Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery.

Authors: Greenwood, John C., Talebi, Fatima M., Jang, David H., Spelde, Audrey E., Gordon, Emily K., Horak, Jiri, Acker, Michael A., Kilbaugh, Todd J., Shofer, Frances S., Augoustides, John G.T., Bakker, Jan, Brenner, Jacob S., Muzykantov, Vladimir R., Abella, Benjamin S.

Source: In Microvascular Research November 2023 150

Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol.

Authors: Greenwood, John C.¹ (AUTHOR), Morgan, Ryan W.^2,3 (AUTHOR), Abella, Benjamin S.¹ (AUTHOR), Shofer, Frances S.¹ (AUTHOR), Baker, Wesley B.^2,4,5 (AUTHOR), Lewis, Alistair^5,6 (AUTHOR), Ko, Tiffany S.^2,3 (AUTHOR), Forti, Rodrigo M.^4,5 (AUTHOR), Yodh, Arjun G.⁷ (AUTHOR), Kao, Shih-Han² (AUTHOR), Shin, Samuel S.⁸ (AUTHOR), Kilbaugh, Todd J.^2,3 (AUTHOR), Jang, David H.^1,2 (AUTHOR) david.jang@pennmedicine.uphs.edu

Source: PLoS ONE. 5/15/2024, Vol. 19 Issue 5, p1-13. 13p.

Subject Terms: *CARDIAC arrest, *CARBON monoxide, *RETURN of spontaneous circulation, *CARDIAC resuscitation, *HEME oxygenase

Geographic Terms: UNITED States

Severe Impairment of Microcirculatory Perfused Vessel Density Is Associated With Postoperative Lactate and Acute Organ Injury After Cardiac Surgery

Authors: Greenwood, John C., Jang, David H., Hallisey, Stephen D., Gutsche, Jacob T., Horak, Jiri, Acker, Michael A., Bermudez, Christian A., Zhou, Victoria L., Chatterjee, Shampa, Shofer, Frances S., Kilbaugh, Todd J., Augoustides, John G.T., Meyer, Nuala J., Bakker, Jan, Abella, Benjamin S.

Source: In Journal of Cardiothoracic and Vascular Anesthesia January 2021 35(1):106-115

Low Microcirculatory Perfused Vessel Density and High Heterogeneity are Associated With Increased Intensity and Duration of Lactic Acidosis After Cardiac Surgery with Cardiopulmonary Bypass

Authors: Greenwood, John C., Jang, David H., Spelde, Audrey E., Gutsche, Jacob T., Horak, Jiri, Acker, Michael A., Kilbaugh, Todd J., Shofer, Frances S., Augoustides, John G.T., Bakker, Jan, Abella, Benjamin S.

Source: Shock. 56(2):245-254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181585102.0x000001&indx=1&recIds=ETOCvdc_100181585102.0x000001

Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning

Authors: Jang, David H., Piel, Sarah, Greenwood, John C., Kelly, Matthew, Mazandi, Vanessa M., Ranganathan, Abhay, Lin, Yuxi, Starr, Jonathan, Hallowell, Thomas, Shofer, Frances S., Baker, Wesley B., Lafontant, Alec, Andersen, Kristen, Ehinger, Johannes K., Kilbaugh, Todd J.

Source: Clinical toxicology. 59(9):801-809

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124961836.0x000001&indx=1&recIds=ETOCvdc_100124961836.0x000001

In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning

Authors: Owiredu, Shawn, Ranganathan, Abhay, Greenwood, John C., Piel, Sarah, Janowska, Joanna I., Eckmann, David M., Kelly, Matthew, Ehinger, Johannes K., Kilbaugh, Todd J., Jang, David H. ^*

Source: In Toxicology Reports 2020 7:1263-1271

Combining qSOFA criteria with initial lactate levels: Improved screening of septic patients for critical illness

Authors: Baumann, Brigitte M., Greenwood, John C., Lewis, Kristin, Nuckton, Thomas J., Darger, Bryan, Shofer, Frances S., Troeger, Dawn, Jung, Soo Y., Kilgannon, J. Hope, Rodriguez, Robert M.

Source: American journal of emergency medicine. 38(5):883-889

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115628903.0x000001&indx=1&recIds=ETOCvdc_100115628903.0x000001

The management of the poisoned patient using a novel emergency department-based resuscitation and critical care unit (ResCCU)

Authors: Mudan, Anita, Love, Jennifer S., Greenwood, John C., Stickley, Carolyn, Zhou, Victoria L., Shofer, Frances S., Jang, David H.

Source: American journal of emergency medicine. 38(10):2070-2073

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112826403.0x000001&indx=1&recIds=ETOCvdc_100112826403.0x000001

Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass.

Authors: Greenwood, John C.^1,2, Talebi, Fatima M.¹, Jang, David H.¹, Spelde, Audrey E.², Gordon, Emily K.², Horak, Jiri², Acker, Michael A.³, Kilbaugh, Todd J.⁴, Shofer, Frances S.⁵, Augoustides, John G. T.², Brenner, Jacob S.⁶, Muzykantov, Vladimir R.⁷, Bakker, Jan⁸, Abella, Benjamin S.^1,2

Source: Critical Care Medicine. Aug2024, Vol. 52 Issue 8, p1239-1250. 12p.

Subject Terms: *CARDIOVASCULAR surgery, *BLOOD flow, *RESPIRATION, *KREBS cycle, *LACTATES, *CARDIOPULMONARY bypass

Mitochondrial networking in human blood cells with application in acute care illnesses

Authors: Jang, David H., Greenwood, John C., Owiredu, Shawn, Ranganathan, Abhay, Eckmann, David M.

Source: In Mitochondrion January 2019 44:27-34

Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study.

Authors: Greenwood, John C.^1,2,3 (AUTHOR) john.greenwood@pennmedicine.upenn.edu, Talebi, Fatima M.¹ (AUTHOR), Jang, David H.¹ (AUTHOR), Spelde, Audrey E.² (AUTHOR), Tonna, Joseph E.⁴ (AUTHOR), Gutsche, Jacob T.² (AUTHOR), Horak, Jiri² (AUTHOR), Acker, Michael A.⁵ (AUTHOR), Kilbaugh, Todd J.⁶ (AUTHOR), Shofer, Frances S.⁷ (AUTHOR), Augoustides, John G. T.² (AUTHOR), Bakker, Jan^8,9 (AUTHOR), Brenner, Jacob S.¹⁰ (AUTHOR), Muzykantov, Vladimir R.¹¹ (AUTHOR), Abella, Benjamin S.¹ (AUTHOR)

Source: Scientific Reports. 9/10/2022, Vol. 12 Issue 1, p1-9. 9p.

Subject Terms: *CARDIOGENIC shock, *CARDIOVASCULAR surgery, *NITROGLYCERIN, *BLOOD flow, *SCIENTIFIC observation, *LEVOSIMENDAN

Protocol for the MicroRESUS study: The impact of circulatory shock and resuscitation on microcirculatory function and mitochondrial respiration after cardiovascular surgery.

Authors: Greenwood, John C.^1,2 (AUTHOR) john.greenwood@pennmedicine.upenn.edu, Talebi, Fatima M.² (AUTHOR), Jang, David H.² (AUTHOR), Spelde, Audrey E.³ (AUTHOR), Kilbaugh, Todd J.⁴ (AUTHOR), Shofer, Frances S.⁵ (AUTHOR), Acker, Michael A.⁶ (AUTHOR), Augoustides, John G. T.³ (AUTHOR), Bakker, Jan⁷ (AUTHOR), Meyer, Nuala J.⁸ (AUTHOR), Brenner, Jacob S.⁸ (AUTHOR), Muzykantov, Vladimir R.⁹ (AUTHOR), Abella, Benjamin S.² (AUTHOR)

Source: PLoS ONE. 8/26/2022, Vol. 17 Issue 8, p1-12. 12p.

Subject Terms: *CARDIOGENIC shock, *CARDIOVASCULAR surgery, *MONONUCLEAR leukocytes, *SURGICAL complications, *RESPIRATION, *MITOCHONDRIA, *DIASTOLE (Cardiac cycle)

Alterations in Mitochondrial Function in Blood Cells Obtained From Patients With Sepsis Presenting to an Emergency Department

Authors: Jang, David H., Orloski, Clinton J., Owiredu, Shawn, Shofer, Frances S., Greenwood, John C., Eckmann, David M.

Source: Shock. 51(5):580-584

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Predictors of Short Intensive Care Unit Stay for Patients with Diabetic Ketoacidosis Using a Novel Emergency Department–Based Resuscitation and Critical Care Unit

Authors: Zhou, Victoria L., Shofer, Frances S., Desai, Nikita G., Lorincz, Ilona S., Mull, Nikhil K., Adler, David H., Greenwood, John C.

Source: Journal of emergency medicine. 56(2):127-134

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100075926468.0x000001&indx=1&recIds=ETOCvdc_100075926468.0x000001

Student-Generated Challenges to Instructor's Answers on Tests.

Authors: Greenwood, John C.

Peer Reviewed: N

Page Count: 13

Descriptors: Answer Keys, Convergent Thinking, Error Correction, Feedback, Higher Education, Instructional Innovation, Logical Thinking, Multiple Choice Tests, Scoring Formulas, Self Esteem, Student Development, Test Use

Geographic Terms: U.S.; Illinois

Journal Code: RIEDEC1992

Automated estimation of microcirculation capillary density using relative perfusion maps

Authors: Colliot, Olivier, Mitra, Jhimli, Jena, Rohit, Wu, Yifan, Greenwood, John C., Chaudhari, Pratik, Gee, James

Source: Proceedings of SPIE; April 2024, Vol. 12926 Issue: 1 p129260U-129260U-7, 1163348p

Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning.

Authors: Mavroudis, Constantine D., Lewis, Alistair, Greenwood, John C., Kelly, Matthew, Ko, Tiffany S., Forti, Rodrigo M., Shin, Samuel S., Shofer, Frances S., Ehinger, Johannes K., Baker, Wesley B., Kilbaugh, Todd J., Jang, David H.

Source: Journal of Medical Toxicology; Jan2024, Vol. 20 Issue 1, p39-48, 10p

Subject Terms: CARBON monoxide poisoning, CARBOXYHEMOGLOBIN, CYTOCHROME oxidase, MITOCHONDRIA, BEHAVIORAL assessment, CELL physiology, PORCINE reproductive & respiratory syndrome

End Points of Sepsis Resuscitation

Authors: Greenwood, John C., Orloski, Clinton J.

Source: Emergency medicine clinics of North America. 35(1):93-107

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183206341.0x000001&indx=1&recIds=ETOCvdc_100183206341.0x000001

Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning

Authors: Jang, David H., Greenwood, John C., Spyres, Meghan B., Eckmann, David M.

Source: Journal of intensive care medicine. 32(1):86-94

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609227200&indx=1&recIds=ETOCRN609227200

The authors reply.

Authors: Greenwood, John C.^1,2 (AUTHOR) john.greenwood@pennmedicine.upenn.edu, Jang, David H.¹ (AUTHOR) david.jang@pennmedicine.upenn.edu

Source: Critical Care Medicine. Jan2025, Vol. 53 Issue 1, pe237-e238. 2p.

Subject Terms: *HYPOXIA-inducible factor 1, *PROPOFOL infusion syndrome, *FREE fatty acids, *MITOCHONDRIAL pathology, *CYTOCHROME c