Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

Authors: Hernandez-Pacheco, Natalia, Kilanowski, Anna, Kumar, Ashish, Curtin, John A., Olvera, Núria, Kress, Sara, Bertels, Xander, Lahousse, Lies, Bhatta, Laxmi, Granell, Raquel, Marí, Sergi, Bilbao, Jose Ramon, Sun, Yidan, Tingskov Pedersen, Casper-Emil, Karramass, Tarik, Thiering, Elisabeth, Dardani, Christina, Kebede Merid, Simon, Wang, Gang, Hallberg, Jenny, Koch, Sarah, Garcia-Aymerich, Judith, Esplugues, Ana, Torrent, Maties, Ibarluzea, Jesus, Lowe, Lesley, Simpson, Angela, Gehring, Ulrike, Vermeulen, Roel C.H., Roberts, Graham, Bergström, Anna, Vonk, Judith M., Felix, Janine F., Duijts, Liesbeth, Bønnelykke, Klaus, Timpson, Nic, Brusselle, Guy, Brumpton, Ben M., Langhammer, Arnulf, Turner, Stephen, Holloway, John W., Arshad, Syed Hasan, Ullah, Anhar, Custovic, Adnan, Cullinan, Paul, Murray, Clare S., van den Berge, Maarten, Kull, Inger, Schikowski, Tamara, Wedzicha, Jadwiga A., Koppelman, Gerard, Faner, Rosa, Agustí, Àlvar, Standl, Marie, Melén, Erik

Source: In eClinicalMedicine September 2024 75

Lung-function trajectories: relevance and implementation in clinical practice

Authors: Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin, Melén, Erik ^{*, *}, Faner, Rosa ^*, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, Agusti, Alvar

Source: In The Lancet 13-19 April 2024 403(10435):1494-1503

Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies

Authors: Ainsworth, John, Couch, Philip, Cullinan, Paul, Devereux, Graham, Woodcock, Ashley, Ullah, Anhar, Granell, Raquel, Haider, Sadia, Lowe, Lesley, Fontanella, Sara, Arshad, Hasan, Murray, Clare S., Turner, Steve, Holloway, John W., Simpson, Angela, Roberts, Graham, Custovic, Adnan

Source: In eClinicalMedicine January 2024 67

Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers

Authors: Tutino, Mauro, Granell, Raquel, Curtin, John A., Haider, Sadia, Fontanella, Sara, Murray, Clare S., Roberts, Graham, Arshad, S. Hasan, Turner, Stephen, Morris, Andrew P., Custovic, Adnan, Simpson, Angela

Source: Journal of allergy and clinical immunology. 151(2):423-430

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180520914.0x000001&indx=1&recIds=ETOCvdc_100180520914.0x000001

Identification of OCA2 as a novel locus for the co‐morbidity of asthma‐plus‐eczema

Authors: Margaritte‐Jeannin, Patricia, Budu‐Aggrey, Ashley, Ege, Markus, Madore, Anne‐Marie, Linhard, Christophe, Mohamdi, Hamida, Mutius, Erika, Granell, Raquel, Demenais, Florence, Laprise, Catherine, Bouzigon, Emmanuelle, Dizier, Marie‐Hélène

Source: Clinical & experimental allergy. 52(1):70-81

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138804940.0x000001&indx=1&recIds=ETOCvdc_100138804940.0x000001

Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK Biobank cohort analysis

Authors: Higbee, Daniel H, Granell, Raquel, Davey Smith, George, Dodd, James W

Source: Lancet.Respiratory medicine. 10(2):149-157

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154752870.0x000001&indx=1&recIds=ETOCvdc_100154752870.0x000001

Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates

Authors: Haider, Sadia, Granell, Raquel, Curtin, John, Fontanella, Sara, Cucco, Alex, Turner, Stephen, Simpson, Angela, Roberts, Graham, Murray, Clare S., Holloway, John W.

Source: American journal of respiratory and critical care medicine. 205(8):883-893

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629290369&indx=1&recIds=ETOCRN629290369

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index

Authors: Hartley, April, Sanderson, Eleanor, Granell, Raquel, Paternoster, Lavinia, Zheng, Jie, Smith, George Davey, Southam, Lorraine, Hatzikotoulas, Konstantinos, Boer, Cindy G, van Meurs, Joyce, Zeggini, Eleftheria, Gregson, Celia L, Tobias, Jon H

Source: International journal of epidemiology. 51(4):1254-1267

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157433263.0x000001&indx=1&recIds=ETOCvdc_100157433263.0x000001

High Insulin in Early Childhood Is Associated with Subsequent Asthma Risk Independent of Body Mass Index

Authors: Carr, Tara F., Granell, Raquel, Stern, Debra A., Guerra, Stefano, Wright, Anne, Halonen, Marilyn, Henderson, John, Martinez, Fernando D.

Source: In The Journal of Allergy and Clinical Immunology: In Practice March 2022 10(3):785-792

Are single‐nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese‐asthma in children?

Authors: Longo, Cristina, Chiv, Richard, Xu, Zhongli, Forno, Erick, Chen, Wei, Boeck, Andreas, Granell, Raquel, Salvermoser, Michael, Schaub, Bianca, Celedón, Juan C., Turner, Stephen, Vijverberg, Susanne, Maitland‐van der Zee, Anke H.

Source: Pediatric Allergy & Immunology; Nov2024, Vol. 35 Issue 11, p1-5, 5p

Subject Terms: ASTHMA in children, OVERWEIGHT children, SINGLE nucleotide polymorphisms, REGULATOR genes, RANDOM effects model, ASTHMATICS

Residential greenspace and lung function up to 24 years of age: The ALSPAC birth cohort

Authors: Fuertes, Elaine, Markevych, Iana, Thomas, Richard, Boyd, Andy, Granell, Raquel, Mahmoud, Osama, Heinrich, Joachim, Garcia-Aymerich, Judith, Roda, Célina, Henderson, John, Jarvis, Debbie

Source: In Environment International July 2020 140

Causes of variability in latent phenotypes of childhood wheeze

Authors: Oksel, Ceyda, Granell, Raquel, Mahmoud, Osama, Custovic, Adnan, Henderson, A. John

Source: In The Journal of Allergy and Clinical Immunology May 2019 143(5):1783-1790

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Authors: Ferreira, Manuel A.R., Mathur, Riddhima, Vonk, Judith M., Szwajda, Agnieszka, Brumpton, Ben, Granell, Raquel, Brew, Bronwyn K., Ullemar, Vilhelmina, Lu, Yi, Jiang, Yunxuan, Magnusson, Patrik K.E., Karlsson, Robert, Hinds, David A., Paternoster, Lavinia, Koppelman, Gerard H., Almqvist, Catarina

Source: In The American Journal of Human Genetics 4 April 2019 104(4):665-684

Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort

Authors: Cai, Yutong, Hansell, Anna L., Granell, Raquel, Blangiardo, Marta, Zottoli, Mariagrazia, Fecht, Daniela, Gulliver, John, Henderson, A. John, Elliott, Paul

Source: American journal of respiratory and critical care medicine. 202(1):112-123

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624211090&indx=1&recIds=ETOCRN624211090

The Simple 10-Item Predicting Asthma Risk in Children Tool to Predict Childhood Asthma—An External Validation

Authors: Pedersen, Eva S.L., Spycher, Ben D., de Jong, Carmen C.M., Halbeisen, Florian, Ramette, Alban, Gaillard, Erol A., Granell, Raquel, Henderson, A. John, Kuehni, Claudia E.

Source: In The Journal of Allergy and Clinical Immunology: In Practice March 2019 7(3):943-953

Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk.

Authors: Granell, Raquel, Haider, Sadia, Deliu, Matea, Ullah, Anhar, Mahmoud, Osama, Fontanella, Sara, Lowe, Lesley, Simpson, Angela, Dodd, James William, Arshad, Seyed Hasan, Murray, Clare S., Roberts, Graham, Hughes, Alun, Park, Chloe, Holloway, John W., Custovic, Adnan

Source: Thorax; Aug2024, Vol. 79 Issue 8, p770-777, 40p

Subject Terms: STROKE volume (Cardiac output), LIFE sciences, VASCULAR remodeling, VITAL capacity (Respiration), FORCED expiratory volume, WHEEZE, ATOPY, BREASTFEEDING promotion

Mid‐childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C‐reactive protein.

Authors: Peralta, Gabriela P.^1,2,3,4 (AUTHOR) gabriela.peralta@isglobal.org, Granell, Raquel⁵ (AUTHOR), Bédard, Annabelle⁶ (AUTHOR), Carsin, Anne‐Elie^1,2,3,7 (AUTHOR), Fuertes, Elaine^8,9 (AUTHOR), Howe, Laura D.⁵ (AUTHOR), Márquez, Sandra^1,2,3 (AUTHOR), Jarvis, Deborah L.^8,9 (AUTHOR), Garcia‐Aymerich, Judith^1,2,3 (AUTHOR)

Source: Pediatric Allergy & Immunology. Dec2022, Vol. 33 Issue 12, p1-8. 8p.

Subject Terms: *ADIPOSE tissues, *INSULIN resistance, *C-reactive protein, *AIR flow, *EXPIRATORY flow

Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies

Authors: Belgrave, Danielle C M, Granell, Raquel, Turner, Steve W, Curtin, John A, Buchan, Iain E, Le Souëf, Peter N, Simpson, Angela, Henderson, A John ^*, Custovic, Adnan

Source: In The Lancet Respiratory Medicine July 2018 6(7):526-534

Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis

Authors: Clark, Hannah, Granell, Raquel, Curtin, John A., Belgrave, Danielle, Simpson, Angela, Murray, Clare, Henderson, A. John, Custovic, Adnan, Paternoster, Lavinia

Source: Clinical & experimental allergy. 49(11):1475-1486

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103170585.0x000001&indx=1&recIds=ETOCvdc_100103170585.0x000001

Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study

Authors: Peralta, Gabriela P., Fuertes, Elaine, Granell, Raquel, Mahmoud, Osama, Roda, Célina, Serra, Ignasi, Jarvis, Deborah, Henderson, John, Garcia-Aymerich, Judith

Source: American journal of respiratory and critical care medicine. 200(1):75-83

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620679778&indx=1&recIds=ETOCRN620679778