CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms.

Authors: Greenman, Raanan¹ (AUTHOR) raanan.greenman@chemomab.com, Weston, Chris J.^2,3 (AUTHOR)

Source: Cells (2073-4409). Jan2025, Vol. 14 Issue 2, p105. 16p.

Subject Terms: *SYSTEMIC scleroderma, *EXTRACELLULAR matrix, *EPITHELIAL cells, *CHRONIC wounds & injuries, *WOUND healing

Machine Learning Identifies Key Proteins in Primary Sclerosing Cholangitis Progression and Links High CCL24 to Cirrhosis.

Authors: Snir, Tom¹ (AUTHOR), Greenman, Raanan¹ (AUTHOR), Aricha, Revital¹ (AUTHOR), Frankel, Matthew¹ (AUTHOR), Lawler, John¹ (AUTHOR), Saffioti, Francesca^2,3,4 (AUTHOR), Pinzani, Massimo^2,3 (AUTHOR), Thorburn, Douglas^2,3 (AUTHOR), Mor, Adi¹ (AUTHOR), Vaknin, Ilan¹ (AUTHOR) ilan.vaknin@chemomab.com

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p6042. 13p.

Subject Terms: *MACHINE learning, *CHOLANGITIS, *HEPATIC fibrosis, *PROGNOSIS, *BILE ducts, *CHEMOKINES

The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data.

Authors: Greenman, Raanan¹ (AUTHOR), Snir, Tom¹ (AUTHOR), Katav, Avi¹ (AUTHOR), Aricha, Revital¹ (AUTHOR), Mishalian, Inbal² (AUTHOR), Hay, Ophir² (AUTHOR), Frankel, Matthew¹ (AUTHOR), Lawler, John¹ (AUTHOR), Saffioti, Francesca^3,4,5 (AUTHOR), Pinzani, Massimo^3,4 (AUTHOR), Thorburn, Douglas^3,4 (AUTHOR), Peled, Amnon² (AUTHOR), Mor, Adi¹ (AUTHOR), Vaknin, Ilan¹ (AUTHOR) ilan.vaknin@chemomab.com

Source: Cells (2073-4409). Feb2024, Vol. 13 Issue 3, p209. 18p.

Subject Terms: *CHOLANGITIS, *LIVER cells, *NEUTROPHILS, *BILE ducts, *BILIOUS diseases & biliousness, *INTRAPERITONEAL injections, *PROTEOMICS, *CHEMOKINE receptors

Serum proteomics reveals association of CCL24 with key aspects of primary sclerosing cholangitis

Authors: Greenman, Raanan, Snir, Tom, Katav, Avi, Levi, Omer, Aricha, Revital, Lawler, John, Thorburn, Douglas, Pinzani, Massimo, Vaknin, Ilan

Source: Journal of hepatology. 78(S1):S415-S415

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195507364.0x000001&indx=1&recIds=ETOCvdc_100195507364.0x000001

Novel approach combining whole liver single-cell RNA sequencing and spatial gene profiling using Nanostring GEOMX enables identification of specific cell sub-populations and pathways regulated by CCL24

Authors: Segal-Salto, Michal, Greenman, Raanan, Aharon, Arnon, Hay, Ophir, Peled, Amnon, Mor, Adi

Source: Journal of hepatology. 77(S1):S27-S28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167078205.0x000001&indx=1&recIds=ETOCvdc_100167078205.0x000001

SAT-158 Machine learning-driven identification of serum protein signature for primary sclerosing cholangitis and enhanced liver fibrosis score

Authors: Snir, Tom, Greenman, Raanan, Katav, Avi, Aricha, Revital, Frankel, Matthew, Lawler, John, Saffioti, Francesca, Thorburn, Douglas, Pinzani, Massimo, Vaknin, Ilan, Mor, Adi

Source: In Journal of Hepatology June 2024 80 Supplement 1:S295-S295

THU-547 Ex-vivo translational assay of hepatic stellate cells using patientderived serum characterizes the anti-fibrotic activity of CM-101

Authors: Amer, Johnny, Salhab, Ahmad, Greenman, Raanan, Snir, Tom, Katav, Avi, Aricha, Revital, Frankel, Matthew, Lawler, John, Saffioti, Francesca, Thorburn, Douglas, Pinzani, Massimo, Vaknin, Ilan, Mor, Adi, Safadi, Rifaat

Source: In Journal of Hepatology June 2024 80 Supplement 1:S268-S269

Functional Interactions of Kluyveromyces lactis Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA.

Authors: Al-Shareef, Wasif, Brown, Yogev, Bryan, Christopher, Shuvaeva, Elena, Bsoul, Shhadeh, Greenman, Raanan, Kabaha, Majdi M., Ulyanov, Nikolai B., Skordalakes, Emmanuel, Tzfati, Yehuda

Source: International Journal of Molecular Sciences; Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG, 18p

Subject Terms: TELOMERASE, TELOMERASE reverse transcriptase, REVERSE transcriptase, KLUYVEROMYCES marxianus, DNA replication, RNA, RNA-protein interactions

FRI-345 - Serum proteomics reveals association of CCL24 with key aspects of primary sclerosing cholangitis

Authors: Greenman, Raanan, Snir, Tom, Katav, Avi, Levi, Omer, Aricha, Revital, Lawler, John, Thorburn, Douglas, Pinzani, Massimo, Vaknin, Ilan

Source: In Journal of Hepatology June 2023 78 Supplement 1:S415-S415

OS022 - Novel approach combining whole liver single-cell RNA sequencing and spatial gene profiling using Nanostring GEOMX enables identification of specific cell sub-populations and pathways regulated by CCL24

Authors: Segal-Salto, Michal, Greenman, Raanan, Aharon, Arnon, Hay, Ophir, Peled, Amnon, Mor, Adi

Source: In Journal of Hepatology July 2022 77 Supplement 1:S27-S28

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