NADPH oxidase 2 activity disrupts Calmodulin/CaMKIIα complex via redox modifications of CaMKIIα-contained Cys30 and Cys289: Implications in Parkinson's disease

Authors: Pullara, Filippo, Forsmann, Madison C., General, Ignacio J., Ayoob, Joseph C., Furbee, Emily, Castro, Sandra L., Hu, Xiaoping, Greenamyre, J. Timothy, Di Maio, Roberto

Source: In Redox Biology September 2024 75

LRRK2 kinase inhibition protects against Parkinson's disease-associated environmental toxicants

Authors: Ilieva, Neda M., Hoffman, Eric K., Ghalib, Mohammed A., Greenamyre, J. Timothy, De Miranda, Briana R.

Source: In Neurobiology of Disease 15 June 2024 196

LRRK2 and idiopathic Parkinson's disease

Authors: Rocha, Emily M., Keeney, Matthew T., Di Maio, Roberto, De Miranda, Briana R., Greenamyre, J. Timothy

Source: Trends in neurosciences. 45(3):224-236

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155652577.0x000001&indx=1&recIds=ETOCvdc_100155652577.0x000001

NADPH oxidase 2 activity in Parkinson's disease

Authors: Keeney, Matthew T., Hoffman, Eric K., Farmer, Kyle, Bodle, Christopher R., Fazzari, Marco, Zharikov, Alevtina, Castro, Sandra L., Hu, Xiaoping, Mortimer, Amanda, Kofler, Julia K., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Burton, Edward A., Hastings, Teresa G., Greenamyre, J. Timothy, Di Maio, Roberto

Source: In Neurobiology of Disease August 2022 170

The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

Authors: Hallacli, Erinc, Kayatekin, Can, Nazeen, Sumaiya, Wang, Xiou H., Sheinkopf, Zoe, Sathyakumar, Shubhangi, Sarkar, Souvarish, Jiang, Xin, Dong, Xianjun, Di Maio, Roberto, Wang, Wen, Keeney, Matthew T., Felsky, Daniel, Sandoe, Jackson, Vahdatshoar, Aazam, Udeshi, Namrata D., Mani, D.R., Carr, Steven A., Lindquist, Susan, De Jager, Philip L., Bartel, David P., Myers, Chad L., Greenamyre, J. Timothy, Feany, Mel B., Sunyaev, Shamil R., Chung, Chee Yeun, Khurana, Vikram

Source: In Cell 9 June 2022 185(12):2035-2056

The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease

Authors: De Miranda, Briana R., Castro, Sandra L., Rocha, Emily M., Bodle, Christopher R., Johnson, Katrina E., Greenamyre, J. Timothy

Source: In Neurobiology of Disease June 2021 153

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease.

Authors: Keeney, Matthew T., Rocha, Emily M., Hoffman, Eric K., Farmer, Kyle, Di Maio, Roberto, Weir, Julie, Wagner, Weston G., Hu, Xiaoping, Clark, Courtney L., Castro, Sandra L., Scheirer, Abigail, Fazzari, Marco, De Miranda, Briana R., Pintchovski, Sean A., Shrader, William D., Pagano, Patrick J., Hastings, Teresa G., Greenamyre, J. Timothy

Source: Science Translational Medicine; 10/2/2024, Vol. 16 Issue 767, p1-15, 15p

Subject Terms: DARDARIN, LABORATORY rats, MULTIENZYME complexes, PARKINSON'S disease, NADPH oxidase, KINASES

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Authors: Van Laar, Victor S., Chen, Jianming, Zharikov, Alevtina D., Bai, Qing, Di Maio, Roberto, Dukes, April A., Hastings, Teresa G., Watkins, Simon C., Greenamyre, J. Timothy, St Croix, Claudette M., Burton, Edward A.

Source: In Redox Biology October 2020 37

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Authors: Rocha, Emily M., De Miranda, Briana R., Castro, Sandra, Drolet, Robert, Hatcher, Nathan G., Yao, Lihang, Smith, Sean M., Keeney, Matthew T., Di Maio, Roberto, Kofler, Julia, Hastings, Teresa G., Greenamyre, J. Timothy

Source: In Neurobiology of Disease February 2020 134

Spectrum of tau pathologies in Huntington's disease

Authors: Baskota, Swikrity Upadhyay, Lopez, Oscar L., Greenamyre, J. Timothy, Kofler, Julia

Source: In Laboratory Investigation July 2019 99(7):1068-1077

Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease

Authors: Tapias, Victor, McCoy, Jennifer L., Greenamyre, J. Timothy

Source: In Redox Biology June 2019 24

Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

Authors: Zharikov, Alevtina, Bai, Qing, De Miranda, Briana R., Van Laar, Amber, Greenamyre, J. Timothy, Burton, Edward A.

Source: In Neurobiology of Disease May 2019 125:146-153

Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease

Authors: De Miranda, Briana R., Greenamyre, J. Timothy

Source: Environmental science.Processes & impacts. 22(3):543-554

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108598473.0x000001&indx=1&recIds=ETOCvdc_100108598473.0x000001

RAD52 is required for RNA-templated recombination repair in post-mitotic neurons

Authors: Welty, Starr, Teng, Yaqun, Liang, Zhuobin, Zhao, Weixing, Sanders, Laurie H. ^**, Greenamyre, J. Timothy, Rubio, Maria Eulalia, Thathiah, Amantha, Kodali, Ravindra, Wetzel, Ronald, Levine, Arthur S., Lan, Li

Source: In Journal of Biological Chemistry 26 January 2018 293(4):1353-1362

Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson's Disease Incidence

Authors: De Miranda, Briana R, Fazzari, Marco, Rocha, Emily M, Castro, Sandra, Greenamyre, J Timothy

Source: Toxicological sciences. 170(1):133-143

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087543980.0x000001&indx=1&recIds=ETOCvdc_100087543980.0x000001

Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative.

Authors: Wyse, Richard K., Isaacs, Tom, Barker, Roger A., Cookson, Mark R., Dawson, Ted M., Devos, David, Dexter, David T., Duffen, Joy, Federoff, Howard, Fiske, Brian, Foltynie, Thomas, Fox, Susan, Greenamyre, J. Timothy, Kieburtz, Karl, Kordower, Jeffrey H., Krainc, Dimitri, Matthews, Helen, Moore, Darren J., Mursaleen, Leah, Schwarzschild, Michael A.

Source: Journal of Parkinson's Disease; 2024, Vol. 14 Issue 4, p657-666, 10p

Subject Terms: PARKINSON'S disease, CLINICAL trials, MEDICAL charities, MOVEMENT disorders, MEDICAL research

Geographic Terms: GRAND Rapids (Mich.)

Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration

Authors: Buck, Silas A., Steinkellner, Thomas, Aslanoglou, Despoina, Villeneuve, Michael, Bhatte, Sai H., Childers, Victoria C., Rubin, Sophie A., De Miranda, Briana R., O'Leary, Emma I., Neureiter, Elizabeth G., Fogle, Keri J., Palladino, Michael J., Logan, Ryan W., Glausier, Jill R., Fish, Kenneth N., Lewis, David A., Greenamyre, J. Timothy, McCabe, Brian D., Cheetham, Claire E. J., Hnasko, Thomas S., Freyberg, Zachary

Source: Aging cell. 20(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120810032.0x000001&indx=1&recIds=ETOCvdc_100120810032.0x000001

Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats

Authors: Di Maio, Roberto, Cannon, Jason R., Greenamyre, J. Timothy

Source: In Neurobiology of Disease January 2015 73:356-365

Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats

Authors: Lee, Jang-Won, Tapias, Victor, Di Maio, Roberto, Greenamyre, J. Timothy, Cannon, Jason R.

Source: In Neurobiology of Aging January 2015 36(1):505-518

Parkinson's: Divergent Causes, Convergent Mechanisms

Authors: Greenamyre, J. Timothy, Hastings, Teresa G.

Source: Science, 2004 May . 304(5674), 1120-1122.

Access URL: https://www.jstor.org/stable/3836863