Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine.

Authors: Silmon de Monerri, Natalie C.¹, natalie.silmondemonerri@pfizer.com, Che, Ye², Lees, Joshua A.², Jasti, Jayasankar², Wu, Huixian², Griffor, Matthew C.², Kodali, Srinivas¹, Hawkins, Julio Cesar¹, Lypowy, Jacqueline¹, Ponce, Christopher¹, Curley, Kieran¹, Esadze, Alexandre¹, Carcamo, Juan¹, McLellan, Thomas², Keeney, David¹, Illenberger, Arthur¹, Matsuka, Yury V.¹, Shanker, Suman², Chorro, Laurent¹, Gribenko, Alexey V.¹

Source: PLoS Pathogens; 2/19/2025, Vol. 21 Issue 2, p1-26, 26p

Machine Learning for Prioritization of Thermostabilizing Mutations for G-Protein Coupled Receptors

Authors: Muk, Sanychen, Ghosh, Soumadwip, Achuthan, Srisairam, Chen, Xiaomin, Yao, XiaoJie, Sandhu, Manbir, Griffor, Matthew C., Fennell, Kimberly F., Che, Ye, Shanmugasundaram, Veerabahu, Qiu, Xiayang, Tate, Christopher G., Vaidehi, Nagarajan

Source: In Biophysical Journal 3 December 2019 117(11):2228-2239

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

Authors: Wasilko, David Jonathan, Johnson, Zachary Lee, Ammirati, Mark, Che, Ye, Griffor, Matthew C., Han, Seungil, Wu, Huixian

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174591287.0x000001&indx=1&recIds=ETOCvdc_100174591287.0x000001

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

Authors: Gerstenberger, Brian S., Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Fensome, Andrew, Gifford, Roger, Griffor, Matthew C., Hegen, Martin, Hollingshead, Brett D., Knafels, John D., Lin, Tsung H., Smith, James F., Vajdos, Felix F.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174634006.0x000001&indx=1&recIds=ETOCvdc_100174634006.0x000001

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line

Authors: Geoghegan, Kieran F., Song, Xi, Hoth, Lise R., Feng, Xidong, Shanker, Suman, Quazi, Amira, Luxenberg, Deborah P., Wright, Jill F., Griffor, Matthew C.

Source: In Protein Expression and Purification January 2013 87(1):27-34

Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors

Authors: Liu, Shenping, Mistry, Anil, Reynolds, Jennifer M., Lloyd, David B., Griffor, Matthew C., Perry, David A., Ruggeri, Roger B., Clark, Ronald W., Qiu, Xiayang

Source: In Journal of Biological Chemistry 26 October 2012 287(44):37321-37329

Structural basis of the acyl-transfer mechanism of human GPAT1

Authors: Johnson, Zachary Lee, Ammirati, Mark, Wasilko, David Jonathan, Chang, Jeanne S., Noell, Stephen, Foley, Timothy L., Yoon, Hyejin, Smith, Kathleen, Asano, Shoh, Hales, Katherine, Wan, Min, Yang, Qingyi, Piotrowski, Mary A., Farley, Kathleen A., Gilbert, Tamara, Aschenbrenner, Lisa M., Fennell, Kimberly F., Dutra, Jason K., Xu, Mary, Guo, Chunyang, Varghese, Alison E., Bellenger, Justin, Quinn, Alandra, am Ende, Christopher W., West, Graham M., Griffor, Matthew C., Bennett, Donald, Calabrese, Matthew, Steppan, Claire M., Han, Seungil, Wu, Huixian

Source: Nature Structural and Molecular Biology; January 2023, Vol. 30 Issue: 1 p22-30, 9p

Anthranilate synthase gene and method for increasing tryptophan production

Anthranilate synthase gene and method for increasing tryptophan production

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor.

Authors: Griffith, David A., Edmonds, David J., Fortin, Jean-Philippe, Kalgutkar, Amit S., Kuzmiski, J. Brent, Loria, Paula M., Saxena, Aditi R., Bagley, Scott W., Buckeridge, Clare, Curto, John M., Derksen, David R., Dias, João M., Griffor, Matthew C., Han, Seungil, Jackson, V. Margaret, Landis, Margaret S., Lettiere, Daniel, Limberakis, Chris, Liu, Yuhang, Mathiowetz, Alan M.

Source: Journal of Medicinal Chemistry; 6/23/2022, Vol. 65 Issue 12, p8208-8226, 19p

Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction

Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases

Authors: Board, Philip G. ^{‡, §}, Coggan, Marjorie ^‡, Chelvanayagam, Gareth ^{¶, ‖}, Easteal, Simon ^¶, Jermiin, Lars S. ^**, Schulte, Gayle K. ^‡, Danley, Dennis E. ^‡, Hoth, Lise R. ^‡, Griffor, Matthew C. ^‡, Kamath, Ajith V. ^‡, Rosner, Michele H. ^‡, Chrunyk, Boris A. ^‡, Perregaux, David E. ^‡, Gabel, Christopher A. ^‡, Geoghegan, Kieran F. ^‡, Pandit, Jayvardhan ^{§, ‡}

Source: In Journal of Biological Chemistry 11 August 2000 275(32):24798-24806

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Authors: Vogel, Annette B., Kanevsky, Isis, Che, Ye, Swanson, Kena A., Muik, Alexander, Vormehr, Mathias, Kranz, Lena M., Walzer, Kerstin C., Hein, Stephanie, Güler, Alptekin, Loschko, Jakob, Maddur, Mohan S., Ota-Setlik, Ayuko, Tompkins, Kristin, Cole, Journey, Lui, Bonny G., Ziegenhals, Thomas, Plaschke, Arianne, Eisel, David, Dany, Sarah C., Fesser, Stephanie, Erbar, Stephanie, Bates, Ferdia, Schneider, Diana, Jesionek, Bernadette, Sänger, Bianca, Wallisch, Ann-Kathrin, Feuchter, Yvonne, Junginger, Hanna, Krumm, Stefanie A., Heinen, André P., Adams-Quack, Petra, Schlereth, Julia, Schille, Stefan, Kröner, Christoph, de la Caridad Güimil Garcia, Ramón, Hiller, Thomas, Fischer, Leyla, Sellers, Rani S., Choudhary, Shambhunath, Gonzalez, Olga, Vascotto, Fulvia, Gutman, Matthew R., Fontenot, Jane A., Hall-Ursone, Shannan, Brasky, Kathleen, Griffor, Matthew C., Han, Seungil, Su, Andreas A. H., Lees, Joshua A., Nedoma, Nicole L., Mashalidis, Ellene H., Sahasrabudhe, Parag V., Tan, Charles Y., Pavliakova, Danka, Singh, Guy, Fontes-Garfias, Camila, Pride, Michael, Scully, Ingrid L., Ciolino, Tara, Obregon, Jennifer, Gazi, Michal, Carrion, Ricardo, Alfson, Kendra J., Kalina, Warren V., Kaushal, Deepak, Shi, Pei-Yong, Klamp, Thorsten, Rosenbaum, Corinna, Kuhn, Andreas N., Türeci, Özlem, Dormitzer, Philip R., Jansen, Kathrin U., Sahin, Ugur

Source: Nature; 20210101, Issue: Preprints p1-7, 7p

Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors

Authors: Bhattacharya, Samit K., Aspnes, Gary E., Bagley, Scott W., Boehm, Markus, Brosius, Arthur D., Buckbinder, Leonard, Chang, Jeanne S., Dibrino, Joseph, Eng, Heather, Frederick, Kosea S., Griffith, David A., Griffor, Matthew C., Guimarães, Cristiano R.W., Guzman-Perez, Angel, Han, Seungil, Kalgutkar, Amit S., Klug-McLeod, Jacquelyn, Garcia-Irizarry, Carmen, Li, Jianke, Lippa, Blaise, Price, David A., Southers, James A., Walker, Daniel P., Wei, Liuqing, Xiao, Jun, Zawistoski, Michael P., Zhao, Xumiao

Source: In Bioorganic & Medicinal Chemistry Letters 15 December 2012 22(24):7523-7529

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.

Authors: Cunningham, David¹, Danley, Dennis E.¹, Geoghegan, Kieran F.¹, Griffor, Matthew C.¹, Hawkins, Julie L.¹, Subashi, Timothy A.¹, Varghese, Alison H.¹, Ammirati, Mark J.¹, Culp, Jeffrey S.¹, Hoth, Lise R.¹, Mansour, Mahmoud N.¹, McGrath, Katherine M.¹, Seddon, Andrew P.¹, Shenolikar, Shirish², Stutzman-Engwall, Kim J.¹, Warren, Laurie C.¹, Donghui Xia¹, Xiayang Qiu¹, xiayang.qiu@pfizer.com

Source: Nature Structural & Molecular Biology; May2007, Vol. 14 Issue 5, p413-419, 7p, 4 Diagrams, 2 Charts, 1 Graph

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.

Authors: Xiayang Qiu¹, xiayang.qiu@pfizer.com, Mistry, Anil¹, Ammirati, Mark J.¹, Chrunyk, Boris A.¹, Clark, Ronald W.¹, Yang Cong¹, Culp, Jeffrey S.¹, Danley, Dennis E.¹, Freeman, Thomas B.¹, Geoghegan, Kieran F.¹, Griffor, Matthew C.¹, Hawrylik, Steven J.¹, Hayward, Cheryl M.¹, Hensley, Preston¹, Hoth, Lise R.¹, Karam, George A.¹, Lira, Maruja E.¹, Lloyd, David B.¹, McGrath, Katherine M.¹, Stutzman-Engwall, Kim J.¹

Source: Nature Structural & Molecular Biology; Feb2007, Vol. 14 Issue 2, p106-113, 8p, 1 Graph

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Authors: Walker, Daniel P., Christopher Bi, F., Kalgutkar, Amit S., Bauman, Jonathan N., Zhao, Sabrina X., Soglia, John R., Aspnes, Gary E., Kung, Daniel W., Klug-McLeod, Jacquelyn, Zawistoski, Michael P., McGlynn, Molly A., Oliver, Robert, Dunn, Matthew, Li, Jian-Cheng, Richter, Daniel T., Cooper, Beth A., Kath, John C., Hulford, Catherine A., Autry, Christopher L., Luzzio, Michael J., Ung, Ethan J., Roberts, W. Gregory, Bonnette, Peter C., Buckbinder, Leonard, Mistry, Anil, Griffor, Matthew C., Han, Seungil, Guzman-Perez, Angel

Source: In Bioorganic & Medicinal Chemistry Letters 1 December 2008 18(23):6071-6077

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