Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri.

Authors: Alice M Banks, Lijiang Song, Gregory L Challis, Andy M Bailey, Gary D Foster

Source: PLoS ONE, Vol 15, Iss 4, p e0229925 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c3b5de183f3249d8af435fee64c63e51

Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases

Authors: Christopher D. Fage, Munro Passmore, Ben P. Tatman, Helen G. Smith, Xinyun Jian, Upeksha C. Dissanayake, Mia E. Foran, G. Andrés Cisneros, Gregory L. Challis, Józef R. Lewandowski, Matthew Jenner

Source: JACS Au, Vol 5, Iss 1, Pp 144-157 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2691-3704

Access URL: https://doaj.org/article/66437954fb434bc6a17f2b006ef127e7

Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements

Authors: Claudia Simm, Tzong-Hsien Lee, Harshini Weerasinghe, Dean Walsh, Ioanna T. Nakou, Madhu Shankar, Wai Chung Tse, Yu Zhang, Rebecca Inman, Roger J. Mulder, Freya Harrison, Marie-Isabel Aguilar, Gregory L. Challis, Ana Traven

Source: mBio, Vol 15, Iss 11 (2024)

Subject Terms: Candida albicans, amphotericin B, antifungal agents, natural product, Cryptococcus, polyketide, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/19fb737237544dd1ace8e32c2584b530

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin.

Authors: Amy J Gerc, Lijiang Song, Gregory L Challis, Nicola R Stanley-Wall, Sarah J Coulthurst

Source: PLoS ONE, Vol 7, Iss 9, p e44673 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3445576?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f34bec3c2fc9477683f24f7db7de8fdd

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.

Authors: Nicholas R Thomson, Sarah Howard, Brendan W Wren, Matthew T G Holden, Lisa Crossman, Gregory L Challis, Carol Churcher, Karen Mungall, Karen Brooks, Tracey Chillingworth, Theresa Feltwell, Zahra Abdellah, Heidi Hauser, Kay Jagels, Mark Maddison, Sharon Moule, Mandy Sanders, Sally Whitehead, Michael A Quail, Gordon Dougan, Julian Parkhill, Michael B Prentice

Source: PLoS Genetics, Vol 2, Iss 12, p e206 (2006)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC1698947?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/8fe38ca6fa8b475bbd8c911e7cef83a0

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Authors: Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

Authors: Daniel Zabala, Lijiang Song, Yousef Dashti, Gregory L. Challis, José A. Salas, Carmen Méndez

Source: Microbial Cell Factories, Vol 19, Iss 1, Pp 1-12 (2020)

Subject Terms: Streptomyces argillaceus, Mithramycin, Premithramycinone, Aureolic acid, Acyl-CoA ligase, Cyclase, Microbiology, QR1-502

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12934-020-01368-3; https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/50b1fd8fbd2a4622a5923c0d6b17dc07

Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

Authors: Alex J. Mullins, Gordon Webster, Hak Joong Kim, Jinlian Zhao, Yoana D. Petrova, Christina E. Ramming, Matthew Jenner, James A. H. Murray, Thomas R. Connor, Christian Hertweck, Gregory L. Challis, Eshwar Mahenthiralingam

Source: mBio, Vol 12, Iss 4 (2021)

Subject Terms: Pseudomonas, biosynthetic gene clusters, natural products, phylogenetics, polyynes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/b1b4253ed1464c9da85b6b1a1b4667c8

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

Authors: Lauren Ray, Timothy R. Valentic, Takeshi Miyazawa, David M. Withall, Lijiang Song, Jacob C. Milligan, Hiroyuki Osada, Shunji Takahashi, Shiou-Chuan Tsai, Gregory L. Challis

Source: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f13d3b5a30894fbfb9a232d6e4194380

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis.

Authors: Daniel Oves-Costales, Nadia Kadi, Gregory L. Challis

Source: Chemical Communications; Oct2009, Vol. 2009 Issue 43, p6530-6541, 12p

Subject Terms: ENZYMOLOGY, MICROBIAL virulence, SIDEROPHORES, BIOSYNTHESIS, IRON chelates, HOST-parasite relationships, MICROBIAL enzymes

New natural product biosynthetic chemistry discovered by genome mining.

Authors: Christophe Corre¹, Gregory L. Challis¹

Source: Natural Product Reports. Jul2009, Vol. 26 Issue 8, p977-986. 10p.

Subject Terms: *NATURAL products, *BIOSYNTHESIS, *GENOMES, *BIOCHEMISTRY, *NEW product development

A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases.

Authors: Gregory L. Challis

Source: ChemBioChem; Apr2005, Vol. 6 Issue 4, p601-611, 11p

Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbAElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI: 10.1039/b823147h.

Authors: Daniel Oves-Costales, Lijiang Song, Gregory L. Challis

Source: Chemical Communications; Mar2009, Vol. 2009 Issue 11, p1389-1391, 3p

Subject Terms: ASYMMETRIC synthesis, CITRIC acid, SIDEROPHORES, SPECTRUM analysis, CHEMICAL synthesis, ENZYMES, CONDENSATION

Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine.

Authors: Nadia Kadi, Lijiang Song, Gregory L. Challis

Source: Chemical Communications; Oct2008, Vol. 2008 Issue 41, p5119-5121, 3p

Subject Terms: BIOCHEMICAL templates, ORGANIC synthesis, BIOCHEMICAL engineering, BIOPOLYMERS

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N⁸-citryl-spermidine and its N¹-(3,4-dihydroxybenzoyl) derivative.

Authors: Daniel Oves-Costales, Nadia Kadi, Mark J. Fogg, Lijiang Song, Keith S. Wilson, Gregory L. Challis

Source: Chemical Communications; Sep2008, Vol. 2008 Issue 34, p4034-4036, 3p

Subject Terms: BIOSYNTHESIS, BACTERIAL proteins, SPERMIDINE, ENZYMES, BACILLUS anthracis, ORGANIC synthesis

Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis.

Authors: Stuart W. Haynes, Paulina K. Sydor, Anna E. Stanley, Lijiang Song, Gregory L. Challis

Source: Chemical Communications; Apr2008, Vol. 2008 Issue 16, p1865-1867, 3p

Subject Terms: STREPTOMYCES coelicolor, STREPTOMYCETACEAE, ORGANIC synthesis, BIOCHEMISTRY

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.

Authors: Anna E. Stanley, Laura J. Walton, Malek Kourdi Zerikly, Christophe Corre, Gregory L. Challis

Source: Chemical Communications; Sep2006, Vol. 2006 Issue 38, p3981-3983, 3p

Evidence for the Unusual Condensation of a Diketide with a Pentulose in the Methylenomycin Biosynthetic Pathway of Streptomyces coelicolor A3(2).

Authors: Christophe Corre, Gregory L. Challis

Source: ChemBioChem; Dec2005, Vol. 6 Issue 12, p2166-2170, 0p

Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development

Authors: Yoana D. Petrova, Jinlian Zhao, Gordon Webster, Alex J. Mullins, Katherine Williams, Amal S. Alswat, Gregory L. Challis, Andy M. Bailey, Eshwar Mahenthiralingam

Source: Microbial Biotechnology, Vol 15, Iss 10, Pp 2547-2561 (2022)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/65ebf345b1164a598faba768867e02b0

Anti-microfouling Activity of Glycomyces sediminimaris UTMC 2460 on Dominant Fouling Bacteria of Iran Marine Habitats

Authors: Sheida Heidarian, Fatemeh Mohammadipanah, Abdolvahab Maghsoudlou, Yousef Dashti, Gregory L. Challis

Source: Frontiers in Microbiology, Vol 9 (2019)

Subject Terms: surface microlayer, antifouling substances, fouling organisms, marine Actinobacteria, secondary metabolites, marine sediment, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2018.03148/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/52e2cac234c1491bbd7b22d7c817fbb8