Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies.

Authors: Jarvi, Nicole L., Patel, Manali, Shetty, Krithika A., Nguyen, Nhan H., Grasperge, Brooke F., Mager, Donald E., Straubinger, Robert M., Balu-Iyer, Sathy V.

Source: Frontiers in Immunology; 2024, p1-16, 16p

Subject Terms: PLASMA cells, BONE marrow cells, IMMUNE response, IMMUNOLOGICAL tolerance, DENDRITIC cells

Acellular Biologic Nipple–Areolar Complex Graft: In Vivo Murine and Nonhuman Primate Host Response Evaluation

Authors: Pashos, Nicholas C., Graham, David M., Burkett, Brian J., O'Donnell, Ben, Sabol, Rachel A., Helm, Joshua, Martin, Elizabeth C., Bowles, Annie C., Heim, William M., Caronna, Vince C., Miller, Kristin S., Grasperge, Brooke, Sullivan, Scott, Chaffin, Abigail E., Bunnell, Bruce A.

Source: Tissue engineering.Part A. 26(15/16):872-885

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154476494.0x000001&indx=1&recIds=ETOCvdc_100154476494.0x000001

The Association between IL-1β and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection and Long-Term Suppressive Antiretroviral Therapy.

Authors: Thirugnanam, Siva, Wang, Chenxiao, Zheng, Chen, Grasperge, Brooke F., Datta, Prasun K., Rappaport, Jay, Qin, Xuebin, Rout, Namita

Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 16, p8702, 14p

Subject Terms: MONONUCLEAR leukocytes, FATTY acid-binding proteins, INFLAMMATORY mediators, RHESUS monkeys, NEUROBEHAVIORAL disorders, SIMIAN immunodeficiency virus, HIV

Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model

Authors: Stahl, Elizabeth C., Bonvillain, Ryan W., Skillen, Clint D., Burger, Brandon L., Hara, Hidetaka, Lee, Whayoung, Trygg, Cynthia B., Didier, Peter J., Grasperge, Brooke F., Pashos, Nicholas C., Bunnell, Bruce A., Bianchi, John, Ayares, David L., Guthrie, Kelly I., Brown, Bryan N., Petersen, Thomas H.

Source: In Biomaterials December 2018 187:93-104

Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques.

Authors: Nemphos, Sydney M., Green, Hannah C., Prusak, James E., Fell, Sallie L., Goff, Kelly, Varnado, Megan, Didier, Kaitlin, Guy, Natalie, Moström, Matilda J., Tatum, Coty, Massey, Chad, Barnes, Mary B., Rowe, Lori A., Allers, Carolina, Blair, Robert V., Embers, Monica E., Maness, Nicholas J., Marx, Preston A., Grasperge, Brooke, Kaur, Amitinder

Source: Viruses (1999-4915); Jul2024, Vol. 16 Issue 7, p1036, 28p

Subject Terms: MONOCYTE chemotactic factor, SIMIAN immunodeficiency virus, LEUKOCYTE elastase, PATHOLOGY, RHESUS monkeys, HIV

Integrin α~4β~7 Blockade Preferentially Impacts CCR6^+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

Authors: Calenda, Giulia, Keawvichit, Rassamon, Arrode-Brusés, Géraldine, Pattanapanyasat, Kovit, Frank, Ines, Byrareddy, Siddappa N., Arthos, James, Cicala, Claudia, Grasperge, Brooke, Blanchard, James L.

Source: Journal of immunology. 200(2):810-820

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614569321&indx=1&recIds=ETOCRN614569321

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Authors: Derby, Nina, Lal, Manjari, Aravantinou, Meropi, Kizima, Larisa, Barnable, Patrick, Rodriguez, Aixa, Lai, Manshun, Wesenberg, Asa, Ugaonkar, Shweta, Levendosky, Keith, Mizenina, Olga, Kleinbeck, Kyle, Lifson, Jeffrey, Peet, M., Lloyd, Zachary, Benson, Michael, Heneine, Walid, O'Keefe, Barry, Robbiani, Melissa, Martinelli, Elena, Grasperge, Brooke, Blanchard, James, Gettie, Agegnehu, Teleshova, Natalia, Fernández-Romero, José, Zydowsky, Thomas

Source: Nature communications. 9(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183801660.0x000001&indx=1&recIds=ETOCvdc_100183801660.0x000001

A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy

Authors: Ugaonkar, Shweta R., Wesenberg, Asa, Wilk, Jolanta, Seidor, Samantha, Mizenina, Olga, Kizima, Larisa, Rodriguez, Aixa, Zhang, Shimin, Levendosky, Keith, Kenney, Jessica, Aravantinou, Meropi, Derby, Nina, Grasperge, Brooke, Gettie, Agegnehu, Blanchard, James, Kumar, Narender, Roberts, Kevin, Robbiani, Melissa, Fernández-Romero, José A., Zydowsky, Thomas M.

Source: In Journal of Controlled Release 10 September 2015 213:57-68

A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates.

Authors: Phung, Ivy, Rodrigues, Kristen A., Marina-Zárate, Ester, Maiorino, Laura, Pahar, Bapi, Lee, Wen-Hsin, Melo, Mariane, Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Lopez, Paul G., Torres, Jonathan L., Ozorowski, Gabriel, Eskandarzadeh, Saman, Kubitz, Michael, Georgeson, Erik

Source: Nature Communications; 11/4/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: IMMUNOGLOBULINS, HIV antibodies, GERMINAL centers, HUMORAL immunity, BONE marrow cells, B cells, B cell receptors

Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques.

Authors: Walker, Edith M., Merino, Kristen M., Slisarenko, Nadia, Grasperge, Brooke F., Mehra, Smriti, Roy, Chad J., Kaushal, Deepak, Rout, Namita

Source: Frontiers in Immunology; 1/16/2023, Vol. 13, p1-15, 15p, 9 Graphs

Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques.

Authors: Pahar, Bapi, Gray, Wayne, Fahlberg, Marissa, Grasperge, Brooke, Hunter, Meredith, Das, Arpita, Mabee, Christopher, Aye, Pyone Pyone, Schiro, Faith, Hensley, Krystle, Ratnayake, Aneeka, Goff, Kelly, LaBranche, Celia, Shen, Xiaoying, Tomaras, Georgia D., DeMarco, C. Todd, Montefiori, David, Kissinger, Patricia, Marx, Preston A., Traina-Dorge, Vicki

Source: Viruses (1999-4915); Dec2022, Vol. 14 Issue 12, p2819, 27p

Subject Terms: RHESUS monkeys, CELL physiology, VIRAL vaccines, CHICKENPOX, B cells, IMMUNOGLOBULINS, VACCINE effectiveness, T cells

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.

Authors: Calenda, Giulia¹, Frank, Ines¹, Arrode-Brusés, Géraldine¹, Pegu, Amarendra², Wang, Keyun², Arthos, James³, Cicala, Claudia³, Rogers, Kenneth A.⁴, Shirreff, Lisa⁴, Grasperge, Brooke⁵, Blanchard, James L.⁵, Maldonado, Stephanie¹, Roberts, Kevin¹, Gettie, Agegnehu⁶, Villinger, Francois⁴, Fauci, Anthony S.³, Mascola, John R.², Martinelli, Elena¹, emartinelli@popcouncil.org

Source: PLoS Pathogens; 5/13/2019, Vol. 15 Issue 5, p1-22, 22p

Long-primed germinal centres with enduring affinity maturation and clonal migration

Authors: Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., Crotty, Shane

Source: Nature; September 2022, Vol. 609 Issue: 7929 p998-1004, 7p

Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies.

Authors: Frank, Ines, Cigoli, Mariasole, Arif, Muhammad S., Fahlberg, Marissa D., Maldonado, Stephanie, Calenda, Giulia, Pegu, Amarendra, Yang, Eun Sung, Rawi, Reda, Chuang, Gwo-Yu, Geng, Hui, Liu, Cuiping, Zhou, Tongqing, Kwong, Peter D., Arthos, James, Cicala, Claudia, Grasperge, Brooke F., Blanchard, James L., Gettie, Agegnehu, Fennessey, Christine M.

Source: Science Translational Medicine; 8/18/2021, Vol. 13 Issue 607, p1-13, 13p

Subject Terms: SIMIAN immunodeficiency virus, MONOCLONAL antibodies, MACAQUES, INTEGRINS, RHESUS monkeys, IMMUNOGLOBULINS, VIRAL load

Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model.

Authors: Caronna, Vincent C., Rosenberg, Allison F., Graham, David M., Heim, William M., Grasperge, Brooke F., Sullivan, Scott K., Chaffin, Abigail E., Bunnell, Bruce A., Pashos, Nicholas C.

Source: Scientific Reports; 7/23/2021, Vol. 11 Issue 1, p1-10, 10p

Subject Terms: BREAST cancer, MASTECTOMY, HOMOGRAFTS, BLOOD cell count, PRIMATES as laboratory animals

Dysregulation of IL-17/IL-22 Effector Functions in Blood and Gut Mucosal Gamma Delta T Cells Correlates With Increase in Circulating Leaky Gut and Inflammatory Markers During cART-Treated Chronic SIV Infection in Macaques.

Authors: Walker, Edith M., Slisarenko, Nadia, Gerrets, Giovanni L., Grasperge, Brooke F., Mattison, Julie A., Kissinger, Patricia J., Welsh, David A., Veazey, Ronald S., Jazwinski, S. Michal, Rout, Namita

Source: Frontiers in Immunology; 2/25/2021, Vol. 11, pN.PAG-N.PAG, 18p

Subject Terms: T cells, LYMPHOCYTE subsets, MACAQUES, CYTOKINES, PREMATURE aging (Medicine), IMMUNE reconstitution inflammatory syndrome, INTERLEUKIN-9, INTERLEUKIN-7

Once-Weekly Oral Dosing of MK-8591 Protects Male Rhesus Macaques From Intrarectal Challenge With SHIV109CP3.

Authors: Markowitz, Martin, Gettie, Agegnehu, Bernard, Leslie St., Andrews, Chasity D, Mohri, Hiroshi, Horowitz, Amir, Grasperge, Brooke F, Blanchard, James L, Niu, Tao, Sun, Li, Fillgrove, Kerry, Hazuda, Daria J, Grobler, Jay A, St Bernard, Leslie

Source: Journal of Infectious Diseases; 5/1/2020, Vol. 221 Issue 9, p1398-1406, 9p

Subject Terms: RHESUS monkeys, LOG-rank test, HIV

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

Authors: Arrode-Brusés, Géraldine¹, Goode, Diana¹, Kleinbeck, Kyle¹, Wilk, Jolanta¹, Frank, Ines¹, Byrareddy, Siddappa², Arthos, James³, Grasperge, Brooke⁴, Blanchard, James⁴, Zydowsky, Thomas¹, Gettie, Agegnehu⁵, Martinelli, Elena¹, emartinelli@popcouncil.org

Source: PLoS Pathogens; 6/27/2016, Vol. 12 Issue 6, p1-27, 27p

Acellular Biologic Nipple–Areolar Complex Graft: In VivoMurine and Nonhuman Primate Host Response Evaluation

Authors: Pashos, Nicholas C., Graham, David M., Burkett, Brian J., O'Donnell, Ben, Sabol, Rachel A., Helm, Joshua, Martin, Elizabeth C., Bowles, Annie C., Heim, William M., Caronna, Vince C., Miller, Kristin S., Grasperge, Brooke, Sullivan, Scott, Chaffin, Abigail E., Bunnell, Bruce A.

Source: Tissue Engineering: Part A; August 2020, Vol. 26 p872-885, 14p

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