie, Bormans, Guy, Thurecht, Kristofer J, Ahamed, Muneer

Source: Journal of Medicinal Chemistry; 1/12/2023, Vol. 66 Issue 1, p538-552, 15p

Chapter 5 - Cannabinoid receptor CB1 and CB2 interacting proteins: Techniques, progress and perspectives

Authors: Oyagawa, Caitlin R.M., Grimsey, Natasha L. ^*

Source: In Methods in Cell Biology 2021 166:83-132

Specific detection of CB 1 receptors; cannabinoid CB 1 receptor antibodies are not all created equal!

Authors: Grimsey, Natasha L., Goodfellow, Catherine E., Scotter, Emma L., Dowie, Megan J., Glass, Michelle, Graham, E. Scott

Source: In Journal of Neuroscience Methods 2008 171(1):78-86

Cannabinoids

Authors: Dowie, Megan J, Grimsey, Natasha L, Glass, Michelle

Source: Encyclopedia of Neuroscience. 2009, v. 1, p556-559.

Subject Terms: Cannabinoids, G proteins, Cell receptors, Drug therapy