IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ

Authors: Yip, Kwok Ho, Chao, Jessica, Coolen, Carl, Pant, Harshita, Kral, Anita, Smith, William, Schwarz, Quenten, Grimbaldeston, Michele A., Pitson, Stuart, Lopez, Angel F., Woodcock, Joanna, Tumes, Damon J.

Source: In The Journal of Allergy and Clinical Immunology September 2023 152(3):725-735

Phase 2 randomized clinical trial of astegolimab in patients with moderate to severe atopic dermatitis

Authors: Maurer, Marcus, Cheung, Dorothy S., Theess, Wiebke, Yang, Xiaoying, Dolton, Michael, Guttman, Anna, Choy, David F., Dash, Ajit, Grimbaldeston, Michele A., Soong, Weily

Source: In The Journal of Allergy and Clinical Immunology December 2022 150(6):1517-1524

Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways

Authors: Aliee, Hananeh, Massip, Florian, Qi, Cancan, Stella de Biase, Maria, Nijnatten, Jos, Kersten, Elin T. G., Kermani, Nazanin Z., Khuder, Basil, Vonk, Judith M., Vermeulen, Roel C. H., Neighbors, Margaret, Tew, Gaik W., Grimbaldeston, Michele A., Hacken, Nick H. T., Hu, Sile, Guo, Yike, Zhang, Xiaoyu, Sun, Kai, Hiemstra, Pieter S., Ponder, Bruce A., Mäkelä, Mika J., Malmström, Kristiina, Rintoul, Robert C, Reyfman, Paul A., Theis, Fabian J., Brandsma, Corry‐Anke, Adcock, Ian M., Timens, Wim, Xu, Cheng‐Jian, Berge, Maarten, Schwarz, Roland F., Koppelman, Gerard H., Nawijn, M.C., Faiz, Alen

Source: Allergy. 77(2):690-694

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Astegolimab, an anti-ST2, in chronic obstructive pulmonary disease (COPD-ST2OP): a phase 2a, placebo-controlled trial

Authors: Yousuf, Ahmed J, Mohammed, Seid, Carr, Liesl, Yavari Ramsheh, Mohammadali, Micieli, Claudia, Mistry, Vijay, Haldar, Kairobi, Wright, Adam, Novotny, Petr, Parker, Sarah, Glover, Sarah, Finch, Joanne, Quann, Niamh, Brookes, Cassandra L, Hobson, Rachel, Ibrahim, Wadah, Russell, Richard J, John, Catherine, Grimbaldeston, Michele A, Choy, David F, Cheung, Dorothy, Steiner, Michael, Greening, Neil J, Brightling, Christopher E

Source: Lancet.Respiratory medicine. 10(5):469-477

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Effects of inhaled JAK inhibitor GDC-4379 on exhaled nitric oxide and peripheral biomarkers of inflammation

Authors: Chen, Hubert, Kunder, Rebecca, Zou, Yixuan, Staton, Tracy, Zhu, Rui, Galanter, Joshua, Gugelmann, Hallam, Owen, Ryan, Grimbaldeston, Michele A., Chang, Joanna K., Durk, Matthew R., Eliahu, Avi, Wilson, Mark S., Choy, David F., Wilson, Maria, Black, Melissa, Doppen, Marjan, Kung, Stacey, Oldfield, Karen, Sparks, Jenny, Beasley, Richard, Braithwaite, Irene

Source: In Pulmonary Pharmacology & Therapeutics August 2022 75

Targeting the Human βc Receptor Inhibits Contact Dermatitis in a Transgenic Mouse Model

Authors: Yip, Kwok Ho, McKenzie, Duncan, Ramshaw, Hayley S., Chao, Jessica, McClure, Barbara J., Raquet, Elmar, Kraushaar, Timo, Röder, Joachim, Maxwell, Mhairi, Alhamdoosh, Monther, Hammet, Andrew, Fong, Jia Hong, Zeglinski, Kathleen, Monaghan, Katherine, Pant, Harshita, Grimbaldeston, Michele A., Vairo, Gino, Wilson, Nicholas J., Owczarek, Catherine M., Hercus, Timothy R., Lopez, Angel F., Tumes, Damon J.

Source: In Journal of Investigative Dermatology April 2022 142(4):1103-1113

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

Authors: Allam, Venkata Sita Rama Raju, Faiz, Alen, Lam, Maggie, Rathnayake, Senani N. H., Ditz, Benedikt, Pouwels, Simon D., Brandsma, Corry‐Anke, Timens, Wim, Hiemstra, Pieter S., Tew, Gaik W., Neighbors, Margaret, Grimbaldeston, Michele, van den Berge, Maarten, Donnelly, Sheila, Phipps, Simon, Bourke, Jane E., Sukkar, Maria B.

Source: Allergy. 76(4):1123-1135

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Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases

Authors: Cildir, Gökhan, Toubia, John, Yip, Kwok Ho, Zhou, Mingyan, Pant, Harshita, Hissaria, Pravin, Zhang, Jingxian, Hong, Wanjin, Robinson, Nirmal, Grimbaldeston, Michele A., Lopez, Angel F., Tergaonkar, Vinay

Source: In Immunity 19 November 2019 51(5):949-965

Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Authors: Yip, Kwok Ho, Wilson, Nicholas J., Pant, Harshita, Brown, Christopher L., Busfield, Samantha, Ng, Milica, Alhamdoosh, Monther, Woodman, Naomi, Schembri, Mark, Tumes, Damon J., Vairo, Gino, Lopez, Angel F., Nash, Andrew D., Wilson, Michael J., Grimbaldeston, Michele A., Owczarek, Catherine M.

Source: Allergy. 75(2):475-478

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Identification of Mast Cell Progenitors in Adult Mice

Authors: Chen, Ching-Cheng, Grimbaldeston, Michele A., Tsai, Mindy, Weissman, Irving L., Galli, Stephen J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 01. 102(32), 11408-11413.

Access URL: https://www.jstor.org/stable/3376280

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Authors: Eissmann, Moritz, Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh, Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas, Hibbs, Margaret, Boussioutas, Alex, Grimbaldeston, Michele, Buchert, Michael, O'Donoghue, Robert, Masson, Frederick, Ernst, Matthias

Source: Nature communications. 10(1):1-16

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181228197.0x000001&indx=1&recIds=ETOCvdc_100181228197.0x000001

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Authors: Slob, Elise M. A., Faiz, Alen, Nijnatten, Jos, Vijverberg, Susanne J. H., Longo, Cristina, Kutlu, Merve, Chew, Fook Tim, Sio, Yang Yie, Herrera‐Luis, Esther, Espuela‐Ortiz, Antonio, Perez‐Garcia, Javier, Pino‐Yanes, Maria, Burchard, Esteban G., Potočnik, Uroš, Gorenjak, Mario, Palmer, Colin, Maroteau, Cyrielle, Turner, Steve, Verhamme, Katia, Karimi, Leila, Mukhopadhyay, Somnath, Timens, Wim, Hiemstra, Pieter S., Pijnenburg, Mariëlle W., Neighbors, Margaret, Grimbaldeston, Michele A., Tew, Gaik W., Brandsma, Corry A., Berce, Vojko, Aliee, Hananeh, Theis, Fabian, Sin, Don D., Li, Xuan, Berge, Maarten, Maitland‐van der Zee, Anke H., Koppelman, Gerard H.

Source: Clinical and translational allergy. 12(8)

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Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe Chronic Obstructive Pulmonary Disease.

Authors: Khalenkow, Dmitry, Brandsma, Corry-Anke, Timens, Wim, Choy, David F., Grimbaldeston, Michele A., Rosenberger, Carrie M., Slebos, Dirk-Jan, Kerstjens, Huib A. M., Faiz, Alen, Koppelman, Gerard H., Nawijn, Martijn C., van den Berge, Maarten, Guryev, Victor

Source: American Journal of Respiratory Cell & Molecular Biology; May2024, Vol. 70 Issue 5, p414-423, 10p

Subject Terms: ALTERNATIVE RNA splicing, CHRONIC obstructive pulmonary disease, GENE expression, TRANSCRIPTOMES

Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D

Authors: Gorman, Shelley, Geldenhuys, Sian, Weeden, Clare E., Grimbaldeston, Michele A., Hart, Prue H.

Source: Archives of dermatological research. 310(3):221-230

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141524800.0x000001&indx=1&recIds=ETOCvdc_100141524800.0x000001

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

Authors: Kular, Jasreen, Scheer, Kaitlin G., Pyne, Natasha T., Allam, Amr H., Pollard, Anthony N., Magenau, Astrid, Wright, Rebecca L., Kolesnikoff, Natasha, Moretti, Paul A., Wullkopf, Lena, Stomski, Frank C., Cowin, Allison J., Woodcock, Joanna M., Grimbaldeston, Michele A., Pitson, Stuart M., Timpson, Paul, Ramshaw, Hayley S., Lopez, Angel F., Samuel, Michael S.

Source: In Developmental Cell 21 December 2015 35(6):759-774

The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy

Authors: Tong, Philip L. ^*, Roediger, Ben, Kolesnikoff, Natasha, Biro, Maté, Tay, Szun S., Jain, Rohit, Shaw, Lisa E., Grimbaldeston, Michele A., Weninger, Wolfgang ^*

Source: In Journal of Investigative Dermatology January 2015 135(1):84-93

Su1582: QUANTITATIVE IMMUNOHISTOCHEMICAL ANALYSIS OF IMMUNE CELLS REVEALS IMMUNOPHENOTYPES ASSOCIATED WITH INTESTINAL FIBROSIS AND POSTOPERATIVE STRICTURE RECURRENCE IN CROHN'S DISEASE

Authors: Levitte, Steven, Jhun, Iny, Neighbors, Margaret, Peale, Frank, Grimbaldeston, Michele, Haileselassie, Yeneneh, Habtezion, Aida, Park, KT, Rogalla, Stephan

Source: Gastroenterology. 162(7):S-639-S-640

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Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice

Authors: Arac, Ahmet, Grimbaldeston, Michele A., Nepomuceno, Andrew R.B., Olayiwola, Oluwatobi, Pereira, Marta P., Nishiyama, Yasuhiro, Tsykin, Anna, Goodall, Gregory J., Schlecht, Ulrich, Vogel, Hannes, Tsai, Mindy, Galli, Stephen J., Bliss, Tonya M., Steinberg, Gary K.

Source: In The American Journal of Pathology September 2014 184(9):2493-2504

Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation

Authors: Yip, Kwok-Ho, Kolesnikoff, Natasha, Yu, Chunping, Hauschild, Nicholas, Taing, Houng, Biggs, Lisa, Goltzman, David, Gregory, Philip A., Anderson, Paul H., Samuel, Michael S., Galli, Stephen J., Lopez, Angel F., Grimbaldeston, Michele A.

Source: In The Journal of Allergy and Clinical Immunology May 2014 133(5):1356-1364

Topical Application of Fingolimod Perturbs Cutaneous Inflammation

Authors: Sun, Wai Y., Dimasi, David P., Pitman, Melissa R., Zhuang, YiZhong, Heddle, Robert, Pitson, Stuart M., Grimbaldeston, Michele A., Bonder, Claudine S.

Source: Journal of immunology. 196(9):3854-3864

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605789740&indx=1&recIds=ETOCRN605789740