DHODH inhibitors: What will it take to get them into the clinic as antivirals?

Authors: Luganini, Anna ^a, Boschi, Donatella ^b, Lolli, Marco L. ^b, Gribaudo, Giorgio ^{a, ⁎}

Source: In Antiviral Research April 2025 236

Synthesis of SARS-CoV-2 Mpro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronavirusesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ob00381g

Authors: Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Dimasi, Alessandro, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Giannini, Clelia, Passarella, Daniele

Source: Organic & biomolecular chemistry. 21(18):3811-3824

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182250364.0x000001&indx=1&recIds=ETOCvdc_100182250364.0x000001

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication

Authors: Luganini, Anna, Sibille, Giulia, Pavan, Marta, Mello Grand, Maurizia, Sainas, Stefano, Boschi, Donatella, Lolli, Marco L., Chiorino, Giovanna, Gribaudo, Giorgio

Source: In Antiviral Research November 2023 219

HCMV-controlling NKG2C+ NK cells originate from novel circulating inflammatory precursors

Authors: Bozzano, Federica, Della Chiesa, Mariella, Pelosi, Andrea, Antonini, Francesca, Ascierto, Maria Libera, Del Zotto, Genny, Moretta, Francesca, Muccio, Letizia, Luganini, Anna, Gribaudo, Giorgio, Cenderello, Giovanni, Dentone, Chiara, Nicolini, Laura, Moretta, Alessandro, Moretta, Lorenzo, De Maria, Andrea

Source: In The Journal of Allergy and Clinical Immunology June 2021 147(6):2343-2357

The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs

Authors: Mercorelli, Beatrice, Celegato, Marta, Luganini, Anna, Gribaudo, Giorgio, Lepesheva, Galina I., Loregian, Arianna

Source: In Antiviral Research May 2021 189

Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication

Authors: Luganini, Anna, Sibille, Giulia, Mognetti, Barbara, Sainas, Stefano, Pippione, Agnese Chiara, Giorgis, Marta, Boschi, Donatella, Lolli, Marco L., Gribaudo, Giorgio

Source: In Antiviral Research May 2021 189

The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity.

Authors: Luganini, Anna, Mercorelli, Beatrice, Messa, Lorenzo, Palù, Giorgio, Gribaudo, Giorgio, Loregian, Arianna

Source: In Antiviral Research April 2019 164:52-60

The Novel A-Type Proanthocyanidin-Rich Phytocomplex SP4™ Acts as a Broad-Spectrum Antiviral Agent against Human Respiratory Viruses.

Authors: Sibille, Giulia, Mannino, Giuseppe, Frasson, Ilaria, Pavan, Marta, Luganini, Anna, Salata, Cristiano, Maffei, Massimo E., Gribaudo, Giorgio

Source: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 13, p7370, 22p

Subject Terms: RESPIRATORY syncytial virus, SARS-CoV-2, VIRUS diseases, INFLUENZA A virus, ANTIVIRAL agents, INFLUENZA B virus, INFLUENZA viruses

Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis

Authors: Luganini, Anna, Di Nardo, Giovanna, Munaron, Luca, Gilardi, Gianfranco, Pla, Alessandra Fiorio, Gribaudo, Giorgio

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec . 115(52), E12370-E12377.

Access URL: https://www.jstor.org/stable/26573975

Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein

Authors: Mercorelli, Beatrice, Luganini, Anna, Celegato, Marta, Palù, Giorgio, Gribaudo, Giorgio, Loregian, Arianna

Source: In Antiviral Research February 2018 150:130-136

Nucleic acids from agro-industrial wastes: A green recovery method for fire retardant applications

Authors: Bosco, Francesca, Casale, Annalisa, Gribaudo, Giorgio, Mollea, Chiara, Malucelli, Giulio

Source: In Industrial Crops & Products 1 December 2017 108:208-218

Effect of Bioactivation on Traditional Surfaces and Zirconium Nitride: Adhesion and Proliferation of Preosteoblastic Cells and Bacteria

Authors: Pistilli, Roberto, Genova, Tullio, Canullo, Luigi, Faga, Maria Giulia, Terlizzi, Maria Elena, Gribaudo, Giorgio, Mussano, Federico

Source: International journal of oral & maxillofacial implants. 33(6):1247-1254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618187961&indx=1&recIds=ETOCRN618187961

Inhibition of herpes simplex type 1 and type 2 infections by Oximacro®, a cranberry extract with a high content of A-type proanthocyanidins (PACs-A)

Authors: Terlizzi, Maria Elena, Occhipinti, Andrea, Luganini, Anna, Maffei, Massimo E., Gribaudo, Giorgio

Source: In Antiviral Research August 2016 132:154-164

DNA coatings on cotton fabrics: Effect of molecular size and pH on flame retardancy

Authors: Bosco, Francesca, Casale, Annalisa, Mollea, Chiara, Terlizzi, Maria Elena, Gribaudo, Giorgio, Alongi, Jenny, Malucelli, Giulio

Source: In Surface & Coatings Technology 25 June 2015 272:86-95

Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

Authors: Charpak-Amikam, Yoav, Kubsch, Tobias, Seidel, Einat, Oiknine-Djian, Esther, Cavaletto, Noemi, Yamin, Rachel, Schmiedel, Dominik, Wolf, Dana, Gribaudo, Giorgio, Messerle, Martin, Cicin-Sain, Luka, Mandelboim, Ofer

Source: Scientific reports. 7(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175115808.0x000001&indx=1&recIds=ETOCvdc_100175115808.0x000001

Drug Repurposing Approach Identifies Inhibitors of the Prototypic Viral Transcription Factor IE2 that Block Human Cytomegalovirus Replication

Authors: Mercorelli, Beatrice, Luganini, Anna, Nannetti, Giulio, Tabarrini, Oriana, Palù, Giorgio, Gribaudo, Giorgio, Loregian, Arianna

Source: Cell chemical biology. 23(3):340-351

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042754459.0x000001&indx=1&recIds=ETOCvdc_100042754459.0x000001

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression

Authors: Pignoloni, Benedetta, Fionda, Cinzia, Dell Oste, Valentina, Luganini, Anna, Cippitelli, Marco, Zingoni, Alessandra, Landolfo, Santo, Gribaudo, Giorgio, Santoni, Angela, Cerboni, Cristina

Source: Journal of immunology. 197(10):4066-4078

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608727487&indx=1&recIds=ETOCRN608727487

Synthesis of SARS-CoV-2 M^pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses.

Authors: Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Dimasi, Alessandro, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Giannini, Clelia, Passarella, Daniele

Source: Organic & Biomolecular Chemistry; 5/14/2023, Vol. 21 Issue 18, p3811-3824, 14p

Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate

Authors: Luganini, Anna, Giuliani, Andrea, Pirri, Giovanna, Pizzuto, Lorena, Landolfo, Santo, Gribaudo, Giorgio

Source: In Antiviral Research 2010 85(3):532-540

Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 M pro.

Authors: Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Passarella, Daniele, Giannini, Clelia

Source: Molecules; Jan2023, Vol. 28 Issue 2, p514, 8p

Subject Terms: SARS-CoV-2, DIAZOMETHANE, BIOCOMPATIBILITY, HYDROLASES, CORONAVIRUSES, ENZYME inhibitors, SERINE proteinase inhibitors