Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer

Authors: Zucker, Mark ^{1, 15}, Perry, Maria A. ^{2, 3, 15}, Gould, Samuel I. ^{4, 5}, Elkrief, Arielle ^{3, 6, 7}, Safonov, Anton ⁶, Thummalapalli, Rohit ⁶, Mehine, Miika ³, Chakravarty, Debyani ^{2, 3}, Brannon, A. Rose ³, Ladanyi, Marc ³, Razavi, Pedram ⁶, Donoghue, Mark T.A. ², Murciano-Goroff, Yonina R. ⁶, Grigoriadis, Kristiana ^{8, 9, 10}, McGranahan, Nicholas ^{9, 10}, Jamal-Hanjani, Mariam ^{9, 11, 12}, Swanton, Charles ^{8, 9, 12}, Chen, Yuan ¹³, Shen, Ronglai ¹³, Chandarlapaty, Sarat ^{6, 7}, Solit, David B. ^{2, 6}, Schultz, Nikolaus ^{1, 2, 7, 14}, Berger, Michael F. ^{1, 2, 3, 7, 14}, Chang, Jason ³, Schoenfeld, Adam J. ⁶, Sánchez-Rivera, Francisco J. ^{4, 5}, Reznik, Ed ^{1, 2, ∗}, Bandlamudi, Chaitanya ^{2, 3, 16, ∗∗}

Source: In Cell 6 February 2025 188(3):851-867

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma

Authors: Black, James R. M., Bartha, Gabor, Abbott, Charles W., Boyle, Sean M., Karasaki, Takahiro, Li, Bailiang, Chen, Rui, Harris, Jason, Veeriah, Selvaraju, Colopi, Martina, Bakir, Maise Al, Liu, Wing Kin, Lyle, John, Navarro, Fábio C. P., Northcott, Josette, Pyke, Rachel Marty, Hill, Mark S., Thol, Kerstin, Huebner, Ariana, Bailey, Chris, Colliver, Emma C., Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Pawlik, Piotr, Moore, David A., Marinelli, Daniele, Shutkever, Oliver G., Murphy, Cian, Sivakumar, Monica, Shaw, Jacqui A., Hackshaw, Allan, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Frankell, Alexander M., Chen, Richard O., Swanton, Charles

Source: Nature Medicine; 20250101, Issue: Preprints p1-7, 7p

CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction.

Authors: Grigoriadis, Kristiana, Huebner, Ariana, Bunkum, Abigail, Colliver, Emma, Frankell, Alexander M., Hill, Mark S., Thol, Kerstin, Birkbak, Nicolai J., Swanton, Charles, Zaccaria, Simone, McGranahan, Nicholas

Source: Nature Protocols; Jan2024, Vol. 19 Issue 1, p159-183, 25p

The evolution of lung cancer and impact of subclonal selection in TRACERx.

Authors: Frankell, Alexander M., Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L., Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S., Grigoriadis, Kristiana, Moore, David A., Black, James R. M., Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas B. K., Naceur-Lombardelli, Cristina, Cook, Daniel E.

Source: Nature; Apr2023, Vol. 616 Issue 7957, p525-533, 9p

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.

Authors: Abbosh, Christopher, Frankell, Alexander M., Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L., Weiss, Jakob, Schroeder, Morgan R., Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R. M.

Source: Nature; Apr2023, Vol. 616 Issue 7957, p553-562, 10p

The evolution of non-small cell lung cancer metastases in TRACERx.

Authors: Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B. K., Pich, Oriol, Moore, David A., Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma

Source: Nature; Apr2023, Vol. 616 Issue 7957, p534-542, 9p

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

Authors: Karasaki, Takahiro, Moore, David A., Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Magno, Neil, Ward, Sophia, Bakir, Maise Al, Watkins, Thomas B. K., Grigoriadis, Kristiana, Huebner, Ariana, Hill, Mark S., Frankell, Alexander M., Abbosh, Christopher, Puttick, Clare, Zhai, Haoran, Gimeno-Valiente, Francisco, Saghafinia, Sadegh, Kanu, Nnennaya, Dietzen, Michelle, Pich, Oriol, Lim, Emilia L., Martínez-Ruiz, Carlos, Black, James R. M., Biswas, Dhruva, Campbell, Brittany B., Lee, Claudia, Colliver, Emma, Enfield, Katey S. S., Hessey, Sonya, Hiley, Crispin T., Zaccaria, Simone, Litchfield, Kevin, Birkbak, Nicolai J., Cadieux, Elizabeth Larose, Demeulemeester, Jonas, Van Loo, Peter, Adusumilli, Prasad S., Tan, Kay See, Cheema, Waseem, Sanchez-Vega, Francisco, Jones, David R., Rekhtman, Natasha, Travis, William D., Hackshaw, Allan, Marafioti, Teresa, Salgado, Roberto, Le Quesne, John, Nicholson, Andrew G., McGranahan, Nicholas, Swanton, Charles, Jamal-Hanjani, Mariam

Source: Nature Medicine; April 2023, Vol. 29 Issue: 4 p833-845, 13p

Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC.

Authors: Harrasser, Micaela, Gohil, Satyen Harish, Lau, Hiu, Della Peruta, Marco, Muczynski, Vincent, Patel, Dominic, Miranda, Elena, Grigoriadis, Kristiana, Grigoriadis, Anita, Granger, David, Evans, Rachel, Nathwani, Amit Chunilal

Source: Breast Cancer Research; 6/3/2022, Vol. 24 Issue 1, p1-10, 10p

Subject Terms: CHIMERIC antigen receptors, HEMATOLOGY, LYMPHOCYTES, BREAST cancer, CELL-mediated cytotoxicity

Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx.

Authors: Frankell, Alexander M., Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L., Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S., Grigoriadis, Kristiana, Moore, David A., Black, James R. M., Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas B. K., Naceur-Lombardelli, Cristina, Cook, Daniel E.

Source: Nature; Jul2024, Vol. 631 Issue 8022, pE15-E15, 1p

Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Authors: Muliaditan, Tamara, Halim, Leena, Whilding, Lynsey M., Draper, Benjamin, Achkova, Daniela Y., Kausar, Fahima, Glover, Maya, Bechman, Natasha, Arulappu, Appitha, Sanchez, Jenifer, Flaherty, Katie R., Obajdin, Jana, Grigoriadis, Kristiana, Antoine, Pierre, Larcombe-Young, Daniel, Hull, Caroline M., Buus, Richard, Gordon, Peter, Grigoriadis, Anita, Davies, David M., Schurich, Anna, Maher, John

Source: Cell Reports Medicine; December 2021, Vol. 2 Issue: 12