Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure

Authors: Verdino, Petra, Lee, Stacey L., Cooper, Fariba N., Cottle, Steven R., Grealish, Patrick F., Hu, Charlie C., Meyer, Catalina M., Lin, Joanne, Copeland, Victoria, Porter, Gina, Schroeder, Richard L., Thompson, Tyran D., Porras, Leah L., Dey, Asim, Zhang, Hong Y., Beebe, Emily C., Matkovich, Scot J., Coskun, Tamer, Balciunas, Aldona M., Ferrante, Andrea, Siegel, Robert, Malherbe, Laurent, Bivi, Nicoletta, Paavola, Chad D., Hansen, Ryan J., Abernathy, Matthew M., Nwosu, Sylvia O., Carr, Molly C., Heuer, Josef G., Wang, Xiaojun

Source: British journal of pharmacology. 180(15):1965-1980

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187354866.0x000001&indx=1&recIds=ETOCvdc_100187354866.0x000001

Long‐Duration and Non‐Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent

Authors: Khadria, Anjul, Paavola, Chad D., Zhang, Yang, Davis, Samuel P. X., Grealish, Patrick F., Maslov, Konstantin, Shi, Junhui, Beals, John M., Oladipupo, Sunday S., Wang, Lihong V.

Source: Advanced science. 9(28)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165221934.0x000001&indx=1&recIds=ETOCvdc_100165221934.0x000001

Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia.

Authors: Khadria, Anjul, Paavola, Chad D., Maslov, Konstantin, Brown-Augsburger, Patricia L., Grealish, Patrick F., Lozano, Emmanuel, Blankenship, Ross L., Cao, Rui, Shi, Junhui, Beals, John M., Oladipupo, Sunday S., Wang, Lihong V.

Source: Journal of Biomedical Optics; Nov2023, Vol. 28 Issue 11, p116002-116002, 1p

Subject Terms: ACOUSTIC imaging, MONOCLONAL antibodies, EXTRACELLULAR fluid, OXYGEN in the blood, OXYGEN saturation, ANESTHESIA

Company/Entity: UNITED States. Food & Drug Administration

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

Authors: Kanakaraj, Palanisamy, Schafer, Peter H., Cavender, Druie E., Wu, Ying, Ngo, Karen, Grealish, Patrick F., Wadsworth, Scott A., Peterson, Per A., Siekierka, John J., Harris, Crafford A., Fung-Leung, Wai-Ping

Source: The Journal of Experimental Medicine; June 1998, Vol. 187 Issue: 12 p2073-2079, 7p