Advances abound in immune mediated inflammatory diseases

Authors: Gravallese, Ellen M., McInnes, Iain B.

Source: In Seminars in Arthritis and Rheumatism February 2024 64 Supplement

Immunomodulator use, risk factors and management of flares, and mortality for patients with pre-existing rheumatoid arthritis after immune checkpoint inhibitors for cancer

Authors: McCarter, Kaitlin R., Arabelovic, Senada, Wang, Xiaosong, Wolfgang, Taylor, Yoshida, Kazuki, Qian, Grace, Kowalski, Emily N., Vanni, Kathleen M.M., LeBoeuf, Nicole R., Buchbinder, Elizabeth I., Gedmintas, Lydia, MacFarlane, Lindsey A., Rao, Deepak A., Shadick, Nancy A., Gravallese, Ellen M., Sparks, Jeffrey A.

Source: In Seminars in Arthritis and Rheumatism February 2024 64

Mortality and immune-related adverse events after immune checkpoint inhibitor initiation for cancer among patients with pre-existing rheumatoid arthritis: a retrospective, comparative, cohort study

Authors: McCarter, Kaitlin R, Wolfgang, Taylor, Arabelovic, Senada, Wang, Xiaosong, Yoshida, Kazuki, Banasiak, Emily P, Qian, Grace, Kowalski, Emily N, Vanni, Kathleen M M, LeBoeuf, Nicole R, Buchbinder, Elizabeth I, Gedmintas, Lydia, MacFarlane, Lindsey A, Rao, Deepak A, Shadick, Nancy A, Gravallese, Ellen M, Sparks, Jeffrey A ^*

Source: In The Lancet Rheumatology May 2023 5(5):e274-e283

Laboratory trends, hyperinflammation, and clinical outcomes for patients with a systemic rheumatic disease admitted to hospital for COVID-19: a retrospective, comparative cohort study

Authors: Hsu, Tiffany Y-T, D'Silva, Kristin M, Patel, Naomi J, Wang, Jiaqi, Mueller, Alisa A, Fu, Xiaoqing, Prisco, Lauren, Martin, Lily, Vanni, Kathleen M M, Zaccardelli, Alessandra, Cook, Claire, Choi, Hyon K, Zhang, Yuqing, Gravallese, Ellen M, Wallace, Zachary S, Sparks, Jeffrey A ^*

Source: In The Lancet Rheumatology September 2021 3(9):e638-e647

Safety of CAR T-cell therapy for cancer in pre-existing autoimmune or inflammatory disease: a retrospective comparative cohort study

Authors: Vanni, Kathleen M M ^a, McCarter, Kaitlin R ^{a, d}, Wang, Xiaosong ^a, Duffy, Caitlyn ^e, Cruz, Jamie P Dela ^e, Wobma, Holly ^{d, f}, Nikiforow, Sarah ^{b, d, e}, Massarotti, Elena M ^{a, d}, Costenbader, Karen H ^{a, d}, Little, Jessica S ^{c, d}, Gravallese, Ellen M ^{a, d}, McDermott, Gregory C ^{a, d}, Jacobson, Caron A ^{b, d, e}, Sparks, Jeffrey A ^{a, d}

Source: In The Lancet Rheumatology April 2025 7(4):e226-e229

Mediators of inflammation and bone remodeling in rheumatic disease

Authors: Shaw, Anita T., Gravallese, Ellen M.

Source: In Seminars in Cell and Developmental Biology January 2016 49:2-10

Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.

Authors: Bai, Zilong, Bartelo, Nicholas, Aslam, Maryam, Murphy, Elisabeth A., Hale, Caryn R., Blachere, Nathalie E., Parveen, Salina, Spolaore, Edoardo, DiCarlo, Edward, Gravallese, Ellen M., Smith, Melanie H., Frank, Mayu O., Jiang, Caroline S., Zhang, Haotan, Pyrgaki, Christina, Lewis, Myles J., Sikandar, Shafaq, Pitzalis, Costantino, Lesnak, Joseph B., Mazhar, Khadijah

Source: Science Translational Medicine; 4/10/2024, Vol. 16 Issue 742, p1-16, 16p

Subject Terms: RHEUMATOID arthritis, GENE expression, DORSAL root ganglia, RNA sequencing, JOINT pain, CALCITONIN gene-related peptide

97 - Pathogenesis and pathology of rheumatoid arthritis

Authors: Gravallese, Ellen M., Helena Jonsson, Anna

Source: In Rheumatology, 2-Volume Set Edition: Eighth Edition. 2023:815-834

Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles

Authors: Sakaue, Saori, Weinand, Kathryn, Isaac, Shakson, Dey, Kushal K., Jagadeesh, Karthik, Kanai, Masahiro, Watts, Gerald F. M., Zhu, Zhu, Albrecht, Jennifer, Anolik, Jennifer H., Apruzzese, William, Banda, Nirmal, Barnas, Jennifer L., Bathon, Joan M., Ben-Artzi, Ami, Boyce, Brendan F., Boyle, David L., Bridges, S. Louis, Bykerk, Vivian P., Campbell, Debbie, Carr, Hayley L., Ceponis, Arnold, Chicoine, Adam, Cordle, Andrew, Curtis, Michelle, Deane, Kevin D., DiCarlo, Edward, Dunn, Patrick, Filer, Andrew, Firestein, Gary S., Forbess, Lindsy, Geraldino-Pardilla, Laura, Goodman, Susan M., Gravallese, Ellen M., Gregersen, Peter K., Guthridge, Joel M., Gutierrez-Arcelus, Maria, Gurajala, Siddarth, Michael Holers, V., Horowitz, Diane, Hughes, Laura B., Ishigaki, Kazuyoshi, Ivashkiv, Lionel B., James, Judith A., Jonsson, Anna Helena, Kang, Joyce B., Keras, Gregory, Korsunsky, Ilya, Lakhanpal, Amit, Lederer, James A., Li, Zhihan J., Li, Yuhong, Liao, Katherine P., Mandelin, Arthur M., Mantel, Ian, Maybury, Mark, Mears, Joseph, Meednu, Nida, Millard, Nghia, Moreland, Larry W., Nathan, Aparna, Nerviani, Alessandra, Orange, Dana E., Perlman, Harris, Pitzalis, Costantino, Rangel-Moreno, Javier, Rao, Deepak A., Raza, Karim, Reshef, Yakir, Ritchlin, Christopher, Rivellese, Felice, Robinson, William H., Rumker, Laurie, Sahbudin, Ilfita, Seifert, Jennifer A., Slowikowski, Kamil, Smith, Melanie H., Tabechian, Darren, Scheel-Toellner, Dagmar, Utz, Paul J., Weisenfeld, Dana, Weisman, Michael H., Xiao, Qian, Zhang, Fan, Brenner, Michael B., McDavid, Andrew, Donlin, Laura T., Wei, Kevin, Price, Alkes L., Raychaudhuri, Soumya

Source: Sakaue, Saori, Kathryn Weinand, Shakson Isaac, Kushal K. Dey, Karthik Jagadeesh, Masahiro Kanai, Gerald F. M. Watts et al. "Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles." Nat Genet 56, no. 4 (2024): 615-626. DOI: 10.1038/s41588-024-01682-1

File Description: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: Nature Genetics; Nat Genet

Access URL: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37379190

Assessment of control of rheumatoid arthritis disease activity

Authors: Salomon-Escoto, Karen I., Gravallese, Ellen M., Kay, Jonathan

Source: In Best Practice & Research Clinical Rheumatology 2011 25(4):497-507

Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention

Authors: Karmakar, Sougata, Kay, Jonathan, Gravallese, Ellen M.

Source: In Rheumatic Disease Clinics of North America 2010 36(2):385-404

Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.

Authors: Stavre, Zheni¹, Jung-Min Kim¹, Yeon-Suk Yang¹, Nündel, Kerstin¹, Chaugule, Sachin¹, Tadatoshi Sato^1,2,3,4, Kwang Hwan Park⁵, Guangping Gao^2,3,6,7, Gravallese, Ellen M.⁸, egravallese@bwh.harvard.edu, Jae-Hyuck Shim^1,2,3, jaehyuck.shim@umassmed.edu

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/9/2023, Vol. 120 Issue 19, p1-12, 30p

Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2022.

Authors: Winthrop, Kevin L., Isaacs, John D., Mease, Philip J., Boumpas, Dimitrios T., Baraliakos, Xenofon, Gottenberg, Jacques- Eric, Siebert, Stefan, Mosca, Marta, Basu, Neil, Orange, Dana, Lories, R., Aletaha, Daniel, McInnes, Iain B., Huizinga, Tom W. J., Voll, Reinhard E., Gravallese, Ellen M., Breedveld, Ferry C., Smolen, Josef S.

Source: Annals of the Rheumatic Diseases; May2023, Vol. 82 Issue 5, p594-598, 5p

STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.

Authors: MacLauchlan, Susan¹, Kushwaha, Priyanka¹, Tai, Albert², Jia Chen¹, Manning, Catherine¹, Swarnkar, Gaurav³, Abu-Amer, Yousef³, Fitzgerald, Katherine A.⁴, Sharma, Shruti², Gravallese, Ellen M.¹

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/11/2023, Vol. 120 Issue 15, p1-12, 19p

Cytokines in Murine Lyme Carditis: Thl Cytokine Expression Follows Expression of Proinflammatory Cytokines in a Susceptible Mouse Strain

Authors: Doyle, Mittie Kelleher, Telford III, Sam R., Criscione, Lisa, Lin, Shin Ru, Spielman, Andrew, Gravallese, Ellen M.

Source: The Journal of Infectious Diseases, 1998 Jan 01. 177(1), 242-246.

Access URL: https://www.jstor.org/stable/30107683

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Authors: Kang, Joyce B., Shen, Amber Z., Gurajala, Saisriram, Nathan, Aparna, Rumker, Laurie, Aguiar, Vitor R. C., Valencia, Cristian, Lagattuta, Kaitlyn A., Zhang, Fan, Jonsson, Anna Helena, Yazar, Seyhan, Alquicira-Hernandez, Jose, Khalili, Hamed, Ananthakrishnan, Ashwin N., Jagadeesh, Karthik, Dey, Kushal, Albrecht, Jennifer, Apruzzese, William, Banda, Nirmal, Barnas, Jennifer L., Bathon, Joan M., Ben-Artzi, Ami, Boyce, Brendan F., Boyle, David L., Bridges, S. Louis, Bykerk, Vivian P., Campbell, Debbie, Carr, Hayley L., Ceponis, Arnold, Chicoine, Adam, Cordle, Andrew, Curtis, Michelle, Deane, Kevin D., DiCarlo, Edward, Dunn, Patrick, Filer, Andrew, Firestein, Gary S., Forbess, Lindsy, Geraldino-Pardilla, Laura, Goodman, Susan M., Gravallese, Ellen M., Gregersen, Peter K., Guthridge, Joel M., Holers, V. Michael, Horowitz, Diane, Hughes, Laura B., Ishigaki, Kazuyoshi, Ivashkiv, Lionel B., James, Judith A., Keras, Gregory, Korsunsky, Ilya, Lakhanpal, Amit, Lederer, James A., Lewis, Myles, Li, Zhihan J., Li, Yuhong, Liao, Katherine P., Mandelin, Arthur M., Mantel, Ian, Marks, Kathryne E., Maybury, Mark, McDavid, Andrew, McGeachy, Mandy J., Mears, Joseph, Meednu, Nida, Millard, Nghia, Moreland, Larry W., Nayar, Saba, Nerviani, Alessandra, Orange, Dana E., Perlman, Harris, Pitzalis, Costantino, Rangel-Moreno, Javier, Raza, Karim, Reshef, Yakir, Ritchlin, Christopher, Rivellese, Felice, Robinson, William H., Sahbudin, Ilfita, Singaraju, Anvita, Seifert, Jennifer A., Slowikowski, Kamil, Smith, Melanie H., Tabechian, Darren, Scheel-Toellner, Dagmar, Utz, Paul J., Watts, Gerald F. M., Wei, Kevin, Weinand, Kathryn, Weisenfeld, Dana, Weisman, Michael H., Wyse, Aaron, Xiao, Qian, Zhu, Zhu, Daly, Mark J., Xavier, Ramnik J., Donlin, Laura T., Anolik, Jennifer H., Powell, Joseph E., Rao, Deepak A., Brenner, Michael B., Gutierrez-Arcelus, Maria, Luo, Yang, Sakaue, Saori, Raychaudhuri, Soumya

Source: Kang, Joyce B., Amber Z. Shen, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R. C. Aguiar, Cristian Valencia et al. "Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution." Nat Genet 55, no. 12 (2023): 2255-2268. DOI: 10.1038/s41588-023-01586-6

Subject Terms: Genetics

File Description: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: Nature Genetics; Nat Genet

Access URL: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37377786

Rheumatoid Arthritis -- Common Origins, Divergent Mechanisms.

Authors: Gravallese, Ellen M.¹ egravallese@bwh.harvard.edu, Firestein, Gary S.²

Source: New England Journal of Medicine. 2/9/2023, Vol. 388 Issue 6, p529-542. 14p.

Subject Terms: *RHEUMATOID arthritis, *INTERSTITIAL lung diseases, *SYNOVITIS, *DISEASE risk factors, *JOINT pain

American College of Rheumatology Guidance for COVID‐19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 5.

Authors: Curtis, Jeffrey R., Johnson, Sindhu R., Anthony, Donald D., Arasaratnam, Reuben J., Baden, Lindsey R., Bass, Anne R., Calabrese, Cassandra, Gravallese, Ellen M., Harpaz, Rafael, Kroger, Andrew, Sadun, Rebecca E., Turner, Amy S., Williams, Eleanor Anderson, Mikuls, Ted R.

Source: Arthritis & Rheumatology; Jan2023, Vol. 75 Issue 1, pE1-E16, 16p

Subject Terms: MUSCULOSKELETAL system diseases, CONSENSUS (Social sciences), IMMUNIZATION, COVID-19 vaccines, TIME, PUBLIC health, VACCINE effectiveness, DESCRIPTIVE statistics, RHEUMATISM, PATIENT care, DELPHI method, PATIENT safety

Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.

Authors: MacLauchlan, Susan, Fitzgerald, Katherine A., Gravallese, Ellen M.

Source: Arthritis & Rheumatology; Oct2022, Vol. 74 Issue 10, p1615-1624, 10p

Subject Terms: DNA, GENETIC mutation, INFLAMMATION, CELL physiology, AUTOIMMUNE diseases, INTERFERONS, CELLULAR signal transduction, RHEUMATISM, DISEASE risk factors

A Novel Role for GADD45β as a Mediator of MMP-13 Gene Expression during Chondrocyte Terminal Differentiation

Authors: Ijiri, Kosei ^{‡, 1}, Zerbini, Luiz F. ^‡, Peng, Haibing ^‡, Correa, Ricardo G. ^§, Lu, Binfeng ^¶, Walsh, Nicole ^‡, Zhao, Yani ^¶, Taniguchi, Noboru ^∥, Huang, Xu-Ling ^‡, Otu, Hasan ^‡, Wang, Hong ^‡, Wang, Jian Fei ^‡, Komiya, Setsuro ^∥, Ducy, Patricia ^**, Rahman, Mahboob U. ^{‡‡, 2}, Flavell, Richard A. ^§§, Gravallese, Ellen M. ^‡, Oettgen, Peter ^‡, Libermann, Towia A. ^‡, Goldring, Mary B. ^{‡, 3}

Source: In Journal of Biological Chemistry 18 November 2005 280(46):38544-38555