Deep phenotyping of patients with MASLD upon high-intensity interval training

Authors: Houttu, Veera ^{1, 2, 3, 4, †}, Boulund, Ulrika ^{1, 2, 3, 4, †}, Troelstra, Marian ⁵, Csader, Susanne ⁶, Stols-Gonçalves, Daniela ^{1, 4}, Mak, Anne Linde ^{1, 4}, Dijk, Anne-Marieke van ^{1, 4}, Bouts, Julia ¹, Winkelmeijer, Maaike ², Verdoes, Xanthe ², van den Berg-Faay, Sandra ⁵, Lek, Donne ⁷, Ronteltap, Ted ⁷, de Haan, Ferdinand ⁷, Jorstad, Harald ⁸, Männistö, Ville ⁹, Savonen, Kai ^{6, 10}, Pentikäinen, Heikki ¹⁰, Hanhineva, Kati ^{6, 11, 12}, Babu, Ambrin Farizah ^{6, 11}, Panagiotou, Gianni ^{13, 14, 15, 16}, van Delden, Otto ¹⁷, Verheij, Joanne ¹⁸, Doukas, Michial ¹⁹, Nederveen, Aart ⁵, Schwab, Ursula ⁶, Grefhorst, Aldo ^{1, 2, 3, 4}, Nieuwdorp, Max ^{1, 2, 3, 4}, Holleboom, Adriaan Georgius ^{1, 2, 3, 4, ⁎}

Source: In JHEP Reports March 2025 7(3)

Intronic variant screening with targeted next-generation sequencing reveals first pseudoexon in LDLR in familial hypercholesterolemia

Authors: Reeskamp, Laurens F., Balvers, Manon, Peter, Jorge, van de Kerkhof, Laura, Klaaijsen, Lisette N., Motazacker, Mahdi M., Grefhorst, Aldo, van Riel, Natal A.W., Hovingh, G. Kees, Defesche, Joep C., Zuurbier, Linda

Source: In Atherosclerosis March 2021 321:14-20

The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease.

Authors: Heymann, Clément J. F., Mak, Anne Linde, Holleboom, Adriaan G., Verheij, Joanne, Shiri-Sverdlov, Ronit, van Mil, Saskia W. C., Tushuizen, Maarten E., Koek, Ger H., Grefhorst, Aldo

Source: Lipids in Health & Disease; 12/18/2024, Vol. 23 Issue 1, p1-13, 13p

Subject Terms: BLOOD lipids, GLYCEROLIPIDS, LIVER diseases, SPHINGOLIPIDS, LIPOPROTEINS

Ursodeoxycholic Acid for Trans Intestinal Cholesterol Excretion Stimulation: A Randomized Placebo Controlled Crossover Study.

Authors: Oostveen, Reindert F., Kaiser, Yannick, Hartgers, Merel L., Meessen, Emma C. E., Grefhorst, Aldo, Hovingh, G. Kees, Kuipers, Folkert, Stroes, Erik S. G., Groen, Albert K., Reeskamp, Laurens F.

Source: Journal of the American Heart Association; 10/15/2024, Vol. 13 Issue 20, p1-8, 8p

Commentary: Nonalcoholic or metabolic dysfunction-associated fatty liver disease? The epidemic of the 21st century in search of the most appropriate name

Authors: Polyzos, Stergios A., Kang, Eun Seok, Tsochatzis, Emmanuel A., Kechagias, Stergios, Ekstedt, Mattias, Xanthakos, Stavra, Lonardo, Amedeo, Mantovani, Alessandro, Tilg, Herbert, Côté, Isabelle, Grefhorst, Aldo, Greene, Michael W., Araujo-Vilar, David, Alisi, Anna, Casanueva, Felipe, Mantzoros, Christos S.

Source: In Metabolism December 2020 113

Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation

Authors: Reeskamp, Laurens F., Tromp, Tycho R., Huijgen, Roeland, Stroes, Erik S.G., Hovingh, G. Kees, Grefhorst, Aldo

Source: In Atherosclerosis December 2020 315:68-75

Differential DNA methylation in familial hypercholesterolemia

Authors: Reeskamp, Laurens F., Venema, Andrea, Pereira, Joao P. Belo, Levin, Evgeni, Nieuwdorp, Max, Groen, Albert K., Defesche, Joep C., Grefhorst, Aldo, Henneman, Peter, Hovingh, G. Kees

Source: In EBioMedicine November 2020 61

ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia

Authors: Reeskamp, Laurens F., Volta, Andrea, Zuurbier, Linda, Defesche, Joep C., Hovingh, G. Kees, Grefhorst, Aldo

Source: In Journal of Clinical Lipidology March-April 2020 14(2):207-217

Taking One Step Back in Familial Hypercholesterolemia

Authors: Loaiza, Natalia, Hartgers, Merel L., Reeskamp, Laurens F., Balder, Jan-Willem, Rimbert, Antoine, Bazioti, Venetia, Wolters, Justina C., Winkelmeijer, Maaike, Jansen, Hans P.G., Dallinga-Thie, Geesje M., Volta, Andrea, Huijkman, Nicolette, Smit, Marieke, Kloosterhuis, Niels, Koster, Mirjam, Svendsen, Arthur F., van de Sluis, Bart, Hovingh, G. Kees, Grefhorst, Aldo, Kuivenhoven, Jan Albert

Source: Arteriosclerosis, thrombosis, and vascular biology. 40(4):973-985

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180889639.0x000001&indx=1&recIds=ETOCvdc_100180889639.0x000001

Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE^-/- Mice.

Authors: Kane, Jamie, Vos, Winnie G., Bosmans, Laura A., van Os, Bram W., den Toom, Myrthe, Hackmann, Sanne Hoeksema, Moen-de Wit, Denise, Gijbels, Marion J., Beckers, Linda, Grefhorst, Aldo, Levels, Johannes H. M., Jakulj, Lily, Vervloet, Marc G., Lutgens, Esther, Eringa, Etto C.

Source: Journal of the American Heart Association; 7/16/2024, Vol. 13 Issue 14, p1-15, 15p

Sex difference in cold perception and shivering onset upon gradual cold exposure

Authors: Kaikaew, Kasiphak, van den Beukel, Johanna C., Neggers, Sebastian J.C.M.M., Themmen, Axel P.N., Visser, Jenny A., Grefhorst, Aldo

Source: In Journal of Thermal Biology October 2018 77:137-144

Remnant cholesterol and systemic inflammation: Unraveling their association with cardiovascular disease

Authors: Kraaijenhof, Jordan, Kerkvliet, Marije, Nurmohamed, Nick, Grefhorst, Aldo, Kroon, Jeffrey, Reeskamp, Laurens, Gill, Dipender, Wareham, Nicholas, Hovingh, G., Stroes, Erik, Boekholdt, Matthijs

Source: In Atherosclerosis August 2024 395 Supplement 1

Prospective study on blood pressure, lipid metabolism and erythrocytosis during and after androgen abuse.

Authors: Smit, Diederik L.¹ (AUTHOR) smit_diederik@hotmail.com, Grefhorst, Aldo² (AUTHOR), Buijs, Madelon M.³ (AUTHOR), de Hon, Olivier⁴ (AUTHOR), den Heijer, Martin⁵ (AUTHOR), de Ronde, Willem¹ (AUTHOR)

Source: Andrologia. May2022, Vol. 54 Issue 4, p1-9. 9p.

Subject Terms: *LIPID metabolism, *BLOOD pressure, *DIASTOLIC blood pressure, *SYSTOLIC blood pressure, *POLYCYTHEMIA

Genetics of familial hypercholesterolemia: a tool for development of novel lipid lowering pharmaceuticals?

Authors: Volta, Andrea, Hovingh, G. Kees, Grefhorst, Aldo

Source: Current opinion in lipidology. 29(2):80-86

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100056167675.0x000001&indx=1&recIds=ETOCvdc_100056167675.0x000001

Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure

Authors: Shushimita, Shushimita, Grefhorst, Aldo, Steenbergen, Jacobie, de Bruin, Ron W.F., Ijzermans, Jan N.M., Themmen, Axel P.N., Dor, Frank J.M.F.

Source: In Life Sciences 1 January 2016 144:69-79

Anaerobutyricum soehngenii Reduces Hepatic Lipogenic Pathways and Increases Intestinal Gluconeogenic Gene Expression in Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) Mice.

Authors: Mak, Anne Linde, Augustijn, Quinten J. J., Heymann, Clément J. F., Havik, Stefan, Verdoes, Xanthe, Rios-Morales, Melany, Bosmans, Laura A., Verheij, Joanne, Meijnikman, Abraham S., de Jonge, Patrick A., Herrema, Hilde, de Vos, Willem M., Nieuwdorp, Max, Grefhorst, Aldo, Holleboom, Adriaan G.

Source: International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 6, p3481, 15p

Subject Terms: INSULIN-like growth factor-binding proteins, GENE expression, LIVER diseases, WESTERN diet, INTERLEUKIN receptors, INSULIN

Genome-wide coexpression of steroid receptors in the mouse brain : Identifying signaling pathways and functionally coordinated regions

Authors: Mahfouz, Ahmed, Lelieveldt, Boudewijn P. F., Grefhorst, Aldo, van Weert, Lisa T. C. M., Mol, Isabel M., Sips, Hetty C. M., van den Heuvel, José K., Datson, Nicole A., Visser, Jenny A., Reinders, Marcel J. T., Meijer, Onno C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Mar 01. 113(10), 2738-2743.

Access URL: https://www.jstor.org/stable/26468618

Sex difference in thermal preference of adult mice does not depend on presence of the gonads

Authors: Kaikaew, Kasiphak, Steenbergen, Jacobie, Themmen, Axel, Visser, Jenny, Grefhorst, Aldo

Source: Biology of sex differences. 8(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136236665.0x000001&indx=1&recIds=ETOCvdc_100136236665.0x000001

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

Authors: Hijmans, Brenda S., Grefhorst, Aldo, Oosterveer, Maaike H., Groen, Albert K.

Source: In Biochimie January 2014 96:121-129

ANGPTL3 (Angiopoietin-Like 3) Preferentially Resides on High-Density Lipoprotein in the Human Circulation, Affecting Its Activity.

Authors: Kraaijenhof, Jordan M., Tromp, Tycho R., Nurmohamed, Nick S., Reeskamp, Laurens F., Langenkamp, Marije, Levels, Johannes H. M., Boekholdt, S. Matthijs, Wareham, Nicholas J., Hoekstra, Menno, Stroes, Erik S. G., Hovingh, G. Kees, Grefhorst, Aldo

Source: Journal of the American Heart Association; 11/7/2023, Vol. 12 Issue 21, p1-12, 12p